287
Views
22
CrossRef citations to date
0
Altmetric
Review Articles

Antioxidant, Anti-inflammatory, and Genomic Stability Enhancement Effects of Zinc l-carnosine: A Potential Cancer Chemopreventive Agent?

, &
Pages 201-210 | Received 19 Jul 2016, Accepted 04 Nov 2016, Published online: 17 Jan 2017

References

  • Stewart BW and Wild CP: World Cancer Report 2014. International Agency for Research on Cancer, Lyon, France, 2014.
  • Bradley CJ, Yabroff KR, Dahman B, Feuer EJ, Mariotto A, et al.: Productivity costs of cancer mortality in the United States: 2000–2020. J Natl Cancer Inst 100, 1763–1770, 2008.
  • Yabroff KR, Bradley CJ, Mariotto AB, Brown ML, and Feuer EJ: Estimates and projections of value of life lost from cancer deaths in the United States. J Natl Cancer Inst 100, 1755–1762, 2008.
  • Yabroff KR, Lund J, Kepka D, and Mariotto A: Economic burden of cancer in the United States: estimates, projections, and future research. Cancer Epidemiol Biomarkers Prev 20, 2006–2014, 2011.
  • Drummond MF and Mason AR: European perspective on the costs and cost-effectiveness of cancer therapies. J Clin Oncol 25, 191–195, 2007.
  • Bach PB: Limits on Medicare's ability to control rising spending on cancer drugs. N Engl J Med 360, 626–633, 2009.
  • Neumann PJ, Palmer JA, Nadler E, Fang C, and Ubel P: Cancer therapy costs influence treatment: a national survey of oncologists. Health Aff (Millwood) 29, 196–202, 2010.
  • Galmarini D, Galmarini CM, and Galmarini FC: Cancer chemotherapy: a critical analysis of its 60 years of history. Crit Rev Oncol Hematol 84, 181–199, 2012.
  • Morgan G, Ward R, and Barton M: The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol) 16, 549–560, 2004.
  • DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, et al.: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin 64, 252–271, 2014.
  • Bhosle J and Hall G: Principles of cancer treatment by chemotherapy. Surgery (Oxford) 27, 173–177, 2009.
  • Fisher R, Pusztai L, and Swanton C: Cancer heterogeneity: implications for targeted therapeutics. Br J Cancer 108, 479–485, 2013.
  • Rebucci M and Michiels C: Molecular aspects of cancer cell resistance to chemotherapy. Biochem Pharmacol 85, 1219–1226, 2013.
  • Marusyk A and Polyak K: Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 1805, 105–117, 2010.
  • Steward WP and Brown K: Cancer chemoprevention: a rapidly evolving field. Br J Cancer 109, 1–7, 2013.
  • Sporn MB and Suh N: Chemoprevention of cancer. Carcinogenesis 21, 525–530, 2000.
  • Cuzick J, Forbes JF, Sestak I, Cawthorn S, Hamed H, et al.: Long-term results of tamoxifen prophylaxis for breast cancer—96-month follow-up of the randomized IBIS-I trial. J Natl Cancer Inst 99, 272–282, 2007.
  • Cuzick J, Sestak I, Cawthorn S, Hamed H, Holli K, et al.: Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial. Lancet Oncol 16, 67–75, 2015.
  • Reddy BS, Hirose Y, Lubet R, Steele V, Kelloff G, et al.: Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res 60, 293–297, 2000.
  • Reddy BS, Patlolla JM, Simi B, Wang SH, and Rao CV: Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids. Cancer Res 65, 8022–8027, 2005.
  • Matsukura T, Takahashi T, Nishimura Y, Ohtani T, Sawada M, et al.: Characterization of crystalline l-carnosine Zn(II) complex (Z-103), a novel anti-gastric ulcer agent: tautomeric change of imidazole moiety upon complexation. Chem Pharm Bull (Tokyo) 38, 3140–3146, 1990.
  • Salgueiro MJ, Zubillaga M, Lysionek A, Sarabia MI, Caro R, et al.: Zinc as an essential micronutrient: a review. Nutr Res 20, 737–755, 2000.
  • Boldyrev AA, Aldini G, and Derave W: Physiology and pathophysiology of carnosine. Physiol Rev 93, 1803–1845, 2013.
