References
- Anika , SM , Nouws , JFM , Vree , TB and Miert , ASJPAM van . 1986 . The efficacy and plasma disposition of chloramphenicol and spiramycin in tick‐borne fever‐infected dwarf goats . J Vet Pharmacol Ther , 9 : 433 – 5 .
- Baggot , JD . 1992 . Clinical pharmacokinetics in veterinary medicine . Clin Pharmacokinet , 22 : 254 – 73 .
- Baggot , JD . 1970 . Some aspects of drug persistence in domestic animals . Res Vet Sci , 11 : 130 – 7 .
- Baggot , JD . 1984 . “ Some aspects of veterinary pharmacology ” . In Basic and Clinical Pharmacology , 2nd edition , Edited by: Katzung , B.G. 798 – 809 . Los Altos : Lange Medical Publ. .
- Barragry , TB . 1987 . A review of the pharmacology and clinical uses of ivermectin . Can Vet J , 28 : 512 – 7 .
- Beck , FJ and Whitehouse , MW . 1974 . Impaired drug metabolism in rats associated with acute inflammation: a possible assay for anti‐injury agents . Proc Soc Expl Biol Med , 145 : 135 – 40 .
- Bertz , RJ and Granneman , GR . 1997 . Use of in vitro and in vivo data to estimate the likelyhood of metabolic pharmacokinetic interactions . Clin Pharmacokinet , 32 : 210 – 58 .
- Bywater , RJ , Hamilton , P and Palmer , GH . 1991 . Comparative bioavailability of two apparently similar injectable ampicillin formulations in pigs . Acta Vet Scand , : 374 – 5 .
- Caldwell , J . 1986 . “ Comparative aspects of drug conjugation in laboratory animals, exotic species and man ” . In Comparative Veterinary Pharmacology, Toxicology and Therapy , Edited by: Miert , ASJPAM van , Bogaert , MG and Debackere , M . 285 – 94 . Lancaster, UK : MTP‐Press Ltd .
- Davis , LE . 1982 . “ Veterinary pharmacology: an introduction to the discipline ” . In Veterinary Pharmacology and Therapeutics, , 5th edition , Edited by: Booth , N.H. and McDonald , L.E. 1 – 7 . Ames, USA : Iowa State University Press .
- Derkx‐Overduin , LM . 1994 . “ Slow‐release phenytoin in canine epilepsy ” . Utrecht University . Ph.D. thesis,, ISBN 90–393–0893–4,
- Dorrestein , GM . 1986 . “ Studies on pharmacokinetics of some antibacterial agents in homing pigeons (Colombia livia) ” . Utrecht University, Optimax, Wijk bij Duurstede . Ph.D. thesis
- Duijkeren , E van . 1995 . “ Trimethoprim‐sulfonamide combinations in relation to equine salmonellosis ” . Utrecht : Utrecht University, Elinkwijk Press . Ph.D. thesis, ISBN 90–393–0517‐X,
- Ensink , JM , Klein , WR , Barneveld , A , Miert , ASJPAM van and Vulto , AG . 1996 . Side effects of oral antimicrobial agents in the horse: a comparison of pivampicillin and trimethoprim/sulphadiazine . Vet Rec , 138 : 253 – 6 .
- Ensink , JM . 1995 . “ Pharmacokinetics and clinical aspects of oral broad‐spectrum penicillines in the horse ” . Utrecht University . Ph.D. thesis, ISBN 90–393–0898–5,
- Fink‐Gremmels , J and Miert , ASJPAM van . 1996 . Species differences in biotransformation: Conventional models in unconventional animal species . Exp Toxicol Pathol , 48 (11) : 120 – 7 .
- Fink‐Gremmels , J and Miert , ASJPAM van . 1994 . Veterinary drugs: disposition, biotransformation and risk evaluation . The Analist , 119 : 2521 – 8 .
- Fink‐Gremmels , J . 1999 . Mycotoxins: Their implications for human and animal health . Vet Quart , 21 : 115 – 20 .
