Chronological history and current advancements of dental adhesive systems development: a narrative review

References

• McLean JW. The pioneers of enamel and dentin bonding. J Adhes Dent. 1999;1(3):185–187.
   PubMedGoogle Scholar
• Soderholm KJ. Dental adhesives …. how it all started and later evolved. J Adhes Dent. 2007;9(2):227–230.
   PubMed Web of Science ®Google Scholar
• Kramer IRH, McLean JW. The response of the human pulp to self-polymerizing acrylic. Br Dent J. 1952;93:150–153.
   Google Scholar
• Anusavice KJ, Shen C, Rawls HR. Phillips’ science of dental materials. 12th ed. St. Louis: Saunders; 2012.
   Google Scholar
• Buonocore MG. A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. J Dent Res. 1955;34(6):849–853.
   PubMedGoogle Scholar
• von Fischer W, Bobalek EG. Organic protective coatings. New York: Reinhold Publishing Corporation; 1953.
   Google Scholar
• Buonocore MG. Principles of adhesive retention and adhesive restorative materials. J Am Dent Assoc. 1963;67:382–391.
   PubMed Web of Science ®Google Scholar
• Proceedings of an international symposium on the acid etch technique. St. Paul: North Central; 1975.
   Google Scholar
• Brudevold F, Buonocore M, Wileman W. A report on a resin composition capable of bonding to human dentin surfaces. J Dent Res. 1956;35(6):846–851.
   PubMedGoogle Scholar
• Kugel G, Ferrari M. The science of bonding: from first to sixth generation. J Am Dent Assoc. 2000;131:20S–25S.
   PubMed Web of Science ®Google Scholar
• Bowen RL. Use of epoxy resins in restorative materials. J Dent Res. 1956;35(3):360–369.
   PubMedGoogle Scholar
• Bowen RL. Adhesive bonding of various materials to hard tooth tissues. I. Method of determining bond strength. J Dent Res. 1965;44:690–695.
   PubMed Web of Science ®Google Scholar
• Bowen RL. Adhesive bonding of various materials to hard tooth tissues. II. Bonding to dentin promoted by a surface-active comonomer. J Dent Res. 1965;44(5):895–902.
   PubMed Web of Science ®Google Scholar
• Bowen RL. Adhesive bonding of various materials to hard tooth tissues. 3. Bonding to dentin improved by pre-treatment and the use of surface-active comonomer. J Dent Res. 1965;44(5):903–905.
   PubMed Web of Science ®Google Scholar
• Bowen RL. Adhesive bonding of various materials to hard tooth tissues. IV. Bonding to dentin, enamel, and fluorapatite improved by the use of a surface-active comonomer. J Dent Res. 1965;44(5):906–911.
   PubMed Web of Science ®Google Scholar
• Bowen RL. Adhesive bonding of various materials to hard tooth tissues. VI. Forces developing in direct-filling materials during hardening. J Am Dent Assoc. 1967;74(3):439–445.
   PubMed Web of Science ®Google Scholar
• Singh K, Naik R, Hegde S, et al. Shear bond strength of superficial, intermediate and deep dentin in vitro with recent generation self-etching primers and single nano composite resin. J Int Oral Health. 2015;7(Suppl 1):28–32.
   PubMedGoogle Scholar
• Nakabayashi N, Pashley DH. Hybridization of dental hard tissues. 1st ed. Chicago: Quintessence Publishing Co. Ltd; 1998.
   Google Scholar
• Google Patents. Method of preparing a monomer having phenoxy and methacrylate groups linked by hydroxy glyceryl groups; 1965 [cited 2020 March 25]. Available from: https://patents.google.com/patent/US3179623A/en.
   Google Scholar
• Alexieva C. Character of the hard tooth tissue-polymer bond. I. Study of the interaction of calcium phosphate with N-phenylglycine and with N-phenylglycine-glycidyl methacrylate adduct. J Dent Res. 1979;58(9):1879–1883.
   PubMed Web of Science ®Google Scholar
• Alexieva C. Character of the hard tooth tissue-polymer bond. II. Study of the interaction of human tooth enamel and dentin with N-phenylglycine-glycidyl methacrylate adduct. J Dent Res. 1979;58(9):1884–1886.
