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Reports

Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices

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Pages 167-181 | Received 25 Jan 1996, Accepted 17 Apr 1996, Published online: 04 Aug 2009

References

  • Pisani , P . 1992 . “Breast Cancer: Geographic Variation and Risk Factors” . J Environ Pathol Toxicol Oncol , 11 : 313 – 316 .
  • National Cancer Institute of Canada . 1995 . Canadian Cancer Statistics 1995 , 42 – 13 . Toronto, Ontario : Natl Cancer Inst .
  • Wingo , PA , Tong , T and Bolden , S . 1995 . “Cancer Statistics, 1995” . CA Cancer J Clin , 45 : 8 – 30 .
  • Cassady , JM , Baird , WM and Chang , C‐J . 1990 . “Natural Products as a Source of Potential Cancer Chemotherapeutic and Chemopreventive Agents” . J Nat Prod , 53 : 23 – 41 .
  • Steinmetz , KA and Potter , JD . 1991 . “Vegetables, Fruit, and Cancer. I. Epidemiology” . Cancer Causes Control , 2 : 325 – 357 .
  • Block , G , Patterson , B and Subar , A . 1992 . “Fruits, Vegetables, and Cancer Prevention: A Review of the Epidemiological Evidence” . Nutr Cancer , 18 : 1 – 29 .
  • Steinmetz , KA and Potter , JD . 1991 . “Vegetables, Fruit, and Cancer. II. Mechanisms” . Cancer Causes Control , 2 : 427 – 142 .
  • The Alpha‐Tocopherol, Beta Carotene Cancer Prevention Study Group . 1994 . “The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers” . N Engl J Med , 330 : 1029 – 1035 .
  • Smigel , K . 1996 . “Beta Carotene Fails to Protect Cancer in Two Major Studies: CARET Intervention Stopped” . JNCI , 88 : 145
  • Wattenberg , LW . 1992 . “Inhibition of Carcinogenesis by Minor Dietary Constituents” . Cancer Res , 52 : 2085s – 2091s .
  • Messina , M and Erdman , JW Jr . 1995 . “First International Symposium on the Role of Soy in Preventing and Treating Chronic Disease” . J Nutr , 125 ( Suppl ) : 5675 – 8085 .
  • American Institute for Cancer Research . in press . “Proceedings of Conference on Dietary Phytochemicals in Cancer Prevention and Treatment” . Adv Exp Med Biol ,
  • Kiihnau , J . 1976 . “The Flavonoids. A Class of Semi‐Essential Food Components: Their Role in Human Nutrition” . World Rev Nutr Diet , 24 : 117 – 191 .
  • Havsteen , B . 1983 . “Flavonoids, a Class of Natural Products of High Pharmacological Potency” . Biochem Pharmacol , 32 : 1141 – 1148 .
  • Middleton , E Jr . 1984 . “The Flavonoids” . Trends Pharmacol Sci , 5 : 335 – 338 .
  • Hertog , MGL , Hollman , PCH , Katan , MB and Kromhout , D . 1993 . “Intake of Potentially Anticarcinogenic Flavonoids and Their Determinants in Adults in The Netherlands” . Nutr Cancer , 20 : 21 – 29 .
  • Edwards , JM , Raffauf , RF and Le Quesne , PW . 1979 . “Antineoplastic Activity and Cytotoxicity of Flavones, Isoflavones, and Flavanones” . J Nat Prod , 42 : 85 – 91 .
  • Cody , V , Middleton , E Jr , Harborne , JB and Beretz , A , eds. 1987 . Plant Flavonoids in Biology and Medicine. Biochemical, Cellular, and Medicinal Properties , vol. II , New York : Liss .
  • Middleton , E Jr and Kandaswami , C . 1994 . “Potential Health‐Promoting Properties of Citrus Flavonoids” . Food Technol , 48 : 115 – 119 .
  • Mori , A , Nishino , C , Enoki , N and Tawata , S . 1988 . “Cytotoxicity of Plant Flavonoids Against HeLa Cells” . Phytochemistry , 27 : 1017 – 1020 .
