References
- World Health Organization. Cancer; 2018. http://www.who.int/news-room/fact-sheets/detail/cancer.
- National Cancer Institute. Risk factors for cancer; 2015. https://www.cancer.gov/about-cancer/causes-prevention/risk.
- GBD. Risk factors collaborators: Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2015;388:1659–724.
- National Cancer Institute of Brazil. Incidence of cancer in Brazil; 2018. http://www.inca.gov.br/estimativa/2018/sintese-de-resultados-comentarios.asp.
- Smetana K, Lacina L, Szabo P, Dvořánková B, Brož P, Šedo A. Ageing as an important risk factor for cancer. Anticancer Res. 2016;36(10):5009–17. doi:https://doi.org/10.21873/anticanres.11069
- Stewart BW, Wild CP. World Cancer Report 2014. Lyon: World Health Organization; 2014.
- Brown C. Targeted therapy: An elusive cancer target. Nature. 2016;537(7620):S106–S108. doi:https://doi.org/10.1038/537S106a
- Aggarwal S. Targeted cancer therapies. Nat Rev Drug Discov. 2010;9(6):427–8. doi:https://doi.org/10.1038/nrd3186
- Kirkwood JM, Tarhini A, Sparano JA, Patel P, Schiller JH, Vergo MT, Benson Iii AB, Tawbi H. Comparative clinical benefits of systemic adjuvant therapy for paradigm solid tumors. Cancer Treat Rev. 2013;39(1):27–43. doi:https://doi.org/10.1016/j.ctrv.2012.03.007
- Majolo F, Delwing LKOB, Marmitt DJ, Bustamante-Filho IC, Goettert MI. Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery. Phytochem. Lett. 2019;31:196–207. doi:https://doi.org/10.1016/j.phytol.2019.04.003
- Dias DA, Sylvia U, Ute R. A historical overview of natural products in drug discovery. Metabolites. 2012;2(2):303–36. doi:https://doi.org/10.3390/metabo2020303
- Marmitt DJ, Bitencourt S, Silva AC, Rempel C, Goettert MI. The healing properties of medicinal plants used in the Brazilian public health system: a systematic review. J Wound Care. 2018;27(Sup6):S4–S13. doi:https://doi.org/10.12968/jowc.2018.27.Sup6.S4
- RENAME. Portal da Saúde: Relação Nacional de Medicamentos Essenciais (RENAME). Brasil: Ministério da Saúde; 2013. http://bvsms.saude.gov.br/bvs/saudelegis/gm/2012/prt0533_28_03_2012.html.
- Memento Fitoterápico. Memento Fitoterápico. Brasil: Ministério da Saúde; 2016. http://portal.anvisa.gov.br/documents/33832/2909630/Memento±Fitoterapico/a80ec477-bb36-4ae0-b1d2-e2461217e06b
- Marmitt DJ, Bitencourt S, Silva AC, Rempel C, Goettert MI. Medicinal plants used in Brazil public health system with neuroprotective potential – A systematic review. Bol Latinoam Caribe Plant Med Aromat. 2018;17(2):84–103.
- Marmitt DJ, Bitencourt S, Silva AC, Goettert MI, Rempel C. Scientific production of plant species included in the Brazilian national list of medicinal plants of interest to the unified health system (RENISUS) from 2010 to 2013. J Chem Pharm Res. 2016;8:123–32.
- Marmitt DJ, Rempel C, Goettert MI, Silva AC, Pombo CNF. Revisão sistemática sobre as plantas da Relação Nacional de Plantas Medicinais de Interesse ao SUS com potencial terapêutico para doenças cardiovasculares. Rev Cubana Plant Med. 2016;21:108–24.
- Marmitt DJ, Bitencourt S, Silva AC, Goettert MI, Rempel C. Medicinal plants of RENISUS with analgesic activity. J Crit Rev. 2016;3(3):1–4.
- Kiesel VA, Stan SD. Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells. Biochem Biophys Res Commun. 2017;484(4):833–8. doi:https://doi.org/10.1016/j.bbrc.2017.01.184
- Jeena K, Liju VB, Viswanathan R, Kuttan R. Antimutagenic potential and modulation of carcinogen-metabolizing enzymes by ginger essential oil. Phytother Res. 2014;28(6):849–55. doi:https://doi.org/10.1002/ptr.5064
- Chen H, Chen L, Wang L, Zhou X, Chan JY, et al. Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer. Cancer Biol Ther. 2016;11:1–8.
- ClinicalTrials.gov, 2018. https://clinicaltrials.gov/.
- Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod. 2020;83(3):770–803. doi:https://doi.org/10.1021/acs.jnatprod.9b01285
- Reyes-Aldasoro CC. The proportion of cancer-related entries in PubMed has increased considerably; is cancer truly “the emperor of all Maladies?” PLoS One. 2017;12(3):e0173671. doi:https://doi.org/10.1371/journal.pone.0173671
- Gong C, Deng S, Wu Q, Xiang M, Wei X, Li L, Gao X, Wang B, Sun L, Chen Y, et al. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials. 2013;34(4):1413–32. doi:https://doi.org/10.1016/j.biomaterials.2012.10.068
- Datta R, Halder SK, Zhang B. Role of TGF-β signaling in curcumin-mediated inhibition of tumorigenicity of human lung cancer cells. J Cancer Res Clin Oncol. 2013;139(4):563–72. doi:https://doi.org/10.1007/s00432-012-1352-6
- Na H-K, Kim E-H, Choi M-A, Park J-M, Kim D-H, Surh Y-J. Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1. Biochem Pharmacol. 2012;84(10):1241–50. doi:https://doi.org/10.1016/j.bcp.2012.08.024
- Choi YH, Park HS. Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species. J Biomed Sci. 2012;19:50. doi:https://doi.org/10.1186/1423-0127-19-50
- Dong X, Xu W, Sikes RA, Wu C. Apoptotic effects of cooked and in vitro digested soy on human prostate cancer cells. Food Chem. 2012;135(3):1643–52. doi:https://doi.org/10.1016/j.foodchem.2012.06.023
- Rayaprolu SJ, Hettiarachchy NS, Horax R, Phillips GK, Mahendran M, Chen P. Soybean peptide fractions inhibit human blood, breast and prostate cancer cell proliferation. J Food Sci Technol. 2017;54(1):38–44. doi:https://doi.org/10.1007/s13197-016-2426-2
- Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR. Differential control of growth, apoptotic activity, and gene expression in human breast cancer cells by extracts derived from medicinal herbs Zingiber officinale. J Biomed Biotechnol. 2012;2012:614356. doi:https://doi.org/10.1155/2012/614356
- Cheng XL, Liu Q, Peng YB, Qi LW, Li P. Steamed ginger (Zingiber officinale): Changed chemical profile and increased anticancer potential. Food Chem. 2011;129(4):1785–92. doi:https://doi.org/10.1016/j.foodchem.2011.06.026
- El-Azab M, Hishe H, Moustafa Y, El-Awady ES. Anti-angiogenic effect of resveratrol or curcumin in Ehrlich ascites carcinoma-bearing mice. Eur J Pharmacol. 2011;652(1–3):7–14. doi:https://doi.org/10.1016/j.ejphar.2010.11.008
- Rana C, Vaish V, Piplani H, Nehru B, Sanyal SN. Nuclear Factor-κB is expressed in early colon cancer and its down-regulation by Curcumin and Diclofenac is associated with the suppression of proliferation and the induction of apoptosis. Biomed Prev Nutr. 2012;2(4):228–38. doi:https://doi.org/10.1016/j.bionut.2012.07.004
- Zeng T, Li Y, Zhang C-L, Yu L-H, Zhu Z-P, Zhao X-L, Xie K-Q. Garlic oil suppressed the hematological disorders induced by chemotherapy and radiotherapy in tumor-bearing mice. J Food Sci. 2013;78(6):H936–42. doi:https://doi.org/10.1111/1750-3841.12137
- Ebrahimi M, Mohammad Hassan Z, Mostafaie A, Zare Mehrjardi N, Ghazanfari T. Purified protein fraction of garlic extract modulates cellular immune response against breast transplanted tumors in BALB/c mice model. Cell J. 2013;15(1):65–75.
- Al-Ashaal HA, Fahmy MA, Melek FR, Aly NH, Hasan ZM. Effect of supplemented soybean (Glycine max L) diet and extracts on aluminum sulfate-induced genotoxicity. Toxicol Environ Chem. 2012;94(5):965–86. doi:https://doi.org/10.1080/02772248.2012.684688
- Ghaemi A, Soleimanjahi H, Razeghi S, Gorji A, Tabaraei A. Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer. Iran J Immunol. 2012;9(2):119–27.
- Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, et al. Daikenchuto (TU-100) suppresses tumor development in the azoxymethane and APCmin/+ mouse models of experimental colon cancer. Phytother Res. 2017;31(1):90–9. doi:https://doi.org/10.1002/ptr.5735
- Rubila S, Ranganathan TV, Sakthivel KM. Protective effect of Zingiber officinale against Dalton's lymphoma ascites tumour by regulating inflammatory mediator and cytokines. Appl Biochem Biotechnol. 2016;180(8):1482–96. doi:https://doi.org/10.1007/s12010-016-2181-x
- Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, et al. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2012;12(2):368–77. doi:https://doi.org/10.1016/j.intimp.2011.12.009
- Mahmoud TS, Marques MR, Pessoa C. d Ó, Lotufo LVC, Magalhães HIF, Moraes M. O d, Lima D. P d, Tininis AG, Oliveira J. E d. In vitro cytotoxic activity of Brazilian Middle West plant extracts. Rev Bras Farmacogn. 2011;21(3):456–64. doi:https://doi.org/10.1590/S0102-695X2011005000061
- Hsieh CC, Hernández-Ledesma B, de Lumen BO. Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells. Food Chem. 2011;125(2):630–6. doi:https://doi.org/10.1016/j.foodchem.2010.09.051
- Astuti P, Utami ED, Nugrahani AW, Sudjadi S. Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells. J Pharm Sci. 2012;20(1):82.