- Firth , EC , Nouws , JFM , Driessens , F , Schmaetz , P , Peperkamp , K and Klein , WR . 1986 . Effect of the injection site of the pharmacokinetics of procaine penicillin G in horses . Am J Vet Res , 47 : 2380 – 4 .
- Frens , J . 1971 . “ Thermoregulation and fever. The influence of bacterial lipopolysaccharides on thermoregulation in the goat ” . Utrecht : Utrecht university, Elinkwijk Press . Ph.D. thesis,
- Genderen , H van . 1981 . “ Farmacologie en Toxicologie ” . In Van Gildestein naar Uithof: 150 jaar Diergeneeskundig Onderwijs in Utrecht, deel 2 , Edited by: Offringa , C. 288 – 300 . Utrecht : e.a. Rijksuniversiteit te Utrecht, Faculteit der Diergeneeskunde .
- Ghosh , S , May , MJ and Kopp , EB . 1998 . NF‐kappa B and Rel proteins: evolutionary conserved mediators of immune responses . Ann Rev Immunol , 16 : 225 – 60 .
- Gogh , H van , Deurzen , EJM van , Duin , CTM van and Miert , ASJPAM van . 1984 . Effect of staphylococcal enterotoxin Binduced diarrhoea on the pharmacokinetics of sulphadimidine in the goat . J Vet Pharmacol Ther , 7 : 303 – 5 .
- Gogh , H van , Watson , ADJ , Nouws , JFM , Nieuwenhuijs , J and Miert , ASJPAM van . 1989 . Effect of tick‐borne fever (Ehrlichia phagocytophila) and trypanosomiasis (Trypanosoma brucei 1066) on the pharmacokinetics of sulfadimidine and its metabolites in goats . Drug Metab Dispos , 17 : 1 – 6 .
- Gogh , H van . 1980 . Pharmacokinetics of nine sulphonamides in goats . J Vet Pharmacol Therap , 3 : 69 – 81 .
- Groothuis , DG , Werdler , MEB , Miert , ASJPAM van and Duin , CTM van . 1980 . Factors affecting the absorption of ampicillin administered intramuscularly in dwarf goats . Res Vet Sci , 29 : 116 – 7 .
- Groothuis , DG . 1983 . “ Pharmacokinetics of some antimicrobial drugs in veal calves and their activity in relation to Salmonella dublin infections ” . Utrecht University . Ph.D. thesis,
- Hammond , RA , Hannon , R , Frean , S , Armstrong , S , Flower , RJ and Bryant , CE . 1999 . Endotoxin induces nitric oxide synthase and cyclooxygenase‐2 in equine alveolar macrophages . Am J Vet Res , 60 : 426 – 31 .
- Harris , RZ , Benet , LZ and Schwartz , JB . 1995 . Gender effects in pharmacokinetics and pharmacodynamics . Drugs , 50 : 222 – 39 .
- Hoebe KHW. Activated Kupffer cells: release of inflammatory mediators and their effects on acute phase proteins and hepatic drug metabolism (research project 1997–2001).
- Hugnet , C , Cadore , JL , Buronfosse , F , Pineau , X , Mathet , T and Berny , PJ . 1996 . Loperamide poisoning in the dog . Vet Hum Toxicol , 38 : 31 – 3 .
- Izeboud CA. Activated macrophages (including Kupffer cells) and neutrophils: signal transduction and release of inflammatory mediators (research project 1996–2000).
- Klooster , GAE van't , Blaauboer , BJ , Noordhoek , J and Miert , ASJPAM van . 1993 . Sulphadimidine metabolism in vitro; II: comparative studies in cultured rat, goat, sheep and cattle hepatocytes . J Vet Pharmacol Therap , 16 : 454 – 61 .