  • Ramanathan , R , Tan , CH and Das , NP . 1992 . “Cytotoxic Effect of Plant Polyphenols and Fat‐Soluble Vitamins on Malignant Human Cultured Cells” . Cancer Lett , 62 : 217 – 224 .
  • Mookerjee , BK , Lee , T‐P , Lippes , HA and Middleton , E Jr . 1986 . “Some Effects of Flavonoids on Lymphocyte Proliferative Responses” . J Immunopharmacol , 8 : 371 – 392 .
  • Hirano , T , Oka , K and Akiba , M . 1989 . “Antiproliferative Effects of Synthetic and Naturally Occurring Flavonoids on Tumor Cells of the Human Breast Carcinoma Cell Line, ZR‐75–1” . Res Commun Chem Pathol Pharmacol , 64 : 69 – 78 .
  • Wei , H , Tye , L , Bresnick , E and Birt , DF . 1990 . “Inhibitory Effect of Apigenin, a Plant Flavonoid, on Epidermal Ornithine Decarboxylase and Skin Tumor Promotion in Mice” . Cancer Res , 50 : 499 – 502 .
  • Markaverich , BM , Roberts , RR , Alejandro , MA , Johnson , GA Middleditch , BS . 1988 . “Bioflavonoid Interaction With Rat Uterine Type II Binding Sites and Cell Growth Inhibition” . J Steroid Biochem , 30 : 71 – 78 .
  • Scambia , G , Ranelletti , FO , Benedetti Panici , P , Bonnano , G DeVincenzo , R . 1991 . “Quercetin Inhibits the Growth of a Multidrug‐Resistant Estrogen‐Receptor‐Negative MCF‐7 Human Breast‐Cancer Cell Line Expressing Type II Estrogen‐Binding Sites” . Cancer Chemother Pharmacol , 28 : 255 – 258 .
  • Singhal , RL , Yeh , YA , Prajda , N , Olah , E Sledge , GW Jr . 1995 . “Quercetin Down‐Regulates Signal Transduction in Human Breast Carcinoma Cells” . Biochem Biophys Res Commun , 208 : 425 – 431 .
  • Ranelletti , FO , Ricci , R , Larocca , LM , Maggiano , N Capelli , A . 1992 . “Growth‐Inhibitory Effect of Quercetin and Presence of Type II Estrogen‐Binding Sites in Human Colon‐Cancer Cell Lines and Primary Colorectal Tumors” . Int J Cancer , 50 : 486 – 492 .
  • Scambia , G , Ranelletti , FO , Benedetti Panici , P , Piantelli , M Rumi , C . 1990 . “Type‐II Estrogen Binding Sites in a Lymphoblastoid Cell Line and Growth‐Inhibitory Effect of Estrogen, Anti‐Estrogen and Bioflavonoids” . Int J Cancer , 46 : 1112 – 1116 .
  • Larocca , LM , Piantelli , M , Leone , G , Sica , S Teofili , L . 1990 . “Type II Oestrogen Binding Sites in Acute Lymphoid and Myeloid Leukaemias: Growth Inhibitory Effect of Oestrogen and Flavonoids” . Br J Haematol , 75 : 489 – 495 .
  • Castillo , MH , Perkins , E , Campbell , JH , Doerr , R Hassett , JM . 1989 . “The Effects of the Bioflavonoid Quercetin on Squamous Cell Carcinoma of Head and Neck Origin” . Am J Surg , 158 : 351 – 355 .
  • Verma , AK , Johnson , JA , Gould , MN and Tanner , MA . 1988 . “Inhibition of 7,12‐Dimethylbenz[a]anthracene‐ and N‐Nitrosomethylurea‐Induced Rat Mammary Cancer by Dietary Flavonol Quercetin” . Cancer Res , 48 : 5754 – 5758 .
  • Barnes , S . 1995 . “Effect of Genistein on In Vitro and In Vivo Models of Cancer” . J Nutr , 125 : 777S – 783S .
  • Peterson , G and Barnes , S . 1991 . “Genistein Inhibition of the Growth of Human Breast Cancer Cells: Independence From Estrogen Receptors and the Multi‐Drug Resistance Gene” . Biochem Biophys Res Commun , 179 : 661 – 667 .
  • Messina , MJ , Persky , V , Setchell , KDR and Barnes , S . 1994 . “Soy Intake and Cancer Risk: A Review of the In Vitro and In Vivo Data” . Nutr Cancer , 21 : 113 – 131 .
