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Review

Folate and cancer: A review of the literature

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Pages 101-119 | Received 08 Feb 1994, Accepted 22 Apr 1994, Published online: 04 Aug 2009

References

  • Wills , L . 1931 . “Treatment of Pernicious Anemia of Pregnancy and Tropical Anemia” . Br Med J , 1 : 1059 – 1064 .
  • Wills , L . 1932 . “Tropical Macrocytic Anemia” . Proc R Soc Med , 25 : 1720 – 1726 .
  • Mitchell , HK , Snell , EE and Williams , RJ . 1941 . “The Concentration of Folic Acid” . J Am Chem Soc , 63 : 2284
  • Bender , DA . 1992 . “Folic Acid and Other Pterins and Vitamin B12” . In Nutritional Biochemistry of the Vitamins , Edited by: Bender , DA . 269 – 317 . Cambridge, , UK : Cambridge University Press .
  • Gregory , JF . 1989 . “Chemical and Nutritional Aspects of Folate Research: Analytical Procedures, Methods of Folate Synthesis, Stability, and Bioavailability of Dietary Folates” . Adv Food Nutr Res , 33 : 1 – 101 .
  • Huennekens , FM , Duffy , TH and Vitols , KS . 1987 . “Folic Acid Metabolism and Its Disruption by Pharmacologic Agents” . Natl Cancer Inst Monogr , 5 : 1 – 8 .
  • Milunsky , A , Jick , H , Jick , SS , Bruell , CL MacLaughlin , DS . 1989 . “Multivitamin/Folic Acid Supplementation in Early Pregnancy Reduces the Prevalence of Neural Tube Defects” . J Am Med Assoc , 262 : 2847 – 2852 .
  • Bower , C and Stanley , F . 1989 . “Dietary Folate as a Risk Factor for Neural‐Tube Defects: Evidence From a Case‐Control Study in Western Australia” . Med J Aust , 150 : 613 – 619 .
  • MRC Vitamin Study Research Group . 1991 . “Prevention of Neural Tube Defects: Results of the Medical Research Council Vitamin Study” . Lancet , 338 : 131 – 137 .
  • Brattstrom , LE , Israelsson , B , Jeppsson , JO and Hultberg , BL . 1988 . “Folic Acid—An Innocuous Means to Reduce Plasma Homocysteine” . Scand J Clin Lab Invest , 48 : 215 – 221 .
  • Clarke , R , Daly , L , Robinson , K , Naughten , E Cahalane , S . 1991 . “Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease” . N Engl J Med , 324 : 1149 – 1155 .
  • Herbert , V . 1990 . “Development of Human Folate Deficiency” . In Folic Acid Metabolism in Health and Disease , Edited by: Picciano , MF , Stokstad , ELR and Gregory , JF III . 195 – 210 . New York : Wiley‐Liss .
  • Senti , FR and Pilch , SM . 1985 . “Analysis of Folate Data From the Second National Health and Nutrition Examination Survey (NHANES II)” . J Nutr , 115 : 1398 – 1402 .
  • Subar , AF , Block , G and James , LD . 1989 . “Folate Intake and Food Sources in the US Population” . Am J Clin Nutr , 50 : 508 – 516 .
  • Herbert , V . 1987 . “Recommended Dietary Intakes (RDI) of Folate in Humans” . Am J Clin Nutr , 45 : 661 – 670 .
  • Subcommittee on the 10th Edition of the RDAs. Food and Nutrition Board. National Research Council . 1989 . “Folate” . In Recommended Dietary Allowances , 150 – 158 . Washington, DC : National Academy Press .
  • Heath , CW . 1966 . “Cytogenic Observations in Vitamin B12 and Folate Deficiency” . Blood , 27 : 800 – 815 .
  • Chen , ATL , Reidy , JA , Annest , JL , Welty , TK and Zhou , H . 1989 . “Increased Chromosome Fragility as a Consequence of Blood Folate Levels, Smoking Status, and Coffee Consumption” . Environ Mol Mutagen , 13 : 319 – 324 .
