Guaraná, a Highly Caffeinated Food, Presents in vitro Antitumor Activity in Colorectal and Breast Cancer Cell Lines by Inhibiting AKT/mTOR/S6K and MAPKs Pathways

References

• Tanaka S, Hosokawa M, Yonezawa T, Hayashi W, Ueda K, et al.: Induction of epithelial-mesenchymal transition and down-regulation of miR-200c and miR-141 in oxaliplatin-resistant colorectal cancer cells. Biol Pharm Bull 38, 435–440, 2015.
   PubMed Web of Science ®Google Scholar
• Wang T, Srivastava S, Hartman M, Buhari SA, Chan CW, et al.: High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer. Oncotarget 2016, 1–14, 2016.
   Google Scholar
• Pópulo H, Lopes JM, and Soares P: The mTOR signaling pathway in human cancer. Int J Mol Sci 13, 1886–1918, 2012.
   PubMed Web of Science ®Google Scholar
• Dhillon AS, Hagan S, Rath O, and Kolch W: MAP kinase signaling pathways in cancer. Oncogene 26, 3279–3290. 2007.
   PubMed Web of Science ®Google Scholar
• Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell 149, 274–293, 2012.
   PubMed Web of Science ®Google Scholar
• Zhou H, Luo Y, and Huang S: Updates of mTOR inhibitors. Anticancer Agents Med Chem 10, 571–581, 2010.
   PubMed Web of Science ®Google Scholar
• Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, et al.: Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 7, 176–187, 2011.
   PubMed Web of Science ®Google Scholar
• Son Y, Cheong Y, Kim N, Chung H, Kang DG, et al.: Mitogen-activated protein kinases and reactive oxygen species: How can ROS activate MAPK pathways? J Signal Transduct 2011, 1–6, 2011.
   Google Scholar
• Zarubin T and Han J: Activation and signaling of the p38 MAP kinase pathway. Cell Res 15, 11–18, 2005.
   PubMed Web of Science ®Google Scholar
• Deguchi H, Fujii T, and Nakagawa S: Analysis of cell growth inhibitory effects of catechin through the MAPK human breast cancer cell line T47D. Int J Oncol 21, 1301–1305, 2003.
   Web of Science ®Google Scholar
• Cheng YC, Ding YM, Hueng DY, Chen JY, and Chen Y: Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway. J Nutr Biochem 33, 63–72, 2016.
   PubMed Web of Science ®Google Scholar
• Schimpl FC, da Silva JF, Gonçalves JF, and Mazzafera P: Guarana: revisiting a highly caffeinated plant from the Amazon. J Ethnopharmacol 28, 14–31, 2013.
   Web of Science ®Google Scholar
• Fukumasu H, da Silva TC, Avanzo JL, de Lima CE, Mackowiak II, et al.: Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepato carcinogenesis. Cancer Lett 1, 158–164, 2006.
   Web of Science ®Google Scholar
• Fukumasu H, Avanzo JL, Nagamine MK, Barbuto JA, Rao KV, et al.: Paullinia cupana Mart var. sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice. Braz J Med Biol Res 41, 305–310, 2008.
   PubMed Web of Science ®Google Scholar
• Fukumasu H, Latorre AO, and Zaidan-Dagli ML: Paullinia cupana Mart. var. sorbilis, guaraná, increases survival of Ehrlich ascites carcinoma (EAC) bearing mice by decreasing cyclin-D1 expression and inducing a G0/G1 cell cycle arrest in EAC cells. Phytother Res 25, 11–16, 2010.
   Web of Science ®Google Scholar
• Cadoná FC, Machado AK, Azzolin VF, Barbisan F, Dornelles EB, et al.: Guaraná a richest caffeine food increase oxaliplatin sensitivity of colorectal HT-29 cells by apoptosis pathway modulation. Anticancer Agents Med Chem 16, 1055–1065, 2015.
