Association of Body Mass Index and the Risk of Gastro-Esophageal Cancer: A Mendelian Randomization Study in a Japanese Population

References

• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Omran AR. The epidemiologic transition. A theory of the epidemiology of population change. Bull World Health Organ. 2001;79(2):161–70. 2001
   PubMed Web of Science ®Google Scholar
• Noto H, Goto A, Tsujimoto T, Osame K, Noda M. Latest insights into the risk of cancer in diabetes. J Diabetes Investig. 2013;4(3):225–32. doi: 10.1111/jdi.12068.
   PubMed Web of Science ®Google Scholar
• Murphy N, Jenab M, Gunter MJ. Adiposity and gastrointestinal cancers: epidemiology, mechanisms and future directions. Nat Rev Gastroenterol Hepatol. 2018;15(11):659–70. doi: 10.1038/s41575-018-0038-1.
   PubMed Web of Science ®Google Scholar
• Cho JH, Shin CM, Han KD, Yoon H, Park YS, Kim N, Lee DH. Abdominal obesity increases risk for esophageal cancer: a nationwide population-based cohort study of South Korea. J Gastroenterol. 2020;55(3):307–16. doi: 10.1007/s00535-019-01648-9.
   PubMed Web of Science ®Google Scholar
• Bae JM. Body mass index and risk of gastric cancer in Asian adults: a meta-epidemiological meta-analysis of population-based cohort studies. Cancer Res Treat. 2020;52(2):369–73. doi: 10.4143/crt.2019.241.
   PubMed Web of Science ®Google Scholar
• Wang SM, Fan JH, Jia MM, Yang Z, Zhang YQ, Qiao YL, Taylor PR. Body mass index and long-term risk of death from esophageal squamous cell carcinoma in a Chinese population. Thorac Cancer. 2016;7(4):387–92. doi:10.1111/1759-7714.12340
   PubMed Web of Science ®Google Scholar
• Tian J, Zuo C, Liu G, Che P, Li G, Li X, Chen H. Cumulative evidence for the relationship between body mass index and the risk of esophageal cancer: an updated meta-analysis with evidence from 25 observational studies. J Gastroenterol Hepatol. 2020;35(5):730–43. doi:10.1111/jgh.14917
   PubMed Web of Science ®Google Scholar
• Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res. 2017;26(5):2333–55. doi: 10.1177/0962280215597579.
   PubMed Web of Science ®Google Scholar
• Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–65. doi: 10.1002/gepi.21758.
   PubMed Web of Science ®Google Scholar
• Thrift AP, Shaheen NJ, Gammon MD, Bernstein L, Reid BJ, Onstad L, Risch HA, Liu G, Bird NC, Wu AH, et al. Obesity and risk of esophageal adenocarcinoma and Barrett’s esophagus: a Mendelian randomization study. J Natl Cancer Inst. 2014;106(11):dju252. doi:10.1093/jnci/dju252
   PubMedGoogle Scholar
• Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, Relton CL, Martin RM, Davey SG, Brennan P. The role of obesity, type 2 diabetes, and metabolic factors in pancreatic cancer: a Mendelian randomization study. J Natl Cancer Inst. 2017;109(9):djx012. doi:10.1093/jnci/djx012
   PubMedGoogle Scholar
• Zhou W, Liu G, Hung RJ, Haycock PC, Aldrich MC, Andrew AS, Arnold SM, Bickeboller H, Bojesen SE, Brennan P, et al. Causal relationships between body mass index, smoking and lung cancer: univariable and multivariable Mendelian randomization. Int J Cancer. 2021;148(5):1077–86. doi: 10.1002/ijc.33292.
   PubMed Web of Science ®Google Scholar
• Bull CJ, Bell JA, Murphy N, Sanderson E, Davey SG, Timpson NJ, Banbury BL, Albanes D, Berndt SI, Bezieau S, et al. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. BMC Med. 2020;18(1):396. doi: 10.1186/s12916-020-01855-9.
