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Chlorophyll: The active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro

Pages 19-21 | Published online: 04 Aug 2009

References and notes

  • Atuma , SS , Lundström , K and Lindquist , J . 1975 . “The Electrochemical Determination of Vitamin A” . Analyst , 100 : 827 – 834 .
  • De Vries , T . 1968–1969 . “Potentials of Electrochemical Reactions at 25° C” . In CRC Handbook of Chemistry and Physics, , 49th Edition , Edited by: Weast , RC . D‐86 Cleveland : The Chemical Rubber Co. .
  • Gruskin , B . 1940 . “Chlorophyll—Its Therapeutic Place in Acute and Suppurative Disease” . Am J Surg , 49 : 49 – 55 .
  • Kazakova , AA , Kiselev , BA and Yevstigneyev , VB . 1976 . “Redox Potential of the Chlorophyll Pigments of Photosynthesizing Organisms at Different Levels of Evolutionary Development” . Biophys , 21 : 445 – 449 .
  • Lai , CN , Dabney , BJ and Shaw , CR . 1978 . “Inhibition of In Vitro Metabolic Activation of Carcinogens by Wheat Sprout Extracts” . Nutr and Cancer , 1 : 27 – 30 .
  • Morita , K , Inoue , T and Kada , T . 1978 . “Desmutagenic Factor of Vegetable Extracts on Mutagenic Principles of Tryptophan Pyrolysates” . Mut Res , 54 : 243 – 244 .
  • Volkov , AG , Lozhkin , BT and Boguslavskii , LI . 1975 . “Proton and Electron Transfer Across Bilayer Membranes and a Decane/Water Interface in Presence of Chlorophyll” . Doklady Biophys , 220 : 14 – 16 .
  • Wattenberg , LW . 1978 . “Inhibitors of Chemical Carcinogenesis” . Adv Cancer Res , 25 : 197 – 226 .
  • The author would like to thank El duPont de Nemours, CR Shaw, M Arnott, and AC Griffin for their help.
  • This work was supported in part by Grant GM‐15597 from the National Institute of Medical Sciences.

Note added in proof

  • Baxter , JH . 1968 . “Absorption of Chlorophyll Phytol in Normal Man and in Patients with Refsum's Disease” . J Lipid Res , 9 : 636 – 641 . The metabolism of chlorophyll in vivo has not been studied extensively. reported that most of the ingested dietary chlorophylls (95%) were recovered in the feces as pheophytins, a chlorophyll‐like compound rendered free of Mg ++ by stomach acid. Since free phytol is readily absorbed, the author suggested that the phytyl‐ester linkage in the chlorophyll molecule is resistant to action of intestinal enzymes.

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