Development and Characterization of a Novel Congenic Rat Strain for Obesity and Cancer Research

References

• Ogden CL, Carroll MD, Kit BK, and Flegal KM: Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311, 806–814, 2014. doi:10.1001/jama.2014.732.
   PubMed Web of Science ®Google Scholar
• Calle EE and Kaaks R: Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4, 579–591, 2004. doi:10.1038/nrc1408.
   PubMed Web of Science ®Google Scholar
• Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, and Bianchini F, et al.: Body fatness and cancer—viewpoint of the IARC working group. New Engl J Med 375, 794–798, 2016. doi:10.1056/NEJMsr1606602.
   PubMed Web of Science ®Google Scholar
• Campbell PT, Newton CC, Dehal AN, Jacobs EJ, and Patel AV, et al.: Impact of body mass index on survival after colorectal cancer diagnosis: the cancer prevention study-II nutrition cohort. J Clin Oncol 30, 42–52, 2012. doi:10.1200/JCO.2011.38.0287.
   PubMed Web of Science ®Google Scholar
• Durko L and Malecka-Panas E: Lifestyle modifications and colorectal cancer. Curr Colorectal Cancer Rep 10, 45–54, 2014. doi:10.1007/s11888-013-0203-4.
   PubMedGoogle Scholar
• Fujisawa T, Endo H, Tomimoto A, Sugiyama M, and Takahashi H, et al.: Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 57, 1531–1538, 2008. doi:10.1136/gut.2008.159293.
   PubMed Web of Science ®Google Scholar
• Boddicker RL, Whitley E, Birt DF, and Spurlock ME: Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice. Nutr Cancer 63, 1297–1306, 2011. doi:10.1080/01635581.2011.606954.
   PubMed Web of Science ®Google Scholar
• Yakar S, Nunez NP, Pennisi P, Brodt P, and Sun H, et al.: Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology 147, 5826–5834, 2006. doi:10.1210/en.2006-0311.
   PubMed Web of Science ®Google Scholar
• Rondini EA, Harvey AE, Steibel JP, Hursting SD, and Fenton JI: Energy balance modulates colon tumor growth: interactive roles of insulin and estrogen. Mol Carcinog 50, 370–382, 2011. doi:10.1002/mc.20720.
   PubMed Web of Science ®Google Scholar
• Flores MB, Rocha GZ, Damas-Souza DM, Osorio-Costa F, and Dias MM, et al.: Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice. Gastroenterology 143, 741–753 e1-4, 2012. doi:10.1053/j.gastro.2012.05.045.
   PubMed Web of Science ®Google Scholar
• Park H, Kim M, Kwon GT, Lim do Y, Yu R, et al.: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. Mol Carcinog 51, 869–880, 2012. doi:10.1002/mc.20856.
   PubMed Web of Science ®Google Scholar
• Phillips MS, Liu Q, Hammond HA, Dugan V, and Hey PJ, et al.: Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13, 18–19, 1996. doi:10.1038/ng0596-18.
   PubMed Web of Science ®Google Scholar
• Halaas JL, Gajiwala KS, Maffei M, Cohen SL, and Chait BT, et al.: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543–546, 1995. doi:10.1126/science.7624777.
   PubMed Web of Science ®Google Scholar
• Kuramoto T, Serikawa T, Hayasaka N, Mori M, and Yamada J: Regional mapping of the Rowett nude gene (RONU) to rat chromosome 10q24–>q32 by localizing linked SYB2 and GH loci. Cytogenet Cell Genet 63, 107–110, 1993. doi:10.1159/000133511.
   PubMedGoogle Scholar
• Nehls M, Pfeifer D, Schorpp M, Hedrich H, and Boehm T: New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 372, 103–107, 1994. doi:10.1038/372103a0.
   PubMed Web of Science ®Google Scholar
• Rolstad B: The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses? Immunol Rev 184, 136–144, 2001. doi:10.1034/j.1600-065x.2001.1840113.x.
   PubMed Web of Science ®Google Scholar
• Mashimo T, Voigt B, Tsurumi T, Naoi K, and Nakanishi S, et al.: A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains, 2006.
