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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

ORCID Icon, , &
Pages 386-397 | Received 08 May 2019, Accepted 21 Jun 2019, Published online: 09 Jul 2019

References

  • Millimouno FM, Dong J, Yang L, Li J, and Li X: Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev Res 12, 1081–1107, 2014.
  • Esteller M: Epigenetics in cancer. N Engl J Med 358, 1148–1159, 2008.
  • Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, et al.: Supervised risk predictor of breast cancer based on intrinsic subtypes. JCO 27, 1160, 2009.
  • Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, et al.: Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol, 35, S276–S304, 2015.
  • Bray F, Ren JS, Masuyer E, and Ferlay J: Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer 132, 1133–1145, 2013.
  • Nosheen M, Ishrat M, Malik F, Baig R, and Kayani M: Association of GSTM1 and GSTT1 gene deletions with risk of head and neck cancer in Pakistan: a case control study. Asian Pac J Cancer Prev 11, 881–885, 2010.
  • Manach C, Scalbert A, Morand C, Rémésy C, and Jiménez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr 79, 727–747, 2004.
  • Neveu V, Perez-Jiménez J, Vos F, Crespy V, Du Chaffaut L, et al. : Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database 2010, bap024, 2010.
  • D'Archivio M, Filesi C, Varì R, Scazzocchio B, and Masella R: Bioavailability of the polyphenols: status and controversies. Int J Mol Sci 11, 1321–1342, 2010.
  • Quideau S, Deffieux D, Douat‐Casassus C, and Pouysegu L: Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl 50, 586–621, 2011.
  • Ramos S: Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 52, 507–526, 2008.
  • Gopalakrishnan A and Kong A-N: Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells. Food Chem Toxicol 46, 1257–1270, 2008.
  • Dhillon AS, Hagan S, Rath O, and Kolch W: MAP kinase signalling pathways in cancer. Oncogene 26, 3279–3290, 2007.
  • Vauzour D, Rodriguez-Mateos A, Corona G, Oruna-Concha MJ, and Spencer JP: Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients 2, 1106–1131, 2010.
  • Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, et al.: Global cancer statistics, 2012. CA Cancer J Clin 65, 87–108, 2015.
  • Siegel RL, Miller KD, and Jemal A: Cancer statistics, 2015. CA Cancer J Clin 65, 5–29, 2015.
  • Akhtar A, Hussain I, Talha M, Shakeel M, Faisal M, et al.: Prevalence and diagnostic of head and neck cancer in Pakistan. Pak J Pharm Sci 29, 1839–1846, 2016.
  • Zamora-Ros R, Not C, Guinó E, Luján-Barroso L, García RM, et al.: Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case–control study (the Bellvitge Colorectal Cancer Study). Cancer Causes Control 24, 549–557, 2013.
  • Christensen KY, Naidu A, Parent M-É, Pintos J, Abrahamowicz M, et al.: The risk of lung cancer related to dietary intake of flavonoids. Nutr Cancer 64, 964–974, 2012.
  • Petrick J, Steck S, Bradshaw P, Trivers K, Abrahamson P, et al.: Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). Br J Cancer 112, 1291–1300, 2015.
  • Zamora‐Ros R, Fedirko V, Trichopoulou A, González CA, Bamia C, et al.: Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study. Int J Cancer 133, 2429–2443, 2013.
  • Zamora-Ros R, Agudo A, Luján-Barroso L, Romieu I, Ferrari P, et al.: Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr 96, 1398–1408, 2012.
  • Geybels MS, Verhage BA, Arts IC, Van Schooten FJ, Goldbohm RA, et al.: Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer. Am J Epidemiol 177, 1388–1398, 2013.
  • Pandey K and Rizvi S: Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2, 270–278, 2009.
  • Hui C, Qi X, Qianyong Z, Xiaoli P, Jundong Z, et al.: Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies. PLoS One 8, e54318, 2013.
  • Wang Y, Gapstur SM, Gaudet MM, Peterson JJ, Dwyer JT, et al.: Evidence for an association of dietary flavonoid intake with breast cancer risk by estrogen receptor status is limited–3. J Nutr 144, 1603–1611, 2014.
  • Xi Q, Chen M-L, Qin Y, Zhang Q-Y, Xu H-X, et al.: Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies. Asia Pac J Clin Nutr 22, 118–127, 2013.
  • Woo HD, Lee J, Choi IJ, Kim CG, Lee JY, et al.: Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients 6, 4961–4973, 2014.
  • Hasima N and Aggarwal BB: Cancer-linked targets modulated by curcumin. Int J Biochem Mol Biol 3, 328–351, 2012.
  • Cragg GM and Pezzuto JM: Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents. Med Princ Pract 25, 41–59, 2016.