- Ko J-C, Tsai M-S, Weng S-H, Kuo Y-H, Chiu Y-F, Lin Y-W. Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2011;255(3):327–38. doi:https://doi.org/10.1016/j.taap.2011.07.012
- Wu J, Wan Z, Yi J, Wu Y, Peng W, Wu J. Investigation of the extracts from Bidens pilosa Linn. var. radiata Sch. Bip. for antioxidant activities and cytotoxicity against human tumor cells. J Nat Med. 2013;67(1):17–26. doi:https://doi.org/10.1007/s11418-012-0639-x
- Matsuo AL, Figueiredo CR, Arruda DC, Pereira FV, Scutti JAB, Massaoka MH, Travassos LR, Sartorelli P, Lago JHG. α-Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model. Biochem Biophys Res Commun. 2011;411(2):449–54. doi:https://doi.org/10.1016/j.bbrc.2011.06.176
- Lu K-H, Yang H-W, Su C-W, Lue K-H, Yang S-F, Hsieh Y-S. Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. Food Chem Toxicol. 2013;52:193–9. doi:https://doi.org/10.1016/j.fct.2012.11.019
- Wong RSY. Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res. 2011;30(1):87. doi:https://doi.org/10.1186/1756-9966-30-87
- Folkman J. Angiogenesis and apoptosis. Semin Cancer Biol. 2003;13(2):159–67. doi:https://doi.org/10.1016/s1044-579x(02)00133-5
- Hossain M, Banik NL, Ray SK. Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells. Neurochem Int. 2012;61(7):1102–13. doi:https://doi.org/10.1016/j.neuint.2012.08.002
- Zhao Y, Adjei AA. Targeting angiogenesis in cancer therapy: Moving beyond vascular endothelial growth factor. Oncologist. 2015;20(6):660–73. doi:https://doi.org/10.1634/theoncologist.2014-0465
- Miranzadeh S, Adib-Hajbaghery M, Soleymanpoor L, Ehsani M. Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial. Eur J Oncol Nurs. 2015;19(3):207–13. doi:https://doi.org/10.1016/j.ejon.2014.10.019
- Charron CS, Dawson HD, Albaugh GP, Solverson PM, Vinyard BT, Solano-Aguilar GI, Molokin A, Novotny JA. A single meal containing raw, crushed garlic influences expression of immunity and cancer-related genes in whole blood of humans. J Nutr. 2015;145(11):2448–55. doi:https://doi.org/10.3945/jn.115.215392
- Gatt ME, Strahilevitz J, Sharon N, Lavie D, Goldschmidt N, Kalish Y, Gural A, Paltiel OB. A randomized controlled study to determine the efficacy of garlic compounds in patients with hematological malignancies at risk for chemotherapy-related febrile neutropenia. Integr Cancer Ther. 2015;14(5):428–35. doi:https://doi.org/10.1177/1534735415588928
- Ma J-L, Zhang L, Brown LM, Li J-Y, Shen L, Pan K-F, Liu W-D, Hu Y, Han Z-X, Crystal-Mansour S, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012;104(6):488–92. doi:https://doi.org/10.1093/jnci/djs003
- Wang Y, Zhang L, Moslehi R, Ma J, Pan K, Zhou T, Liu W, Brown LM, Hu Y, Pee D, et al. Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population. J Nutr. 2009;139(1):106–12. doi:https://doi.org/10.3945/jn.108.091389
- Millen AE, Subar AF, Graubard BI, Peters U, Hayes RB, Weissfeld JL, Yokochi LA, Ziegler RG. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. Am J Clin Nutr. 2007;86(6):1754–64. doi:https://doi.org/10.1093/ajcn/86.6.1754
- Tanaka S, Haruma K, Yoshihara M, Kajiyama G, Kira K, Amagase H, Chayama K. Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. J Nutr. 2006;136(3 Suppl):821S–6S. doi:https://doi.org/10.1093/jn/136.3.821S
- Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, Fukuda S, Morimoto K. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr. 2006;136(3 Suppl):816S–20S. doi:https://doi.org/10.1093/jn/136.3.816S
- Bespalov VG, Barash NI, Ivanova OA, Krzhivitskiĭ PI, Semiglazov VF, Aleksandrov VA, Sobenin NA, Orekhov AN. Study of an antioxidant dietary supplement “Karinat” in patients with benign breast disease. Vopr Onkol. 2004;50(4):467–72.
- Li H, Li HQ, Wang Y, Xu HX, Fan WT, et al. An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum. Chin Med J (Engl). 2004;117(8):1155–60.
- Sahebnasagh A, Ghasemi A, Akbari J, Alipour A, Lashkardoost H, Ala S, Salehifar E. Successful treatment of acute radiation proctitis with Aloe Vera: A preliminary randomized controlled clinical trial. J Altern Complement Med. 2017;23(11):858–65. doi:https://doi.org/10.1089/acm.2017.0047
- Sahebjamee M, Mansourian A, Hajimirzamohammad M, Mohammad HMM, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K, et al. Comparative efficacy of Aloe vera and benzydamine mouthwashes on radiation-induced oral mucositis: A triple-blind, randomised, controlled clinical trial. Oral Health Prev Dent. 2015;13(4):309–15. doi:https://doi.org/10.3290/j.ohpd.a33091
- Basu P, Dutta S, Begum R, Mittal S, Dutta PD, Bharti AC, Panda CK, Biswas J, Dey B, Talwar GP, et al. Clearance of cervical human papillomavirus infection by topical application of curcumin and curcumin containing polyherbal cream: a phase II randomized controlled study. Asian Pac J Cancer Prev. 2013;14(10):5753–9. doi:https://doi.org/10.7314/apjcp.2013.14.10.5753
- Haddad P, Amouzgar-Hashemi F, Samsami S, Chinichian S, Oghabian MA. Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial. Curr Oncol. 2013;20(4):e345–e348. doi:https://doi.org/10.3747/co.20.1356
- Di Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S, Di Lecce A, Giugliano FM, Murino P, Manzo R, Cappabianca S, et al. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams. Radiat Oncol. 2013;8:57. doi:https://doi.org/10.1186/1748-717X-8-57
- Su CK, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J, Koong A, Goffinet D, Le Q-T. Phase II double-blind randomized study comparing oral Aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Int J Radiat Oncol Biol Phys. 2004;60(1):171–7. doi:https://doi.org/10.1016/j.ijrobp.2004.02.012
- Olsen DL, Raub W, Bradley C, Johnson M, Macias JL, et al. The effect of Aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol Nurs Forum. 2001;28(3):543–7.
- Lissoni P, Giani L, Zerbini S, Trabattoni P, Rovelli F. Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms. Nat Immun. 1998;16(1):27–33. doi:https://doi.org/10.1159/000069427
- Santos Filho EXD, Arantes DAC, Oton Leite AF, Batista AC, Mendonça E. F d, Marreto RN, Naves LN, Lima EM, Valadares MC. Randomized clinical trial of a mucoadhesive formulation containing curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae) extract (FITOPROT) for prevention and treatment of oral mucositis - phase I study. Chem Biol Interact. 2018;291:228–36. doi:https://doi.org/10.1016/j.cbi.2018.06.010
- Schneider F, Danski MT, Vayego SA. Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial. Rev Esc Enferm Usp. 2015;49(2):221–8. doi:https://doi.org/10.1590/S0080-623420150000200006
- Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. JCO. 2004;22(8):1447–53. doi:https://doi.org/10.1200/JCO.2004.07.063
- Tavakoli Ardakani M, Ghassemi S, Mehdizadeh M, Mojab F, Salamzadeh J, Ghassemi S, Hajifathali A. Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial. Complement Ther Med. 2016;29:29–34. doi:https://doi.org/10.1016/j.ctim.2016.08.001
- Sanaati F, Najafi S, Kashaninia Z, Sadeghi M. Effect of ginger and chamomile on nausea and vomiting caused by chemotherapy in Iranian women with breast cancer. Asian Pac J Cancer Prev. 2016;17(8):4125–9.
