References
- Li H, Xu K, Pian G, Sun S. Artesunate and sorafenib: combinatorial inhibition of liver cancer cell growth. Oncol Lett. 2019;18(5):4735–4743. doi: https://doi.org/10.3892/ol.2019.10810.
- Zhang K, Wang T, Zhou H, Feng B, Chen Y, Zhi Y, Wang R. A novel aurora-A Inhibitor (MLN8237) synergistically enhances the antitumor activity of sorafenib in hepatocellular carcinoma. Mol Ther Nucleic Acids. 2018;13:176–188. doi: https://doi.org/10.1016/j.omtn.2018.08.014.
- Zhang L, Li S, Wang R, Chen C, Ma W, Cai H. Cytokine augments the sorafenib-induced apoptosis in Huh7 liver cancer cell by inducing mitochondrial fragmentation and activating MAPK-JNK signalling pathway. Biomed Pharmacother. 2019;110:213–223. doi: https://doi.org/10.1016/j.biopha.2018.11.037.
- Alnajjar AM, Elsiesy HA. Natural products and hepatocellular carcinoma: a review. Hepatoma Res. 2015;1(3):119–124. doi:https://doi.org/10.4103/2394-5079.167379
- Yang J, Wang J, Luo J. Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib. Pathol Res Pract. 2019;215(10):152565. doi: https://doi.org/10.1016/j.prp.2019.152565.
- Fikry EM, Gad AM, Eid AH, Arab HH. Arab HH: caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis. Biomed Pharmacother. 2019;110:878–886. doi: https://doi.org/10.1016/j.biopha.2018.12.041.
- Li A, Zhang R, Zhang Y, Liu X, Wang R, Liu J, Liu X, Xie Y, Cao W, Xu R, et al. BEZ235 increases sorafenib inhibition of hepatocellular carcinoma cells by suppressing the PI3K/AKT/mTOR pathway. Am J Transl Res. 2019;11(9):5573–5585.
- Sonntag R, Gassler N, Bangen J, Trautwein C, Liedtke C. Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo. Cell Death Dis. 2014;5:e1030. doi:https://doi.org/10.1038/cddis.2013.557
- Jakubowicz-Gil J, Langner E, Bądziul D, Wertel I, Rzeski W. Quercetin and sorafenib as a novel and effective couple in programmed cell death induction in human gliomas. Neurotox Res. 2014;26(1):64–77. doi: https://doi.org/10.1007/s12640-013-9452-x.
- Dhingra A, Jayas R, Afshar P, Guberman M, Maddaford G, Gerstein J, Lieberman B, Nepon H, Margulets V, Dhingra R, et al. Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes. Free Radic Biol Med. 2017;112:411–422. doi: https://doi.org/10.1016/j.freeradbiomed.2017.08.010.
- Li L-W, Na C, Tian S-Y, Chen J, Ma R, Gao Y, Lou G. Ellagic acid induces HeLa cell apoptosis via regulating signal transducer and activator of transcription 3 signaling. Exp Ther Med. 2018;16(1):29–36. doi: https://doi.org/10.3892/etm.2018.6182.
- Liu Q, Liang X, Liang M, Qin R, Qin F, Wang X. Ellagic acid ameliorates renal ischemic-reperfusion injury through NOX4/JAK/STAT signaling pathway. Inflammation. 2020;43(1):298–309. doi: https://doi.org/10.1007/s10753-019-01120-z.
- Arab HH, Gad AM, Fikry EM, Eid AH. Ellagic acid attenuates testicular disruption in rheumatoid arthritis via targeting inflammatory signals, oxidative perturbations and apoptosis. Life Sci. 2019;239:117012. doi: https://doi.org/10.1016/j.lfs.2019.117012.
- Boehning AL, Essien SA, Underwood EL, Dash PK, Boehning D. Cell type-dependent effects of ellagic acid on cellular metabolism. Biomed Pharmacother. 2018;106:411–418. doi: https://doi.org/10.1016/j.biopha.2018.06.142.
- Firdaus F, Zafeer MF, Anis E, Ahmad M, Afzal M. Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis. Toxicol Rep. 2018;5:411–417. doi: https://doi.org/10.1016/j.toxrep.2018.02.017.
- Rios JL, Giner RM, Marin M, Recio MC. A pharmacological update of ellagic acid. Planta Med. 2018;84(15):1068–1093. doi: https://doi.org/10.1055/a-0633-9492.
- Liu Q, Liang X, Niu C, Wang X. Ellagic acid promotes A549 cell apoptosis via regulating the phosphoinositide 3-kinase/protein kinase B pathway. Exp Ther Med. 2018;16(1):347–352. doi: https://doi.org/10.3892/etm.2018.6193.
- Salimi A, Roudkenar MH, Sadeghi L, Mohseni A, Seydi E, Pirahmadi N, Pourahmad J. Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting mitochondria. Redox Biol. 2015;6:461–471. doi: https://doi.org/10.1016/j.redox.2015.08.021.
- Wang N, Wang Z-Y, Mo S-L, Loo TY, Wang D-M, Luo H-B, Yang D-P, Chen Y-L, Shen J-G, Chen J-P, et al. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res Treat. 2012;134(3):943–955: doi: https://doi.org/10.1007/s10549-012-1977-9.
- Kannan MM, Quine SD. Ellagic acid protects mitochondria from β-adrenergic agonist induced myocardial damage in rats; evidence from in vivo, in vitro and ultra structural study. Food Res Int. 2012;45:1–8.
- Seydi E, Rasekh HR, Salimi A, Mohsenifar Z, Pourahmad J. Selective toxicity of apigenin on cancerous hepatocytes by directly targeting their mitochondria. Anticancer Agents Med Chem. 2016;16(12):1576–1586. doi: https://doi.org/10.2174/1871520616666160425110839.