- Klooster , GAE van't . 1992 . “ Drug metabolism in ruminants: an in vitro approach ” . Utrecht University . Ph.D. thesis,, ISBN 90–393–0334–7,
- Klooster , GAE van't , Horbach , GJMJ , Natsuhori , M , Blaauboer , BJ , Noordhoek , J and Miert , ASJPAM van . 1993 . Hepatic cytochrome P450 induction in goats; Effects of model inducers on the metabolism of alkoxyresorufins, testosterone and ethylmorphine and on apoprotein and mRNA levels . Biochem Pharmacol , 45 : 113 – 22 .
- Klooster , GAE van't , Woutersen‐van Nijnanten , FMA , Blaauboer , BJ , Noordhoek , J and Miert , ASJPAM van . 1994 . The applicability of cultured hepatocytes derived from goats, sheep and cattle in comparative drug metabolism studies . Xenobiotica , 24 : 417 – 28 .
- Knoppert , NW , Nijmeijer , SM , Duin , CTM van , Korstanje , C , Gogh , H van and Miert , ASJPAM van . 1988 . Some pharmacokinetic data of aditoprim and trimethoprim in healthy and tick‐borne fever infected dwarf goats . J Vet Pharmacol Therap , 11 : 135 – 44 .
- Ladage , CA , Kleinepier , JF and Miert , ASJPAM van . 1989 . Some pharmacokinetic data of the liver‐fluke anthelmintic nitroclofene in ruminant and pre‐ruminant kids . J Vet Pharmacol Ther , 12 : 451 – 4 .
- Ladage , CA , Walstijn , ThA van and Riessen , HA van . 1980 . “ Comparative macroscopic evaluation of muscle damage in rats and in cattle after intramuscular administration of some commercially available injectable medicines ” . In Trends in Veterinary Pharmacology and Toxicology , Developments in Animal and Veterinary Sciences Edited by: Miert , ASJPAM van , Frens , J and Kreek , FW van der . vol. 6 , 34 – 40 . Amsterdam : Elsevier Sci Publ. .
- Ladage , CA . 1979 . “ The development of a new injectable anti‐liver‐fluke compound ” . Maarssen : Utrecht University, ACF Chemiefarma Press . Ph.D. thesis,
- Lee , RM and Pickering , WR . 1967 . The toxicity of haloxon to geese, ducks and hens, and its relationship to the stability of the di‐ (2‐chloro‐ethyl) phosphoryl cholinesterase derivatives . Biochem Pharmacol , 16 : 941 – 8 .
- Lees , P , Armstrong , S , Frean , S , Landoni , MF and Shojaee Ali‐Abadi , F . 1998 . Pharmacology, toxicology and therapeutic uses of NSAIDs . Proc. EAVPT‐ECVPT workshop on animal pain and inflammation and their control . Dec 14–18th 1998 , Hatfield, UK. pp. 93 – 115 .
- Lohse , MJ . 1998 . The future of pharmacology . Trends Pharmacol Sci (TIPS) , 19 : 198 – 200 .
- Lohuis , JACM , Werven , T van , Brand , A , Miert , ASJPAM van , Rohde , E , Ludwig , B , Heizmann , P and Rehm , W.F. 1991 . Pharmacodynamics and pharmacokinetics of carprofen, a non‐steroidal anti‐inflammatory drug, in healthy cows and cows with Escherichia coli endotoxin‐induced mastitis . J Vet Pharmacol Ther , 14 : 219 – 29 .
- Lohuis , JACM . 1989 . “ Escherichia coli mastitis in the cow. Some aspects of symptomatic treatment and defence mechanisms ” . Utrecht : Utrecht University, Elinkwijk Press . Ph.D. thesis,
- Maas , CL . 1984 . “ Modulation of forestomach motility in small ruminants: opioid and nonopioid mechanisms ” . Utrecht : Utrecht University, Elinkwijk Press . Ph.D. thesis,
- May , MJ and Ghosh , S . 1997 . Rel/NF‐kappa B and I kappa B proteins: an overview . Cancer Biol , 8 : 63 – 73 .
