References
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. doi:https://doi.org/10.3322/caac.20107
- El-Serag HB, Mason A, Key C. Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States. Hepatology. 2001;33(1):62–65. doi:https://doi.org/10.1053/jhep.2001.21041
- Di Bisceglie AM. Malignant neoplasms of the live. In: Schiff ER, Sorrel MF, Maddrey WC, editors. Schiff's disease of the liver. Philadelphia: Lippincott-Raven; 2009. p. 1281–1304.
- Bergsland EK. Molecular mechanisms underlying the development of hepatocellular carcinoma. Semin Oncol. 2001;28(5):521–531. doi:https://doi.org/10.1053/sonc.2001.26955
- Hagen TM, Huang S, Curnutte J, Fowler P, Martinez V, Wehr CM, Ames BN, Chisari FV. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci USA. 1994;91(26):12808–12812. doi:https://doi.org/10.1073/pnas.91.26.12808
- Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan S-T, Luk JM, Wigler M, Hannon GJ, Mu D, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 2006;125(7):1253–1267. doi:https://doi.org/10.1016/j.cell.2006.05.030
- Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell. 1997;88(3):347–354. doi:https://doi.org/10.1016/S0092-8674(00)81873-5
- Fadeel B, Orrenius S, Zhivotovsky B. Apoptosis in human disease: a new skin for the old ceremony. Biochem Biophys Res Commun. 1999;266(3):699–717. doi:https://doi.org/10.1006/bbrc.1999.1888
- Ghobrial IM, Witzig TE, Adjei AA. Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin. 2005;55(3):178–194. doi:https://doi.org/10.3322/canjclin.55.3.178
- Pulido MD, Parrish AR. Metal-induced apoptosis: mechanisms. Mutat Res. 2003;533(1-2):227–241. doi:https://doi.org/10.1016/j.mrfmmm.2003.07.015
- Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura KI, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13(6):688–694. doi:https://doi.org/10.1038/nm1577
- Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med. 2001;7(7):314–319. doi:https://doi.org/10.1016/s1471-4914(01)02026-3
- Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371(6495):346–347. doi:https://doi.org/10.1038/371346a0
- Ji HF, Li XJ, Zhang HY. Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep. 2009;10(3):194–200. doi:https://doi.org/10.1038/embor.2009.12
- Teo SP, Chua HP. Leonurus sibiricus L. plant resources of South-East Asia. In: Valkenburg JLCH, Bunyapraphatsara N, editors. Medicinal and poisonous plants. Vol. 2. Leiden: Backhuys Publishers; 2001.
- Sitarek P, Skała E, Toma M, Wielanek M, Szemraj J, Skorski T, Białas AJ, Sakowicz T, Kowalczyk T, Radek M, et al. Transformed root extract of Leonurus sibiricus induces apoptosis through intrinsic and extrinsic pathways in various grades of human glioma cells. J Pathol Oncol Res. 2017;23(3):679–687. doi:https://doi.org/10.1007/s12253-016-0170-6
- Su LJ, Chang CC, Yang CH, Hsieh SJ, Wu YC, Lai JM, Tseng TL, Huang CY, Hsu SL. Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. PLoS One. 2013;8(1):e53988. doi:https://doi.org/10.1371/journal.pone.0053988
- Aman R, Carle R, Conrad J, Beifuss U, Schieber A. Isolation of carotenoids from plant materials and dietary supplements by high-speed counter-current chromatography. J Chromatogr A. 2005;1074(1-2):99–105. doi:https://doi.org/10.1016/j.chroma.2005.03.055
- Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res. 1982;42(9):3858–3863.
- Carmichael J, Degraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 1987;47(4):936–942.
- Tundis R, Iacopetta D, Sinicropi MS, Bonesi M, Leporini M, Passalacqua NG, Ceramella J, Menichini F, Loizzo MR. Assessment of antioxidant, antitumor and pro-apoptotic effects of Salvia fruticosa Mill. subsp. thomasii (Lacaita) Brullo, Guglielmo, Pavone & Terrasi (Lamiaceae). Food Chem Toxicol. 2017;106(Pt A):155–164. doi:https://doi.org/10.1016/j.fct.2017.05.040
- Leon-Bollotte L, Subramaniam S, Cauvard O, Plenchette–Colas S, Paul C, Godard C, Martinez–Ruiz A, Legembre P, Jeannin JF, Bettaieb A. S-nitrosylation of the death receptor Fas promotes Fas ligand-mediated apoptosis in cancer cells. Gastroenterology. 2011;140(7):2009–2018. doi:https://doi.org/10.1053/j.gastro.2011.02.053
- Brunet M, Didelot C, Subramaniam S, Rérole AL, de Thonel A, Garrido C. Hsp70 and hsp27 as pharmacological targets in apoptosis modulation for cancer therapy. In: Calderwood SK, Sherman MY, Ciocca DR, eds., Heat shock proteins in cancer. Dordrecht: Springer; 2007. pp. 209–230.
