Characterization of axonal transport defects in Drosophila Huntingtin mutants

References

• Caviston, J.P., Zajac, A.L., Tokito, M., & Holzbaur, E.L. (2011). Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes. Molecular Biology of the Cell, 22, 478–492.
   PubMed Web of Science ®Google Scholar
• Choi, Y.B., Kadakkuzha, B.M., Liu, X.A., Akhmedov, K., Kandel, E.R., & Puthanveettil, S.V. (2014). Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in aplysia. PLoS One, 9, e103004.
   PubMed Web of Science ®Google Scholar
• Colin, E., Zala, D., Liot, G., Rangone, H., Borrell-Pagès, M., Li, X.J. … Saudou, F. (2008). Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. The EMBO Journal, 27, 2124–2134.
   PubMed Web of Science ®Google Scholar
• Dietz, K.N., Di Stefano, L., Maher, R.C., Zhu, H., Macdonald, M.E., Gusella, J.F., & Walker, J.A. (2015). The Drosophila Huntington’s disease gene ortholog dhtt influences chromatin regulation during development. Human Molecular Genetics, 24, 330–345.
   PubMed Web of Science ®Google Scholar
• Dragatsis, I., Efstratiadis, A., & Zeitlin, S. (1998). Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues. Development, 125, 1529–1539.
   PubMed Web of Science ®Google Scholar
• Engelender, S., Sharp, A.H., Colomer, V., Tokito, M.K., Lanahan, A., Worley, P. … Holzbaur, E. L. (1997). Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Human Molecular Genetics, 6, 2205–2212.
   PubMed Web of Science ®Google Scholar
• Finley, K.D., Edeen, P.T., Cumming, R.C., Mardahl-Dumesnil, M.D., Taylor, B.J., Rodriguez, M.H. … Hwang, C.E. (2003). blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. The Journal of Neuroscience, 23, 1254–1264.
   PubMed Web of Science ®Google Scholar
• Fu, M.M., & Holzbaur, E.L. (2014). Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends in Cell Biology, 24, 564–574.
   PubMed Web of Science ®Google Scholar
• Fuger, P., Behrends, L.B., Mertel, S., Sigrist, S.J., & Rasse, T.M. (2007). Live imaging of synapse development and measuring protein dynamics using two-color fluorescence recovery after photo-bleaching at Drosophila synapses. Nature Protocols, 2, 3285–3298.
   PubMed Web of Science ®Google Scholar
• Gauthier, L.R., Charrin, B.C., Borrell-Pagès, M., Dompierre, J. P., Rangone, H., Cordelières, F.P. … De Mey, J. (2004). Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell, 118, 127–138.
   PubMed Web of Science ®Google Scholar
• Godin, J.D., Colombo, K., Molina-Calavita, M., Keryer, G., Zala, D., Charrin, B.C. … Dietrich, P. (2010). Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron, 67, 392–406.
   PubMed Web of Science ®Google Scholar
• Gunawardena, S., Her, L.S., Brusch, R.G., Laymon, R.A., Niesman, I.R., Gordesky-Gold, B. … Sintasath, L. (2003). Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron, 40, 25–40.
   PubMed Web of Science ®Google Scholar
• Guo, X., Macleod, G.T., Wellington, A., Hu, F., Panchumarthi, S., Schoenfield, M. … Marin, L. (2005). The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron, 47, 379–393.
   PubMed Web of Science ®Google Scholar
• Haghnia, M., Cavalli, V., Shah, S.B., Schimmelpfeng, K., Brusch, R., Yang, G. … Herrera, C. (2007). Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Molecular Biology of the Cell, 18, 2081–2089.
   PubMed Web of Science ®Google Scholar
• Hollenbeck, P.J., & Saxton, W.M. (2005). The axonal transport of mitochondria. Journal of Cell Science, 118, 5411–5419.
   PubMed Web of Science ®Google Scholar
• Kratter, I.H., & Finkbeiner, S. (2010). PolyQ disease: Too many Qs, too much function? Neuron, 67, 897–899.