- Mengelers , MJB , Kleter , GA , Hoogenboom , LAP , Kuiper , HA and Miert , ASJPAM van . 1997 . The biotransformation of sulfadimethoxine, sulfadimidine, sulfamethoxazole, trimethoprim and aditoprim by primary cultures of pig hepatocytes . J Vet Pharmacol Ther , 20 : 24 – 32 .
- Mengelers , MJB . 1991 . “ The prophylaxis of pleuropneumonia in pigs with sulfonamide‐trimethoprim combinations: microbiological, pharmacokinetic and residual aspects ” . Utrecht University . Ph.D. thesis,
- Mevius , DJ . 1990 . “ Microbiological and pharmacokinetical aspects of flumequine in healthy and diseased calves ” . Utrecht University, Addix, Wijk bij Duurstede . Ph.D. thesis,
- Miert , ASJPAM van and Duin , CTM van . 1998 . Pharmacological and pathophysiological modulation of food intake and forestomach motility in small ruminants . J Vet Pharmacol Therap , 21 : 1 – 17 .
- Miert , ASJPAM van and Duin , CTM van . 1979 . The effect of flurbiprofen upon fever and ruminal stasis induced by Escherichia coli endotoxin, Poly I: Poly C and sodium nucleinate from yeast in conscious goats . J vet Pharmacol Therap , 2 : 69 – 79 .
- Miert , ASJPAM van , Duin , CTM and Wensing , T . 1994 . Effects of flurbiprofen on recombinant human IL‐1α‐induced fever and associated clinical, haematological and blood biochemical changes in the dwarf goat . Vet Quart , 16 : 1 – 6 .
- Miert , ASJPAM van , Peters , RHM , Basudde , CDK , Nijmeijer , SM , Duin , CTM van , Gogh , H van and Korstanje , C . 1988 . Effect of trenbolone and testosterone on the plasma elimination rates of sulfamethazine, trimethoprim, and antipyrine in female dwarf goats . Am J Vet Res , 49 : 2060 – 4 .
- Miert , ASJPAM van . 1995 . ‘Off‐label use’ van lincomycine‐hydrochloride bij twee paarden. Dysbacteriose en daarbij optredende fatale complicaties door insufficiente symptomatische therapie . Tijdschr Diergeneeskd , 120 : 361 – 3 .
- Mien , ASJPAM van . 1984 . Van Materia medica tot rationele farmacotherapie . Tijdschr Diergeneeskd , 109 : 3 – 11 .
- Miert , ASJPAM van . 1991 . “ Acute phase response and non cellular defence mechanisms ” . In New Insights Into The Pathogenisis of Mastitis , Edited by: Burvenich , C , Vandeputte‐Van Messon , G and Hill , AW . Vol. 62 , 69 – 91 . Ghent : Vlaams Diergeneeskd Tijdschr .
- Mien , ASJPAM van . 1998 . Cytokines as inflammatory mediators . Proc. EAVPT‐ECVPT workshop on animal pain and inflammation and their control . Dec. 14–18th 1998 , Hatfield, UK. pp. 5 – 6 .
- Miert , ASJPAM van . 1996 . “ Efficacy of drugs and good veterinary practice ” . In Residues of Veterinary Drugs and Mycotoxins in Animal Products , Edited by: Enne , G , Kuiper , HA and Valentini , A . 87 – 94 . Wageningen : Wageningen Press .
- Miert , ASJPAM van . 1989 . Extrapolation of pharmacological and toxicological data based on metabolic weight . Arch experim Veterinärmedizin (Leipzig) , 43 : 481 – 8 .
- Miert , ASJPAM van . 1997 . Good Veterinary Practice (GVP) and the prevention of drug residues in food products of animal origin . Proc. World Congress on Food Hygiene . August 24–29 1997 . pp. 103 Wageningen Press .
