Association Between Vitamin B6 and the Risk of Colorectal Cancer: A Meta-analysis of Observational Studies

References

• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Dekker E, Tanis PJ, Vleugels JL, Kasi PM, Wallace MB. Colorectal cancer. Lancet. 2019;394(10207):1467–80. doi: 10.1016/S0140-6736(19)32319-0.
   PubMed Web of Science ®Google Scholar
• Acikgoz A, Cimrin D, Ergor G. Effect of serum 25-hydroxyvitamin D level on lung, breast, colorectal and prostate cancers: a nested case-control study. East Mediterr Health J. 2020;26(7):794–802. doi: 10.26719/emhj.20.035.
   PubMed Web of Science ®Google Scholar
• Moazzen S, Dastgiri S, Dolatkhah R, Abdolahi HM, Alizadeh BZ, De Bock GH. Folic acid supplement intake and risk of colorectal cancer in women; a case control study. Ann Glob Health. 2020;86(1):23. doi: 10.5334/aogh.2664.
   PubMed Web of Science ®Google Scholar
• Arthur RS, Kirsh VA, Rohan TE. Dietary B-vitamin intake and risk of breast, endometrial, ovarian and colorectal cancer among Canadians. Nutr Cancer. 2019;71(7):1067–77. doi: 10.1080/01635581.2019.1597904.
   PubMed Web of Science ®Google Scholar
• Ueland PM, Ulvik A, Rios-Avila L, Midttun Ø, Gregory JF. Direct and functional biomarkers of vitamin B6 status. Annu Rev Nutr. 2015;35:33–70. doi: 10.1146/annurev-nutr-071714-034330.
   PubMed Web of Science ®Google Scholar
• Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2004;13(4):511–9. 10.1158/1055-9965.511.13.4
   PubMed Web of Science ®Google Scholar
• Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr. 2002;132(8 Suppl):2413s–8s. doi: 10.1093/jn/132.8.2413S.
   PubMed Web of Science ®Google Scholar
• Sbodio JI, Snyder SH, Paul BD. Regulators of the transsulfuration pathway. Br J Pharmacol. 2019;176(4):583–93. doi: 10.1111/bph.14446.
   PubMed Web of Science ®Google Scholar
• Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging. 2002;6:39–42. PMID:11813080.
   PubMedGoogle Scholar
• Huang C-Y, Abulimiti A, Zhang X, Feng X-L, Luo H, Chen Y-M, Fang Y-J, Zhang C-X. Dietary B vitamin and methionine intakes and risk for colorectal cancer: a case-control study in China. Br J Nutr. 2020;123(11):1277–89. doi: 10.1017/S0007114520000501.
   PubMed Web of Science ®Google Scholar
• Chiang FF, Wang HM, Lan YC, Yang MH, Huang SC, Huang YC. High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities. Clin Nutr. 2014;33(6):1054–60. doi: 10.1016/j.clnu.2013.11.007.
   PubMed Web of Science ®Google Scholar
• Jung AY, van Duijnhoven FJB, Nagengast FM, Botma A, Heine-Bröring RC, Kleibeuker JH, Vasen HFA, Harryvan JL, Winkels RM, Kampman E. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study. Cancer Causes Control. 2014;25(9):1119–29. doi: 10.1007/s10552-014-0412-4.
   PubMed Web of Science ®Google Scholar
• Eussen SJPM, Vollset SE, Hustad S, Midttun Ø, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Boffetta P, et al. Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2549–61. doi: 10.1158/1055-9965.Epi-10-0407.
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71.
   PubMed Web of Science ®Google Scholar
• Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P, Wells Ga S, Zello G, Petersen J. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses, Oxford, 2000.[accessed 2021 Oct 16]. http://www.evidencebasedpublichealth.de/download/Newcastle_Ottowa_Scale_Pope_Bruce.pdf.
   Google Scholar
• Gylling B, Myte R, Schneede J, Hallmans G, Häggström J, Johansson I, Ulvik A, Ueland PM, Van Guelpen B, Palmqvist R, et al. Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status. Am J Clin Nutr. 2017;105(4):897–904. doi: 10.3945/ajcn.116.139337.