   Google Scholar
• Blask DE, Brainard GC, Dauchy RT, Hanifin JP, and Davidson LK, et al.: Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Res 65, 11174–11184, 2005. doi:10.1158/0008-5472.CAN-05-1945.
   PubMed Web of Science ®Google Scholar
• Wu J, Dauchy RT, Tirrell PC, Wu SS, and Lynch DT, et al.: Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts. Cancer Res 71, 2622–2631, 2011. doi:10.1158/0008-5472.CAN-10-3837.
   PubMed Web of Science ®Google Scholar
• Greene MW, Burrington CM, Luo Y, Ruhoff MS, and Lynch DT, et al.: PKCδ is activated in the liver of obese Zucker rats and mediates diet-induced whole body insulin resistance and hepatocyte cellular insulin resistance. J Nutr Biochem 25, 281–288, 2014. doi:10.1016/j.jnutbio.2013.10.008.
   PubMed Web of Science ®Google Scholar
• Durham HA and Truett GE: Development of insulin resistance and hyperphagia in Zucker fatty rats. Am J Physiol Regul Integr Comp Physiol 290, R652–658, 2006. doi:10.1152/ajpregu.00428.2004.
   PubMed Web of Science ®Google Scholar
• Zucker LM and Zucker TF: Fatty, a new mutation in the rat. J Hered 52, 275–278, 1961. doi:10.1093/oxfordjournals.jhered.a107093.
   Web of Science ®Google Scholar
• Ikeda H, Shino A, Matsuo T, Iwatsuka H, and Suzuoki Z: A new genetically obese-hyperglycemic rat (Wistar fatty). Diabetes 30, 1045–1050, 1981. doi:10.2337/diab.30.12.1045.
   PubMed Web of Science ®Google Scholar
• Liu RH, Mizuta M, Kurose T, and Matsukura S: Early events involved in the development of insulin resistance in Zucker fatty rat. Int J Obes Relat Metab Disord 26, 318–326, 2002. doi:10.1038/sj.ijo.0801924.
   PubMed Web of Science ®Google Scholar
• Di Nardo F, Burattini R, Cogo CE, Faelli E, and Ruggeri P: Age-related analysis of insulin resistance, body weight and arterial pressure in the Zucker fatty rat. Exp Physiol 94, 162–168, 2009. doi:10.1113/expphysiol.2008.044529.
   PubMed Web of Science ®Google Scholar
• Donnelly HT: Oxygen consumption, activity and body fat in normal and hairless mice. Lab Anim 16, 167–171, 1982. doi:10.1258/002367782781110016.
   PubMed Web of Science ®Google Scholar
• Gordon CJ: Thermal physiology of laboratory mice: defining thermoneutrality. J Therm Biol 37, 654–685, 2012. doi:10.1016/j.jtherbio.2012.08.004.
   Web of Science ®Google Scholar
• Mount LE: Metabolic rate and thermal insulation in albino and hairless mice. J Physiol 217, 315–326, 1971. doi:10.1113/jphysiol.1971.sp009573.
   PubMed Web of Science ®Google Scholar
• Fleshner N, Fair WR, Huryk R, and Heston WD: Vitamin E inhibits the high-fat diet promoted growth of established human prostate LNCaP tumors in nude mice. J Urol 161, 1651–1654, 1999. doi:10.1016/S0022-5347(05)68998-7.
   PubMed Web of Science ®Google Scholar
• Schuller E, Patel N, Item C, Greber-Platzer S, and Baran H, et al.: The genetic background modifies the effects of the obesity mutation, ‘fatty’, on apolipoprotein gene regulation in rat liver. Int J Obes Relat Metab Disord 24, 460–467, 2000. doi:10.1038/sj.ijo.0801179.
   PubMed Web of Science ®Google Scholar
• Kava RA, West DB, Lukasik VA, Wypijewski C, and Wojnar Z, et al.: The effects of gonadectomy on glucose tolerance of genetically obese (fa/fa) rats: influence of sex and genetic background. Int J Obes Relat Metab Disord 16, 103–111, 1992.