- Braga FTMM, Santos ACF, Bueno PCP, Silveira RCCP, Santos CB, Bastos JK, Carvalho EC. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, controlled, phase II clinical trial. Cancer Nurs. 2015;38(4):322–9. doi:https://doi.org/10.1097/NCC.0000000000000194
- Francis M, Williams S. Effectiveness of Indian turmeric powder with honey as complementary therapy on oral mucositis: A nursing perspective among cancer patients in Mysore. Nurs J India. 2014;105(6):258–60.
- Palatty PL, Azmidah A, Rao S, Jayachander D, Thilakchand KR, Rai MP, Haniadka R, Simon P, Ravi R, Jimmy R, et al. Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study. BJR. 2014;87(1038):20130490. doi:https://doi.org/10.1259/bjr.20130490
- Panahi Y, Saadat A, Beiraghdar F, Sahebkar A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res. 2014;28(10):1461–7. doi:https://doi.org/10.1002/ptr.5149
- Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer-the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis. 2014;17(2):180–6. doi:https://doi.org/10.1038/pcan.2014.6
- Rao S, Dinkar C, Vaishnav LK, Rao P, Rai MP, Fayad R, Baliga MS. The Indian spice turmeric delays and mitigates radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer: An investigational study. Integr Cancer Ther. 2014;13(3):201–10. doi:https://doi.org/10.1177/1534735413503549
- Ghalaut VS, Sangwan L, Dahiya K, Ghalaut PS, Dhankhar R, Saharan R. Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia. J Oncol Pharm Pract. 2012;18(2):186–90. doi:https://doi.org/10.1177/1078155211416530
- Bayet-Robert M, Kwiatkowski F, Leheurteur M, Gachon F, Planchat E, Abrial C, Mouret-Reynier M-A, Durando X, Barthomeuf C, Chollet P, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther. 2010;9(1):8–14. doi:https://doi.org/10.4161/cbt.9.1.10392
- Greenlee H, Atkinson C, Stanczyk FZ, Lampe JW. A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007;16(8):1601–9. doi:https://doi.org/10.1158/1055-9965.EPI-06-0938
- Joshi J, Ghaisas S, Vaidya A, Vaidya R, Kamat DV, Bhagwat AN, Bhide S. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J Assoc Physicians India. 2003;51:1055–60.
- Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21(4B):2895–900.
- Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ, Steward WP, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001;7(7):1894–900.
- Paur I, Lilleby W, Bøhn SK, Hulander E, Klein W, Vlatkovic L, Axcrona K, Bolstad N, Bjøro T, Laake P, et al. Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA. Clin Nutr. 2017;36(3):672–9. doi:https://doi.org/10.1016/j.clnu.2016.06.014
- Lesinski GB, Reville PK, Mace TA, Young GS, Ahn-Jarvis J, Thomas-Ahner J, Vodovotz Y, Ameen Z, Grainger E, Riedl K, et al. Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells. Cancer Prev Res (Phila). 2015;8(11):1036–44. doi:https://doi.org/10.1158/1940-6207.CAPR-14-0464
- Ahn-Jarvis JH, Clinton SK, Grainger EM, Riedl KM, Schwartz SJ, Lee M-LT, Cruz-Cano R, Young GS, Lesinski GB, Vodovotz Y, et al. Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer. Cancer Prev Res (Phila). 2015;8(11):1045–54. doi:https://doi.org/10.1158/1940-6207.CAPR-14-0465
- Chi KH, Chiou TJ, Li CP, Chen SY, Chao Y. MS-20, a chemotherapeutical adjuvant, reduces chemo-associated fatigue and appetite loss in cancer patients. Nutr Cancer. 2014;66(7):1211–9. doi:https://doi.org/10.1080/01635581.2014.951731
- Chen WT-L, Yang T-S, Chen H-C, Chen H-H, Chiang H-C, Lin T-C, Yeh C-H, Ke T-W, Chen J-S, Hsiao K-H, et al. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer. Nutr Res. 2014;34(7):585–94. doi:https://doi.org/10.1016/j.nutres.2014.06.010
- Hamilton-Reeves JM, Banerjee S, Banerjee SK, Holzbeierlein JM, Thrasher JB, Kambhampati S, Keighley J, Van Veldhuizen P. Short-term soy isoflavone intervention in patients with localized prostate cancer: a randomized, double-blind, placebo-controlled trial. PLoS One. 2013;8(7):e68331. doi:https://doi.org/10.1371/journal.pone.0068331
- Messing E, Gee JR, Saltzstein DR, Kim K, diSant'Agnese A, Kolesar J, Harris L, Faerber A, Havighurst T, Young JM, et al. A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients. Cancer Prev Res (Phila). 2012;5(4):621–30. doi:https://doi.org/10.1158/1940-6207.CAPR-11-0455
- Lazarevic B, Boezelijn G, Diep LM, Kvernrod K, Ogren O, Ramberg H, Moen A, Wessel N, Berg RE, Egge-Jacobsen W, et al. Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial. Nutr Cancer. 2011;63(6):889–98. doi:https://doi.org/10.1080/01635581.2011.582221
- Ahmad IU, Forman JD, Sarkar FH, Hillman GG, Heath E, Vaishampayan U, Cher ML, Andic F, Rossi PJ, Kucuk O, et al. Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer. Nutr Cancer. 2010;62(7):996–1000. doi:https://doi.org/10.1080/01635581.2010.509839
- Gardner CD, Oelrich B, Liu JP, Feldman D, Franke AA, Brooks JD. Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate. 2009;69(7):719–26. doi:https://doi.org/10.1002/pros.20922
- Vaishampayan U, Hussain M, Banerjee M, Seren S, Sarkar FH, Fontana J, Forman JD, Cher ML, Powell I, Pontes JE, et al. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer. 2007;59(1):1–7. doi:https://doi.org/10.1080/01635580701413934
- Kumar NB, Cantor A, Allen K, Riccardi D, Besterman-Dahan K, Seigne J, Helal M, Salup R, Pow-Sang J. The specific role of isoflavones in reducing prostate cancer risk. Prostate. 2004;59(2):141–7. doi:https://doi.org/10.1002/pros.10362
- Takimoto CH, Glover K, Huang X, Hayes SA, Gallot L, Quinn M, Jovanovic BD, Shapiro A, Hernandez L, Goetz A, et al. Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(11 Pt 1):1213–21.