   PubMed Web of Science ®Google Scholar
• Zschäbitz S, Cheng T-YD, Neuhouser ML, Zheng Y, Ray RM, Miller JW, Song X, Maneval DR, Beresford SAA, Lane D, et al. B vitamin intakes and incidence of colorectal cancer: results from the Women’s Health Initiative Observational Study cohort. Am J Clin Nutr. 2013;97(2):332–43. doi: 10.3945/ajcn.112.034736.
   PubMed Web of Science ®Google Scholar
• Bassett JK, Severi G, Hodge AM, Baglietto L, Hopper JL, English DR, Giles GG. Dietary intake of B vitamins and methionine and colorectal cancer risk. Nutr Cancer. 2013;65(5):659–67. doi: 10.1080/01635581.2013.789114.
   PubMed Web of Science ®Google Scholar
• Key TJ, Appleby PN, Masset G, Brunner EJ, Cade JE, Greenwood DC, Stephen AM, Kuh D, Bhaniani A, Powell N, et al. Vitamins, minerals, essential fatty acids and colorectal cancer risk in the United Kingdom Dietary Cohort Consortium. Int J Cancer. 2012;131(3):E320–325. doi: 10.1002/ijc.27386.
   PubMed Web of Science ®Google Scholar
• Schernhammer ES, Giovannucci E, Baba Y, Fuchs CS, Ogino S. B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PLoS One. 2011;6(6):e21102. doi: 10.1371/journal.pone.0021102.
   PubMed Web of Science ®Google Scholar
• Schernhammer ES, Giovannucci E, Kawasaki T, Rosner B, Fuchs CS, Ogino S. Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut. 2010;59(6):794–9. doi: 10.1136/gut.2009.183707.
   PubMed Web of Science ®Google Scholar
• Shrubsole MJ, Yang G, Gao Y-T, Chow WH, Shu XO, Cai Q, Rothman N, Gao J, Wagner C, Zheng W, et al. Dietary B vitamin and methionine intakes and plasma folate are not associated with colorectal cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev. 2009;18(3):1003–6. doi: 10.1158/1055-9965.EPI-08-1200.
   PubMed Web of Science ®Google Scholar
• Lee JE, Li H, Giovannucci E, Lee I-M, Selhub J, Stampfer M, Ma J. Prospective study of plasma vitamin B6 and risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1197–202. doi: 10.1158/1055-9965.Epi-08-1001.
   PubMed Web of Science ®Google Scholar
• Le Marchand L, White KK, Nomura AMY, Wilkens LR, Selhub JS, Tiirikainen M, Goodman MT, Murphy SP, Henderson BE, Kolonel LN, et al. Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2009;18(8):2195–201. doi: 10.1158/1055-9965.Epi-09-0141.
   PubMed Web of Science ®Google Scholar
• Weinstein SJ, Albanes D, Selhub J, Graubard B, Lim U, Taylor PR, Virtamo J, Stolzenberg-Solomon R. One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev. 2008;17(11):3233–40. doi: 10.1158/1055-9965.Epi-08-0459.
   PubMed Web of Science ®Google Scholar
• de Vogel S, Dindore V, van Engeland M, Goldbohm RA, van den Brandt PA, Weijenberg MP. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr. 2008;138(12):2372–8. doi: 10.3945/jn.108.091157.
   PubMed Web of Science ®Google Scholar
• Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Tsugane S, Japan Public Health Center-based Prospective Study Group. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr. 2007;137(7):1808–14. doi: 10.1093/jn/137.7.1808.
   PubMed Web of Science ®Google Scholar
• Zhang SM, Moore SC, Lin J, Cook NR, Manson JE, Lee I-M, Buring JE. Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol. 2006;163(2):108–15. doi: 10.1093/aje/kwj016.
   PubMed Web of Science ®Google Scholar
• Wei EK, Giovannucci E, Selhub J, Fuchs CS, Hankinson SE, Ma J. Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst. 2005;97(9):684–92. doi: 10.1093/jnci/dji116.