- King A, Young G. Characteristics and occurrence of phenolic phytochemicals. J Am Diet Assoc. 1999;99(2):213–218. doi:https://doi.org/10.1016/S0002-8223(99)00051-6
- Min R, Tong J, Wenjun Y, Wenhu D, Xiaojian Z, Jiacai H, Jian Z, Wantao C, Chenping Z. Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway. Phytother Res. 2008;22(3):407–415. doi:https://doi.org/10.1002/ptr.2340
- Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 2012;45(6):487–498. doi:https://doi.org/10.1111/j.1365-2184.2012.00845.x
- Tao J, Zhang P, Liu G, Yan H, Bu X, Ma Z, Wang N, Wang G, Jia W. Cytotoxicity of Chinese motherwort (YiMuCao) aqueous ethanol extract is non-apoptotic and estrogen receptor independent on human breast cancer cells. J Ethnopharmacol. 2009;122(2):234–239. doi:https://doi.org/10.1016/j.jep.2009.01.013
- Sitarek P, Skała E, Toma M, Wielanek M, Szemraj J, Nieborowska-Skorska M, Kolasa M, Skorski T, Wysokińska H, Śliwiński T. A preliminary study of apoptosis induction in glioma cells via alteration of the Bax/Bcl-2-p53 axis by transformed and non-transformed root extracts of Leonurus sibiricus L. Tumour Biol. 2016;37(7):8753–8764. doi:https://doi.org/10.1007/s13277-015-4714-2
- Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol. 2007;47:143–183. doi:https://doi.org/10.1146/annurev.pharmtox.47.120505.105122
- Fleury C, Mignotte B, Vayssière JL. Mitochondrial reactive oxygen species in cell death signaling. Biochimie. 2002;84(2-3):131–141. doi:https://doi.org/10.1016/S0300-9084(02)01369-X
- Iacopetta D, Mariconda A, Saturnino C, Caruso A, Palma G, Ceramella J, Muià N, Perri M, Sinicropi MS, Caroleo MC, Longo P. Novel gold and silver carbene complexes exert antitumor effects triggering the reactive oxygen species dependent intrinsic apoptotic pathway. ChemMedChem. 2017;12(24):2054–2065. doi:https://doi.org/10.1002/cmdc.201700634
- Chan WH, Wu CC, Yu JS. Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. J Cell Biochem. 2003;90(2):327–338. doi:https://doi.org/10.1002/jcb.10638
- Zheng WE, Chen H, Yuan SF, Wu L, Zhang W, Sun H, Chen W, et al. Overexpression of βIII-tubulin and survivin associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer. J Buon. 2012;17:284–290.
- Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007;87(1):99–163. doi:https://doi.org/10.1152/physrev.00013.2006
- Han J, Goldstein LA, Gastman BR, Rabinowich H. Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis. J Biol Chem. 2006;281(15):10153–10163. doi:https://doi.org/10.1074/jbc.M510349200
- Maier P, Hartmann L, Wenz F, Herskind C. Cellular pathways in response to ionizing radiation and their targetability for tumor radiosensitization. IJMS. 2016;17(1):102–133. doi:https://doi.org/10.3390/ijms17010102
- Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 2000;7(12):1166–1173. doi:https://doi.org/10.1038/sj.cdd.4400783
- Roset R, Ortet L, Gil-Gomez G. Role of Bcl-2 family members on apoptosis: what we have learned from knock-out mice. Front Biosci. 2007;12:4722–4730. doi:https://doi.org/10.2741/2421
- D’Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C. Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention. IJMS. 2008;9(3):213–228. doi:https://doi.org/10.3390/ijms9030213
- Pene F, Claessens YE, Muller O, Viguié F, Mayeux P, Dreyfus F, Lacombe C, Bouscary D. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene. 2002;21(43):6587–6597. doi:https://doi.org/10.1038/sj.onc.1205923
- Brahami N, Subramaniam S, Al-Ddafari MS, Elkaim C, Harmand PO, Sari BE, Lefranc G, Aribi M. Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src. J Negat Results Biomed. 2017;16(1):9. doi:https://doi.org/10.1186/s12952-017-0072-5
- Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007;26(22):3291–3310. doi:https://doi.org/10.1038/sj.onc.1210422
- Kim J, DellaPenna D. Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3. Proc Natl Acad Sci USA. 2006;103(9):3474–3479. doi:https://doi.org/10.1073/pnas.0511207103
- Russell SJ. RNA viruses as virotherapy agents. Cancer Gene Ther. 2002;9(12):961–966. doi:https://doi.org/10.1038/sj.cgt.7700535
- Shvetsov YB, Hernandez BY, Wilkens LR, Thompson PJ, Franke AA, Zhu X, Goodman MT. Plasma micronutrients and the acquisition and clearance of anal human papillomavirus infection: the Hawaii HPV cohort study. Cancer Res. 2010;70(23):9787–9797. doi:https://doi.org/10.1158/0008-5472.CAN-10-1374
- Swanson HM, SmithGong JRX, Rubin LP. Lutein but not other carotenoids, selectively inhibits breast cancer cell growth through several molecular mechanisms. FASEB J. 2016;2:30–34.