- Miert , ASJPAM van . 1992 . Good Veterinary Practice and efficacy . Proc. Int. Conf. Veterinary Medicine in post‐1992. Europe . February 13–14 1992 , Brussels, Belgium. pp. 84 – 98 .
- Miert , ASJPAM van . 1981 . Herman van Genderen Symposion . Vet Quart , 3 : 165 – 8 .
- Miert , ASJPAM van . 1990 . Influence of febrile disease on pharmacokinetics of veterinary drugs . Ann Rech Vet , 21 (suppl. 1) : 21S – 8S .
- Miert , ASJPAM van . 1970 . “ Inhibition of reticulo‐rumen motility during fever induced by bacterial pyrogen ‐ lipopolysaccharides from gram‐negative bacteria ‐ in sheep and goats ” . Grosfeld Offset, Berlicum : Utrecht University . PhD thesis,
- Miert , ASJPAM van . 1995 . Pro‐inflammatory cytokines in a ruminant model: pathophysiological, pharmacological and therapeutic aspects . Vet Quart , 17 : 41 – 50 .
- Miert , ASJPAM van . 1986 . “ The use in animals of drugs licensed for human use only ” . In Comparative Veterinary Pharmacology, Toxicology and Therapy , Edited by: Miert , ASJPAM van , Bogaert , MG and Debackere , M . 489 – 500 . Lancaster : MTP Press Ltd. .
- Miert , ASJPAM van . 1990 . Veterinary drugs and good veterinary practice (Diergeneesmiddelen en ‘good veterinary practice') . Tijdschr Diergeneeskd , 115 : 125 – 31 .
- Miert , ASJPAM van . 1987 . Veterinary pharmacotherapy: from retrospect to future expectations (Veterinaire farmacotherapie: van terugblik naar toekomstverwachting) . Tijdschr Diergeneeskd , 112 : 836 – 43 .
- Monshouwer , M , Witkamp , RF , Leengoed , LAMG van , Vernooy , JCM , Verheijden , JHM and Miert , ASJPAM van . 1996 . A lipopolysaccharide‐induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450‐mediated drug metabolism . J Vet Pharmacol Ther , 19 : 382 – 8 .
- Monshouwer , M , Witkamp , RF , Nijmeijer , SM , Amsterdam , JG van and Miert , ASJPAM van . 1996 . Suppression of cytochrome P450‐ and UDP glucuronosyl transferasedependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes . Toxicol Appl Pharmacol , 137 : 237 – 44 .
- Monshouwer , M , Witkamp , RF , Nijmeijer , SM , Leengoed , LAMG van , Verheijden , JHM and Miert , ASJPAM van . 1995 . Infection (Actinobacillus pleuropneumoniae) mediated suppression of oxidative hepatic drug metabolism and cytochrome P4503A mRNA levels in the pig . Drug Metab Dispos , 23 : 44 – 7 .
- Monshouwer , M , Witkamp , RF , Nijmeijer , SM , Pijpers , A , Verheijden , JHM and Miert , ASJPAM van . 1995 . Selective effects of a bacterial infection model (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig . Xenobiotica , 25 : 491 – 9 .
- Monshouwer , M . 1996 . “ Acute phase response mediated effects on hepatic drug metabolism in pigs: an in vivo and in vitro approach ” . Utrecht University . Ph.D. thesis,, ISBN 90–393–1432–2,
- Monshouwer , M , Klooster , GAE van't , Nijmeijer , SM , Witkamp , RF and Miert , ASJPAM van . 1998 . Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes . Toxicol in Vitro , 12 : 715 – 23 .
- Natsuhori , M , Raak , M van , Ligtenberg , M , Kleij , LA , Berge , D ten , Zweers‐Zeilmaker , WM , Groene , EM de , Miert , ASJPAM van , Witkamp , RF and Horbach , GJ . 1997 . Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells . Environm Toxicol Pharmacol , 3 : 17 – 24 .