  • Ueki S, Seiki M, Yoneta T, Omata T, Hori Y, et al.: Effect of Z-103 on compound 48/80-induced gastric lesions in rats. Scand J Gastroenterol Suppl 162, 202–205, 1989.
  • Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Yasuda M, et al.: Effect of zinc-carnosine chelate compound (Z-103), a novel antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Free Radic Res Commun 14, 289–296, 1991.
  • Yoshikawa T, Yamaguchi T, Yoshida N, Yamamoto H, Kitazumi S, et al.: Effect of Z-103 on TNB-induced colitis in rats. Digestion 58, 464–468, 1997.
  • Ohkawara T, Takeda H, Kato K, Miyashita K, Kato M, et al.: Polaprezinc (N-(3-aminopropionyl)-l-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice. Scand J Gastroenterol 40, 1321–1327, 2005.
  • Yamaguchi M and Kishi S: Prolonged administration of beta-alanyl-l-histidinato zinc prevents bone loss in ovariectomized rats. Jpn J Pharmacol 63, 203–207, 1993.
  • Yamaguchi M: beta-Alanyl-l-histidinato zinc and bone resorption. Gen Pharmacol 26, 1179–1183, 1995.
  • Kato S, Tanaka A, Ogawa Y, Kanatsu K, Seto K, et al.: Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats—role of insulin-like growth factors (IGF)-1. Med Sci Monit 7, 20–25, 2001.
  • Seto K, Yoneta T, Suda H, and Tamaki H: Effect of polaprezinc (N-(3-aminopropionyl)-l-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor I. Biochem Pharmacol 58, 245–250, 1999.
  • Matsuoka S, Matsumura H, Nakamura H, Oshiro S, Arakawa Y, et al.: Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis. J Clin Biochem Nutr 45, 292–303, 2009.
  • Matsumura H, Nirei K, Nakamura H, Arakawa Y, Higuchi T, et al.: Zinc supplementation therapy improves the outcome of patients with chronic hepatitis C. J Clin Biochem Nutr 51, 178–184, 2012.
  • Sakagami M, Ikeda M, Tomita H, Ikui A, Aiba T, et al.: A zinc-containing compound, polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study. Acta Otolaryngol 129, 1115–1120, 2009.
  • Ikeda M, Kurono Y, Inokuchi A, Takeda N, Aiba T, et al.: The effect of zinc agent in 219 patients with zinc deficiency-inductive/idiopathic taste disorder: a placebo controlled randomized study. Nippon Jibiinkoka Gakkai Kaiho 116, 17–26, 2013.
  • Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, and Kondo M: The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-l-histidinato zinc. Biochim Biophys Acta 1115, 15–22, 1991.
  • Hiraishi H, Sasai T, Oinuma T, Shimada T, Sugaya H, et al.: Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacol Ther 13, 261–269, 1999.
  • Shimada T, Watanabe N, Ohtsuka Y, Endoh M, Kojima K, et al.: Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells. J Pharmacol Exp Ther 291, 345–352, 1999.
  • Ohata S, Moriyama C, Yamashita A, Nishida T, Kusumoto C, et al.: Polaprezinc protects mice against endotoxin shock. J Clin Biochem Nutr 46, 234–243, 2010.
  • Sharif R, Thomas P, Zalewski P, Graham RD, and Fenech M: The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line. Mutat Res 720, 22–33, 2011.
  • Sharif R, Thomas P, Zalewski P, and Fenech M: Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells. Genes Nutr 7, 139–154, 2012.
  • Ooi TC, Mohammad NH, and Sharif R: Zinc carnosine protects against hydrogen peroxide-induced DNA damage in WIL2-NS lymphoblastoid cell line independent of poly (ADP-ribose) polymerase expression. Biol Trace Elem Res 162, 8–17, 2014.
  • Sharif R, Thomas P, Zalewski P, and Fenech M: Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Mol Nutr Food Res 59, 1200–1212, 2015.
  • Klaunig JE and Kamendulis LM: The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44, 239–267, 2004.
  • Multhoff G, Molls M, and Radons J: Chronic inflammation in cancer development. Front Immunol 2, 98, 2011.