   Web of Science ®Google Scholar
• Hertz E, Cadoná FC, Machado AK, Azzolin V, Holmrich S, et al.: Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs. Mol Clin Oncol 3, 37–4320, 2014.
   PubMedGoogle Scholar
• Bittencourt LS, Machado DC, Machado MM, Dos Santos GF, Algarve TD, et al.: The protective effects of guaraná extract (Paullinia cupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside. Food Chem Toxicol 53, 119–125, 2013.
   PubMed Web of Science ®Google Scholar
• Reynertson KA, Balick MJ, Lee R, Raynor W, Pelep Y, et al.: A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpean tea. J Ethnopharmacol 102, 269–742, 2005.
   PubMed Web of Science ®Google Scholar
• Sharma OP and Bhat TK: DPPH antioxidant assay revisited. Food Chem 113, 1202–1205, 2009.
   Web of Science ®Google Scholar
• Cadoná FC, Manica-Cattani MF, Machado AK, Oliveira RM, Flôres ERS, et al.: Genomodifier capacity assay: a non-cell test using dsDNA molecules to evaluate the genotoxic/genoprotective properties of chemical compounds. Anal Methods 6, 8559–8568, 2014.
   Web of Science ®Google Scholar
• Cubillos-Rojas M, Amair-Pinedo F, Peiró-Jordán R, Bartrons R, Ventura F, et al.: The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization. J Biol Chem 289, 14782–14795, 2014.
   PubMed Web of Science ®Google Scholar
• Cubillos-Rojas M, Amair-Pinedo F, Tato I, Bartrons R, Ventura F, et al.: Tris-acetate polyacrylamide gradient gels for the simultaneous electrophoretic analysis of proteins of very high and low molecular mass. Methods Mol Biol 869, 205–213, 2012.
   PubMedGoogle Scholar
• Casas-terradellas E, Tato I, Bartrons R, Ventura F, and Rosa JL: ERK and p38 pathways regulate amino acid signalling. Mol Cell Res 1783, 2241–2254, 2008.
   PubMed Web of Science ®Google Scholar
• Zhao X, Huang S, Luo H, Wan X, Gui Y, et al.: Evaluation of vesicular stomatitis virus mutant as an oncolytic agent against prostate cancer. Int J Clin Exp Med 15, 1204–1213, 2014.
   Google Scholar
• Fukui M, Yamabe N, and Zhu BT: Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer 46, 1882–1891, 2010.
   PubMed Web of Science ®Google Scholar
• William-Faltaos S, Rouillard D, Lechat P, and Bastian G: Cell cycle arrest and apoptosis induced by oxaliplatin (L-OHP) on four human cancer cell lines. Anticancer Res 26, 2093–2099, 2006.
   PubMed Web of Science ®Google Scholar
• Sun F, Han DF, Cao BQ, Wang B, Dong N, et al.: Caffeine-induced nuclear translocation of FoxO1 triggers Bim-mediated apoptosis in human glioblastoma cells. Tumour Biol 37, 3417–3423, 2016.
   PubMed Web of Science ®Google Scholar
• Luo X, Yu X, Liu S, Deng Q, Liu X, et al.: The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy. Oncol Rep 34, 547–554, 2015.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Tang J, Du Y, Ding J, and Liu JY: The green tea polyphenol EGCG potentiates the antiproliferative activity of sunitinib in human cancer cells. Tumour Biol 37, 8555–8566, 2016.
   PubMed Web of Science ®Google Scholar
• Kyaw M, Yoshizumi M, Tsuchiya K, Kirima K, and Tamaki T: Antioxidants inhibit JNK and p38 MAPK activation but not ERK 1/2 activation by angiotensin II in rat aortic smooth muscle cells. Hypertens Res 24, 251–261, 2001.
   PubMed Web of Science ®Google Scholar
• Shyu PT, Oyong GG, and Cabrera EC: Cytotoxicity of probiotics from Philippine commercial dairy products on cancer cells and the effect on expression of cfos and cjun early apoptotic-promoting genes and Interleukin-1 β and Tumor Necrosis Factor-α proinflammatory cytokine genes. Biomed Res Int 2014, 1–9, 2014.