- Nijmeijer , SM , Samuriwo , E , Duin , CTM van and Miert , ASJPAM van . 1990 . Oral chloramphenicol in dwarf goats. Influence of vasopressin on its absorption and effect of diet on its biodegradation in ruminal fluid samples . J Vet Pharmacol Ther , 13 : 408 – 17 .
- Noach , EL . 1990 . Pharmacology in the Netherlands . XI th International Congress of Pharmacology . July 1–6 1990 , Amsterdam.
- Noach , EL . 1990 . The history of pharmacology in the Netherlands . Trends Pharmacol Sci (TIPS) , 11 : 236 – 9 .
- Nouws , JFM , Smulders , A and Rappalini , MA . 1990 . comparative study on irritation and residue aspects of five oxytetracycline formulations administered intramuscularly to calves, pigs and sheep. Vet . Quart , 12 : 129 – 38 .
- Nouws , JFM . 1978 . “ Tissue distribution and residues of some antimicrobial drugs in normal and emergency‐slaughtered ruminants ” . Utrecht University . Ph.D. thesis,
- Os , JL van . 1982 . “ Oestrus control in the bitch with proligestone ” . Utrecht University . Ph.D. thesis,
- Park , GR . 1993 . Pharmacokinetics and pharmacodynamics in the critically ill patient . Xenobiotica , 23 : 1195 – 1230 .
- Pickering , WR and Malone , JC . 1967 . The acute toxicity of dichloroalkyl aryl phosphates in relation to chemical structure . Biochem Pharmacol , 16 : 1183 – 94 .
- Pijpers , A , Schoevers , EJ , Gogh , H van , Leengoed , LAMG van , Visser , IJR , Mien , ASJPAM van and Verheijden , JHM . 1991 . The influence of disease on feed and water consumption and on pharmacokinetics of orally administered oxytetracycline in pigs . J Anim Sci , 69 : 2947 – 54 .
- Pijpers , A . 1990 . “ Feed medication with tetracyclines in pigs: a critical evaluation ” . Utrecht University . Ph.D. thesis,
- Pulliam , JD , Seward , RL , Henry , RT and Steinberg , SA . 1985 . Investigating ivermectin toxicity in collies . Vet Med , 80 : 33 – 40 .
- Rasmussen , F and Svendsen , O . 1976 . Tissue damage and concentration at the injection site after intramuscular injection of chemotherapeutics and vehicles in pigs . Res Vet Sci , 20 : 55 – 60 .
- Rasmussen , F . 1983 . Renal clearance: species differences and similarities . Vet Res Commun , 7 : 301 – 6 .
- Rasmussen , F . 1980 . “ Tissue damage at le injection site after intramuscular injection of drugs in food‐producing animals ” . In Trends in Veterinary Pharmacology and Toxicology , Developments in Animal and Veterinary Sciences Edited by: Miert , ASJPAM van , Frens , J and Kreek , FW van der . Vol. 6 , 27 – 33 . Amsterdam : Elsevier Sci. Publ. .
- Roy , TAJM de . 1978 . “ Dopamine in central thermoregulation. A comparative study in the goat, sheep and rabbit ” . Utrecht University . Ph.D. thesis,
- Rutgers , LJE , Miert , ASJPAM van , Nouws , JFM and Ginneken , CAM van . 1980 . Effect of the injection site on the bioavailability of amoxycillin trihydrate in dairy cows . J Vet Pharmacol Therap , 3 : 125 – 32 .
- Schinkel , AH , Smit , JJM , Tellingen , O van , Beynen , JH , Wagenaar , E , Deemter , L van , Mol , CAAM , Valk , MA van der , Robanus‐Maandag , EC , Riele , HPJ te , Berns , AJM and Borst , P . 1994 . Disruption of the mouse mdr 1a P‐glycoprotein gene leads to a deficiency in the blood‐brain barrier and to increased sensitivity to drugs . Cell , 77 : 491 – 502 .
