Pathological changes in cobalt‐supplemented and non‐supplemented twin lambs in relation to blood concentrations of methylmalonic acid and homocysteine

References

• Analytical Software . 1994 . Statistix version 4.1 user's manual , Tallahassee, , USA : Analytical Software .
   Google Scholar
• Araki , A and Sato , Y . 1987 . Determination of free and total homocysteine in human plasma by high‐performance liquid chromatography with fluorescence detection . J Chromatog Biomed Appl , 422 : 43 – 52 .
   Web of Science ®Google Scholar
• Bancroft , JD and Stevens , A . 1977 . Theory and practice of histological techniques , Edinburgh : Churchill Livingstone .
   Google Scholar
• Bishop , YMM , Fienberg , SE and Holland , PW . 1975 . Discrete multivariate analysis , Cambridge, Massachusetts : MIT Press .
   Google Scholar
• Clark , RG , Cornforth , IS , Jones , BAH , McKnight , LJ and Oliver , J . 1978 . A condition resembling ovine white liver disease in lambs on irrigated pasture in South Canterbury . N Z Vet J , 26 : 316
   PubMed Web of Science ®Google Scholar
• Darn , JTP van , Heide , D van der , Hel , W van der , Ingh , TSGAM van den , Verstegen , MWA , Wensing , T and Zwart , D . 1996 . The effect of Trypanosoma vivax infection on energy and metabolism, and serum metabolites and hormones in West‐African dwarf goats on different food intake levels . Anim Sci , 63 : 111 – 21 .
   Web of Science ®Google Scholar
• Doherty , PC , Barlow , RM and Angus , KW . 1969 . Spongy changes in the brains of sheep poisoned by excess dietary copper . Res Vet Sci , 10 : 303 – 5 .
   PubMed Web of Science ®Google Scholar
• Fell , BF . 1981 . Pathological consequences of copper deficiency and cobalt deficiency . Phil Trans R Soc Lond B , 294 : 153 – 69 .
   PubMed Web of Science ®Google Scholar
• Hartley , WJ , Kater , JC and Andrews , ED . 1962 . An outbreak of polio‐encephalomalacia in cobalt‐deficient sheep . N Z Vet J , 10 : 118 – 20 .
   Google Scholar
• Ingh , TSGAM van den , Rothuizen , J and Cupery , R . 1988 . Chronic active hepatitis with cirrhosis in the Doberman Pinscher . Vet Quart , 10 : 84 – 9 .
   PubMed Web of Science ®Google Scholar
• Jungermann , K and Katz , N . 1982 . Functional hepatocellular heterogeneity . Hepatology , 2 : 385 – 95 .
   PubMed Web of Science ®Google Scholar
• Kennedy , DG , Blanchflower , WJ , Scott , JM , Weir , DG , Molloy , AM , Kennedy , S and Young , PB . 1992 . Cobalt‐vitamin B12 deficiency decreases methionine synthase activity and phospholipid methylation in sheep . J Nutr , 122 : 1384 – 90 .
   PubMed Web of Science ®Google Scholar
• Linde van der‐Sipman , JS , Ingh , TSGAM van den and Toor , AJ van . 1990 . Fatty liver syndrome in puppies . J Am Anim Hosp Assoc , 26 : 9 – 12 .
   Web of Science ®Google Scholar
• MacPherson , A , Moon , FE and Voss , RC . 1976 . Biochemical aspects of cobalt deficiency in sheep with special reference to vitamin status and a possible involvement in the aetiology of cerebrocortical necrosis . Br Vet J , 132 : 294 – 308 .
   PubMedGoogle Scholar
• McLoughlin , MF , Rice , DA and Taylor , SM . 1984 . Liver lesions resembling ovine white liver disease in cobalt deficient lambs . Vet Rec , 115 : 325
   PubMed Web of Science ®Google Scholar
• McMurray , CH , Blanchflower , WJ , Rice , DA and McLoughlin , M . 1986 . Sensitive and specific gas chromatographic method for the determination of methylmalonic acid in the plasma and urine of ruminants . J Chromatogr , 378 : 201 – 7 .