   PubMed Web of Science ®Google Scholar
• Jendresen MD. Clinical performance of a new composite resin for class V erosion [IADR abstract 1057]. J Dent Res. 1978;57:339.
   Web of Science ®Google Scholar
• Flynn M. Clinical evaluation of Cervident and Aspa in restoring teeth with cervical abrasions. Oper Dent. 1979;4(3):118–120.
   PubMed Web of Science ®Google Scholar
• Eliades GC, Caputo AA, Vougiouklakis GJ. Composition, wetting properties and bond strength with dentin of 6 new dentin adhesives. Dent Mater. 1985;1(5):1:170–6.
   Google Scholar
• Causton BE. Improved bonding of composite restorative to dentine. A study in vitro of the use of a commercial halogenated phosphate ester. Br Dent J. 1984;156(3):93–95.
   PubMed Web of Science ®Google Scholar
• Chan DC, Reinhardt JW, Boyer DB. Composite resin compatibility and bond longevity of a dentin bonding agent. J Dent Res. 1985;64(12):1402–1404.
   PubMed Web of Science ®Google Scholar
• Heymann HO, Sturdevant JR, Brunson WD, et al. Twelve-month clinical study of dentinal adhesives in class V cervical lesions. J Am Dent Assoc. 1988;116(2):179–183.
   PubMed Web of Science ®Google Scholar
• Tyas MJ. Three-year clinical evaluation of dentine bonding agents. Aust Dent J. 1991;36(4):298–301.
   PubMed Web of Science ®Google Scholar
• Street EV. Effects of various instruments on enamel walls. J Am Dent Assoc. 1953;46(3):274–280.
   PubMed Web of Science ®Google Scholar
• Scott DB, O'neil JR. The microstructure of enamel and dentin related to cavity preparation. In: Phillips RW, editor. Adhesive restorative dental materials. Spencer: Owen Litho Service; 1961. p. 27–37.
   Google Scholar
• Boyde A, Switsur VR, Stewart ADG. An assessment of two new physical methods applied to the study of dental tissues. Arch Oral Biol. 1962;7:185–193.
   PubMed Web of Science ®Google Scholar
• Eick JD, Wilko RA, Anderson CH, et al. Scanning electron microscopy of cut tooth surfaces and identification of debris by use of the electron microprobe. J Dent Res. 1970;49(6):Suppl:1359–68.
   PubMed Web of Science ®Google Scholar
• Gwinnett AJ. Smear layer: morphological considerations. Oper Dent Suppl. 1984;3:2–12.
   PubMedGoogle Scholar
• Pashley DH. Smear layer: physiological considerations. Oper Dent Suppl. 1984;3:13–29.
   PubMedGoogle Scholar
• Tay FR, Pashley DH. Have dentin adhesives become too hydrophilic? J Can Dent Assoc. 2003;69(11):726–731.
   PubMedGoogle Scholar
• Pashley DH. The effects of acid etching on the pulpodentin complex. Oper Dent. 1992;17(6):229–242.
   PubMed Web of Science ®Google Scholar
• Alex G. Is total-etch dead? Evidence suggests otherwise. Compend Contin Educ Dent. 2012;33(1):12–14.
   PubMedGoogle Scholar
• Fusayama T, Nakamura M, Kurosaki N, et al. Non-pressure adhesion of a new adhesive restorative resin. J Dent Res. 1979;58(4):1364–1370.
   PubMed Web of Science ®Google Scholar
• Retief DH, Austin JC, Fatti LP. Pulpal response to phosphoric acid. J Oral Pathol. 1974;3(3):114–122.
   PubMedGoogle Scholar
• Stanley HR, Going RE, Chauncey HH. Human pulp response to acid pretreatment of dentin and to composite restoration. J Am Dent Assoc. 1975;91(4):817–825.
   PubMed Web of Science ®Google Scholar
• Eriksen HM, Leidal TI. Monkey pulpal response to composite resin restorations in cavities treated with various cleansing agents. Scand J Dent Res. 1979;87(4):309–317.