  • Branda , RF , O'Neill , JP , Jacobson‐Kram , D and Albertini , RJ . 1992 . “Factors Influencing Mutation at the Hprt Locus in T‐Lymphocytes: Studies in Normal Women and Women With Benign and Malignant Breast Masses” . Environ Mol Mutagen , 19 : 274 – 281 .
  • Barclay , BJ and Little , JG . 1978 . “Genetic Damage During Thymidylate Starvation in Saccharomyces cerevisiae” . Mol Gen Genet , 160 : 33 – 40 .
  • Tilkian , S , Lefevre , G and DeCilla , P . 1990 . “In Vivo Effect of Folic Acid on Fragile‐Site Expression” . In Chemistry and Biology of Pteridines 1989: Pteridine and Folic Acid Derivatives , Edited by: Curtius , HC , Ghisla , S and Blau , N . 981 – 984 . Berlin : De Gruyter .
  • Laird , C , Jaffe , E , Karpen , G , Lamb , M and Nelson , R . 1987 . “Fragile Sites in Human Chromosomes as Regions of Late‐Replicating DNA” . Trends Genet , 3 : 274 – 281 .
  • Yunis , JJ and Soreng , AL . 1984 . “Constitutive Fragile Sites and Cancer” . Science , 226 : 1199 – 1203 .
  • Shklar , G , Cataldo , E and Fitzgerald , AL . 1966 . “The Effect of Methotrexate on Chemical Carcinogenesis of Hamster Buccal Pouch” . Cancer Res , 26 : 2218 – 2224 .
  • Barich , LL , Schwarz , J and Barich , D . 1962 . “Oral Methotrexate in Mice: A Cocarcinogenic as Well as an Anti‐Tumor Agent to Methylcholanthrene‐Induced Cutaneous Tumors” . J Invest Dermatol , 39 : 615 – 619 .
  • Krumdieck , CL . 1983 . “Role of Folate Deficiency in Carcinogenesis” . In Nutritional Factors in the Induction and Maintenance of Malignancy , Edited by: Butterworth , CE and Huntchinson , ML . vol 2 , 225 – 245 . New York : Academic .
  • Leuchtenberger , C and Leuchtenberger , R . 1983 . “Growth‐Regulating Effects of Naturally Occurring Metabolites of Folate and Ascorbate on Malignant Cells” . In Nutritional Factors in the Induction and Maintenance of Malignancy , Edited by: Butterworth , CE and Huntchinson , ML . 131 – 148 . New York : Academic .
  • Cravo , ML , Mason , JB , Dayal , Y , Hutchinson , M Smith , D . 1992 . “Folate Deficiency Enhances the Development of Colonic Neoplasia in Dimethylhydrazine‐Treated Rats” . Cancer Res , 52 : 5002 – 5006 .
  • Kamei , T , Kohno , T , Ohwada , H , Takeuchi , Y Hayashi , Y . 1993 . “Experimental Study of the Therapeutic Effects of Folate, Vitamin A, and Vitamin B12 on Squamous Metaplasia of the Bronchial Epithelium” . Cancer , 71 : 2477 – 2483 .
  • Baggott , JE , Vaughn , WH , Juliana , MM , Eto , I Kiumdieck , CL . 1992 . “Effects of Folate Deficiency and Supplementation on Methylnitrosourea‐Induced Rat Mammary Tumors” . JNCI , 84 : 1740 – 1744 .
  • Engel , RW and Copeland , DH . 1952 . “The Influence of Dietary Casein Level on Tumor Induction With 2‐Acety‐laminofluorene” . Cancer Res , 12 : 905 – 908 .
  • Engel , RW and Copeland , DH . 1949 . “Relation of Diet to the Development of Mammary Tumors Induced by Feeding 2‐Acetylaminofluorene” . Cancer Res , 9 : 608
  • Miller , EC , Plescia , AM , Miller , JA and Heidelberger , C . 1952 . “The Demethylation of 3'‐Methyl‐4‐Dimethyl‐C14‐Aminoazobenzene In Vivo” . J Biol Chem , 196 : 863 – 874 .
