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Review

Ginseng and Cancer-Related Fatigue: A Systematic Review of Clinical Trials

, , , &
Pages 1270-1281 | Received 24 Jan 2020, Accepted 29 Jun 2020, Published online: 21 Jul 2020

References

  • Bower JE, Ganz PA, Desmond KA, Bernaards C, Rowland JH, Meyerowitz BE, Belin TR. Fatigue in long-term breast carcinoma survivors: a longitudinal investigation. Cancer. 2006;106(4):751–8. doi:10.1002/cncr.21671
  • Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M. It's not over when it's over: long-term symptoms in cancer survivors-a systematic review. Int J Psychiatry Med. 2010;40(2):163–81. doi:10.2190/PM.40.2.c
  • Berger AM, Mooney K, Alvarez-Perez A, Breitbart WS, Carpenter KM, Cella D, Cleeland C, Dotan E, Eisenberger MA, Escalante CP, et al. Cancer-related fatigue, Version 2.2015. J Natl Compr Canc Netw. 2015;13(8):1012–39. doi:10.6004/jnccn.2015.0122
  • Yennu S, Urbauer DL, Bruera E. Factors associated with the severity and improvement of fatigue in patients with advanced cancer presenting to an outpatient palliative care clinic. BMC Palliat Care. 2012;11(1):16. doi:10.1186/1472-684X-11-16
  • Wang XS, Shi Q, Williams LA, Mao L, Cleeland CS, Komaki RR, Mobley GM, Liao Z. Inflammatory cytokines are associated with the development of symptom burden in patients with NSCLC undergoing concurrent chemoradiation therapy. Brain Behav Immun. 2010;24(6):968–74. doi:10.1016/j.bbi.2010.03.009
  • Seruga B, Zhang H, Bernstein LJ, Tannock IF. Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer. 2008;8(11):887–99. doi:10.1038/nrc2507
  • Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol. 2008;26(6):971–82. doi:10.1200/JCO.2007.10.7805
  • Bower JE, Lamkin DM. Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications. Brain Behav Immun. 2013;30:S48–S57. doi:10.1016/j.bbi.2012.06.011
  • Purcell A, Fleming J, Bennett S, McGuane K, Burmeister B, Haines T. A multidimensional examination of correlates of fatigue during radiotherapy. Cancer. 2010;116(2):529–37. doi:10.1002/cncr.24731
  • Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR. Cancer-related fatigue: the scale of the problem. The Oncologist. 2007;12(S1):4–10. doi:10.1634/theoncologist.12-S1-4
  • Bower JE, Bak K, Berger A, Breitbart W, Escalante CP, Ganz PA, Schnipper HH, Lacchetti C, Ligibel JA, Lyman GH, et al. Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. J Clin Oncol. 2014;32(17):1840–50. doi:10.1200/JCO.2013.53.4495
  • Lawson L. Garlic: a review of its medicinal effects and indicated active compounds. Phytomedicine Eur. 1998;691:176–209.
  • Blumenthal M, et al. The complete German commission e monographs–Therapeutic guide to herbal medicines. Boston, MA: Integrative Medicine Communications; Austin, TX: American Botanical Council; 1998.
  • Kim E, Cameron M, Lovera J, Schaben L, Bourdette D, Whitham R. American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study. Mult Scler. 2011;17(12):1523–6. doi:10.1177/1352458511412062
  • Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, McGinn TW, Stella PJ, Seeger GR, Sood A, et al. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013;105(16):1230–8. doi:10.1093/jnci/djt181
  • Etemadifar M, Sayahi F, Abtahi S-H, Shemshaki H, Dorooshi G-A, Goodarzi M, Akbari M, Fereidan-Esfahani M. Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study. Int J Neurosci. 2013;123(7):480–6. doi:10.3109/00207454.2013.764499
  • Kim H-G, Cho J-H, Yoo S-R, Lee J-S, Han J-M, Lee N-H, Ahn Y-C, Son C-G. Antifatigue effects of Panax ginseng CA Meyer: a randomised, double-blind, placebo-controlled trial. PloS One. 2013;8(4):e61271. doi:10.1371/journal.pone.0061271
  • Attele AS, Wu JA, Yuan C-S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58(11):1685–93. doi:10.1016/s0006-2952(99)00212-9
  • Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res. 2009;55:1–99. doi:10.1016/S1043-4526(08)00401-4
  • Bach HV, Kim J, Myung S-K, Cho Y. Efficacy of Ginseng supplements on fatigue and physical performance: a meta-analysis. J Korean Med Sci. 2016;31(12):1879–86. doi:10.3346/jkms.2016.31.12.1879