   PubMed Web of Science ®Google Scholar
• Qian F, Wang S, Mitchell J, McGuffog L, Barrowdale D, Leslie G, Oosterwijk JC, Chung WK, Evans DG, Engel C, et al. Height and body mass index as modifiers of breast cancer risk in BRCA1/2 mutation carriers: a Mendelian randomization study. J Natl Cancer Inst. 2019;111(4):350–64. doi: 10.1093/jnci/djy132.
   PubMedGoogle Scholar
• Wade KH, Carslake D, Sattar N, Davey SG, Timpson NJ. BMI and mortality in UK biobank: revised estimates using Mendelian randomization. Obesity (Silver Spring). 2018;26(11):1796–806. doi: 10.1002/oby.22313.
   PubMed Web of Science ®Google Scholar
• Tobin MD, Minelli C, Burton PR, Thompson JR. Commentary: development of Mendelian randomization: from hypothesis test to ‘Mendelian deconfounding. Int J Epidemiol. 2004;33(1):26–9. doi: 10.1093/ije/dyh016.
   PubMed Web of Science ®Google Scholar
• Smith GD, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32(1):1–22. doi: 10.1093/ije/dyg070.
   PubMed Web of Science ®Google Scholar
• Minelli C, Thompson JR, Tobin MD, Abrams KR. An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization. Am J Epidemiol. 2004;160(5):445–52. doi: 10.1093/aje/kwh228.
   PubMed Web of Science ®Google Scholar
• Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol. 2004;33(1):30–42. doi: 10.1093/ije/dyh132.
   PubMed Web of Science ®Google Scholar
• Palmer TM, Sterne JA, Harbord RM, Lawlor DA, Sheehan NA, Meng S, Granell R, Smith GD, Didelez V. Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses. Am J Epidemiol. 2011;173(12):1392–403. doi: 10.1093/aje/kwr026.
   PubMed Web of Science ®Google Scholar
• Verduijn M, Siegerink B, Jager KJ, Zoccali C, Dekker FW. Mendelian randomization: use of genetics to enable causal inference in observational studies. Nephrol Dial Transplant. 2010;25(5):1394–8. doi: 10.1093/ndt/gfq098.
   PubMed Web of Science ®Google Scholar
• Khankari NK, Shu XO, Wen W, Kraft P, Lindstrom S, Peters U, Schildkraut J, Schumacher F, Bofetta P, Risch A, et al. Association between adult height and risk of colorectal, lung, and prostate cancer: results from meta-analyses of prospective studies and Mendelian randomization analyses. PLoS Med. 2016;13(9):e1002118. doi: 10.1371/journal.pmed.1002118.
   PubMed Web of Science ®Google Scholar
• VanderWeele TJ, Tchetgen TE, Cornelis M, Kraft P. Methodological challenges in mendelian randomization. Epidemiology. 2014;25(3):427–35. doi: 10.1097/EDE.0000000000000081.
   PubMed Web of Science ®Google Scholar
• Burgess S, Scott RA, Timpson NJ, Davey SG, Thompson SG. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol. 2015;30(7):543–52. doi: 10.1007/s10654-015-0011-z.
   PubMed Web of Science ®Google Scholar
• Kubo M. BioBank Japan project: epidemiological study. J Epidemiol. 2017;27(3S):S1. doi: 10.1016/j.je.2016.11.001.
   PubMedGoogle Scholar
• Hirata M, Kamatani Y, Nagai A, Kiyohara Y, Ninomiya T, Tamakoshi A, Yamagata Z, Kubo M, Muto K, Mushiroda T, et al. Cross-sectional analysis of BioBank Japan clinical data: a large cohort of 200,000 patients with 47 common diseases. J Epidemiol. 2017;27(3S):S9–S21. doi: 10.1016/j.je.2016.12.003.
   PubMedGoogle Scholar
• Zhou Y, Sun X, Zhou M. Body shape and Alzheimer’s disease: a Mendelian randomization analysis. Front Neurosci. 2019;13:1084. doi: 10.3389/fnins.2019.01084.
   PubMed Web of Science ®Google Scholar
• Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, et al. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun. 2018;9(1):260. doi: 10.1038/s41467-017-02662-2.
