Advanced search
Publication Cover
Veterinary Quarterly Volume 41, 2021 - Issue 1
Submit an article Journal homepage
1,182
Views
2
CrossRef citations to date
0
Altmetric
Article

Pharmacokinetics of ponazuril after administration of a single oral dose to green turtles (Chelonia mydas)

Elliott R. Jacobsona Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USAView further author information
,
Nicole I. Stacyb Department of Comparative, Diagnostic, and Population Medicine, University of Florida, Gainesville, FL, USAView further author information
,
Douglas R. Maderc The Turtle Hospital, Marathon, FL, USAView further author information
,
Richie Morettic The Turtle Hospital, Marathon, FL, USAView further author information
,
Bette Zirkelbachc The Turtle Hospital, Marathon, FL, USAView further author information
,
Olivia Carlilec The Turtle Hospital, Marathon, FL, USAView further author information
,
Courtney D. O’Connord Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USAView further author information
,
Kaylin J. Capertond Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USAView further author information
&
Lara K. Maxwelld Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USACorrespondence[email protected]
View further author information
 show all
Pages 323-331 | Received 04 Jun 2021, Accepted 15 Nov 2021, Published online: 08 Dec 2021

References

  • Benge SL, Heinrichs MT, Crevasse SE, Mahjoub B, Peloquin CA, Wellehan JFX. 2018. A preliminary analysis of prolonged absorption rate of ponazuril in red-footed tortoises, Chelonoidis Carbonaria. J Zoo Wildl Med. 49(3):802–805.
  • Bogoslavsky B. 2007. The use of ponazuril to treat coccidiosis in eight inland bearded dragons (Pogona vitticeps). Proceedings of the Association of Reptilian and Amphibian Veterinarians, Edited by E. Klaphake and C. Kirk Baer, New Orleans, LA.
  • Darius AK, Mehlhorn H, Heydorn AO. 2004. Effects of toltrazuril and ponazuril on the fine structure and multiplication of tachyzoites of the NC-1 strain of Neospora caninum (a synonym of Hammondia heydorni) in cell cultures. Parasitol Res. 92(6):453–458.
  • de Gouvea Pedroso SB, Phalen DN, Terkildsen M, Blyde D, March DT, Gordon AN, Chapman PA, Mills PC, Owen H, Gillett A, et al. 2020. Coccidiosis in green turtles (Chelonia mydas) in Australia: pathogenesis, spatial and temporal distribution, and climate-related determinants of disease outbreaks. J Wildl Dis. 56(2):359–371.
  • Effinger A, O'Driscoll CM, McAllister M, Fotaki N. 2019. Impact of gastrointestinal disease states on oral drug absorption – implications for formulation design – a PEARRL review. J Pharm Pharmacol. 71(4):674–698.
  • Furr M, Kennedy T. 2001. Cerebrospinal fluid and serum concentrations of ponazuril in horses. Vet Ther. 2(3):232–237.
  • Gordon AN, Kelly WR, Lester RJ. 1993. Epizootic mortality of free-living green turtles, Chelonia mydas, due to coccidiosis. J Wildl Dis. 29(3):490–494.
  • Joachim A, Ruttkowski B. 2021. Cystoisospora suis merozoite development assay for screening of drug efficacy in vitro. Exp Parasitol. 220:108035.
  • Leibovitz L, Rebell G, Boucher GC. 1978. Caryospora cheloniae sp. n.: a coccidial pathogen of mariculture-reared green sea turtles (Chelonia mydas mydas). J Wildl Dis. 14(2):269–275.
  • Lindsay DS, Dubey JP, Kennedy TJ. 2000. Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures. Vet Parasitol. 92(2):165–169.
  • Magalhães M. d. S., Santos AJB, Silva N. B. d., Moura C. E. B. d. 2012. Anatomy of the digestive tube of sea turtles (Reptilia: Testudines). Zoologia (Curitiba). 29(1):70–76.
  • Mitchell SM, Zajac AM, Davis WL, Kennedy TJ, Lindsay DS. 2005. The effects of ponazuril on development of apicomplexans in vitro. J Eukaryot Microbiol. 52(3):231–235.
  • Morrison DA. 2009. Evolution of the Apicomplexa: where are we now? Trends Parasitol. 25(8):375–382.
  • Pelton C, Boylan SM, Stacy N, McIntosh A, Walsh M, Ranly M, Wellehan JFX. 2013. The use of triazinones for the treatment of coccidia morphologically resembling Caryospora cheloniae in green sea turtles (Chelonia mydas). International Association for Aquatic Animal Medicine 44th Annual Conference Proceedings, CA, Sausalito.
  • Stacy BA, Chapman PA, Stockdale-Walden H, Work TM, Dagenais J, Foley AM, Wideroff M, Wellehan JFX, Childress AL, Manire CA, et al. 2019. Caryospora-like coccidia infecting green turtles (Chelonia mydas): an emerging disease with evidence of interoceanic dissemination. Front Vet Sci. 6(372):372.
  • Thron CD. 1974. Linearity and superposition in pharmacokinetics. Pharmacol Rev. 26(1):3–31.
  • Yamaoka K, Nakagawa T, Uno T. 1978. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm. 6(2):165–175.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.