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Special communications

Concentrations of free amino acids and other blood components in a lymphoma patient during intensive hemodialysis

Pages 165-180 | Published online: 04 Aug 2009

References and notes

  • Boiron , M , ed. 1971 . La L‐Asparaginase , Paris : Centre National de la Recherche Scientifique .
  • Boyse , EA , Campbell , HA and Mashburn , LT . 1967 . “Suppression of Murine Leukemias by L ‐Asparaginase” . J Exp Med , 125 : 17 – 31 .
  • Broome , JD . 1961 . “Evidence That the L‐Asparaginase Activity of Guinea Pig Serum is Responsible for Its Antilymphoma Effects” . Nature , 191 : 1114 – 1115 .
  • Dolowy , WC , Hensen , D Cornet , J . 1966 . “Toxic and Antineo‐plastic Effects of L‐Asparaginase. Study of Mice with Lymphoma and Normal Monkeys and Report on a Child with Leukemia” . Cancer , 19 : 1813 – 1819 .
  • Grimsrud , L , Cole , JJ Eschbach , JW . 1967 . “Safety Aspects of Hemodialysis” . Trans Am Soc Artif Intern Organs , XIII : 1 – 4 .
  • Grundmann , E and Oettgen , HF , eds. 1970 . Recent Results in Cancer Research , Vol. 33 , New York : Springer‐Verlag .
  • Holden , JT , ed. 1962 . Amino Acid Pools: Distribution, Formation, and Function of Free Amino Acids , New York : Elsevier Publishing Company .
  • Kidd , JG . 1970 . “Asparaginase and Cancer‐Yesterday and Today” . In Recent Results in Cancer Research , Edited by: Grundmann , E and Oettgen , HF . Vol. 33 , 3 – 14 . New York : Springer‐Verlag .
  • Meister , A , ed. 1965 . Biochemistry of the Amino Acids , 204 New York : Academic Press .
  • Miller , DS , Laszlo , J Lyon , G . 1972 . “Reduction of Human Blood Asparagine by Hemodialysis” . Cancer , 19 : 1347 – 1351 .
  • Oettgen , HF , Old , LJ Boyse , EA . 1968 . “Therapeutic Effects of L‐Asparaginase on Asparagine‐Dependent Neoplasms; Laboratory and Clinical Studies” . J Clin Invest , 47 : 74a
  • Oettgen , HF , Stephenson , PA Schwartz , MK . 1970 . “Toxicity of E. coli L‐Asparaginase in Man” . Cancer , 25 : 253 – 278 .
  • Ohnuma , T , Holland , JF Sinks , L . 1970 . “Biochemical and Pharmacological Studies With Asparaginase in Man” . Cancer Res , 30 : 2297 – 2305 .
  • Riley , V . 1973 . “Dialysis Dementia: Probably Not Asparagine Deficiency” . Lancet , Dec. 1 : 1275
  • Riley , V . 1976 . “Basic Studies on the Hemodialysis of Amino Acids” . Am Soc Artif Intern Organs , 5 : 68 (abstr)
  • Riley , V . 1980 . “Whatever Happened to the Asparaginase Concept of Amino Acid Deprivation Therapy?” . Nutr Cancer , 2 : 4 – 8 .
  • Riley , V . 1981 . “Hemodialysis of Amino Acids: Basic Studies In Vitro” . Nutr Cancer , 2 : 153 – 164 .
  • Riley , V , Spackman , DH and Fitzmaurice , MA . 1971 . “Influence of Asparaginase and Glutaminase Upon Free Amino Acids in Normal and Tumor‐Bearing Mice” . In La L‐Asparaginase , Edited by: Boiron , M . 139 – 158 . Paris : Centre National de la Recherche Scientifique .
  • Riley , V and Spackman , D . 1981 . “Theoretical and Practical Considerations in the Use of Hemodialysis for the Therapeutic Removal of Asparagine and Other Amino Acids” . Nutr Cancer , 2 : 181 – 192 .
  • Roberts , J , Prager , MD and Bachynsky , N . 1966 . “The Antitumor Activity of Escherichia coli L‐Asparaginase” . Cancer Res , 26 : 2214 – 2217 .
  • Rogers , C . 1968 . “Significance of Dialysis Against Enzymes to the Specific Therapy of Cancer and Genetic Deficiency Diseases” . Nature , 220 : 1321 – 1322 .
