TIGAR Protects Against Adenine-Induced Ferroptosis in Human Proximal Tubular Epithelial Cells by Activating the mTOR/S6KP70 Axis

References

• Mulay SR, Anders HJ. Crystal nephropathies: mechanisms of crystal-induced kidney injury. Nat Rev Nephrol. 2017;13(4):226–240. doi: 10.1038/nrneph.2017.10.
   PubMed Web of Science ®Google Scholar
• Daudon M, Frochot V, Bazin D, Jungers P. Drug-induced kidney stones and crystalline nephropathy: pathophysiology, prevention and treatment. Drugs. 2018;78(2):163–201. doi: 10.1007/s40265-017-0853-7.
   PubMed Web of Science ®Google Scholar
• Li X, Bayliss G, Zhuang S. Cholesterol crystal embolism and chronic kidney disease. Int J Mol Sci. 2017;18(6):1120. doi: 10.3390/ijms18061120. 10.3390/ijms18061120
   PubMed Web of Science ®Google Scholar
• Cochran B, Kovačíková T, Hodaňová K, Živná M, Hnízda A, Niehaus AG, Bonnecaze A, Balasubraminiam G, Ceballos-Picot I, Hawfield A, et al. Chronic tubulointerstitial kidney disease in untreated adenine phosphoribosyl transferase (APRT) deficiency: a case report. Clin Nephrol. 2018;90(4):296–301. doi: 10.5414/CN109460.
   PubMed Web of Science ®Google Scholar
• Auler K, Broock R, Nyhan WL. Determination of activity of the enzymes hypoxanthine phosphoribosyl transferase (HPRT) and adenine phosphoribosyl transferase (APRT) in blood spots on filter paper. Curr Protoc Hum Genet. 2015;86:17.19.1.
   PubMedGoogle Scholar
• Rule AD, Krambeck AE, Lieske JC. Chronic kidney disease in kidney tone formers. Clin J Am Soc Nephrol. 2011;6(8):2069–2075. doi: 10.2215/CJN.10651110.
   PubMed Web of Science ®Google Scholar
• Su Y, Zhao B, Zhou L, Zhang Z, Shen Y, Lv H, AlQudsy LHH, Shang P. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020;483:127–136. doi: 10.1016/j.canlet.2020.02.015.
   PubMed Web of Science ®Google Scholar
• Khan MA, Nag P, Grivei A, Giuliani KTK, Wang X, Diwan V, Hoy W, Healy H, Gobe G, Kassianos AJ. Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells. Cell Death Dis. 2022;13(2):104. doi: 10.1038/s41419-022-04527-z.
   PubMed Web of Science ®Google Scholar
• Kim S, Kang SW, Joo J, Han SH, Shin H, Nam BY, Park J, Yoo TH, Kim G, Lee P, et al. Characterization of ferroptosis in kidney tubular cell death under diabetic conditions. Cell Death Dis. 2021;12(2):160. doi: 10.1038/s41419-021-03452-x.
   PubMed Web of Science ®Google Scholar
• Eleftheriadis T, Pissas G, Filippidis G, Liakopoulos V, Stefanidis I. Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor. Mol Med Rep. 2021;23(1):41.
   PubMed Web of Science ®Google Scholar
• Zhang B, Chen X, Ru F, Gan Y, Li BS, Xia WP, Dai GY, He Y, Chen Z. Liproxstatin-1 attenuates unilateral ureteral obstruction induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis. Cell Death Dis. 2021;12(9):843. doi: 10.1038/s41419-021-04137-1.
   PubMed Web of Science ®Google Scholar
• Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res. 2020;30(2):146–162. doi: 10.1038/s41422-019-0263-3.
   PubMed Web of Science ®Google Scholar
• Chen X, Yu C, Kang R, Kroemer G, Tang D. Cellular degradation systems in ferroptosis. Cell Death Differ. 2021;28(4):1135–1148. doi: 10.1038/s41418-020-00728-1.
