139
Views
1
CrossRef citations to date
0
Altmetric
Original Article

A Protective Role of Coenzyme Q10 in Ethambutol-Induced Retinal Ganglion Cell Toxicity: A Randomised Controlled Trial in Mice

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 298-303 | Received 10 Dec 2021, Accepted 17 Feb 2022, Published online: 24 May 2022

References

  • Centers for Disease Control and Prevention (CDC). CDC at the Forefront of Innovation in the Global Fight against TB. USA: CDC; 2021.
  • Alisjahbana B, Koesoemadinata RC, Hadisoemarto PF, et al. Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding. Hasnain SE, ed. PLoS One. 2021;16(8):e0256043.doi:10.1371/journal.pone.0256043.
  • Centers for Disease Control and Prevention (CDC). CDC in Indonesia. 2021. https://www.cdc.gov/globalhealth/countries/indonesia/pdf/indonesia-fs.pdf. Accessed December 5, 2021.
  • Kementerian Kesehatan Republik Indonesia. Situasi Tuberkulosis Indonesia Tahun 2020. Indonesia: Indonesian Ministry of Health; 2021.
  • Arya V. A review on anti-tubercular plants. Int J PharmTech Res. 2011; 3(2):872–880.
  • Sadun AA, Wang MY. Ethambutol optic neuropathy: how we can prevent 100,000 new cases of blindness each year. Journal of Neuro Ophthalmol. 2008;28(4):265–268. doi:10.1097/WNO.0b013e31818f138f.
  • Sadli N, Barrow CJ, McGee S, Suphioglu C. Effect of DHA and CoenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. Cell Physiol Biochem. 2013;32(2):243–252. doi:10.1159/000354433.
  • Koul P. Ocular toxicity with ethambutol therapy: timely recaution. Lung India. 2015;32(1):1. doi:10.4103/0970-2113.148395.
  • van Dijk BW, Spekreijse H. Ethambutol changes the color coding of carp retinal ganglion cells reversibly. Invest Ophthalmol Vis Sci. 1983;24:128–133.
  • Heng JE, Vorwerk CK, Lessell E, Zurakowski D, Levin LA, Dreyer EB. Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway. Invest Ophthalmol Vis Sci. 1999;40:190–196.
  • Palisoc E, Asakawa K, Uga S, Mashimo K, Ishikawa H. The role of zinc in ethambutol-induced neuroretinopathy: Functional and morphologic assessment in a rabbit model. Japanese Neuro Ophthalmol Soc. 2019;36(1):95–105. doi:10.11476/shinkeiganka.36.95.
  • Xu J, Dai Q, Wu S, Sheng W, Zhao S, Zhong L. Treatment of ethambutol-induced optic neuropathy by buqihuoxue formula combined with methycobal. Int J Clin Exp Med. 2017;10:7011–7015.
  • Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P, Choi D-S. Coenzyme Q10 supplementation in aging and disease. Front Physiol. 2018;9:9. doi:10.3389/fphys.2018.00044.
  • Tiseo BC, Gaskins AJ, Hauser R, Chavarro JE, Tanrikut C. Coenzyme Q10 intake from food and semen parameters in a subfertile population. Urology. 2017;102:100–105. doi:10.1016/j.urology.2016.11.022.
  • Xu Z, Huo J, Ding X, et al. Coenzyme Q10 improves lipid metabolism and ameliorates obesity by regulating CaMKII-mediated PDE4 inhibition. Sci Rep. 2017;7(1):8253.doi:10.1038/s41598-017-08899-7.
  • Hardwiyani S. Perbandingan Perubahan Sensitivitas Kontras Penderita Tuberkulosis Baru yang diberi Etambutol dengan dan Tanpa Suplementasi Koenzim Q10. 2016. Published online.
  • Kartika A, Sri Astri N, Setiohadji B, Iwan Sovani I, Mose JC. Retinal ganglion cell density after coenzyme Q10 treatment in a rat model of methanol toxic optic neuropathy. Neuro Ophthalmol Japan. 2017;34(2):239–243.
  • Cui Y. Haematoxylin Eosin (H&E) Staining. China: Protocols.io; 2017. doi:10.17504/protocols.io.ihxcb7n.
  • Center for Musculoskeletal Research. Hematoxylin and Eosin Stain. University of Rochester Medical Center, New York, USA: H&E; 2017.
  • Goude R, Amin AG, Chatterjee D, Parish T. The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2009;53(10):4138–4146. doi:10.1128/AAC.00162-09.
  • Zhang L, Zhao Y, Gao Y, et al. Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Science. 2020;368(6496):1211–1219.doi:10.1126/science.aba9102.
  • Amin AG, Goude R, Shi L, Zhang J, Chatterjee D, Parish T. EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis. Microbiology. 2008;154(1):240–248. doi:10.1099/mic.0.2007/012153-0.
  • Takayama K, Armstrong EL, Kunugi KA, Kilburn JO. Inhibition by ethambutol of mycolic acid transfer into the cell wall of mycobacterium smegmatis. Antimicrob Agents Chemother. 1979;16(2):240–242. doi:10.1128/AAC.16.2.240.
  • Yamada D, Saiki S, Furuya N, et al. Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation. Biochem Biophys Res Commun. 2016;471(1):109–116.doi:10.1016/j.bbrc.2016.01.171.
  • Deep SN, Mitra S, Rajagopal S, Paul S, Poddar R. GluN2A-NMDA receptor–mediated sustained Ca2+ influx leads to homocysteine-induced neuronal cell death. J Biol Chem. 2019;294(29):11154–11165. doi:10.1074/jbc.RA119.008820.
  • Tevaraj JMP, Keong TC, Min ETL, Julieana M, Noor RAM, Hitam W-HW. Evaluation of anatomical and visual function for early detection of ethambutol toxicity among tuberculosis patients. Int Eye Sci. 2017;17(11):2005–2009. doi:10.3980/j.1672-5123.2017.11.04.
  • World Health Organization (WHO). Ethambutol Efficacy and Toxicity: Literature Review and Recommendations for Daily and Intermittent Dosage in Children. Geneva: WHO莉; 2006.
  • National Center for Biotechnology Information. Coenzyme Q10 | Compound Summary. Bethesda: National Center for Biotechnology Information; 2005.
  • Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain. Fundam Clin Pharmacol. 2013;27(6):603–622. doi:10.1111/fcp.12003.
  • Alcázar-Fabra M, Navas P, Brea-Calvo G. Coenzyme Q biosynthesis and its role in the respiratory chain structure. Biochim Biophys Acta Bioenergy. 2016;1857(8):1073–1078. doi:10.1016/j.bbabio.2016.03.010.
  • Schniertshauer D, Müller S, Mayr T, Sonntag T, Gebhard D, Bergemann J. Accelerated regeneration of ATP level after irradiation in human skin fibroblasts by Coenzyme Q 10. Photochem Photobiol. 2016;92(3):488–494. doi:10.1111/php.12583.
  • Kędziora-Kornatowska K, Czuczejko J, Motyl J, et al. Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study. Arch Med Sci. 2010;4:513–518. doi:10.5114/aoms.2010.14461.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.