- McMichael-Phillips DF, Harding C, Morton M, Roberts SA, Howell A, Potten CS, Bundred NJ. Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. Am J Clin Nutr. 1998;68(6):1431S–5S. doi:https://doi.org/10.1093/ajcn/68.6.1431S
- Heydarirad G, Rezaeizadeh H, Choopani R, Mosavat SH, Ameri A. Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia: a randomized, open-label, active-controlled trial. J Integr Med. 2017;15(3):201–8. doi:https://doi.org/10.1016/S2095-4964(17)60333-9
- Ameri A, Heydarirad G, Rezaeizadeh H, Choopani R, Ghobadi A, Gachkar L. Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial. J Evid Based Complementary Altern Med. 2016;21(1):30–3. doi:https://doi.org/10.1177/2156587215590232
- Pongnikorn S, Fongmoon D, Kasinrerk W, Limtrakul PN. Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy. J Med Assoc Thai. 2003;86(1):61–8.
- Demir Doğan M, Can G, Meral R. Effectiveness of black mulberry molasses in prevention of radiotherapy-induced oral mucositis: A randomized controlled study in head and neck cancer patients. J Altern Complement Med. 2017;23(12):971–9. doi:https://doi.org/10.1089/acm.2016.0425
- Tong G-d, Zhang X, Zhou D-q, Wei C-s, He J-s, Xiao C-l, Liu X-l, Zheng Y-j, Chen S-n, Tang H-h, et al. Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L. Chin J Integr Med. 2014;20(4):263–71. doi:https://doi.org/10.1007/s11655-013-1320-7
- Nuñez-Sánchez MA, González-Sarrías A, García-Villalba R, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, et al. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. J Nutr Biochem. 2017;42:126–33. doi:https://doi.org/10.1016/j.jnutbio.2017.01.014
- Nuñez-Sánchez MA, García-Villalba R, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, et al. Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. Mol Nutr Food Res. 2014;58(6):1199–211. doi:https://doi.org/10.1002/mnfr.201300931
- Paller CJ, Ye X, Wozniak PJ, Gillespie BK, Sieber PR, Greengold RH, Stockton BR, Hertzman BL, Efros MD, Roper RP, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis. 2013;16(1):50–5. doi:https://doi.org/10.1038/pcan.2012.20
- Freyer G, You B, Villet S, Tartas S, Fournel-Federico C, Trillet-Lenoir V, Hamizi S, Colomban O, Chavernoz N, Falandry C, et al. Open-label uncontrolled pilot study to evaluate complementary therapy with Ruta graveolens 9c in patients with advanced cancer. Homeopathy. 2014;103(4):232–8. doi:https://doi.org/10.1016/j.homp.2014.06.001
- Powles TJ, Howell A, Evans DG, McCloskey EV, Ashley S, Greenhalgh R, Affen J, Flook LA, Tidy A. Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer. Menopause Int. 2008;14(1):6–12. doi:https://doi.org/10.1258/mi.2007.007033
- Lukaczer D, Darland G, Tripp M, Liska DAnn, Lerman RH, Schiltz B, Bland JS. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Altern Ther Health Med. 2005;11(5):60–5.
- Jarred RA, Keikha M, Dowling C, McPherson SJ, Clare AM, Husband AJ, Pedersen JS, Frydenberg M, Risbridger GP. Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1689–96.
- de Paula LCL, Fonseca F, Perazzo F, Cruz FM, Cubero D, Trufelli DC, Martins SPDS, Santi PX, da Silva EA, Del Giglio A, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22–30. doi:https://doi.org/10.1089/acm.2014.0127
- Santos Araújo M. d C, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J, Morsch VM, Chitolina Schetinger MR, et al. Uncaria tomentosa-Adjuvant treatment for breast cancer: clinical trial. Evid Based Complement Alternat Med. 2012;2012:676984. doi:https://doi.org/10.1155/2012/676984
- Marx W, McCarthy A, Ried K, McKavanagh D, Vitetta L, Sali A, Lohning A, Isenring E. The Effect of a standardized ginger extract on chemotherapy-induced nausea-related quality of life in patients undergoing moderately or highly emetogenic chemotherapy: a double blind, randomized, placebo controlled trial. Nutrients. 2017;9(8):867. doi:https://doi.org/10.3390/nu9080867
- Konmun J, Danwilai K, Ngamphaiboon N, Sripanidkulchai B, Sookprasert A, Subongkot S. A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy. Med Oncol. 2017;34(4):69. doi:https://doi.org/10.1007/s12032-017-0931-4
- Nakayama M, Okizaki A, Takahashi K. A randomized controlled trial for the effectiveness of aromatherapy in decreasing salivary gland damage following radioactive iodine therapy for differentiated thyroid cancer. Biomed Res Int. 2016;2016:1–6. doi:https://doi.org/10.1155/2016/9509810
- Arslan M, Ozdemir L. Oral intake of ginger for chemotherapy-induced nausea and vomiting among women with breast cancer. Clin J Oncol Nurs. 2015;19(5):E92–97. doi:https://doi.org/10.1188/15.CJON.E92-E97
- Liu Y-q, Sun S, Dong H-j, Zhai D-x, Zhang D-y, Shen W, Bai L-l, Yu J, Zhou L-h, Yu C-q, et al. Wrist-ankle acupuncture and ginger moxibustion for preventing gastrointestinal reactions to chemotherapy: A randomized controlled trial. Chin J Integr Med. 2015;21(9):697–702. doi:https://doi.org/10.1007/s11655-014-2009-x
- Yekta ZP, Ebrahimi SM, Hosseini M, Nasrabadi AN, Sedighi S, Surmaghi M-HS, Madani H. Ginger as a miracle against chemotherapy-induced vomiting. Iran J Nurs Midwifery Res. 2012;17(5):325–9.
