174
Views
0
CrossRef citations to date
0
Altmetric
Review Article

Effect of Oral Consumption of Vitamin D on Uterine Fibroids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

ORCID Icon, , , , , , , , , & show all
Pages 226-235 | Received 24 Aug 2023, Accepted 22 Nov 2023, Published online: 17 Jan 2024

References

  • Giuliani E, As-Sanie S, Marsh EE. Epidemiology and management of uterine fibroids. Int J Gynaecol Obstet. 2020;149(1):3–9. 10.1002/ijgo.13102
  • Ciebiera M, Ali M, Zgliczyńska M, Skrzypczak M, Al-Hendy A. Vitamins and uterine fibroids: current data on pathophysiology and possible clinical relevance. Int J Mol Sci. 2020;21(15):5528. 10.3390/ijms21155528
  • Ulin M, Ali M, Chaudhry ZT, Al-Hendy A, Yang Q. Uterine fibroids in menopause and perimenopause. Menopause. 2020;27(2):238–42. 10.1097/GME.0000000000001438
  • Wallace K, Zhang S, Thomas L, Stewart EA, Nicholson WK, Wegienka GR, Wise LA, Laughlin-Tommaso SK, Diamond MP, Marsh EE, et al. Comparative effectiveness of hysterectomy versus myomectomy on one-year health-related quality of life in women with uterine fibroids. Fertil Steril. 2020;113(3):618–26. 10.1016/j.fertnstert.2019.10.028
  • Marsh EE, Al-Hendy A, Kappus D, Galitsky A, Stewart EA, Kerolous M. Burden, prevalence, and treatment of uterine fibroids: a survey of US women. J Womens Health. 2018;27(11):1359–67. 10.1089/jwh.2018.7076
  • Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, Islam MS, Tranquilli AL, Reis FM, Ciarmela P, et al. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstet Gynecol Int. 2013;2013:173184–11. 10.1155/2013/173184
  • Faustino F, Martinho M, Reis J, Águas F. Update on medical treatment of uterine fibroids. Eur J Obstet Gynecol Reprod Biol. 2017;216:61–8. 10.1016/j.ejogrb.2017.06.047
  • Sabry M, Halder SK, Allah ASA, Roshdy E, Rajaratnam V, Al-Hendy A. Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study. Int J Womens Health. 2013;5:93–100. 10.2147/IJWH.S38800
  • Paffoni A, Somigliana E, Vigano’ P, Benaglia L, Cardellicchio L, Pagliardini L, Papaleo E, Candiani M, Fedele L. Vitamin D status in women with uterine leiomyomas. J Clin Endocrinol Metab. 2013;98(8):E1374–E1378. 10.1210/jc.2013-1777
  • Okoro CC, Ikpeze OC, Eleje GU, Udigwe GO, Ezeama CO, Ugboaja JO, Enechukwu CI, Umeononihu OS, Ogabido CA, Oguejiofor C, et al. Association between serum vitamin D status and uterine leiomyomas: a case-control study. Obstet Gynecol Sci. 2023. 10.5468/ogs.23413
  • Mohammadi R, Tabrizi R, Hessami K, Ashari H, Nowrouzi-Sohrabi P, Hosseini-Bensenjan M, Asadi N. Correlation of low serum vitamin-D with uterine leiomyoma: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2020;18(1):1–8. 10.1186/s12958-020-00644-6
  • Sassi F, Tamone C, D’Amelio P. Vitamin D: nutrient, hormone, and immunomodulator. Nutrients. 2018;10(11):1656. 10.3390/nu10111656
  • Jeon S-M, Shin E-A. Exploring vitamin D metabolism and function in cancer. Exp Mol Med. 2018;50(4):1–14.