   PubMedGoogle Scholar
• Jennings RE, Ranly DM. Autoradiographic studies of 32 P penetration into enamel and dentin during acid etching. ASDC J Dent Child. 1972;39(1):69–71.
   PubMedGoogle Scholar
• Lee HL, Jr Orlowski JA, Scheidt GC, et al. Effects of acid etchants on dentin. J Dent Res. 1973;52(6):1228–1233.
   PubMed Web of Science ®Google Scholar
• Chan DC, Jensen ME. Dentin permeability to phosphoric acid: effect of treatment with bonding resin. Dent Mater. 1986;2(6):251–256.
   PubMed Web of Science ®Google Scholar
• Torney DL. The retentive ability of acid-etched dentin. J Prosthet Dent. 1978;39(2):169–172.
   PubMed Web of Science ®Google Scholar
• Tao L, Pashley DH. Shear bond strengths to dentin: effects of surface treatments, depth and position. Dent Mater. 1988;4(6):371–378.
   PubMed Web of Science ®Google Scholar
• Nakabayashi N, Kojima K, Masuhara E. The promotion of adhesion by the infiltration of monomers into tooth substrates. J Biomed Mater Res. 1982;16(3):265–273.
   PubMed Web of Science ®Google Scholar
• Pashley DH, Ciucchi B, Sano H, et al. Permeability of dentin to adhesive agents. Quintessence Int. 1993;24(9):618–631.
   PubMedGoogle Scholar
• Van Meerbeek B, Dhem A, Goret-Nicaise M, et al. Comparative SEM and TEM examination of the ultrastructure of the resin-dentin interdiffusion zone. J Dent Res. 1993;72(2):495–501.
   PubMed Web of Science ®Google Scholar
• Nakabayashi N, Nakamura M, Yasuda N. Hybrid layer as a dentin-bonding mechanism. J Esthet Dent. 1991;3(4):133–138.
   PubMedGoogle Scholar
• Tagami J, Tao L, Pashley DH. Correlation among dentin depth, permeability, and bond strength of adhesive resins. Dent Mater. 1990;6(1):45–50.
   PubMed Web of Science ®Google Scholar
• Tagami J, Burrow MF. +F brand new SE for you ClearfilTM liner bond F 2-step self-etching adhesive. Tokyo: Kuraray Noritake Dental Inc.; 2014.
   Google Scholar
• Gwinnett AJ. Dentin bonding systems: the latest generation. J Esthet Dent. 1989;1(1):5–9.
   PubMedGoogle Scholar
• Scherer W, Kaim JM, Weiner E, et al. Third generation dentin bonding agents: a microleakage study. J Esthet Dent. 1990;2(2):33–35.
   PubMedGoogle Scholar
• Asmussen E, Antonucci JM, Bowen RL. Adhesion to dentin by means of Gluma resin. Scand J Dent Res. 1988;96(6):584–589.
   PubMedGoogle Scholar
• Chappell RP, Spencer P, Eick JD. The effects of current dentinal adhesives on the dentinal surface. Quintessence Int. 1994;25(12):851–859.
   PubMedGoogle Scholar
• Camps J, Saradell JM, Dejou J, et al. Influence of concentration and application time of maleic acid on dentin permeability. Dent Mater. 1995;11(3):177–181.
   PubMed Web of Science ®Google Scholar
• Fanchi M, Breschi L. Effects of acid-etching solutions on human enamel and dentin. Quintessence Int. 1995;26(6):431–435.
   PubMedGoogle Scholar
• Erickson RL. Mechanism and clinical implications of bond formation for two dentin bonding agents. Am J Dent. 1989;2:117–123.
   PubMedGoogle Scholar
• Dickinson GL, Stevens JT, Overberger JE, et al. Comparison of shear bond strengths of some third-generation dentin bonding agents. Oper Dent. 1991;16(6):223–230.
   PubMed Web of Science ®Google Scholar
• Oilo G, Olsson S. Tensile bond strength of dentin adhesives: a comparison of materials and methods. Dent Mater. 1990;6(2):138–144.