- Karimi N, Roshan VD. Change in adiponectin and oxidative stress after modifiable lifestyle interventions in breast cancer cases. Asian Pac J Cancer Prev. 2013;14(5):2845–50. doi:https://doi.org/10.7314/apjcp.2013.14.5.2845
- Montazeri AS, Raei M, Ghanbari A, Dadgari A, Montazeri AS, Hamidzadeh A. Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients. Iran Red Crescent Med J. 2013;15(2):101–6. doi:https://doi.org/10.5812/ircmj.4392
- Citronberg J, Bostick R, Ahearn T, Turgeon DK, Ruffin MT, Djuric Z, Sen A, Brenner DE, Zick SM. Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trial. Cancer Prev Res (Phila). 2013;6(4):271–81. doi:https://doi.org/10.1158/1940-6207.CAPR-12-0327
- Panahi Y, Saadat A, Sahebkar A, Hashemian F, Taghikhani M, Abolhasani E. Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial. Integr Cancer Ther. 2012;11(3):204–11. doi:https://doi.org/10.1177/1534735411433201
- Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, Hickok JT, Morrow GR. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20(7):1479–89. doi:https://doi.org/10.1007/s00520-011-1236-3
- Pillai AK, Sharma KK, Gupta YK, Bakhshi S. Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer. 2011;56(2):234–8. doi:https://doi.org/10.1002/pbc.22778
- Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. J Altern Complement Med. 2008;14(5):545–51. doi:https://doi.org/10.1089/acm.2007.0817
- Golan DE, Armstrong EJ, Armstrong AW, Vahle JL, Tashjian Jr AH. Princípios de Farmacologia - A Base Fisiopatológica da Farmacoterapia. 2a ed. Rio de Janeiro: Guanabara Koogan; 2009.
- Rao KV, Faso A. Chemotherapy-induced nausea and vomiting: optimizing prevention and management. Am Health Drug Benefits. 2012;5(4):232–40.
- Janelsins MC, Tejani MA, Kamen C, Peoples AR, Mustian KM, Morrow GR. Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. Expert Opin Pharmacother. 2013;14(6):757–66. doi:https://doi.org/10.1517/14656566.2013.776541
- Hesketh PJ, Kris MG, Grunberg SM, Beck T, Hainsworth JD, Harker G, Aapro MS, Gandara D, Lindley CM. Proposal for classifying the acute emetogenicity of cancer chemotherapy. JCO. 1997;15(1):103–9. doi:https://doi.org/10.1200/JCO.1997.15.1.103
- Marx W, Ried K, McCarthy AL, Vitetta L, Sali A, McKavanagh D, Isenring L. Ginger-mechanism of action in chemotherapy-induced nausea and vomiting: A review. Crit Rev Food Sci Nutr. 2017;57(1):141–6. doi:https://doi.org/10.1080/10408398.2013.865590
- Naidu MUR, Ramana GV, Rani PU, Mohan IK, Suman A, Roy P. Chemotherapy-induced and/or radiation therapy-induced oral mucositis-complicating the treatment of cancer. Neoplasia. 2004;6(5):423–31. doi:https://doi.org/10.1593/neo.04169
- Pagano E, Romano B, Izzo AA, Borrelli F. The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews. Pharmacol Res. 2018;134:79–91. doi:https://doi.org/10.1016/j.phrs.2018.06.007
- Ezat WP, Noraziani K, Sabrizan O. Improving quality of life among cancer patients in Malaysia. Asian Pac J Cancer Prev. 2012;13(3):1069–75. doi:https://doi.org/10.7314/apjcp.2012.13.3.1069
- Meyskens F. Phase II A trial of curcumin among patients with prevalent subclinical neoplastic lesions (Aberrant Crypt Foci); 2015. https://clinicaltrials.gov/ct2/show/NCT00365209?term=Phase±II±A±Trial±of±Curcumin±Among±Patients±With±Prevalent±Subclinical±Neoplastic±Lesions±%28Aberrant±Crypt±Foci%29.&rank=1
- Ryan JL. Curcumin for the prevention of radiation-induced dermatitis in breast cancer patients; 2012. https://clinicaltrials.gov/ct2/show/NCT01042938?term=Curcumin±for±the±Prevention±of±Radiation-induced±Dermatitis±in±Breast±Cancer±Patients&rank=
- Ryan JL. Oral curcumin for radiation dermatitis; 2016. https://clinicaltrials.gov/ct2/show/NCT01246973?term=Oral±Curcumin±for±Radiation±Dermatitis&rank=1
- Cruz-Correa M, Hylind LM, Marrero JH, Zahurak ML, Murray-Stewart T, Casero RA, Montgomery EA, Iacobuzio-Donahue C, Brosens LA, Offerhaus GJ, et al. Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Gastroenterology. 2018;155(3):668–73. doi:https://doi.org/10.1053/j.gastro.2018.05.031
- Elting LS, Keefe DM, Sonis ST, Garden AS, Spijkervet FKL, Barasch A, Tishler RB, Canty TP, Kudrimoti MK, Vera-Llonch M, Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer. 2008;113(10):2704–13. doi:https://doi.org/10.1002/cncr.23898
- Balaji KC. Vitamin D and soy supplements in treating patients with recurrent prostate cancer; 2014. https://clinicaltrials.gov/ct2/show/NCT00499408?term=Vitamin±D±and±Soy±Supplements±in±Treating±Patients±With±Recurrent±Prostate±Cancer.&rank=1