   PubMedGoogle Scholar
• Larsson SC, Giovannucci E, Wolk A. Vitamin B6 intake, alcohol consumption, and colorectal cancer: a longitudinal population-based cohort of women. Gastroenterology. 2005;128(7):1830–7. doi: 10.1053/j.gastro.2005.03.005.
   PubMed Web of Science ®Google Scholar
• Harnack L, Jacobs DR, Nicodemus K, Lazovich D, Anderson K, Folsom AR. Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers. Nutr Cancer. 2002;43(2):152–8. doi: 10.1207/S15327914NC432_5.
   PubMed Web of Science ®Google Scholar
• Le Marchand L, Wilkens LR, Kolonel LN, Henderson BE. The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14(5):1198–203. doi: 10.1158/1055-9965.Epi-04-0840.
   PubMed Web of Science ®Google Scholar
• Xu L, Fang Y-J, Che M-M, Abulimiti A, Huang C-Y, Zhang C-X. Association of serum pyridoxal-5′-phosphate, pyridoxal, and PAr with colorectal cancer risk: a large-scale case-control study. Nutrients. 2022;14(12):2389. doi: 10.3390/nu14122389.
   PubMed Web of Science ®Google Scholar
• Banqué M, Raidó B, Masuet C, Ramon JM. Food groups and nutrient intake and risk of colorectal cancer: a hospital-based case-control study in Spain. Nutr Cancer. 2012;64(3):386–92. doi: 10.1080/01635581.2012.657334.
   PubMed Web of Science ®Google Scholar
• Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS. Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer. Cancer Causes Control. 2010;21(8):1171–81. doi: 10.1007/s10552-010-9544-3.
   PubMed Web of Science ®Google Scholar
• Kune G, Watson L. Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins B6, B12, C, E, selenium, and lycopene. Nutr Cancer. 2006;56(1):11–21. doi: 10.1207/s15327914nc5601_3.
   PubMed Web of Science ®Google Scholar
• Le Marchand L, Donlon T, Hankin JH, Kolonel LN, Wilkens LR, Seifried A. B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control. 2002;13(3):239–48. doi: 10.1023/a:1015057614870.
   PubMed Web of Science ®Google Scholar
• La Vecchia C, Braga C, Negri E, Franceschi S, Russo A, Conti E, Falcini F, Giacosa A, Montella M, Decarli A, et al. Intake of selected micronutrients and risk of colorectal cancer. Int J Cancer. 1997;73(4):525–30. doi: 10.1002/(sici)1097-0215(19971114)73:4 < 525::aid-ijc12 > 3.0.co;2-8. 10.1002/(SICI)1097-0215(19971114)73:4<525::AID-IJC12>3.0.CO;2-8
   PubMed Web of Science ®Google Scholar
• Larsson SC, Orsini N, Wolk A. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA. 2010;303(11):1077–83. doi: 10.1001/jama.2010.263.
   PubMed Web of Science ®Google Scholar
• Jia K, Wang R, Tian J. Vitamin B6 intake and the risk of colorectal cancer: a meta-analysis of cohort studies. Nutr Cancer. 2017;69(5):723–31. doi: 10.1080/01635581.2017.1324633.
   PubMed Web of Science ®Google Scholar
• Choi SW, Friso S. Vitamins B6 and cancer. Dordrecht: Springer Netherlands, 2012. p. 247–264. doi: 10.1007/978-94-007-2199-9_13.
   Google Scholar
• Long AG, Lundsmith ET, Hamilton KE. Inflammation and colorectal cancer. Curr Colorectal Cancer Rep. 2017;13(4):341–51. doi: 10.1007/s11888-017-0373-6.
   PubMed Web of Science ®Google Scholar
• Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr. 2010;91(2):337–42. doi: 10.3945/ajcn.2009.28571.
   PubMed Web of Science ®Google Scholar
• Janson WT, Jenkins LJ, Chionh F, Mariadason JM. Aberrant DNA methylation in colorectal cancer: what should we target? Trends Cancer. 2017;3(10):698–712. doi: 10.1016/j.trecan.2017.08.003.
   PubMed Web of Science ®Google Scholar
• Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta‐analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther. 2009;30(2):113–25. doi: 10.1111/j.1365-2036.2009.04022.x.
   PubMed Web of Science ®Google Scholar