  • Shen Z: Genomic instability and cancer: an introduction. J Mol Cell Biol 3, 1–3, 2011.
  • Powell SR: The antioxidant properties of zinc. J Nutr 130, 1447s–1454s, 2000.
  • Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Oyamada H, et al.: Effect of zinc-carnosine chelate compound (Z-103) on burn-induced gastric mucosal injury in rats. J Clin Biochem Nutr 7, 107–113, 1989.
  • Ito M, Shii D, Segami T, Kojima R, and Suzuki Y: Preventive actions of N-(3-aminopropionyl)-l-histidinato zinc (Z-103) through increases in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol-induced gastric mucosal damage in rats. Jpn J Pharmacol 59, 267–274, 1992.
  • Choi HS, Lim JY, Chun HJ, Lee M, Kim ES, et al.: The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide. Life Sci 93, 69–77, 2013.
  • Ueda K, Ueyama T, Oka M, Ito T, Tsuruo Y, et al.: Polaprezinc (zinc l-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1—a new mechanism of gastric mucosal protection. J Pharmacol Sci 110, 285–294, 2009.
  • Gozzelino R, Jeney V, and Soares MP: Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50, 323–354, 2010.
  • Ohkawara T, Nishihira J, Nagashima R, Takeda H, and Asaka M: Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins. World J Gastroenterol 12, 6178–6181, 2006.
  • Feder ME and Hofmann GE: Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol 61, 243–282, 1999.
  • Li Y and Maret W: Human metallothionein metallomics. J Anal At Spectrom 23, 1055, 2008.
  • Ruttkay-Nedecky B, Nejdl L, Gumulec J, Zitka O, Masarik M, et al.: The role of metallothionein in oxidative stress. Int J Mol Sci 14, 6044–6066, 2013.
  • Matsukura T and Tanaka H: Applicability of zinc complex of l-carnosine for medical use. Biochemistry (Mosc) 65, 817–823, 2000.
  • Naito Y, Yoshikawa T, Yagi N, Matsuyama K, Yoshida N, et al.: Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis Sci 46, 845–851, 2001.
  • Suzuki H, Mori M, Seto K, Miyazawa M, Kai A, et al.: Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils—a study using intravital videomicroscopy. Aliment Pharmacol Ther 15, 715–725, 2001.
  • Ishihara R, Iishi H, Sakai N, Yano H, Uedo N, et al.: Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils. Helicobacter 7, 384–389, 2002.
  • Handa O, Yoshida N, Tanaka Y, Ueda M, Ishikawa T, et al.: Inhibitory effects of polaprezine on the inflammatory response to Helicobacter pylori. Can J Gastroenterol 16, 785–789, 2002.
  • Lawrence T: The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1, a001651, 2009.
  • Odashima M, Otaka M, Jin M, Wada I, Horikawa Y, et al.: Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation. Life Sci 79, 2245–2250, 2006.
  • Ooi TC, Chan KM, and Sharif R: Zinc carnosine inhibits lipopolysaccharide-induced inflammatory mediators by suppressing NF-kappaB activation in raw 264.7 macrophages, independent of the MAPKs signaling pathway. Biol Trace Elem Res 172, 458–464, 2016.
  • Yoo CG, Lee S, Lee CT, Kim YW, Han SK, et al.: Anti-inflammatory effect of heat shock protein induction is related to stabilization of I B through preventing I B kinase activation in respiratory epithelial cells. J Immunol 164, 5416–5423, 2000.
  • King TA, Ghazaleh RA, Juhn SK, Adams GL, and Ondrey FG: Induction of heat shock protein 70 inhibits NF-kappa-B in squamous cell carcinoma. Otolaryngol Head Neck Surg 133, 70–79, 2005.
  • Tang D, Kang R, Xiao W, Wang H, Calderwood SK, et al.: The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol 179, 1236–1244, 2007.
  • Kryston TB, Georgiev AB, Pissis P, and Georgakilas AG: Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711, 193–201, 2011.
  • Hoesel B and Schmid JA: The complexity of NF-kappaB signaling in inflammation and cancer. Mol Cancer 12, 86, 2013.
  • Sharma S, Kelly TK, and Jones PA: Epigenetics in cancer. Carcinogenesis 31, 27–36, 2010.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.