   PubMed Web of Science ®Google Scholar
• Barkmeier WW, Cooley RL. Shear bond strength of the tenure solution dentin bonding system. Am J Dent. 1989;2(5):263–265.
   PubMedGoogle Scholar
• Fasbinder DJ, Burgess JO, Robbins JW, et al. Tensile bond strength of dental adhesives to dentin and enamel. Dent Mater. 1989;5(4):272–275.
   PubMed Web of Science ®Google Scholar
• Chappell RP, Eick JD, Mixson JM, et al. Shear bond strength and scanning electron microscopic observation of four dentinal adhesives. Quintessence Int. 1990;21(4):303–310.
   PubMedGoogle Scholar
• Prati C, Nucci C, Montanari G. Shear bond strength and microleakage of dentin bonding systems. J Prosthet Dent. 1991;65(3):401–407.
   PubMed Web of Science ®Google Scholar
• Triolo PT Jr, Swift EJ Jr. Shear bond strengths of ten dentin adhesive systems. Dent Mater. 1992;8(6):370–374.
   PubMed Web of Science ®Google Scholar
• Eick JD, Robinson SJ, Chappell RP, et al. The dentinal surface: its influence on dentinal adhesion. Part III. Quintessence Int. 1993;24(8):571–582.
   PubMedGoogle Scholar
• Kanca J. 3rd Microleakage of five dentin bonding systems. Dent Mater. 1989;5(6):415–416.
   PubMed Web of Science ®Google Scholar
• Jordan RE, Suzuki M, MacLean DF. Early clinical evaluation of tenure and Scotchbond 2 for conservative restoration of cervical erosion lesions. J Esthet Dent. 1989;1(1):10–13.
   PubMedGoogle Scholar
• Van Meerbeek B, Braem M, Lambrechts P, et al. Evaluation of two dentin adhesives in cervical lesions. J Prosthet Dent. 1993;70(4):308–314.
   PubMed Web of Science ®Google Scholar
• Tao L, Pashely DH, Boyd L. Effect of different types of smear layers on dentin and enamel shear bond strengths. Dent Mater. 1988;4(4):208–216.
   PubMed Web of Science ®Google Scholar
• Taira Y, Imai Y. Review of methyl methacrylate (MMA)/tributylborane (TBB)-initiated resin adhesive to dentin. Dent Mater J. 2014;33(3):291–304.
   PubMed Web of Science ®Google Scholar
• Swift EJ Jr. Bonding systems for restorative materials–a comprehensive review. Pediatr Dent. 1998;20(2):80–84.
   PubMedGoogle Scholar
• Kanca J 3rd.Bonding to tooth structure: a rational rationale for a clinical protocol. J Esthet Dent. 1989;1(4):135–138.
   PubMedGoogle Scholar
• Fusayama T. Total etch technique and cavity isolation. J Esthet Dent. 1992;4(4):105–109.
   PubMedGoogle Scholar
• Koibuchi H, Yasuda N, Nakabayashi N. Bonding to dentin with a self-etching primer: the effect of smear layers. Dent Mater. 2001;17(2):122–126.
   PubMed Web of Science ®Google Scholar
• Gwinnett AJ. Moist versus dry dentin: its effect on shear bond strength. Am J Dent. 1992;5(3):127–129.
   PubMedGoogle Scholar
• Kanca J 3rd.Improving bond strength through acid etching of dentin and bonding to wet dentin surfaces. J Am Dent Assoc. 1992;123(9):35–43.
   PubMed Web of Science ®Google Scholar
• Pashley DH, Tay FR, Breschi L, et al. Tezvergil-Mutluay A. State of the art etch-and-rinse adhesives. Dent Mater. 2011;27(1):1–16.
   PubMed Web of Science ®Google Scholar
• Tay FR, Gwinnett JA, Wei SH. Relation between water content in acetone/alcohol-based primer and interfacial ultrastructure. J Dent. 1998;26(2):147–156.
   PubMed Web of Science ®Google Scholar
• Pereira GD, Paulillo LA, De Goes MF, et al. How wet should dentin be? Comparison of methods to remove excess water during moist bonding. J Adhes Dent. 2001;3(3):257–264.