  • Bills , ND , Hinrichs , SH , Morgan , R and Clifford , AJ . 1992 . “Delayed Tumor Onset in Transgenic Mice Fed a Low‐Folate Diet” . JNCI , 84 : 332 – 337 .
  • Oleson , JJ and Little , PA . 1949 . “Effect of Pteroylglutamic Acid and Vitamin B12 on Growth of Rous Tumor Implants” . Proc Soc Exp Biol Med , 71 : 226 – 227 .
  • Little , PA , Sampath , A , Paganelli , V , Locke , E and Subbarow , Y . 1948 . “The Effect of Folic Acid and Its Antagonists on Rous Chicken Sarcoma” . Trans NY Acad Sci Ser II , 10 : 91 – 98 .
  • Rosen , F and Nichol , CA . 1962 . “Inhibition of the Growth of an Amethopterin‐Refractory Tumor by Dietary Restriction of Folic Acid” . Cancer Res , 22 : 495 – 500 .
  • Poirier , LA . 1975 . “Hepatocarcinogenesis by Diethylnitrosamine in Rats Fed High Dietary Levels of Lipotropes” . JNCI , 54 : 137 – 140 .
  • US Department of Agriculture, Human Nutrition . 1976–1992 . “Composition of Foods” . In USDA Agriculture Handbooks , Washington, DC : US Dept of Agriculture . nos. 8–1‐8–16
  • Paul , AA and Southgate , DAT . 1978 . McCance and Widdowson's Composition of Foods, , 4th ed. , New York : Elsevier/North Holland .
  • Perloff , BP and Butrum , RR . 1977 . “Folacin in Selected Foods” . J Am Diet Assoc , 70 : 161 – 172 .
  • Herbert , V . 1987 . “The 1986 Herman Award Lecture. Nutrition Science as a Continually Unfolding Story: The Folate and Vitamin B12 Paradigm” . Am J Clin Nutr , 46 : 387 – 402 .
  • Herbert , V . 1987 . “Making Sense of Laboratory Tests of Folate Status: Folate Requirements to Sustain Normality” . Am J Hematol , 26 : 199 – 207 .
  • Butterworth , CE , Hatch , KD , Soong , SJ , Cole , P Tamura , T . 1992 . “Oral Folic Acid Supplementation for Cervical Dysplasia: A Clinical Intervention Trial” . Am J Obstet Gynecol , 166 : 803 – 809 .
  • VanEenwyk , J , Davis , FG and Colman , N . 1992 . “Folate, Vitamin C, and Cervical Intraepithelial Neoplasia” . Cancer Epidemiol Biomarkers Prev , 1 : 119 – 124 .
  • Verreault , R , Chu , J , Mandelson , M and Shy , K . 1989 . “A Case‐Control Study of Diet and Invasive Cervical Cancer” . Int J Cancer , 43 : 1050 – 1054 .
  • Herrero , R , Potischman , N , Brinton , LA , Reeves , WC Brenes , MM . 1991 . “A Case‐Control Study of Nutrient Status and Invasive Cervical Cancer” . Am J Epidemiol , 134 : 1335 – 1346 .
  • Butterworth , CE , Hatch , KD , Gore , H , Mueller , H and Krumdieck , CL . 1982 . “Improvement in Cervical Dysplasia Associated With Folic Acid Therapy in Users of Oral Contraceptives” . Am J Clin Nutr , 35 : 73 – 82 .
  • Areekul , S , Panatampon , P and Doungbarn , J . 1977 . “Serum Vitamin B12, Serum and Red Cell Folates, Vitamin B12 and Folic Acid Binding Proteins in Women Taking Oral Contraceptives” . Southeast Asian J Trop Med Public Health , 4 : 480 – 485 .
  • Streiff , RR . 1970 . “Folate Deficiency and Oral Contraceptives” . J Am Med Assoc , 214 : 105 – 108 .