   Web of Science ®Google Scholar
• Alexander E, Hildebrand DG, Kriebs A, Obermayer K, Manz M, et al.: IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence. J Cell Sci 126, 3738–3745, 2013.
   PubMed Web of Science ®Google Scholar
• Deng Y: Inhibitory effect of bleomycin A6 on human colon cancer xenografts in nude mice. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 12, 335–340, 1990.
   PubMedGoogle Scholar
• Hasty P, Sharp ZD, Curiel TJ, and Campisi J: mTORC1 and p53: clash of the gods? Cell Cycle 12, 20–25, 2013.
   PubMed Web of Science ®Google Scholar
• Aller GSV, Carson JD, Tang W, Peng H, Zhao L, et al.: Biochemical and Biophysical Research Communications Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun 406, 194–199, 2011.
   PubMed Web of Science ®Google Scholar
• Liu S, Wang XJ, Liu Y, and Cui YF: PI3K/AKT/mTOR signaling is involved in (−)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells. Am J Chin Med 41, 629–642, 2013.
   PubMed Web of Science ®Google Scholar
• Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, et al.: Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B. Nutr Cancer 66, 419–423, 2014.
   PubMed Web of Science ®Google Scholar
• Dong S, Kong J, Kong J, Shen Q, Kong F, et al.: Low concentration of caffeine inhibits the progression of hepatocellular carcinoma via the Akt signaling pathway. Anticancer Agents Med Chem 15, 484–492, 2015.
   PubMed Web of Science ®Google Scholar
• Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, et al.: Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 7, 176–187, 2011.
   PubMed Web of Science ®Google Scholar
• D'Angelo L, Piazzi G, Pacilli A, Prossomariti A, Fazio CA, et al.: Combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells. Carcinogenesis 35, 2314–2320, 2014.
   PubMed Web of Science ®Google Scholar
• Fernandes R, Mazzarello S, Stober C, Vandermeer L, Dudani S, et al.: Optimal primary febrile neutropenia prophylaxis for patients receiving docetaxel-cyclophosphamide chemotherapy for breast cancer: a systematic review. Breast Cancer Res Treat 161, 1–10, 2017.
   PubMed Web of Science ®Google Scholar
• Basile A, Ferrara L, Pezzo MD, Mele G, Sorbo S, et al.: Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana Mart. J Ethnopharmacol 102, 32–36, 2005.
   PubMed Web of Science ®Google Scholar
• de Oliveira DM, Barreto G, Galeano P, Romero JI, Holubiec MI, et al.: Paullinia cupana Mart. var. Sorbilis protects human dopaminergic neuroblastoma SH-SY5Y cell line against rotenone-induced cytotoxicity. Hum Exp Toxicol 30, 1382–1391, 2011.
   PubMed Web of Science ®Google Scholar
• Mattei R, Dias R, Espínola E, Carlini E, and Barros SB: Guarana (Paullinia cupana): toxic behavioral effects in laboratory animals and antioxidant activity in vitro. J Ethnopharmacol 60, 111–116, 1998.
   PubMed Web of Science ®Google Scholar
• Santa Maria A, Lopez A, Diaz MM, Muñoz-Mingarro D, and Pozuelo JM: Evaluation of the toxicity of guarana with in vitro bioassays. Ecotoxicol Environ Saf 39, 164–167, 1998.
   PubMed Web of Science ®Google Scholar
• Bittencourt LS, Machado DC, Machado MM, Santos GFF, Algarve TD, et al.: The protective effects of guaraná extract (Paullinia cupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside. Food Chem Toxicol 53, 119–125, 2013.
   PubMed Web of Science ®Google Scholar
• de Oliveira Campos MP, Riechelmann R, Martins LC, Hassan BJ, Casa FB, et al.: Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy. J Altern Complement Med 17, 505–512, 2011.
   PubMed Web of Science ®Google Scholar