  • Ansari J and Inamdar N: The promise of traditional medicines. Int J Pharmacol 6, 808–812, 2010.
  • Popa V, Dumitru M, Volf I, and Anghel N: Lignin and polyphenols as allelochemicals. Ind Crops Prod 27, 144–148, 2008. doi:10.1016/j.indcrop.2007.07.019
  • Papadopoulou A and Frazier RA: Characterization of protein–polyphenol interactions. Trends Food Sci Technol 15, 186–190, 2004.
  • Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP, et al.: Dietary polyphenolic phytochemicals-promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer 120, 451–458, 2007.
  • Bonfili L, Cecarini V, Amici M, Cuccioloni M, Angeletti M, et al.: Natural polyphenols as proteasome modulators and their role as anti‐cancer compounds. Febs J 275, 5512–5526, 2008.
  • Tait S, Salvati AL, Desideri N, and Fiore L: Antiviral activity of substituted homoisoflavonoids on enteroviruses. Antiviral Res 72, 252–255, 2006.
  • Hendrich AB: Flavonoid‐membrane interactions: possible consequences for biological effects of some polyphenolic compounds 1. Acta Pharmacol Sin 27, 27–40, 2006.
  • Arabbi PR, Genovese MI, and Lajolo FM: Flavonoids in vegetable foods commonly consumed in Brazil and estimated ingestion by the Brazilian population. J Agric Food Chem 52, 1124–1131, 2004.
  • Justesen U, Knuthsen P, and Leth T: Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection. J Chromatogr A 799, 101–110, 1998.
  • McCann SE, Ambrosone CB, Moysich KB, Brasure J, Marshall JR, et al.: Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York. Nutr Cancer 53, 33–41, 2005.
  • Sakakibara H, Honda Y, Nakagawa S, Ashida H, and Kanazawa K: Simultaneous determination of all polyphenols in vegetables, fruits, and teas. J Agric Food Chem 51, 571–581, 2003.
  • Mattila P, Astola J, and Kumpulainen J: Determination of flavonoids in plant material by HPLC with diode-array and electro-array detections. J Agric Food Chem 48, 5834–5841, 2000.
  • Khan N and Mukhtar H: Tea and health: studies in humans. Curr Pharm Des 19, 6141–6147, 2013.
  • Shah S, Stapleton P, and Taylor P: The polyphenol (−)‐epicatechin gallate disrupts the secretion of virulence‐related proteins by Staphylococcus aureus. Lett Appl Microbiol 46, 181–185, 2007.
  • Nifli A-P, Bosson-Kouamé A, Papadopoulou N, Kogia C, Kampa M, et al.: Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res 309, 329–339, 2005.
  • Kuzuhara T, Tanabe A, Sei Y, Yamaguchi K, Suganuma M, et al.: Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins. Mol Carcinog 46, 640–645, 2007.
  • Singh BN, Shankar S, and Srivastava RK: Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82, 1807–1821, 2011.
  • Bhagwat S, Haytowitz DB, and Holden JM: USDA database for the flavonoid content of selected foods, Release 3.1. US Dep Agric Beltsville 11, 145–149, 2014.
  • Deng YT and Lin JK: EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest. J Agric Food Chem 59, 13318–13327, 2011.
  • Banerjee S: Inhibition of mackerel (Scomber scombrus) muscle lipoxygenase by green tea polyphenols. Food Res Int 39, 486–491, 2006.
  • Sen T, Dutta A, and Chatterjee A: 3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. Anticancer Drugs 21, 632–624, 2010.
  • Khan N and Mukhtar H: Modulation of signaling pathways in prostate cancer by green tea polyphenols. Biochem Pharmacol 85, 667–672, 2013.
  • Chuang JC, Yoo CB, Kwan JM, Li TW, Liang G, et al.: Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine. Mol Cancer Ther 4, 1515–1520, 2005.
  • Gilbert E and Liu D: Flavonoids influence epigenetic-modifying enzyme activity: structure-function relationships and the therapeutic potential for cancer. CMC 17, 1756–1768, 2010.
  • Lin Z, Fischer J, and Wicker L: Intermolecular binding of blueberry pectin-rich fractions and anthocyanin. Food Chem 194, 986–993, 2016.
  • Stoner GD, Wang LS, and Casto BC: Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 29, 1665–1674, 2008.
  • Bin Hafeez B, Asim M, Siddiqui IA, Adhami VM, Murtaza I, et al.: Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: a new weapon to blunt prostate cancer growth. Cell Cycle 7, 3320–3326, 2008.
  • Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, et al.: Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett 325, 54–62, 2012.
  • Liu W, Xu J, Wu S, Liu Y, Yu X, et al.: Selective anti-proliferation of HER2-positive breast cancer cells by anthocyanins identified by high-throughput screening. PLoS One 8, e81586, 2013.