   PubMedGoogle Scholar
• Milia E, Cumbo E, Cardoso RJ, et al. Current dental adhesives systems. A narrative review. Curr Pharm Des. 2012;18(34):5542–5552.
   PubMed Web of Science ®Google Scholar
• Lopes GC, Baratieri LN, de Andrada MA, et al. Dental adhesion: present state of the art and future perspectives. Quintessence Int. 2002;33(3):213–224.
   PubMed Web of Science ®Google Scholar
• Loguercio AD, Luque-Martinez I, Munoz MA, et al. A comprehensive laboratory screening of three-step etch-and-rinse adhesives. Oper Dent. 2014;39(6):652–662.
   PubMed Web of Science ®Google Scholar
• Ozer F, Blatz MB. Self-etch and etch-and-rinse adhesive systems in clinical dentistry. Compend Contin Educ Dent. 2013;34(1):12–14.
   PubMedGoogle Scholar
• Davidson CL, de Gee AJ, Feilzer A. The competition between the composite-dentin bond strength and the polymerization contraction stress. J Dent Res. 1984;63(12):1396–1399.
   PubMed Web of Science ®Google Scholar
• Komatsu M, Finger W. Dentin bonding agents: correlation of early bond strength with margin gaps. Dent Mater. 1986;2(6):257–262.
   PubMed Web of Science ®Google Scholar
• Ferracane JL, Hilton TJ. Polymerization stress-is it clinically meaningful? Dent Mater. 2016;32(1):1–10.
   PubMed Web of Science ®Google Scholar
• Munksgaard EC, Irie M, Asmussen E. Dentin-polymer bond promoted by Gluma and various resins. J Dent Res. 1985;64(12):1409–1411.
   PubMed Web of Science ®Google Scholar
• Heintze SD. Clinical relevance of tests on bond strength, microleakage and marginal adaptation. Dent Mater. 2013;29(1):59–84.
   PubMed Web of Science ®Google Scholar
• Gwinnett AJ, Yu S. Shear bond strength, microleakage and gap formation with fourth generation dentin bonding agents. Am J Dent. 1994;7:312–314.
   Google Scholar
• May KN Jr. Swift EJ, Jr, Bayne SC. Bond strengths of a new dentin adhesive system. Am J Dent. 1997;10(4):195–198.
   PubMed Web of Science ®Google Scholar
• Wilder AD Jr. Swift EJ, Jr May KN, Jr, et al. Bond strengths of conventional and simplified bonding systems. Am J Dent. 1998;11(3):114–117.
   PubMed Web of Science ®Google Scholar
• Inoue S, Vargas MA, Abe Y, et al. Microtensile bond strength of eleven contemporary adhesives to dentin. J Adhes Dent. 2001;3(3):237–245.
   PubMedGoogle Scholar
• De Munck J, Van Meerbeek B, Yoshida Y, et al. Four-year water degradation of total-etch adhesives bonded to dentin. J Dent Res. 2003;82(2):136–140.
   PubMed Web of Science ®Google Scholar
• Freitas PH, Giannini M, Franca R, et al. Correlation between bond strength and nanomechanical properties of adhesive interface. Clin Oral Investig. 2017;21(4):1055–1062.
   PubMed Web of Science ®Google Scholar
• van Dijken JW, Pallesen U. Long-term dentin retention of etch-and-rinse and self-etch adhesives and a resin-modified glass ionomer cement in non-carious cervical lesions. Dent Mater. 2008;24(7):915–922.
   PubMed Web of Science ®Google Scholar
• Wilder AD, Jr Swift EJ, Jr Heymann HO, et al. A 12-year clinical evaluation of a three-step dentin adhesive in noncarious cervical lesions. J Am Dent Assoc. 2009;140(5):526–535.
   PubMed Web of Science ®Google Scholar
• Peumans M, De Munck J, Van Landuyt KL, et al. A 13-year clinical evaluation of two three-step etch-and-rinse adhesives in non-carious class-V lesions. Clin Oral Investig. 2012;16(1):129–137.