  • Whitehead , N , Reyner , F and Lindenbaum , J . 1973 . “Megaloblastic Changes in the Cervical Epithelium, Association With Oral Contraceptive Therapy and Reversal With Folic Acid” . J Am Med Assoc , 226 : 1421 – 1424 .
  • Ran , JY , Li , XF , Rau , HL , Wang , LY and Herbert , V . 1990 . “Selective Folate Deficiency in One but Not Another Cell Line: Despite Normal Red Cell Folate, Folate Therapy Reduced Cervical Dysplasia and Hyperploidy in Women Using Oral Contraceptives” (abstr) . Blood , 76 : 114A
  • Butterworth , CE , Hatch , KD , Macaluso , M , Cole , P Sauberlich , HE . 1992 . “Folate Deficiency and Cervical Dysplasia” . J Am Med Assoc , 267 : 528 – 533 .
  • Harper , JM . 1992 . “Folic Acid Nutriture and Cervical Cytology” (abstr) . Diss Abstr Int B Sci Eng , 53 : 1297
  • McPherson , RS . 1989 . “Nutritional Factors and the Risk of Cervical Dysplasia” (abstr) . Am J Epidemiol , 130 : 830
  • Buckley , DI , McPherson , RS , North , CQ and Becker , TM . 1992 . “Dietary Micronutrients and Cervical Dysplasia in Southwestern American Indian Women” . Nutr Cancer , 17 : 179 – 185 .
  • Brock , KE , Berry , G , Mock , PA , MacLennan , R Truswell , AS . 1988 . “Nutrients in Diet and Plasma and Risk of In Situ Cervical Cancer” . JNCI , 80 : 580 – 585 .
  • Ziegler , RG , Jones , CJ , Brinton , LA , Norman , SA Mallin , K . 1991 . “Diet and the Risk of In Situ Cervical Cancer Among White Women in the United States” . Cancer Causes Control , 2 : 17 – 29 .
  • Van Niekerk , WA . 1966 . “Cervical Cytological Abnormalities Caused by Folic Acid Deficiency” . Acta Cytol , 10 : 67 – 73 .
  • Koss , LG . 1979 . “Various Benign Disorders of the Epithelia of the Uterine Cervix and Vagina Not Related to Inflammation” . In Diagnostic Cytology and Its Histopathologic Bases , Edited by: Koss , LG . vol 1 , 270 – 284 . Philadelphia, PA : Lippincott .
  • Potischman , N , Brinton , LA , Laiming , VA , Reeves , WC Brenes , MM . 1991 . “A Case‐Control Study of Serum Folate Levels and Invasive Cervical Cancer” . Cancer Res , 51 : 4785 – 4789 .
  • Orr , JW , Wilson , K , Bodiford , C , Cornwell , A Soong , Seng Jaw . 1985 . “Nutritional Status of Patients With Untreated Cervical Cancer, Vitamin Assessment” . Am J Obstet Gynecol , 151 : 632 – 635 .
  • Ziegler , RG , Brinton , LA , Hamman , RF , Lehman , HF Levine , RS . 1990 . “Diet and the Risk of Invasive Cervical Cancer Among White Women in the United States” . Am J Epidemiol , 132 : 432 – 445 .
  • Giovannucci , E , Stampfer , MJ , Colditz , GA , Rimm , EB Trichopoulos , D . 1993 . “Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma” . JNCI , 85 : 875 – 883 .
  • Benito , E , Cabeza , E , Moreno , V , Obrador , A and Bosch , FX . 1993 . “Diet and Colorectal Adenomas: A Case‐Control Study in Majorca” . Int J Cancer , 55 : 213 – 219 .
  • Freudenheim , JL , Graham , S , Marshall , JR , Haughey , BP Cholewinski , S . 1991 . “Folate Intake and Carcinogenesis of the Colon and Rectum” . Int J Epidemiol , 20 : 368 – 374 .