   PubMed Web of Science ®Google Scholar
• Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat Genet. 2017;49(10):1458–67. doi:10.1038/ng.3951
   PubMed Web of Science ®Google Scholar
• Pierce BL, Ahsan H, Vanderweele TJ. Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol. 2011;40(3):740–52. doi: 10.1093/ije/dyq151.
   PubMed Web of Science ®Google Scholar
• Spencer EA, Appleby PN, Davey GK, Key TJ. Validity of self-reported height and weight in 4808 EPIC-Oxford participants. Public Health Nutr. 2002;5(4):561–5. doi:10.1079/PHN2001322
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey SG, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25. doi: 10.1093/ije/dyv080.
   PubMed Web of Science ®Google Scholar
• Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey SG. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133–63. doi:10.1002/sim.3034
   PubMed Web of Science ®Google Scholar
• Yang X, Zhang T, Yin X, Yuan Z, Chen H, Plymoth A, Jin L, Chen X, Lu M, Ye W. Adult height, body mass index change, and body shape change in relation to esophageal squamous cell carcinoma risk: a population-based case-control study in China. Cancer Med. 2019;8(12):5769–78. doi: 10.1002/cam4.2444.
   PubMed Web of Science ®Google Scholar
• Hoyo C, Cook MB, Kamangar F, Freedman ND, Whiteman DC, Bernstein L, Brown LM, Risch HA, Ye W, Sharp L, et al. Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol. 2012;41(6):1706–18. doi:10.1093/ije/dys176
   PubMed Web of Science ®Google Scholar
• Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, Shiraishi Y, Chiba K, Imoto S, Takahashi Y, et al. Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. Gastroenterology. 2016;150(5):1171–82. doi: 10.1053/j.gastro.2016.01.035.
   PubMed Web of Science ®Google Scholar
• Fan JH, Wang JB, Wang SM, Abnet CC, Qiao YL, Taylor PR. Body mass index and risk of gastric cancer: a 30-year follow-up study in the Linxian general population trial cohort. Cancer Sci. 2017;108(8):1667–72. doi:10.1111/cas.13292
   PubMed Web of Science ®Google Scholar
• Fang X, Wei J, He X, Lian J, Han D, An P, Zhou T, Liu S, Wang F, Min J. Quantitative association between body mass index and the risk of cancer: a global Meta-analysis of prospective cohort studies. Int J Cancer. 2018;143(7):1595–603. doi:10.1002/ijc.31553
   PubMed Web of Science ®Google Scholar
• Gao C, Patel CJ, Michailidou K, Peters U, Gong J, Schildkraut J, Schumacher FR, Zheng W, Boffetta P, Stucker I, et al. Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer. Int J Epidemiol. 2016;45(3):896–908. doi: 10.1093/ije/dyw129.
   PubMed Web of Science ®Google Scholar
• Carreras-Torres R, Johansson M, Haycock PC, Wade KH, Relton CL, Martin RM, Davey SG, Albanes D, Aldrich MC, Andrew A, et al. Obesity, metabolic factors and risk of different histological types of lung cancer: a Mendelian randomization study. PLoS ONE. 2017;12(6):e177875. doi:10.1371/journal.pone.0177875
   Web of Science ®Google Scholar
• Jiang X, Dimou NL, Al-Dabhani K, Lewis SJ, Martin RM, Haycock PC, Gunter MJ, Key TJ, Eeles RA, Muir K, et al. Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study. Int J Epidemiol. 2019;48(5):1416–24. doi: 10.1093/ije/dyy284.
   PubMed Web of Science ®Google Scholar
• Schizas D, Lidoriki I, Liakakos T. Can we rely on body mass index when predicting postoperative outcomes and survival of esophageal cancer patients? J Buon. 2018;23(7):157.
   PubMedGoogle Scholar
• Boshier PR, Heneghan R, Markar SR, Baracos VE, Low DE. Assessment of body composition and sarcopenia in patients with esophageal cancer: a systematic review and meta-analysis. Dis Esophagus. 2018;31(8):doy047. doi:10.1093/dote/doy047
   Web of Science ®Google Scholar
• Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–64. doi: 10.1093/ije/dyr036.
   PubMed Web of Science ®Google Scholar