   PubMed Web of Science ®Google Scholar
• Labella R, Lambrechts P, Van Meerbeek B, et al. Polymerization shrinkage and elasticity of flowable composites and filled adhesives. Dent Mater. 1999;15(2):128–137.
   PubMed Web of Science ®Google Scholar
• Van Landuyt KL, Snauwaert J, De Munck J, et al. Systematic review of the chemical composition of contemporary dental adhesives. Biomaterials. 2007;28(26):3757–3785.
   PubMed Web of Science ®Google Scholar
• Al-Ehaideb A, Mohammed H. Shear bond strength of ‘one bottle’ dentin adhesives. J Prosthet Dent. 2000;84(4):408–412.
   PubMed Web of Science ®Google Scholar
• Miyazaki M, Tsujimoto A, Tsubota K, et al. Important compositional characteristics in the clinical use of adhesive systems. J Oral Sci. 2014;56(1):1–9.
   PubMed Web of Science ®Google Scholar
• Ye Q, Park J, Parthasarathy R, et al. Quantitative analysis of aqueous phase composition of model dentin adhesives experiencing phase separation. J Biomed Mater Res B Appl Biomater. 2012;100(4):1086–1092.
   PubMed Web of Science ®Google Scholar
• Molla K, Park HJ, Haller B. Bond strength of adhesive/composite combinations to dentin involving total- and self-etch adhesives. J Adhes Dent. 2002;4(3):171–180.
   PubMedGoogle Scholar
• Gallusi G, Galeano P, Libonati A, et al. Evaluation of bond strength of different adhesive systems: shear and microtensile bond strength test. Oral Implantol. 2009;2:19–25.
   Google Scholar
• Oliveira GC, Oliveira GM, Ritter AV, et al. Influence of tooth age and etching time on the microtensile bond strengths of adhesive systems to dentin. J Adhes Dent. 2012;14(3):229–234.
   PubMed Web of Science ®Google Scholar
• Sarr M, Kane AW, Vreven J, et al. Microtensile bond strength and interfacial characterization of 11 contemporary adhesives bonded to bur-cut dentin. Oper Dent. 2010;35(1):94–104.
   PubMed Web of Science ®Google Scholar
• Perdigao J, Sezinando A, Monteiro PC. Effect of substrate age and adhesive composition on dentin bonding. Oper Dent. 2013;38(3):267–274.
   PubMed Web of Science ®Google Scholar
• Jang JH, Lee MG, Woo SU, et al. Comparative study of the dentin bond strength of a new universal adhesive. Dent Mater J. 2016;35(4):606–612.
   PubMed Web of Science ®Google Scholar
• Peumans M, Kanumilli P, De Munck J, et al. Clinical effectiveness of contemporary adhesives: a systematic review of current clinical trials. Dent Mater. 2005;21(9):864–881.
   PubMed Web of Science ®Google Scholar
• Ritter AV, Swift EJ, Jr Heymann HO, et al. An eight-year clinical evaluation of filled and unfilled one-bottle dental adhesives. J Am Dent Assoc. 2009;140(1):28–37.
   PubMed Web of Science ®Google Scholar
• Boushell LW, Heymann HO, Ritter AV, et al. Six-year clinical performance of etch-and-rinse and self-etch adhesives. Dent Mater. 2016;32(9):1065–1072.
   PubMed Web of Science ®Google Scholar
• Cardoso MV, de Almeida Neves A, Mine A, et al. Current aspects on bonding effectiveness and stability in adhesive dentistry. Aust Dent J. 2011;56( Suppl 1):31–44.
   PubMed Web of Science ®Google Scholar
• Van Meerbeek B, Yoshihara K, Yoshida Y, et al. State of the art of self-etch adhesives. Dent Mater. 2011;27(1):17–28.
   PubMed Web of Science ®Google Scholar
• Yoshida Y, Nagakane K, Fukuda R, et al. Comparative study on adhesive performance of functional monomers. J Dent Res. 2004;83(6):454–458.