  • Meyer , F and White , E . 1993 . “Alcohol and Nutrients in Relation to Colon Cancer in Middle‐Aged Adults” . Am J Epidemiol , 138 : 225 – 236 .
  • Benito , E , Stiggelbout , A , Bosch , FX , Obrador , A Kaldor , J . 1991 . “Nutritional Factors in Colorectal Cancer Risk: A Case‐Control Study in Majorca” . Int J Cancer , 49 : 161 – 167 .
  • Lashner , BA , Heidenreich , PA , Su , GL , Kane , SV and Hanauer , SB . 1989 . “Effect of Folate Supplementation on the Incidence of Dysplasia and Cancer in Chronic Ulcerative Colitis” . Gastroenterology , 97 : 255 – 259 .
  • Lashner , BA . 1993 . “Red Blood Cell Folate Is Associated With the Development of Dysplasia and Cancer in Ulcerative Colitis” . J Cancer Res Clin Oncol , 119 : 549 – 554 .
  • Milsom , JW . 1993 . “Pathogenesis of Colorectal Cancer” . Surg Clin North Am , 73 : 1 – 11 .
  • Hill , MJ . 1991 . “From Adenoma to Carcinoma of the Colorectum” . Recent Results Cancer Res , 122 : 71 – 84 .
  • Piyathilake , CJ , Hine , RJ , Dasanayake , AP , Richards , EW Freeberg , LE . 1992 . “Effect of Smoking on Folate Levels in Buccal Mucosal Cells” . Int J Cancer , 52 : 566 – 569 .
  • Hine , RJ , Piyathilake , CJ and Krumdieck , CL . 1990 . “Evidence of Localized Folate Deficiency in Oral Mucosal Cells of Cigarette Smokers” (abstr) . FASEB J , 4 : A1043
  • Nakazawa , Y , Chiba , K , Imatoh , N , Kotorii , T Sakamoto , T . 1983 . “Serum Folk Acid Levels and Antipyrine Clearance Rates in Smokers and Non‐Smokers” . Drug Alcohol Depend , 11 : 201 – 207 .
  • Milne , DB , Johnson , LK , Mahalko , JR and Sandstead , HH . 1983 . “Folate Status of Adult Males Living in a Metabolic Unit: Possible Relationships With Iron Nutriture” . Am J Clin Nutr , 37 : 768 – 773 .
  • Witter , FR , Blake , DA , Baumgardner , R , Mellits , ED and Niebyl , JR . 1982 . “Folate, Carotene and Smoking” . Am J Obstet Gynecol , 144 : 857
  • Heimburger , DC , Krumdieck , CL , Alexander , CB , Birch , R Dill , SR . 1987 . “Localized Folk Acid Deficiency and Bronchial Metaplasia in Smokers: Hypothesis and Preliminary Report” . Nutr Int , 3 : 54 – 60 .
  • Heimburger , DC , Alexander , CB , Birch , R , Butterworth , CE Bailey , WC . 1988 . “Improvement in Bronchial Squamous Metaplasia in Smokers Treated With Folate and Vitamin B12” . J Am Med Assoc , 259 : 1525 – 1530 .
  • Bandera , EV , Graham , S , Freudenheim , JL , Marshall , JR Haughey , BP . 1991 . “Folate and Alcohol Consumption and the Risk of Lung Cancer” (abstr) . FASEB J , 5 : A562
  • Le Marchand , L , Yoshizawa , CN , Kolonel , LN , Hankin , JH and Goodman , MT . 1989 . “Vegetable Consumption and Lung Cancer Risk: A Population‐Based Case‐Control Study in Hawaii” . JNCI , 81 : 1158 – 1164 .
  • Van Helden , PD , Beyers , AD , Bester , AJ and Jaskiewicz , K . 1987 . “Esophageal Cancer: Vitamin and Lipotrope Deficiencies in an At‐Risk South African Population” . Nutr Cancer , 10 : 247 – 255 .