   PubMed Web of Science ®Google Scholar
• Lee, W.C., Yoshihara, M., & Littleton, J.T. (2004). Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington’s disease. Proceedings of the National Academy of Sciences of the United States of America, 101, 3224–3229.
   PubMed Web of Science ®Google Scholar
• Li, J.Y., & Conforti, L. (2013). Axonopathy in Huntington’s disease. Experimental Neurology, 246, 62–71.
   PubMed Web of Science ®Google Scholar
• Li, X.J., Li, S.H., Sharp, A.H., Nucifora, F.C., Schilling, G., Lanahan, A. … Worley, P. (1995). A huntingtin-associated protein enriched in brain with implications for pathology. Nature, 378, 398–402.
   PubMed Web of Science ®Google Scholar
• Li, Z., Karlovich, C.A., Fish, M.P., Scott, M.P., & Myers, R.M. (1999). A putative Drosophila homolog of the Huntington’s disease gene. Human Molecular Genetics, 8, 1807–1815.
   PubMed Web of Science ®Google Scholar
• Ligon, L.A., Tokito, M., Finklestein, J.M., Grossman, F.E., & Holzbaur, E.L. (2004). A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. The Journal of Biological Chemistry, 279, 19201–19208.
   PubMed Web of Science ®Google Scholar
• Lim, A., & Kraut, R. (2009). The Drosophila BEACH family protein, blue cheese, links lysosomal axon transport with motor neuron degeneration. The Journal of Neuroscience, 29, 951–963.
   PubMed Web of Science ®Google Scholar
• Liot, G., Zala, D., Pla, P., Mottet, G., Piel, M., & Saudou, F. (2013). Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites. The Journal of Neuroscience, 33, 6298–6309.
   PubMed Web of Science ®Google Scholar
• Louie, K., Russo, G.J., Salkoff, D.B., Wellington, A., & Zinsmaier, K.E. (2008). Effects of imaging conditions on mitochondrial transport and length in larval motor axons of Drosophila. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 151, 159–172.
   PubMed Web of Science ®Google Scholar
• Lumsden, A.L., Henshall, T.L., Dayan, S., Lardelli, M.T., & Richards, R.I. (2007). Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Human Molecular Genetics, 16, 1905–1920.
   PubMed Web of Science ®Google Scholar
• Ben M’Barek, K., Pla, P., Orvoen, S., Benstaali, C., Godin, J.D., Gardier, A.M. … Saudou, F. (2013). Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. The Journal of Neuroscience, 33, 8608–8620.
   PubMed Web of Science ®Google Scholar
• McGuire, J.R., Rong, J., Li, S.H., & Li, X.J. (2006). Interaction of Huntingtin-associated protein-1 with kinesin light chain: Implications in intracellular trafficking in neurons. The Journal of Biological Chemistry, 281, 3552–3559.
   PubMed Web of Science ®Google Scholar
• Morfini, G.A., You, Y.M., Pollema, S.L., Kaminska, A., Liu, K., Yoshioka, K. … Brady, S.T. (2009). Pathogenic huntingtin inhibits faxt axonal transport by activating JNK3 and phosphorylating kinesin. Nature Neuroscience, 12, 864–871.
   PubMed Web of Science ®Google Scholar
• Nasir, J., Floresco, S.B., O’Kusky, J.R., Diewert, V.M., Richman, J.M., Zeisler, J. … Borowski, A. (1995). Targeted disruption of the Huntington’s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell, 81, 811–823.
   PubMed Web of Science ®Google Scholar
• Orr, H.T. (2012). Polyglutamine neurodegeneration: Expanded glutamines enhance native functions. Current Opinion in Genetics & Development, 22, 251–255.
   PubMed Web of Science ®Google Scholar
• Pardo, R., Molina-Calavita, M., Poizat, G., Keryer, G., Humbert, S., & Saudou, F. (2010). pARIS-htt: An optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking. Molecular Brain, 3, 17.
   PubMed Web of Science ®Google Scholar
• Perlson, E., Maday, S., Fu, M.M., Moughamian, A.J., & Holzbaur, E.L. (2010). Retrograde axonal transport: Pathways to cell death? Trends in Neurosciences, 33, 335–344.