  • Lee SJ, Hong S, Yoo SH, and Kim GW: Cyanidin-3-O-sambubioside from Acanthopanax sessiliflorus fruit inhibits metastasis by downregulating MMP-9 in breast cancer cells MDA-MB-231. Planta Med 79, 1636–1640, 2013.
  • Murakami A, Ashida H, and Terao J: Multitargeted cancer prevention by quercetin. Cancer Lett 269, 315–325, 2008.
  • Busch C, Burkard M, Leischner C, Lauer UM, Frank J, et al.: Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clin Epigenetics 7, 64–67, 2015.
  • Russo M, Spagnuolo C, Tedesco I, Bilotto S, and Russo GL: The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol 83, 6–15, 2012.
  • Ferraresi R, Troiano L, Roat E, Lugli E, Nemes E, et al.: Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin. Free Radic Res 39, 1249–1258, 2005.
  • Chen C, Zhou J, and Ji C: Quercetin: a potential drug to reverse multidrug resistance. Life Sci 87, 333–338, 2010.
  • Yamazaki S, Miyoshi N, Kawabata K, Yasuda M, and Shimoi K: Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking β2-adrenergic signaling. Arch Biochem Biophys 557, 18–27, 2014.
  • Zamora-Ros R, Knaze V, Luján-Barroso L, Slimani N, Romieu I, et al.: Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort. Br J Nutr 106, 1915–1925, 2011.
  • Murti Y and Mishra P: Synthesis and evaluation of flavanones as anticancer agents. Indian J Pharm Sci 76, 163–166, 2014.
  • Choi EJ: Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21. Nutr Cancer 59, 115–119, 2007.
  • Palit S, Kar S, Sharma G, and Das PK: Hesperetin induces apoptosis in breast carcinoma by triggering accumulation of ROS and activation of ASK1/JNK pathway. J Cell Physiol 230, 1729–1739, 2015.
  • Alshatwi AA, Ramesh E, Periasamy V, and Subash‐Babu P: The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways. Fundam Clin Pharmacol 27, 581–592, 2013.
  • Sambantham S, Radha M, Paramasivam A, Anandan B, Malathi R, et al.: Molecular mechanism underlying hesperetin-induced apoptosis by in silico analysis and in prostate cancer PC-3 cells. Asian Pac J Cancer Prev 14, 4347–4352, 2013.
  • Zhang J, Wu D, Song J, Wang J, Yi J, et al.: Hesperetin induces the apoptosis of gastric cancer cells via activating mitochondrial pathway by increasing reactive oxygen species. Dig Dis Sci 60, 2985–2995, 2015.
  • Singh M, Kaur M, and Silakari O: Flavones: An important scaffold for medicinal chemistry. Eur J Med Chem 84, 206–239, 2014.
  • Meyer H, Bolarinwa A, Wolfram G, and Linseisen J: Bioavailability of apigenin from apiin-rich parsley in humans. Ann Nutr Metab 50, 167–172, 2006.
  • Das S, Das J, Samadder A, Paul A, and Khuda-Bukhsh AR: Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro. Toxicol Lett 223, 124–138, 2013.
  • Pandey M, Kaur P, Shukla S, Abbas A, Fu P, et al.: Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Mol Carcinog 51, 952–962, 2012.
  • Duarte S, Arango D, Parihar A, Hamel P, Yasmeen R, et al.: Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. IJMS 14, 17664–17679, 2013.
  • Arango D, Parihar A, Villamena FA, Wang L, Freitas MA, et al.: Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochem Pharmacol 84, 1571–1580, 2012.
  • Kroonen J, Artesi M, Capraro V, Nguyen-Khac M-T, Willems M, et al.: Casein kinase 2 inhibition modulates the DNA damage response but fails to radiosensitize malignant glioma cells. Int J Oncol 41, 776–782, 2012.
  • Gates MA, Vitonis AF, Tworoger SS, Rosner B, Titus‐Ernstoff L, et al.: Flavonoid intake and ovarian cancer risk in a population‐based case‐control study. Int J Cancer 124, 1918–1925, 2009.
  • Szkudelska K and Nogowski L: Genistein-a dietary compound inducing hormonal and metabolic changes. J Steroid Biochem Mol Biol 105, 37–45, 2007.
  • Wang H, Li Q, and Chen H: Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line. PLoS One 7, e40955, 2012.
  • Kelly AM and Green CC: Binding affinities of hepatic nuclear estrogen receptors for genistein in channel catfish. N Am J Aquac 68, 160–116, 2006.
  • Tian T, Li J, Li B, Wang Y, Li M, et al.: Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells. Tumour Biol 35, 4137–4145, 2014.