- Vane , J . 1998 . The mechanism of action of anti‐inflammatory drugs . Naunyn‐Schmiedeberg's Arch Pharmacol , 385 (1) : R8
- Veenendaal , GH . 1979 . “ Role of circulating inflammatory mediators during ruminal stasis induced by experimental fever in goats ” . Utrecht : Utrecht University, Elinkwijk Press . Ph.D. thesis,
- Verheijden , JHM . 1979 . “ Further investigations into some aspects of acute coliform mastitis in cattle ” . Utrecht University . Ph.D thesis,
- Villar , D , Furusawa , N , Monshouwer , M and Miert , ASJPAM van . 1998 . Novobiocin inhibits both UDP‐glucuronosyltransferase and cytochrome P450‐mediated enzyme activities in pig liver microsomes . Vet Res Commun , 22 : 405 – 14 .
- Walker , CH . 1986 . “ Hepatic microsomes as models for comparative metabolism in vivo ” . In Comparative Veterinary Pharmacology Toxicology and Therapy , Edited by: Miert , ASJPAM van , Bogaert , MG and Debackere , M . 295 – 9 . Lancaster, UK : MTP‐Press, Ltd .
- Wit , JG . 1981 . Institute of veterinary pharmacology, pharmacy and toxicology: its research (1961–1980) . Vet Quart , 3 : 169 – 75 .
- Witkamp , RF , Klooster , GAE van't , Nijmeijer , SM , Kolker , HJ , Noordhoek , J and Miert , ASJPAM van . 1993 . Hormonal regulation of oxidative drug metabolism in the dwarf goat: the effect of sex and hormonal treatment on plasma and metabolite formation of sulphadimidine . J Vet Pharmacol Therap , 16 : 55 – 62 .
- Witkamp , RF , Nijmeijer , SM , Csiko , G and Miert , ASJPAM van . 1994 . Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig . J Vet Pharmacol Therap , 17 : 317 – 22 .
- Witkamp , RF , Nijmeijer , SM , Duin , CTM van , Noordhoek , J and Miert , ASJPAM van . 1993 . The regulation of oxidative drug metabolism by growth hormone in the dwarf goat: differences from and similarities to the mechanism in rats . J Endocrinol , 136 : 313 – 7 .
- Witkamp , RF , Nijmeijer , SM , Kolker , HJ , Noordhoek , J and Miert , ASJPAM van . 1993 . Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in dwarf goat . J Vet Pharmacol Therap , 16 : 164 – 73 .
- Witkamp , RF , Nijmeijer , SM , Monshouwer , M and Miert , ASJPAM van . 1995 . The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig . Drug Metab Dispos , 23 : 542 – 7 .
- Witkamp , RF . 1998 . Cellular communication and signal transduction in inflammatory processes: therapeutic targets . Proc. EAVPT‐ECVPT workshop on animal pain and inflammation and their control . Dec 14–18th 1998 , Hatfield, UK. pp. 66 – 83 .
- Witkamp , RF . 1992 . “ Oxidative drug metabolism in ruminants and laboratory species. Comparative aspects and regulation by steriod hormones and somatotropin ” . Enschede : Utrecht University . Ph.D. thesis,, ISBN 90–393–0301–0, FEBO Press,
- Zweers‐Zeilmaker , WM , Batzias , J , Maas , RFM , Horbach , GJ , Miert , ASJPAM van and Witkamp , RF . 1996 . In vitro and in vivo oxidative biotransformation in the West‐African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers . Xenobiotica , 26 : 1131 – 41 .
- Zweers‐Zeilmaker , WM . 1997 . “ Cytochrome P450 in ruminants. Drug metabolism and drug‐drug interactions ” . Utrecht University . Ph.D. thesis,ISBN 90–393–1408‐X,
- Utrecht University, Faculty of Veterinary Medicine, Department of Pharmacology, Pharmacy and Toxicology, P.O. Box 80152, 3508 TD Utrecht, the Netherlands.