   PubMed Web of Science ®Google Scholar
• Turkenkopf IJ, Kava RA, Feldweg A, Horowitz C, and Greenwood MR, et al.: Zucker and Wistar diabetic fatty rats show different response to adrenalectomy. Am J Physiol 261, R912–919, 1991.
   PubMed Web of Science ®Google Scholar
• Alonso-Galicia M, Brands MW, Zappe DH, and Hall JE: Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity. Hypertension 28, 1047–1054, 1996. doi:10.1161/01.HYP.28.6.1047.
   PubMed Web of Science ®Google Scholar
• Kasiske BL, Cleary MP, O'Donnell MP, and Keane WF: Effects of genetic obesity on renal structure and function in the Zucker rat. J Lab Clin Med 106, 598–604, 1985.
   PubMed Web of Science ®Google Scholar
• Kasiske BL, O'Donnell MP, and Keane WF: The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19, I110–115, 1992. doi:10.1161/01.HYP.19.1_Suppl.I110.
   PubMed Web of Science ®Google Scholar
• Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9, 537–549, 2009. doi:10.1038/nrc2694.
   PubMed Web of Science ®Google Scholar
• Grossi V, Peserico A, Tezil T, and Simone C: p38alpha MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol 20, 9744–9758, 2014. doi:10.3748/wjg.v20.i29.9744.
   PubMed Web of Science ®Google Scholar
• Qi Y, Xu Z, Zhu Q, Thomas C, and Kumar R, et al.: Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38alpha MAPK during insulin resistance. Diabetes 62, 3887–3900, 2013. doi:10.2337/db13-0095.
   PubMed Web of Science ®Google Scholar
• Chentouf M, Dubois G, Jahannaut C, Castex F, and Lajoix AD, et al.: Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets. PLoS One 6, e22954, 2011. doi:10.1371/journal.pone.0022954.
   PubMed Web of Science ®Google Scholar
• Picchi A, Gao X, Belmadani S, Potter BJ, and Focardi M, et al.: Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99, 69–77, 2006. doi:10.1161/01.RES.0000229685.37402.80.
   PubMed Web of Science ®Google Scholar
• Dubern B and Clement K: Leptin and leptin receptor-related monogenic obesity. Biochimie 94, 2111–2115, 2012. doi:10.1016/j.biochi.2012.05.010.
   PubMed Web of Science ®Google Scholar
• Chagnon YC, Wilmore JH, Borecki IB, Gagnon J, and Perusse L, et al.: Associations between the leptin receptor gene and adiposity in middle-aged caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 85, 29–34, 2000. doi:10.1210/jcem.85.1.6263.
   PubMed Web of Science ®Google Scholar
• de Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, and Conde R, et al.: Effect of Lys656Asn polymorphism of leptin receptor gene on cardiovascular risk factors and serum adipokine levels after a high polyunsaturated fat diet in obese patients. J Clin Lab Anal 29, 432–436, 2015. doi:10.1002/jcla.21790.
   PubMed Web of Science ®Google Scholar
• Enns JE, Taylor CG, and Zahradka P: Variations in adipokine genes AdipoQ, Lep, and LepR are associated with risk for obesity-related metabolic disease: the modulatory role of gene-nutrient interactions. J Obes 2011, 168659, 2011. doi:10.1155/2011/168659.
   PubMedGoogle Scholar
• Behan JW, Yun JP, Proektor MP, Ehsanipour EA, and Arutyunyan A, et al.: Adipocytes impair leukemia treatment in mice. Cancer Res 69, 7867–7874, 2009. doi:10.1158/0008-5472.CAN-09-0800.
   PubMed Web of Science ®Google Scholar
• Jain R, Chung SM, Jain L, Khurana M, and Lau SW, et al.: Implications of obesity for drug therapy: limitations and challenges. Clin Pharmacol Ther 90, 77–89, 2011. doi:10.1038/clpt.2011.104.
   PubMed Web of Science ®Google Scholar