- Vanveldhuizen P. Role of soy supplementation in prostate cancer development; 2015. https://clinicaltrials.gov/ct2/show/NCT00255125?term=Role±of±Soy±Supplementation±in±Prostate±Cancer±Development&rank=1
- Vitolins MZ, Griffin L, Tomlinson WV, Vuky J, Adams PT, Moose D, Frizzell B, Lesser GJ, Naughton M, Radford JE, et al. Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer. J Clin Oncol. 2013;31(32):4092–8. doi:https://doi.org/10.1200/JCO.2012.48.1432
- Basaria S. Effect of soy on cognition and hot flashes in men with prostate cancer undergoing testosterone suppression therapy; 2017. https://clinicaltrials.gov/ct2/show/NCT00245518?term=Glycine±max&recrs=deh&cond=Cancer&rank=33
- Wolf G. Soy isoflavones in preventing head and neck cancer recurrence in patients with stage I-IV head and neck cancer undergoing surgery; 2016. https://clinicaltrials.gov/ct2/show/NCT02007200?term=Isoflavones±in±Preventing±Head±and±Neck±Cancer±Recurrence±in±Patients±With±Stage±I-IV±Head±and±Neck±Cancer±Undergoing±Surgery&rank=1
- Kumar N. Phase II clinical trial of purified isoflavones in prostate cancer: comparing safety, effectiveness; 2015. https://clinicaltrials.gov/ct2/show/NCT01036321?term=Phase±II±Clinical±Trial±of±Purified±Isoflavones±in±Prostate±Cancer%3A±Comparing±Safety%2C±Effectiveness&rank=1
- Fallon MT, Albert Lux E, McQuade R, Rossetti S, Sanchez R, Sun W, Wright S, Lichtman AH, Kornyeyeva E. Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. Br J Pain. 2017;11(3):119–33. doi:https://doi.org/10.1177/2049463717710042
- Ryan JL. Ginger in treating nausea in patients receiving chemotherapy for cancer; 2015. https://clinicaltrials.gov/ct2/show/NCT00040742?term=Zingiber±officinale&recrs=deh&rslt=With&cond=Cancer&rank=2
- US Food and Drug Administration. Step 3: Clinical research; 2018. https://www.fda.gov/forpatients/approvals/drugs/ucm405622.htm
- European Federation of Pharmaceutical Industries and Associations. Clinical trials; 2018. https://www.efpia.eu/about-medicines/development-of-medicines/clinical-trials/.
- Sahin I, Bilir B, Ali S, Sahin K, Kucuk O. Soy isoflavones in integrative oncology: increased efficacy and decreased toxicity of cancer therapy. Integr Cancer Ther. 2019;18:1534735419835310.
- Eric B, Benjamin R, Heidi W. Do firms underinvest in long-term research? Evidence from cancer clinical trials. Am Econ Rev. 2015;105(7):2044–85.
- Xiaoyan Z, Dezhong S. Traditional Chinese medicine for treating damp heat stagnation type pancreatic cancer and preparation method thereof. European Patent Office, 2015. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20151007&CC=CN&NR=104958474A&KC=A.
- Hengbiao M. Antineoplastic active polypeptide extracted from Allium sativum. European Patent Office, 2017. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170111&CC=CN&NR=106317202A&KC=A.
- Akihiro M, Koji I, Koki O, Kazuaki K, Ryoko A. Antitumor substance originated from vegetable. European Patent Office, 1999. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19990223&CC=JP&NR=H1149793A&KC=A.
- Bapurao MN. Herbal formulations against adenocarcinoma of the prostate. European Patent Office, 2003. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20031127&CC=WO&NR=03097076A1&KC=A1.
- Qiu L, Tang S, Liu P. New pharmacologic application of aloe polysaccharide. European Patent Office, 2010. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20101110&CC=CN&NR=101879180A&KC=A.
- Nandkishore M. Herbo-mineral formulation for refractory leukemias and lymphomas. European Patent Office, 2005. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050317&CC=US&NR=2005058722A1&KC=A1.
- Abdulkarim NA. Composition for treatment and preventative of the human papilloma virus HPV infection, ulcerations and boils. European Patent Office, 2017. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170718&CC=CA&NR=2967506A1&KC=A1.
- Danhof IE. Compositions and methods of aloe polysaccharides. European Patent Office, 2015. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20150220&CC=RU&NR=2013127633A&KC=A.
- Fenglian W. Traditional Chinese medicine composition used for treating stomach câncer. European Patent Office, 2018. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20180126&CC=CN&NR=107625943A&KC=A.
- Guoyu L. Traditional Chinese medicinal composition for treating stomach câncer. European Patent Office, 2016. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20161123&CC=CN&NR=106138919A&KC=A.
- Chunzhi Z, Wansheng L, Zizhi Z. Traditional Chinese medicine preparation for treating rectal cancer and preparation method thereof. European Patent Office, 2015. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20150218&CC=CN&NR=104352781A&KC=A.