  • Hawkes CP, Li D, Hakonarson H, Meyers KE, Thummel KE, Levine MA. CYP3A4 induction by rifampin: an alternative pathway for vitamin D inactivation in patients with CYP24A1 mutations. J Clin Endocrinol Metab. 2017;102(5):1440–6. 10.1210/jc.2016-4048
  • Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–29. 10.1016/j.chembiol.2013.12.016
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. 10.1210/jc.2011-0385
  • Arjeh S, Darsareh F, Asl ZA, Kutenaei MA. Effect of oral consumption of vitamin D on uterine fibroids: a randomized clinical trial. Complement Ther Clin Pract. 2020;39:101159. 10.1016/j.ctcp.2020.101159
  • Tanha FD, Feizabad E, Farahani MV, Amuzegar H, Moradi B, Sadeh SS. The effect of vitamin D deficiency on overgrowth of uterine fibroids: a blinded randomized clinical trial. Int J Fertil Steril. 2021;15(2):95.
  • Hajhashemi M, Ansari M, Haghollahi F, Eslami B. The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency. Caspian J Intern Med. 2019;10(2):125–31. 10.22088/cjim.10.2.125
  • Rahmanian M, Saghafi M, Darban M, Mirmohammadkhani M. Is vitamin D effective in the treatment of uterine leiomyoma? A randomized controlled double-blind clinical trial. Middle East J Rehabil Health Stud. 2018;5(4):e66073. 10.5812/mejrh.66073
  • Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1–9. 10.1186/2046-4053-4-1
  • Vahdat M, Allahqoli L, Mirzaei H, Giovannucci E, Salehiniya H, Mansouri G, Alkatout I. The effect of vitamin D on recurrence of uterine fibroids: a randomized, double-blind, placebo-controlled pilot study. Complement Ther Clin Pract. 2022;46:101536. 10.1016/j.ctcp.2022.101536
  • Ciebiera M, Ali M, Prince L, Zgliczyński S, Jakiel G, Al-Hendy A. The significance of measuring vitamin D serum levels in women with uterine fibroids. Reprod Sci. 2020;28(8):2098–109. 10.1007/s43032-020-00363-8
  • Baird DD, Hill MC, Schectman JM, Hollis BW. Vitamin D and risk of uterine fibroids. Epidemiology. 2013;24(3):447–53. 10.1097/EDE.0b013e31828acca0
  • Houtrow A, Harris D, Molinero A, Levin-Decanini T, Robichaud C. Children with disabilities in the United States and the COVID-19 pandemic. J Pediatr Rehabil Med. 2020;13(3):415–24. 10.3233/PRM-200769
  • Halder SK, Sharan C, Al-Hendy O, Al-Hendy A. Paricalcitol, a vitamin D receptor activator, inhibits tumor formation in a murine model of uterine fibroids. Reprod Sci. 2014;21(9):1108–19. 10.1177/1933719114537721
  • Sharan C, Halder SK, Thota C, Jaleel T, Nair S, Al-Hendy A. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril. 2011;95(1):247–53. 10.1016/j.fertnstert.2010.07.1041
  • Pandolfi F, Franza L, Mandolini C, Conti P. Immune modulation by vitamin D: special emphasis on its role in prevention and treatment of cancer. Clin Ther. 2017;39(5):884–93. 10.1016/j.clinthera.2017.03.012
  • Umar M, Sastry KS, Chouchane AI. Role of vitamin D beyond the skeletal function: a review of the molecular and clinical studies. Int J Mol Sci. 2018;19(6):1618. 10.3390/ijms19061618
  • Zheng S, Yang J, Hu X, Li M, Wang Q, Dancer RCA, Parekh D, Gao-Smith F, Thickett DR, Jin S. Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition. Biochem Pharmacol. 2020;177:113955. 10.1016/j.bcp.2020.113955
  • Gonzalez-Suarez I, Redwood AB, Grotsky DA, Neumann MA, Cheng EH-Y, Stewart CL, Dusso A, Gonzalo S. A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair. Embo J. 2011;30(16):3383–96. 10.1038/emboj.2011.225