  • Jaskiewicz , K , Marasa , WFO , Lazarus , C , Beyers , AD and Van Helden , PD . 1988 . “Association of Esophageal Cytological Abnormalities With Vitamin and Lipotrope Deficiencies in Populations at Risk for Esophageal Cancer” . Anticancer Res , 8 : 711 – 716 .
  • Ran , JY , Dou , P , Wang , LY , Qin , Y , Jin , SY Li , XF . 1993 . “Correlation of Low Serum Folate and Total B12 With High Incidence of Esophageal Carcinoma in Shanxi, China” (abstr) . Blood , 82 : 532a
  • Prasad , MPR , Krishna , TP , Paricha , S , Krishnaswamy , K and Quereshi , MA . 1992 . “Esophageal Cancer and Diet—A Case‐Control Study” . Nutr Cancer , 18 : 85 – 93 .
  • Ehrenbard , LT and Chaganti , RSK . 1981 . “Cancer in the Fetal Hydantoin Syndrome” . Lancet , 2 : 97
  • Pendergrass , TW and Hanson , JW . 1976 . “Fetal Hydantoin Syndrome and Neuroblastoma” . Lancet , 2 : 150
  • Bunin , GR , Kuijten , RR , Buckley , JD , Rorke , LB and Meadows , AT . 1993 . “Relation Between Maternal Diet and Subsequent Primitive Neuroectodermal Brain Tumors in Young Children” . N Engl J Med , 329 : 536 – 541 .
  • Block , G , Patterson , P and Subar , A . 1992 . “Fruit, Vegetables, and Cancer Prevention: A Review of the Epidemiological Evidence” . Nutr Cancer , 18 : 1 – 29 .
  • Eto , I and Krumdieck , CL . 1986 . “Role of Vitamin B12 and Folate Deficiencies in Carcinogenesis” . In Advances in Experimental Medicine and Biology , Edited by: Poirier , LA , Newberne , PM and Pariza , MW . vol 206 , 313 – 330 . New York : Plenum .
  • Wainfan , E , Dizik , M , Stender , M and Christman , JK . 1989 . “Rapid Appearance of Hypomethylated DNA in Livers of Rats Fed Cancer‐Promoting, Methyl‐Deficient Diets” . Cancer Res , 49 : 4094 – 4097 .
  • Wainfan , E , Dizick , M , Sheikhnejad , G and Christman , JK . 1990 . “Early Changes in Nucleic Acid Methylation and Gene Expression in Livers of Rats Fed Cancer‐Promoting, Methyl‐Deficient Diets” (abstr) . FASEB J , 4 : A1043
  • Christman , J , Sheikhnejad , G , Dizik , M , Abileah , S and Waifan , E . 1993 . “Reversibility of Changes in Nucleic Acid Methylation and Gene Expression Induced in Rat Liver by Severe Dietary Methyl Deficiency” . Carcinogenesis , 14 : 551 – 557 .
  • Feinberg , AP , Gehrke , CW , Kuo , KC and Ehrlich , M . 1988 . “Reduced Genomic 5‐Methylcytosine Content in Human Colonic Neoplasia” . Cancer Res , 48 : 1159 – 1161 .
  • Sharrard , RM , Royds , JA , Rogers , S and Shorthouse , AJ . 1992 . “Patterns of Methylation of the C‐myc Gene in Human Colorectal Cancer Progression” . Br J Cancer , 65 : 667 – 672 .
  • El‐Deiry , WS , Nelkin , BD , Celano , P , Chiu Yen , R Falco , JP . 1991 . “High Expression of the DNA Methyltransferase Gene Characterizes Human Neoplastic Cells and Progression Stages of Colon Cancer” . Proc Natl Acad Sci USA , 88 : 3470 – 3474 .
  • Popescu , NC , Amsbaugh , SC and Dipaolo , JA . 1987 . “Human Papillomavirus Type 18 DNA Is Integrated at a Single Chromosome Site in Cervical Carcinoma Cell Line SW756” . J Virol , 51 : 1682 – 1685 .

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