- Linneth H. Treatment for cancer. European Patent Office, 2003. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20030501&CC=US&NR=2003082250A1&KC=A1.
- Christel FP. Use of copaifera oleoresin in pathologies of the prostate. European Patent Office, 2018. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20180927&CC=WO&NR=2018172380A1&KC=A1.
- Jian MA. External medicine for treating rectal cancer and preparation method thereof. European Patent Office, 2016. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=7&ND=3&adjacent=true&locale=en_EP&FT=D&date=20160706&CC=CN&NR=105727193A&KC=A.
- Yeoun HS, Jk C. Composition comprising tumeric for treatment of prostate câncer. European Patent Office, 2012. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=21&ND=3&adjacent=true&locale=en_EP&FT=D&date=20120308&CC=KR&NR=20120020578A&KC=A.
- Feng G. Traditional Chinese medicine preparation for relieving ovary choriocarcinoma and preparation method. World Intellectual Property Organization, 2015. https://patentscope.wipo.int/search/pt/result.jsf?currentNavigationRow=2&prevCurrentNavigationRow=1&office=&prevFilter=&maxRec=58&listLengthOption=10.
- Yang Y. Traditional Chinese medicine composition for treating gastric cancer and preparation method thereof. World Intellectual Property Organization, 2015. https://patentscope.wipo.int/search/pt/result.jsf?currentNavigationRow=2&prevCurrentNavigationRow=1&office=&prevFilter=&maxRec=58&listLengthOption=10.
- Kung-Ming L. Process of using fermented Glycine max (L.) extract for enhancing natural killer cell activity and inhibitory activities to GABA and glutamate receptor binding. European Patent Office, 2004. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=5&ND=3&adjacent=true&locale=en_EP&FT=D&date=20041104&CC=US&NR=2004219237A1&KC=A1.
- Kung-Ming L. Manufacturing method of fermented soybean extract. European Patent Office, 2006. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=8&ND=3&adjacent=true&locale=en_EP&FT=D&date=20060501&CC=TW&NR=I253933B&KC=B.
- Kongming L. Method for utilizing fermentative soybean liquid extract. European Patent Office, 2006. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=12&ND=3&adjacent=true&locale=en_EP&FT=D&date=20060118&CC=CN&NR=1720954A&KC=A.
- Wei Z, Jianru G, Zhi-Hong J, Caiyun W, Buming L. Synergistic combination of a Phyllanthus amarus extract and 5-fluorouracil for treatment of subjects with câncer. European Patent Office, 2006. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20160908&CC=AU&NR=2016101447A4&KC=A4.
- Guangdong T, Yufeng X. Compound Phyllanthus urinaria traditional Chinese medicine composition for treating precancerous lesions of hepatitis B. European Patent Office, 2016. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=2&ND=3&adjacent=true&locale=en_EP&FT=D&date=20160831&CC=CN&NR=105902973A&KC=A.
- Junqiang S, Meiqin S, Xiaolei D, Yuhua C. Preparation method for nasopharynx cancer chemoradiotherapy assisting skin ointment. European Patent Office, 2016. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20150121&CC=CN&NR=104288407A&KC=A.
- Bombardelli E, Corti F. Compositions for treatment of fatigue related to cancer. European Patent Office, 2016. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=2&ND=3&adjacent=true&locale=en_EP&FT=D&date=20160920&CC=RU&NR=2015102002A&KC=A.
- Bombardelli E, Morazzoni P. Compositions, containing extracts of Echinacea angustifolia and Zingiber officinale, useful for reducing inflammation and peripheral pain. European Patent Office, 2014. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=4&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140727&CC=RU&NR=2013103334A&KC=A.
- Hiromichi O, Hiroshi M. Agent for mitigating symptoms of cancer. European Patent Office, 1985. https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=9&ND=3&adjacent=true&locale=en_EP&FT=D&date=19850208&CC=JP&NR=S6025933A&KC=A.
- National Center for Complementary and Integrative Health. Traditional Chinese medicine: in depth; 2018. https://nccih.nih.gov/health/whatiscam/chinesemed.htm.
- Wang H, Khor TO, Shu L, Su Z-Y, Fuentes F, Lee J-H, Kong A-NT. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem. 2012;12(10):1281–305. doi:https://doi.org/10.2174/187152012803833026
- Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. JCO. 2000;18(13):2505–14. doi:https://doi.org/10.1200/JCO.2000.18.13.2505
- Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N, Sarkar S. Drug resistance in cancer: an overview. Cancers (Basel). 2014;6(3):1769–92. doi:https://doi.org/10.3390/cancers6031769
- Zhan T, Rindtorff N, Betge J, Ebert MP, Boutros M. CRISPR/Cas9 for cancer research and therapy. Semin Cancer Biol. 2018;55:106–19.
- Sanmamed MF, Chen L. A paradigm shift in cancer immunotherapy: From enhancement to normalization. Cell. 2018;175(2):313–26. doi:https://doi.org/10.1016/j.cell.2018.09.035
- Mao JJ, Palmer SC, Straton JB, Cronholm PF, Keddem S, Knott K, Bowman MA, Barg FK. Cancer survivors with unmet needs were more likely to use complementary and alternative medicine. J Cancer Surviv. 2008;2(2):116–24. doi:https://doi.org/10.1007/s11764-008-0052-3
- Weiger WA, Smith M, Boon H, Richardson MA, Kaptchuk TJ, Eisenberg DM. Advising patients who seek complementary and alternative medical therapies for cancer. Ann Intern Med. 2002;137(11):889–903. doi:https://doi.org/10.7326/0003-4819-137-11-200212030-00010
- Tasaki K, Maskarinec G, Shumay DM, Tatsumura Y, Kakai H. Communication between physicians and cancer patients about complementary and alternative medicine: exploring patients' perspectives. Psychooncology. 2002;11(3):212–20. doi:https://doi.org/10.1002/pon.552