Systemic inflammatory markers differentiate between orbital cellulitis and non-specific orbital inflammation

References

• Moore GH, Rootman DB. Orbital inflammatory disease management. Expert Rev Ophthalmol. 2016;11:415–428. doi:10.1080/17469899.2016.1233399.
   Web of Science ®Google Scholar
• Gordon LK. Orbital inflammatory disease: a diagnostic and therapeutic challenge. Eye. 2006;20:1196–1206. doi:10.1038/sj.eye.6702383.
   PubMed Web of Science ®Google Scholar
• Mombaerts I, Rose GE, Garrity JA. Orbital inflammation: biopsy first. Surv Ophthalmol. 2016;61:664–669. doi:10.1016/j.survophthal.2016.03.002.
   PubMed Web of Science ®Google Scholar
• Rootman J. Diseases of the Orbit : A Multidisciplinary Approach. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2002:p. 586.
   Google Scholar
• Rubin PA, Foster CS. Etiology and management of idiopathic orbital inflammation. Am J Ophthalmo. 2004;138:1041–1043. doi:10.1016/j.ajo.2004.09.032.
   PubMed Web of Science ®Google Scholar
• Yuen SJ, Rubin PA. Idiopathic orbital inflammation distribution, clinical features, and treatment outcome. Arch Ophthalmol. 2003;121:491–499. doi:10.1001/archopht.121.4.491.
   PubMed Web of Science ®Google Scholar
• Nishikawa Y, Oku H, Tonari M, Matsuo J, Sugasawa J, Ikeda T. C-Reactive protein may be useful to differentiate idiopathic orbital inflammation and orbital cellulitis in cases with acute eyelid erythema and edema. Clin Ophthalmol. 2018;12:1149–1153. doi:10.2147/OPTH.S164306.
   PubMed Web of Science ®Google Scholar
• Cockerham KP, Hong SH, Browne EE. Orbital inflammation. Curr Neurol Neurosci Rep. 2003;3:401–409. doi:10.1007/s11910-003-0023-z.
   PubMedGoogle Scholar
• Sproston NR, Ashworth JJ. Role of C-Reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754. [cited 1 May 2018]. doi:10.3389/fimmu.2018.00754.
   PubMed Web of Science ®Google Scholar
• Davies BW, Smith JM, Hink EM, Durairaj VD. C-Reactive protein as a marker for initiating steroid treatment in children with orbital cellulitis. Ophthalmic Plast Reconstr Surg. 2015;31:364–368. doi:10.1097/IOP.0000000000000349.
   PubMed Web of Science ®Google Scholar
• Aryasit O, Aunruan S, Sanghan N. Predictors of surgical intervention and visual outcome in bacterial orbital cellulitis. Medicine (Baltimore). 2021;100:e26166. 2021 6 24. doi:10.1097/md.0000000000026166.
   PubMed Web of Science ®Google Scholar
• Murphy DC, Meghji S, Alfiky M, Bath AP. Paediatric periorbital cellulitis: a 10-year retrospective case series review. J Paediatr Child Health. 2021;57:227–233. [cited 29 September 2020]. doi:10.1111/jpc.15179.
   PubMed Web of Science ®Google Scholar
• Santos JC, Pinto S, Ferreira S, Maia C, Alves S, da Silva V. Pediatric preseptal and orbital cellulitis: a 10-year experience. Int J Pediatr Otorhinolaryngol. 2019;120:82–88. doi:10.1016/j.ijporl.2019.02.003.
   PubMed Web of Science ®Google Scholar
• Robinson A, Beech T, McDermott AL, Sinha A. Investigation and management of adult periorbital and orbital cellulitis. J Laryngol Otol. 2007;121:545–547. doi:10.1017/S0022215106003434.
   PubMed Web of Science ®Google Scholar
• Cho SW, Lee WW, Ma DJ, Kim JH, Han DH, Kim HJ, et al. Orbital apex lesions: a diagnostic and therapeutic challenge. J Neurol Surg B Skull Base. 2018;79:386–393. [cited 17 July 2018]. doi:10.1055/s-0037-1612616.
   PubMed Web of Science ®Google Scholar
• Morley JJ, Kushner I. Serum C-reactive protein levels in disease. Ann N Y Acad Sci. 1982;389:406–418. [cited 1 January 1982]. doi:10.1111/j.1749-6632.1982.tb22153.x.
   PubMed Web of Science ®Google Scholar
• Magrini L, Gagliano G, Travaglino F, Vetrone F, Marino R, Cardelli P, et al. Comparison between white blood cell count, procalcitonin and C reactive protein as diagnostic and prognostic biomarkers of infection or sepsis in patients presenting to emergency department. Clin Chem Lab Med. 2014;52:1465–1472. [cited 8 May 2014]. doi:10.1515/cclm-2014-0210.
   PubMed Web of Science ®Google Scholar
• Warschkow R, Tarantino I, Torzewski M, Näf F, Lange J, Steffen T. Diagnostic accuracy of C-reactive protein and white blood cell counts in the early detection of inflammatory complications after open resection of colorectal cancer: a retrospective study of 1,187 patients. Int J Colorectal Dis. 2011;26:1405–1413. doi:10.1007/s00384-011-1262-0.