   PubMed Web of Science ®Google Scholar
• Liu MY, Li HM, Wang XY, Xia R, Li X, Ma YJ, Wang M, Zhang HS. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway. Free Radic Biol Med. 2022;182:219–231. doi: 10.1016/j.freeradbiomed.2022.03.002.
   PubMed Web of Science ®Google Scholar
• He X, Cantrell AC, Williams QA, Chen JX, Zeng H. TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury. Physiol Rep. 2022;10(8):e15234.
   PubMed Web of Science ®Google Scholar
• Zhang DM, Zhang T, Wang MM, Wang XX, Qin YY, Wu J, Han R, Sheng R, Wang Y, Chen Z, et al. TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury. Free Radic Biol Med. 2019;137:13–23. doi: 10.1016/j.freeradbiomed.2019.04.002.
   PubMed Web of Science ®Google Scholar
• Huang J, Chen G, Wang J, Liu S, Su J. Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4). Bioengineered. 2022;13(3):6627–6637. 10.1080/21655979.2022.2045834
   PubMed Web of Science ®Google Scholar
• Honarpisheh M, Foresto-Neto O, Desai J, Steiger S, Gómez LA, Popper B, Boor P, Anders HJ, Mulay SR. Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape. Sci Rep. 2017;7(1):15523. doi: 10.1038/s41598-017-15804-9.
   PubMed Web of Science ®Google Scholar
• Wang J, Liu Y, Wang Y, Sun L. The cross-link between ferroptosis and kidney diseases. Oxid Med Cell Longev. 2021;2021:6654887. doi: 10.1155/2021/6654887.
   PubMed Web of Science ®Google Scholar
• Li D, Li Y. The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Ther. 2020;5(1):108.
   PubMed Web of Science ®Google Scholar
• Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, et al. SLC7A11 reduces laser-induced choroidal neovascularization by inhibiting RPE ferroptosis and VEGF production. Front Cell Dev Biol. 2021;9:639851. doi: 10.3389/fcell.2021.639851.
   PubMed Web of Science ®Google Scholar
• Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol. 2021;220(9):e202105043.
   PubMed Web of Science ®Google Scholar
• Li S, Zheng L, Zhang J, Liu X, Wu Z. Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy. Free Radic Biol Med. 2021;162:435–449. doi: 10.1016/j.freeradbiomed.2020.10.323.
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. doi: 10.1038/s41419-020-2298-2.
   PubMed Web of Science ®Google Scholar
• Islam MT. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res. 2017;39(1):73–82. doi: 10.1080/01616412.2016.1251711.
   PubMed Web of Science ®Google Scholar
• Convento MB, Pessoa EA, Cruz E, da Glória MA, Schor N, Borges FT. Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: contribution to oxalate kidney injury. Sci Rep. 2017;7:45740. doi: 10.1038/srep45740.
   PubMed Web of Science ®Google Scholar
• He X, Zeng H, Cantrell AC, Chen JX. Regulatory role of TIGAR on endothelial metabolism and angiogenesis. J Cell Physiol. 2021;236(11):7578–7590. doi: 10.1002/jcp.30401.
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu W, Liu F, Wang Q, Song M, Yu Q, Tang K, Teng T, Wu D, Wang X, et al. IMCA induces ferroptosis mediated by SLC7A11 through the AMPK/mTOR pathway in colorectal cancer. Oxid Med Cell Longev. 2020;2020:1–2. doi: 10.1155/2020/6901472. 10.1155/2020/6901472
   Web of Science ®Google Scholar
• Xie JM, Li B, Yu HP, Gao QG, Li W, Wu HR, Qin ZH. TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy. Cancer Res. 2014;74(18):5127–5138. doi: 10.1158/0008-5472.CAN-13-3517.
   PubMed Web of Science ®Google Scholar
• Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, Yin J, Wang J. SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol. 2020;235(11):8839–8851. doi: 10.1002/jcp.29727.
   PubMed Web of Science ®Google Scholar