  • Fang MZ, Chen D, Sun Y, Jin Z, Christman JK, et al.: Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clin Cancer Res 11, 7033–7041, 2005.
  • Uckun F: Use of EGF genistein to prevent development of EGF-receptor expressing cancers. Parker Hughes Institute; U.S. Patent Application 10/145,798, 2002.
  • Qin J, Teng J, Zhu Z, Chen J, and Huang W-J: Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells. Pharm Biol 54, 74–79, 2016.
  • Tu SH, Ku CY, Ho CT, Chen CS, Huang CS, et al.: Tea polyphenol (−)‐epigallocatechin‐3‐gallate inhibits nicotine‐and estrogen‐induced α9‐nicotinic acetylcholine receptor upregulation in human breast cancer cells. Mol Nutr Food Res 55, 455–466, 2011.
  • Ronnekleiv-Kelly SM, Nukaya M, Díaz-Díaz CJ, Megna BW, Carney PR, et al.: Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells. Cancer Lett 370, 91–99, 2016.
  • Duo J, Ying G-G, Wang G-W, and Zhang L: Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol Med Rep 5, 1453–1456, 2012.
  • Yong WK, Ho YF, and Malek S: Xanthohumol induces apoptosis and S phase cell cycle arrest in A549 non-small cell lung cancer cells. Pharmacogn Mag 11, S275–S283, 2015.
  • Jin CY, Park C, Hwang HJ, Kim GY, Choi BT, et al.: Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells. Mol Nutr Food Res 55, 300–309, 2011.
  • Hong Z, Cao X, Li N, Zhang Y, Lan L, et al.: Luteolin is effective in the non‐small cell lung cancer model with L858R/T790M EGF receptor mutation and erlotinib resistance. Br J Pharmacol 171, 2842–2853, 2014.
  • Siddiqui IA, Asim M, Hafeez BB, Adhami VM, Tarapore RS, et al.: Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer. Faseb J 25, 1198–1207, 2011.
  • Shukla S, Bhaskaran N, Babcook MA, Fu P, MacLennan GT, et al.: Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis 35, 452–460, 2014.
  • Mahmoud AM, Zhu T, Parray A, Siddique HR, Yang W, et al.: Differential effects of genistein on prostate cancer cells depend on mutational status of the androgen receptor. PLoS One 8, e78479, 2013.
  • Yun JM, Afaq F, Khan N, and Mukhtar H: Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells. Mol Carcinog 48, 260–270, 2009.
  • Thakur VS, Deb G, Babcook MA, and Gupta S: Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention. AAPS J 16, 151–163, 2014.
  • Song HM, Park GH, Eo HJ, and Jeong JB: Naringenin-mediated ATF3 expression contributes to apoptosis in human colon cancer. Biomol Ther (Seoul) 24, 140–146, 2016.
  • Chunhua L, Donglan L, Xiuqiong F, Lihua Z, Qin F, et al.: Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT. J Nutr Biochem 24, 1766–1775, 2013.
  • Lim DY, Cho HJ, Kim J, Nho CW, Lee KW, et al.: Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterol 12, 9–14, 2012.
  • Hussain A, Harish G, Prabhu GA, Mohsin J, Khan MA, et al.: Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 expression. Cancer Epidemiol 36, e387–e393, 2012.
  • Bishayee K, Ghosh S, Mukherjee A, Sadhukhan R, Mondal J, et al.: Quercetin induces cytochrome‐c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug‐DNA interaction. Cell Prolif 46, 153–163, 2013.
  • Zhao X, Jiang K, Liang B, and Huang X: Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-κB/p53-apoptosis signaling pathway. Oncol Rep 35, 669–675, 2016.
  • Park HJ, Jeon YK, You DH, and Nam MJ: Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. Food Chem Toxicol 60, 542–549, 2013.
  • Onoda C, Kuribayashi K, Nirasawa S, Tsuji N, Tanaka M, et al.: (-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression. Int J Oncol 38, 1403–1408, 2011.
  • Chen M, Rao Y, Zheng Y, Wei S, Li Y, et al.: Association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women: A meta-analysis of epidemiological studies. PLoS One 9, e89288–e89292, 2014.
  • Fresco P, Borges F, Diniz C, and Marques M: New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26, 747–766, 2006.
  • Han X, Shen T, and Lou H: Dietary polyphenols and their biological significance. IJMS 8, 950–988, 2007.
  • Luo Y, Wang S-x, Zhou Z-q, Wang Z, Zhang Y-g, et al.: Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-κB) pathway. Tumor Biol 35, 11483–11488, 2014.
  • Kwon KH, Barve A, Yu S, Huang MT, and Kong A: Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models 1. Acta Pharmacol Sin 28, 1409–1421, 2007.

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