   PubMed Web of Science ®Google Scholar
• Mardi D, Fwity B, Lobmann R, Ambrosch A. Mean cell volume of neutrophils and monocytes compared with C-reactive protein, interleukin-6 and white blood cell count for prediction of sepsis and nonsystemic bacterial infections. Int J Lab Hematol. 2010;32:410–418. [cited 19 November 2009]. doi:10.1111/j.1751-553X.2009.01202.x.
   PubMed Web of Science ®Google Scholar
• Hsuan JD, Selva D, McNab AA, Sullivan TJ, Saeed P, O’-Donnell BA. Idiopathic sclerosing orbital inflammation. Arch Ophthalmol. 2006;124:1244–1250. doi:10.1001/archopht.124.9.1244.
   PubMedGoogle Scholar
• Zborowska B, Ghabrial R, Selva D, McCluskey P. Idiopathic orbital inflammation with extraorbital extension: case series and review. Eye (Lond). 2006;20:107–113. [cited 28 May 2005]. doi:10.1038/sj.eye.6701780.
   PubMed Web of Science ®Google Scholar
• Teke TA, Kaman A, Metin O, Ozer PA, Kabatas EU, Tanir G. Idiopathic orbital inflammation in a child mimicking orbital cellulitis. Clin Pediatr (Phila). 2016;55:877–879. [cited 18 October 2015]. doi:10.1177/0009922815611643.
   PubMed Web of Science ®Google Scholar
• Jackson H. Pseudo-Tumor of the orbit. Br J Ophthalmol. 1958;42:212–224. [cited 1 April 1958]. doi:10.1136/bjo.42.4.212.
   PubMedGoogle Scholar
• Erşahin Y. Orbital pseudotumor. Pediatr Neurosurg. 1999;31:53. 1999 11 5. doi:10.1159/000028832.
   PubMed Web of Science ®Google Scholar
• Spindle J, Tang SX, Davies B, Wladis EJ, Piozzi E, Pellegrini M, et al. Pediatric idiopathic orbital inflammation: clinical features of 30 cases. Ophthalmic Plast Reconstr Surg. 2016;32:270–274. [cited 24 June 2016]. doi:10.1097/iop.0000000000000494.
   PubMed Web of Science ®Google Scholar
• Watters EC, Wallar PH, Hiles DA, Michaels RH. Acute orbital cellulitis. Arch Ophthalmol. 1976;94:785–788. [cited 1 May 1976]. doi:10.1001/archopht.1976.03910030387007.
   PubMedGoogle Scholar
• Bergin DJ, Wright JE. Orbital cellulitis. Br J Ophthalmol. 1986;70:174–178. 1986 3 1. doi:10.1136/bjo.70.3.174.
   PubMed Web of Science ®Google Scholar
• Ferguson MP, McNab AA. Current treatment and outcome in orbital cellulitis. Aust N Z J Ophthalmol. 1999;27:375–379. [cited 21 January 2000]. doi:10.1046/j.1440-1606.1999.00242.x.
   PubMedGoogle Scholar
• Lavoignet CE, Le Borgne P, Chabrier S, Bidoire J, Slimani H, Chevrolet-Lavoignet J, et al. White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED. Eur J Clin Microbiol Infect Dis. 2019;38:1523–1532. doi:10.1007/s10096-019-03583-2.
   PubMed Web of Science ®Google Scholar
• Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, et al. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol. 2003;23:2063–2069. doi:10.1161/01.ATV.0000084640.21712.9C.
   PubMed Web of Science ®Google Scholar
• Shen J, Ordovas JM. Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents. Clin Chem. 2009;55:256–264. doi:10.1373/clinchem.2008.117754.
   PubMed Web of Science ®Google Scholar
• Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, et al. Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine. WMJ. 2016;115:317–321.
   PubMedGoogle Scholar
• Asher J, Houston M. Statins and C-reactive protein levels. J Clin Hypertens (Greenwich). 2007;9:622–628. [cited 4 August 2007]. doi:10.1111/j.1524-6175.2007.06639.x.
   PubMedGoogle Scholar
• Prasad K. C-Reactive protein (CRP)-lowering agents. Cardiovasc Drug Rev. 2006;24:33–50. [cited 31 August 2006]. doi:10.1111/j.1527-3466.2006.00033.x.
   PubMed Web of Science ®Google Scholar
• Winn BJ, Rootman J. Sclerosing orbital inflammation and systemic disease. Ophthalmic Plast Reconstr Surg. 2012;28:107–118. [cited 14 March 2012]. doi:10.1097/IOP.0b013e31823d2103.
   PubMed Web of Science ®Google Scholar
• Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis. 2004;39:206–217. [cited 13 August 2014]. doi:10.1086/421997.
   PubMed Web of Science ®Google Scholar
• Hu L, Shi Q, Shi M, Liu R, Wang C. Diagnostic value of PCT and CRP for detecting serious bacterial infections in patients with fever of unknown origin: a systematic review and meta-analysis. Appl Immunohistochem Mol Morphol. 2017;25:e61–e69. [cited 1 September 2017]. doi:10.1097/pai.0000000000000552.
   PubMedGoogle Scholar