   PubMed Web of Science ®Google Scholar
• Pilling, A.D., Horiuchi, D., Lively, C.M., & Saxton, W.M. (2006). Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Molecular Biology of the Cell, 17, 2057–2068.
   PubMed Web of Science ®Google Scholar
• Reddy, P.H., & Shirendeb, U.P. (2012). Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington’s disease. Biochimica et Biophysica Acta, 1822, 101–110.
   PubMed Web of Science ®Google Scholar
• Rockabrand, E., Slepko, N., Pantalone, A., Nukala, V.N., Kazantsev, A., Marsh, J.L. … Sullivan, P.G. (2007). The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis. Human Molecular Genetics, 16, 61–77.
   PubMed Web of Science ®Google Scholar
• Romero, E., Cha, G.H., Verstreken, P., Ly, C.V., Hughes, R.E., Bellen, H.J., & Botas, J. (2008). Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron, 57, 27–40.
   PubMed Web of Science ®Google Scholar
• Roux, J.C., Zala, D., Panayotis, N., Borges-Correia, A., Saudou, F., & Villard, L. (2012). Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway. Neurobiology of Disease, 45, 786–795.
   PubMed Web of Science ®Google Scholar
• Rui, Y.N., Xu, Z., Patel, B., Chen, Z., Chen, D., Tito, A. … David, G. (2015). Huntingtin functions as a scaffold for selective macroautophagy. Nature Cell Biology, 17, 262–275.
   PubMed Web of Science ®Google Scholar
• Schulte, J., & Littleton, J.T. (2011). The biological function of the Huntingtin protein and its relevance to Huntington’s Disease pathology. Current Trends in Neurology, 5, 65–78.
   PubMedGoogle Scholar
• Seong, I.S., Woda, J.M., Song, J.J., Lloret, A., Abeyrathne, P.D., Woo, C.J. … Gregory, G. (2010). Huntingtin facilitates polycomb repressive complex 2. Human Molecular Genetics, 19, 573–583.
   PubMed Web of Science ®Google Scholar
• Smith, G.A., Rocha, E.M., McLean, J.R., Hayes, M.A., Izen, S.C., Isacson, O., & Hallett, P.J. (2014). Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington’s disease. Human Molecular Genetics, 23, 4510–4527.
   PubMed Web of Science ®Google Scholar
• Stowers, R.S., Megeath, L.J., Górska-Andrzejak, J., Meinertzhagen, I.A., & Schwarz, T.L. (2002). Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein. Neuron, 36, 1063–1077.
   PubMed Web of Science ®Google Scholar
• Trushina, E., Dyer, R.B., Badger, J.D., Ure, D., Eide, L., Tran, D.D. … Vrieze, B. T. (2004). Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Molecular and Cellular Biology, 24, 8195–8209.
   PubMed Web of Science ®Google Scholar
• De Vos, K.J., Sable, J., Miller, K.E., & Sheetz, M.P. (2003). Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria. Molecular Biology of the Cell, 14, 3636–3649.
   PubMed Web of Science ®Google Scholar
• Weiss, K.R., Kimura, Y., Lee, W.C., & Littleton, J.T. (2012). Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington’s disease model. Genetics, 190, 581–600.
   PubMed Web of Science ®Google Scholar
• Wong, Y.C., & Holzbaur, E.L. (2014). The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. The Journal of Neuroscience, 34, 1293–1305.
   PubMed Web of Science ®Google Scholar
• Zala, D., Hinckelmann, M.V., & Saudou, F. (2013). Huntingtin’s function in axonal transport is conserved in Drosophila melanogaster. PLoS One, 8, e60162.
   PubMed Web of Science ®Google Scholar
• Zhang, S., Feany, M.B., Saraswati, S., Littleton, J.T., & Perrimon, N. (2009). Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model. Disease Models & Mechanisms, 2, 247–266.
   PubMed Web of Science ®Google Scholar
• Zuccato, C., & Cattaneo, E. (2007). Role of brain-derived neurotrophic factor in Huntington’s disease. Progress in Neurobiology, 81, 294–330.
   PubMed Web of Science ®Google Scholar