  • Barnes , S , Grubbs , C , Setchell , KDR and Carlson , J . 1990 . “Soybeans Inhibit Mammary Tumors in Models of Breast Cancer” . In Mutagens and Carcinogens in the Diet , Edited by: Pariza , MW , Aeschbacher , H‐D , Felton , JS and Sato , S . 239 – 253 . New York : Wiley‐Liss .
  • Bailey , DG , Spence , JD , Munoz , C and Arnold , JMO . 1991 . “Interaction of Citrus Juices With Felodipine and Nifedipine” . Lancet , 337 : 268 – 269 .
  • Guthrie , N , Moffatt , M , Chambers , AF , Spence , JD and Carroll , KK . 1993 . “Inhibition of Proliferation of Human Breast Cancer Cells by Naringenin, a Flavonoid in Grapefruit” (abstr) . Natl Forum Breast Cancer, Montreal , : 118
  • Keiser , LW and Capizzi , RL . 1982 . “Principles of Combination Chemotherapy” . In Cancer, A Comprehensive Treatise , 2nd ed , Edited by: Becker , FF . 163 – 190 . New York : Plenum .
  • Price , JE , Polyzos , A , Zhang , RD and Daniels , LM . 1990 . “Tumorigenicity and Metastasis of Breast Carcinoma Cell Lines in Nude Mice” . Cancer Res , 50 : 717 – 721 .
  • Hansen , MB , Nielson , SE and Berg , K . 1989 . “Re‐Examination and Further Development of a Precise and Rapid Dye Method for Measuring Cell Growth/Cell Kill” . J Immunol Methods , 119 : 203 – 210 .
  • Young , S , Cowan , DM and Davidson , C . 1971 . “The Production of Mammary Carcinomas in Rats by 9,10‐Dimethyl‐1,2‐Benzanthracene and Its Relationship to the Oestrous Cycle” . Br J Cancer , 24 : 328 – 332 .
  • Hirano , T , Gotoh , M and Oka , K . 1994 . “Natural Flavonoids and Lignans Are Potent Cytostatic Agents Against Human Leukemic HL‐60 Cells” . Life Sci , 55 : 1061 – 1069 .
  • Budavari , S , ed. 1989 . The Merck Index , 11th ed. , 4590 Rahway, NJ : Merck .
  • Bokkenheuser , VD , Shackleton , CHL and Winter , J . 1987 . “Hydrolysis of Dietary Flavonoid Glycosides by Strains of Intestinal Bacteroides From Humans” . Biochem J , 248 : 953 – 956 .
  • Kandaswami , C , Perkins , E , Soloniuk , DS , Drzewiecki , G and Middleton , E Jr . 1991 . “Antiproliferative Effects of Citrus Flavonoids on Human Squamous Cell Carcinoma In Vitro” . Cancer Lett , 56 : 147 – 152 .
  • Wattenberg , LW , Page , MA and Leong , JL . 1968 . “Induction of Increased Benzpyrene Hydroxylase Activity by Flavones and Related Compounds” . Cancer Res , 28 : 934 – 937 .
  • Bailey , DG , Arnold , JMO and Spence , JD . 1994 . “Grapefruit Juice and Drugs. How Significant Is the Interaction?” . Clin Pharmacokinet , 26 : 91 – 98 .
  • Sharif , SI and Ali , BH . 1994 . “Effect of Grapefruit Juice on Drug Metabolism in Rats” . Food Chem Toxicol , 32 : 1169 – 1171 .
  • Levy , J , Teuerstein , I , Marbach , M , Radian , S and Sharoni , Y . 1984 . “Tyrosine Protein Kinase Activity in the DMBA‐Induced Rat Mammary Tumor: Inhibition by Quercetin” . Biochem Biophys Res Commun , 123 : 1227 – 1233 .
  • Sharoni , Y , Teuerstein , I and Levy , J . 1986 . “Phosphoinositide Phosphorylation Precedes Growth in Rat Mammary Tumors” . Biochem Biophys Res Commun , 134 : 876 – 882 .
  • Ferriola , PC , Cody , V and Middleton , E Jr . 1989 . “Protein Kinase C Inhibition by Plant Flavonoids. Kinetic Mechanisms and Structure‐Activity Relationships” . Biochem Pharmacol , 38 : 1617 – 1624 .

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