  • Abu el Maaty MA, Wölfl S. Vitamin D as a novel regulator of tumor metabolism: insights on potential mechanisms and implications for anti-cancer therapy. Int J Mol Sci. 2017;18(10):2184. 10.3390/ijms18102184
  • Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1α, 25 (OH) 2vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. 2011;25(4):543–59. 10.1016/j.beem.2011.05.010
  • Othman ER, Ahmed E, Sayed AA, Hussein M, Abdelaal II, Fetih AN, Abou-Taleb HA, Yousef A-EA. Human uterine leiomyoma contains low levels of 1, 25 dihdroxyvitamin D3, and shows dysregulated expression of vitamin D metabolizing enzymes. Eur J Obstet Gynecol Reprod Biol. 2018;229:117–22. 10.1016/j.ejogrb.2018.08.018
  • Cardano M, Tribioli C, Prosperi E. Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation. Curr Cancer Drug Targets. 2020;20(4):240–52. 10.2174/1568009620666200115162814
  • Wang X, Sun B, Zhou F, Hu J, Yu X, Peng T. Vitamin D receptor and PCNA expression in severe parathyroid hyperplasia of uremic patients. Chinese Med J. 2001;114(4):410–4.
  • Shen X, Puthran N, Weissman A. A refined HPLC method to measure catecholamine-o-methyltransferase activity in selected brain regions. J Neurosci Methods. 2005;144(1):137–42. 10.1016/j.jneumeth.2004.11.001
  • Li L, Shang F, Zhu Y, Sun Y, Sudi RS. Modulation of VDR and cell cycle-related proteins by vitamin D in normal pancreatic cells and poorly differentiated metastatic pancreatic cancer cells. Nutr Cancer. 2019;71(5):818–24. 10.1080/01635581.2018.1521445
  • Reis FM, Bloise E, Ortiga-Carvalho TM. Hormones and pathogenesis of uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016;34:13–24. 10.1016/j.bpobgyn.2015.11.015
  • Al-Hendy A, Diamond MP, El-Sohemy A, Halder SK. 1, 25-Dihydroxyvitamin D3 regulates expression of sex steroid receptors in human uterine fibroid cells. J Clin Endocrinol Metab. 2015;100(4):E572–E582. 10.1210/jc.2014-4011
  • Tavera-Mendoza LE, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, Cameron LA, Ficarro SB, Marto JA, Klawitter J, et al. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017;114(11):E2186–E2194. 10.1073/pnas.1615015114
  • Krishnan AV, Swami S, Feldman D. Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling. J Steroid Biochem Mol Biol. 2010;121(1-2):343–8. 10.1016/j.jsbmb.2010.02.009
  • Blutt SE, McDonnell TJ, Polek TC, Weigel NL. Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2. Endocrinology. 2000;141(1):10–7. 10.1210/endo.141.1.7289
  • Antonsson B, Martinou J-C. The Bcl-2 protein family. Exp Cell Res. 2000;256(1):50–7. 10.1006/excr.2000.4839
  • Halder SK, Osteen KG, Al-Hendy A. 1, 25-Dihydroxyvitamin d3 reduces extracellular matrix-associated protein expression in human uterine fibroid cells. Biol Reprod. 2013;89(6):150. 10.1095/biolreprod.113.107714
  • Rahman A, Hershey S, Ahmed S, Nibbelink K, Simpson RU. Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice. J Steroid Biochem Mol Biol. 2007;103(3–5):416–9. 10.1016/j.jsbmb.2006.12.081
  • Ali M, Shahin SM, Sabri NA, Al-Hendy A, Yang Q. Hypovitaminosis D exacerbates the DNA damage load in human uterine fibroids, which is ameliorated by vitamin D3 treatment. Acta Pharmacol Sin. 2019;40(7):957–70. 10.1038/s41401-018-0184-6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.