   PubMed Web of Science ®Google Scholar
• Pausch , J and Gerok , W . 1977 . Biochemische und pathophysiologische Aspekten der Hyperammoniaemie . Klin Wochensch , 55 : 97 – 103 .
   PubMedGoogle Scholar
• Peto , R , Pike , MC , Armitage , P , Breslow , NE , Cox , DR , Howard , SV , Mantel , N , McPherson , K , Peto , J and Smith , PG . 1976 . Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design . Br J Cancer , 34 : 585 – 612 .
   PubMed Web of Science ®Google Scholar
• Richards , RB and Harrison , MR . 1981 . White liver disease in lambs . Aust Vet J , 57 : 565 – 8 .
   PubMed Web of Science ®Google Scholar
• Rothman , KJ . 1986 . Modem epidemiology , Boston/Toronto : Little, Brown and Company .
   Google Scholar
• Rothuizen , J , Ingh , TSGAM van den , Voorhout , G , Luer , RJT van der and Wouda , W . 1982 . Congenital portosystemic shunts in sixteen dogs and three cats . J Small Anim Pract , 23 : 67 – 81 .
   Web of Science ®Google Scholar
• Snedecor , GW and Cochran , WG . 1980 . Statistical methods. , 7th ed. , Ames, Iowa : The Iowa State University Press .
   Google Scholar
• Sokal , RR and Rohlf , FJ . 1981 . Biometry , New York : WH Freeman and Company .
   Google Scholar
• Strombeck , DR , Meyer , DJ and Freedland , RA . 1975 . Hyperammoniaemia due to a urea‐cycle deficiency in two dogs . J Am Vet Med Assoc , 166 : 1109 – 11 .
   PubMed Web of Science ®Google Scholar
• Summers , BA , Cummings , JF and Lahunta , A . 1995 . Veterinary Neuropathology , 208 – 80 . St Louis : Mosby .
   Google Scholar
• Sutherland , RJ , Cordes , DO and Carthew , GC . 1979 . Ovine white liver disease ‐ an hepatic dysfunction associated with vitamin B12 deficiency . N Z Vet J , 27 : 227 – 32 .
   PubMed Web of Science ®Google Scholar
• Suttle , NF . 1988 . The role of comparative pathology in the study of copper and cobalt deficiencies in ruminants . J Comp Path , 99 : 241 – 58 .
   PubMed Web of Science ®Google Scholar
• Ulvund , Mi . 1990a . Ovine white‐liver disease (OWLD). Pathology . Acta Vet Scand , 31 : 309 – 24 .
   PubMed Web of Science ®Google Scholar
• Ulvund , MJ . 1990b . “ Ovine white‐liver disease ” . In Manifestations of cobalt/vitamin B12 deficiency in lambs , Oslo, , Norway : The Norwegian College of Veterinary Medicine .
   Google Scholar
• Ulvund , MJ and Overás , J . 1980 . Chronic hepatitis in lambs in Norway, a condition resembling ovine white liver disease in New Zealand . N Z Vet J , 28 : 19
   Web of Science ®Google Scholar
• Vellema , P , Moll , L , Barkema , HW and Schukken , YH . 1997 . Effect of cobalt supplementation on serum vitamin B12 levels, weight gain and survival rate in lambs grazing cobalt‐deficient pastures . Vet Quart , 19 : 1 – 5 .
   PubMed Web of Science ®Google Scholar
• Wensvoort , P and Herweijer , CH . 1975 . Chronische hepatitis bij lammeren . Tijdschr Diergeneeskd , 100 : 221 – 8 .
   PubMedGoogle Scholar
• Department of Ruminant Health, Animal Health Service, P.O. Box 361, 9200 AJ Drachten, the Netherlands.
   Google Scholar
• Corresponding author. Mailing address: Department of Ruminant Health, Animal Health Service, P.O. Box 361, 9200 AJ Drachten, the Netherlands; tel. 31.512570753; fax. 31.512520013; e‐mail: [email protected].
   Google Scholar
• Department of Pathology. Faculty of Veterinary Medicine, Utrecht University, P.O Box 80158, 3508 TD Utrecht, the Netherlands.
   Google Scholar
• Department of Pathology, Animal Health Service, P.O. Box 361, 9200 AJ Drachten, the Netherlands.
   Google Scholar