  • Spackman , DH . 1964 . “Ion Exchange Chromatography of Protein Hydrolysates. A. The Automatic Amino Acid Analyzer and Accelerated Procedures. B. Method for Measurement of Amino Acids in Proteins by Ion Exchange Chromatography on the Amino Acid Analyzer” . In Serum Proteins and the Dysproteinemias , Edited by: Sunderman , FW and Sunderman , FW Jr . 166 – 181 . Philadelphia : Lippincott .
  • Spackman , DH , Stein , WH and Moore , S . 1958 . “Automatic Recording Apparatus for Use in the Chromatography of Amino Acids” . Anal Chem , 30 : 1190
  • Spackman , D and Riley , V . 1972 . “Studies in Leukemia: The Levels of Asparagine, Glutamine, Asparaginase and Glutaminase in the Mouse Following Asparaginase Administration” . Proc Am Assoc Cancer Res , 13 : 81
  • Vrat , V . 1951 . “A Preliminary Report on the Histological and Histo‐chemical Changes in Mammary Carcinoma in Mice after Intraper‐itoneal Injection of Arginase” . Permamente Foundation Med Bull , 9 : 49 – 55 .
  • Young , GA and Parsons , FM . 1966 . “Amino Nitrogen Loss During Hemodialysis, Its Dietary Significance and Replacement” . Clin Sci , 31 : 299 – 307 .
  • Dialysis was carried out in the Swedish Hospital Medical Center, which adjoins the Northwest Kidney Center, Seattle, WA. The conditions for dialysis, the specialized equipment, and the technical indoctrination were under the general guidance of the Medical Director of the Kidney Center and appropriate members of the staff. Hemodialysis‐trained technicians were sufficient in number to provide constant monitoring of the patient while undergoing hemodialysis. Servicing of the artificial kidney apparatus was done by the staff of the Northwest Kidney Center. A Scribner shunt cannulation was performed on the patient in preparation for hemodialysis. The arterial and venous cannulas was installed by a qualified surgeon specially trained in this procedure.
  • The Pacific Northwest Research Foundation subscribes to the requirements of the US Public Health Service concerning research projects involving human subjects. This study satisfied such requirements and was approved by the Pacific NW Research Foundation Medical Board and the Review Committee for Research Involving Humans.
  • Clinical management and evaluation of the patient was provided by Drs. William B. Hutchinson, Quin B. DeMarsh, John L. Cahill, Robert V. Erickson, Allan Lobb, and Orliss Wildermuth. Dr. Darrel Spackman provided counsel in amino acid methodology and interpretations. Hemodialysis training, counsel and technical assistance were provided by Dr. Jerry Pendras and the staff of the Northwest Kidney Center. Mr. Lester Teschner provided technical assistance in the amino acid assays.
  • These studies were supported in part by research grants from the American Cancer Society (T‐522) and the American Cancer Society, Washington State Division; the National Institutes of Health (NIH Grant FR‐5520) National Cancer Institute Grants CA 03192–09, CA 08748, and CA 12188; the Brown‐Hazen Fund of the Research Corporation; the Elsa U. Pardee Foundation; the New York Cancer Research Institute, Inc. and the Fraternal Order of Eagles. Miscellaneous support was possible through the kind interest of CG Zubrod, A Schepartz, and SM Poiley of the National Cancer Institute.
  • I am indebted to Drs. Christopher Blagg and Thomas Sawyer of the Northwest Kidney Center for helpful discussions and informal reviews of this and the related manuscripts appearing in this volume.

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