- Khan MS, Devaraj H, Devaraj N. Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats. Toxicol Appl Pharmacol. 2011;251(1):85–94. doi:https://doi.org/10.1016/j.taap.2010.12.004
- Taha MME, Abdul AB, Abdullah R, Ibrahim TAT, Abdelwahab SI, Mohan S. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem Biol Interact. 2010;186(3):295–305. doi:https://doi.org/10.1016/j.cbi.2010.04.029
- Barogi S, Baracca A, Parenti Castelli G, Bovina C, Formiggini G, Marchetti M, Solaini G, Lenaz G. Lack of major changes in ATPase activity in mitochondria from liver, heart, and skeletal muscle of rats upon ageing. Mech Ageing Dev. 1995;84(2):139–150. doi: https://doi.org/10.1016/0047-6374(95)01640-6.
- Severgnini M, Sherman J, Sehgal A, Jayaprakash NK, Aubin J, Wang G, Zhang L, Peng CG, Yucius K, Butler J, et al. A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development. Cytotechnology. 2012;64(2):187–195. doi: https://doi.org/10.1007/s10616-011-9407-0.
- Zhang Q, Zhao XH, Wang ZJ. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008;46(6):2042–2053. doi: https://doi.org/10.1016/j.fct.2008.01.049.
- Seydi E, Rahimpour Z, Salimi A, Pourahmad J. Selective toxicity of chrysin on mitochondria isolated from liver of a HCC rat model. Bioorg Med Chem. 2019;27(24):115163. doi: https://doi.org/10.1016/j.bmc.2019.115163.
- Kwon KH, Barve A, Yu S, Huang MT, Kong AN. Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models. Acta Pharmacol Sin. 2007;28(9):1409–1421. doi: https://doi.org/10.1111/j.1745-7254.2007.00694.x.
- Hussain T, Siddiqui HH, Fareed S, Sweety K, Vijayakumar M, Rao CV. Chemopreventive effect of Fumaria indica that modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine and CC14-induced hepatocarcinogenesis in Wistar rats. Asian Pacific J Trop Biomed. 2012;2(2):S995–S1001. doi:https://doi.org/10.1016/S2221-1691(12)60350-5
- Liu Y-r, Lin B-b, Zeng D-w, Zhu Y-y, Chen J, Zheng Q, Dong J, Jiang J-j. Alpha-fetoprotein level as a biomarker of liver fibrosis status: a cross-sectional study of 619 consecutive patients with chronic hepatitis B. BMC Gastroenterol. 2014;14(1):145. doi:https://doi.org/10.1186/1471-230X-14-145
- Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem. 2007;18(7):427–42. doi:https://doi.org/10.1016/j.jnutbio.2006.11.004
- Zhong L, Liu H, Zhang W, Liu X, Jiang B, Fei H, Sun Z. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of beta-amyloid production and tau hyperphosphorylation. Exp Ther Med. 2018;16:4951–4958. doi:https://doi.org/10.3892/etm.2018.6860
- Guney Eskiler G, Deveci AO, Bilir C, Kaleli S. Synergistic effects of nobiletin and sorafenib combination on metastatic prostate cancer cells. Nutr Cancer. 2019;71(8):1299–1312. doi:https://doi.org/10.1080/01635581.2019.1601237
- Yurdacan B, Egeli U, Guney Eskiler G, Eryilmaz IE, Cecener G, Tunca B. Investigation of new treatment option for hepatocellular carcinoma: a combination of sorafenib with usnic acid. J Pharm Pharmacol. 2019;71(7):1119–1132. doi:https://doi.org/10.1111/jphp.13097
- Wei J-C, Meng F-D, Qu K, Wang Z-X, Wu Q-F, Zhang L-Q, Pang Q, Liu C. Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1. Acta Pharmacol Sin. 2015;36(2):241–251. doi: https://doi.org/10.1038/aps.2014.122.
- Wang H, Zhang C, Chi H, Meng Z. Synergistic anticancer effects of bufalin and sorafenib by regulating apoptosis associated proteins. Mol Med Rep. 2018;17(6):8101–8110. doi:https://doi.org/10.3892/mmr.2018.8927
- Chobot V, Hadacek F. Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin. Redox Rep. 2011;16(6):242–247. doi: https://doi.org/10.1179/1351000211y.0000000015.
- Kuntz S, Wenzel U, Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr. 1999;38(3):133–142. doi: https://doi.org/10.1007/s003940050054.
- Prochazkova D, Bousova I, Wilhelmova N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82:513–523. doi:https://doi.org/10.1016/j.fitote.2011.01.018
- Gottlieb E, Armour SM, Harris MH, Thompson CB. Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ. 2003;10(6):709–717. doi: https://doi.org/10.1038/sj.cdd.4401231.
- Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis. 2003;8(2):115–128. doi: https://doi.org/10.1023/a:1022945107762.
- Yuan L, Wang J, Xiao H, Xiao C, Wang Y, Liu X. Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. Toxicol Appl Pharmacol. 2012;265(1):83–92. doi:https://doi.org/10.1016/j.taap.2012.09.022
- Man SM, Kanneganti TD. Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol. 2016;16(1):7–21. doi: https://doi.org/10.1038/nri.2015.7.
- McIlwain DR, Berger T, Mak TW. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 2013;5(4):a008656. doi: https://doi.org/10.1101/cshperspect.a008656.
- Shin E-C, Seong YR, Kim CH, Kim H, Ahn YS, Kim K, Kim SJ, Hong S-S, Park JH. Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin. Exp Mol Med. 2002;34(2):114–122. doi: https://doi.org/10.1038/emm.2002.17.