  • Lu G-h, Zhou Q, Sun S-q, Leung K-y, Zhang H, Zhao Z-z. Differentiation of Asian ginseng, American ginseng and Notoginseng by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy. J Mol Struct. 2008;883–884:91–8. doi:10.1016/j.molstruc.2007.12.008
  • Wang CY, Bai XY, Wang CH. Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development. Am J Chin Med. 2014;42(3):543–59. doi:10.1142/S0192415X14500359
  • Jin Y, Hofseth AB, Cui X, Windust AJ, Poudyal D, Chumanevich AA, Matesic LE, Singh NP, Nagarkatti M, Nagarkatti PS, et al. American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells. Cancer Prev Res (Phila). 2010;3(3):339–47. doi:10.1158/1940-6207.CAPR-09-0116
  • Kang A, Hao H, Zheng X, Liang Y, Xie Y, Xie T, Dai C, Zhao Q, Wu X, Xie L, et al. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J Neuroinflammation. 2011;8(1):100. doi:10.1186/1742-2094-8-100
  • Yang C-S, Ko S-R, Cho B-G, Shin D-M, Yuk J-M, Li S, Kim J-M, Evans RM, Jung J-S, Song D-K, et al. The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock . J Cell Mol Med. 2008;12(5A):1739–53. doi:10.1111/j.1582-4934.2007.00181.x
  • Hosseini ST, Mesbah Namin SA. Promoting effect of ginsenoside Rb1 for GLUT-4 gene expression and cellular synthesis in C2Cl2 muscle cells. IJPRAS. 2016; 5(2):151–8.
  • Hosseini s, Alipour m, Zakerkish m, Haghighizadeh m. Effects of standardized extract of ginseng (G115) on biomarkers of systemic low-grade inflammation in patients with type 2 diabetes: A double-blind clinical trial. IJEM. 2014;16(3):175–82.
  • Lee S-H, Oh M, Park J, Jang SY, Cheong SH, Lee H, Moon S-H. Antioxidant and anti-inflammatory activities of the ethanolic extract of fermented red ginseng marc. Food Sci Biotechnol. 2015;24(2):651–7. doi:10.1007/s10068-015-0085-0
  • Coleman C, Hebert J, Reddy P. The effects of Panax ginseng on quality of life. J Clin Pharm Ther. 2003;28(1):5–15. doi:10.1046/j.1365-2710.2003.00467.x
  • Yennurajalingam S, Reddy A, Tannir NM, Chisholm GB, Lee RT, Lopez G, Escalante CP, Manzullo EF, Frisbee Hume S, Williams JL, et al. High-dose Asian ginseng (Panax ginseng) for cancer-related fatigue: a preliminary report. Integr Cancer Ther. 2015;14(5):419–27. doi:10.1177/1534735415580676
  • Arring NM, Millstine D, Marks LA, Nail LM. Ginseng as a treatment for fatigue: a systematic review. J Altern Complement Med. 2018;24(7):624–33. doi:10.1089/acm.2017.0361
  • Chang YD, Smith J, Portman D, Kim R, Oberoi-Jassal R, Rajasekhara S, Davis M. Single institute experience with methylphenidate and American ginseng in cancer-related fatigue. Am J Hosp Palliat Care. 2018;35(1):144–50. doi:10.1177/1049909117695733
  • Peinemann F, Tushabe DA, Kleijnen J. Using multiple types of studies in systematic reviews of health care interventions-a systematic review. PloS ONE. 2013;8(12):e85035. doi:10.1371/journal.pone.0085035
  • Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. The Cochrane Collaboration; 2011. Version 5.1.0 [updated March 2011].
  • Barton DL, Soori GS, Bauer BA, Sloan JA, Johnson PA, Figueras C, Duane S, Mattar B, Liu H, Atherton PJ, et al. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer. 2010;18(2):179–87. doi:10.1007/s00520-009-0642-2
  • Yennurajalingam S, Tannir NM, Williams JL, Lu Z, Hess KR, Frisbee-Hume S, House HL, Lim ZD, Lim K-H, Lopez G, et al. A double-blind, randomized, placebo-controlled trial of Panax ginseng for cancer-related fatigue in patients with advanced cancer. J Natl Compr Canc Netw. 2017;15(9):1111–20. doi:10.6004/jnccn.2017.0149
  • Pourmohamadi K, Ahmadzadeh A, Latifi M. Investigating the effects of oral ginseng on the cancer-related fatigue and quality of life in patients with non-metastatic cancer. Int J Hematol Oncol Stem Cell Res. 2018;12(4):313–7.
  • Kim HS, Kim MK, Lee M, Kwon BS, Suh DH, Song YS. Effect of red ginseng on genotoxicity and health-related quality of life after adjuvant chemotherapy in patients with epithelial ovarian cancer: a randomized, double blind, placebo-controlled trial. Nutrients. 2017;9(7):772. doi:10.3390/nu9070772
  • Jeong JS, Ryu BH, Kim JS, Park JW, Choi WC, Yoon SW. Bojungikki-tang for cancer-related fatigue: a pilot randomized clinical trial. Integr Cancer Ther. 2010;9(4):331–8.
  • Wang XS, Zhao F, Fisch MJ, O'Mara AM, Cella D, Mendoza TR, Cleeland CS. Prevalence and characteristics of moderate to severe fatigue: a multicenter study in cancer patients and survivors. Cancer. 2014;120(3):425–32. doi:10.1002/cncr.28434
  • Dhruva A, Dodd M, Paul SM, Cooper BA, Lee K, West C, Aouizerat BE, Swift PS, Wara W, Miaskowski C, et al. Trajectories of fatigue in patients with breast cancer before, during, and after radiation therapy. Cancer Nurs. 2010;33(3):201–12. doi:10.1097/NCC.0b013e3181c75f2a
  • Donovan KA, Jacobsen PB, Andrykowski MA, Winters EM, Balducci L, Malik U, Kenady D, McGrath P. Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer. J Pain Symptom Manage. 2004;28(4):373–80. doi:10.1016/j.jpainsymman.2004.01.012
  • Schwartz AL, Nail LM, Chen S, Meek P, Barsevick AM, King ME, Jones LS. Fatigue patterns observed in patients receiving chemotherapy and radiotherapy. Cancer Invest. 2000;18(1):11–9. doi:10.3109/07357900009023057
  • Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage. 2006;31(1):58–69. doi:10.1016/j.jpainsymman.2005.06.007
  • Stone P, Hardy J, Broadley K, Tookman AJ, Kurowska A, A'Hern R. Fatigue in advanced cancer: a prospective controlled cross-sectional study. Br J Cancer. 1999;79(9–10):1479–86. doi:10.1038/sj.bjc.6690236
  • Bruera E, Roca E, Cedaro L, Carraro S, Chacon R. Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Cancer Treat Rep. 1985;69(7–8):751–4.
  • Bruera E, Strasser F, Palmer JL, Willey J, Calder K, Amyotte G, Baracos V. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. JCO. 2003;21(1):129–34. doi:10.1200/JCO.2003.01.101
  • de Andrade E, de Mesquita AA, de Almeida Claro J, de Andrade PM, Ortiz V, Paranhos M, Srougi M, Erdogrun T. Study of the efficacy of Korean red ginseng in the treatment of erectile dysfunction. Asian J Androl. 2007;9(2):241–4. doi:10.1111/j.1745-7262.2007.00210.x
  • Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother. 2002;36(3):375–9. doi:10.1345/aph.1A245
  • Han KH, Choe SC, Kim HS, Sohn DW, Nam KY, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, et al. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med. 1998;26(2):199–209. doi:10.1142/S0192415X98000257
  • D'Angelo L, Grimaldi R, Caravaggi M, Marcoli M, Perucca E, Lecchini S, Frigo GM, Crema A. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol. 1986;16(1):15–22. doi:10.1016/0378-8741(86)90063-2
  • Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002;24(6):547–61. doi:10.1016/S0885-3924(02)00529-8
  • Chang VT, Hwang SS, Feuerman M. Validation of the Edmonton symptom assessment scale. Cancer. 2000;88(9):2164–71. doi:10.1002/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5
  • Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, Huber SL. The rapid assessment of fatigue severity in cancer patients: use of the brief fatigue inventory. Cancer. 1999;85(5):1186–96. doi:10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N
  • Stein KD, Jacobsen PB, Blanchard CM, Thors C. Further validation of the multidimensional fatigue symptom inventory-short form. J Pain Symptom Manage. 2004;27(1):14–23. doi:10.1016/j.jpainsymman.2003.06.003
  • Curran SL, Andrykowski MA, Studts JL. Short form of the Profile of Mood States (POMS-SF): psychometric information. Psychol Assess. 1995;7(1):80–3. doi:10.1037/1040-3590.7.1.80
  • Bahrke MS, Morgan WR. Evaluation of the ergogenic properties of ginseng: an update. Sports Med. 2000;29(2):113–33. doi:10.2165/00007256-200029020-00004
  • Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia. Eur J Clin Nutr. 2003;57(2):243–8. doi:10.1038/sj.ejcn.1601550
  • Tabandeh MR, Jafari H, Hosseini SA, Hashemitabar M. Ginsenoside Rb1 stimulates adiponectin signaling in C2C12 muscle cells through up-regulation of AdipoR1 and AdipoR2 proteins. Pharm Biol. 2015;53(1):125–32. doi:10.3109/13880209.2014.912237
  • King ML, Adler SR, Murphy LL. Extraction-dependent effects of American ginseng (Panax quinquefolium) on human breast cancer cell proliferation and estrogen receptor activation. Integr Cancer Ther. 2006;5(3):236–43. doi:10.1177/1534735406291341

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