   PubMed Web of Science ®Google Scholar
• Wang R, Shi Y, Li T, et al. Adhesive interfacial characteristics and the related bonding performance of four self-etching adhesives with different functional monomers applied to dentin. J Dent. 2017;62:72–80.
   PubMed Web of Science ®Google Scholar
• Peumans M, De Munck J, Van Landuyt K, et al. Thirteen-year randomized controlled clinical trial of a two-step self-etch adhesive in non-carious cervical lesions. Dent Mater. 2015;31(3):308–314.
   PubMed Web of Science ®Google Scholar
• Watanabe I, Nakabayashi N. Bonding durability of photocured phenyl-P in TEGDMA to smear layer-retained bovine dentin. Quintessence Int. 1993;24(5):335–342.
   PubMedGoogle Scholar
• Akimoto N, Takamizu M, Momoi Y. 10-year clinical evaluation of a self-etching adhesive system. Oper Dent. 2007;32(1):3–10.
   PubMed Web of Science ®Google Scholar
• Yoshida Y, Inoue S. Chemical analyses in dental adhesive technology. Jpn Dent Sci Rev. 2012;48(2):141–152.
   Google Scholar
• Yoshida Y, Van Meerbeek B, Nakayama Y, et al. Adhesion to and decalcification of hydroxyapatite by carboxylic acids. J Dent Res. 2001;80(6):1565–1569.
   PubMed Web of Science ®Google Scholar
• Yoshioka M, Yoshida Y, Inoue S, et al. Adhesion/decalcification mechanisms of acid interactions with human hard tissues. J Biomed Mater Res. 2002;59(1):56–62.
   PubMed Web of Science ®Google Scholar
• Van Meerbeek B, De Munck J, Yoshida Y, et al. Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges. Oper Dent. 2003;28(3):215–235.
   PubMed Web of Science ®Google Scholar
• Google Patents. Adhesive compositions; 1984 [cited 2020 March 25]. Available from: https://patents.google.com/patent/EP0115410A2/en.
   Google Scholar
• Yoshihara K, Nagaoka N, Okihara T, et al. Functional monomer impurity affects adhesive performance. Dent Mater. 2015;31(12):1493–1501.
   PubMed Web of Science ®Google Scholar
• Feitosa VP, Sauro S, Ogliari FA, et al. Impact of hydrophilicity and length of spacer chains on the bonding of functional monomers. Dent Mater. 2014;30(12):e317-23–e323.
   PubMed Web of Science ®Google Scholar
• Pena CE, Rodrigues JA, Ely C, et al. Two-year randomized clinical trial of self-etching adhesives and selective enamel etching. Oper Dent. 2016;41(3):249–257.
   PubMed Web of Science ®Google Scholar
• Jang JH, Kim HY, Shin SM, et al. Clinical effectiveness of different polishing systems and self-etch adhesives in class V composite resin restorations: two-year randomized controlled clinical trial. Oper Dent. 2017;42(1):19–29.
   PubMed Web of Science ®Google Scholar
• Yoshihara K, Yoshida Y, Hayakawa S, et al. Nanolayering of phosphoric acid ester monomer on enamel and dentin. Acta Biomater. 2011;7(8):3187–3195.
   PubMed Web of Science ®Google Scholar
• Yaguchi T. Layering mechanism of MDP-Ca salt produced in demineralization of enamel and dentin apatite. Dent Mater. 2017;33(1):23–32.
   PubMed Web of Science ®Google Scholar
• Yokota Y, Fujita KN, Uchida R, et al. Quantitative evaluation of MDP-Ca salt and DCPD after application of an MDP-based one-step self-etching adhesive on enamel and dentin. J Adhes Dent. 2016;18(3):205–213.
   PubMed Web of Science ®Google Scholar
• Van Landuyt KL, Yoshida Y, Hirata I, et al. Influence of the chemical structure of functional monomers on their adhesive performance. J Dent Res. 2008;87(8):757–761.
   PubMed Web of Science ®Google Scholar
• Salvio LA, Hipolito VD, Martins AL, et al. Hybridization quality and bond strength of adhesive systems according to interaction with dentin. Eur J Dent. 2013;07(03):315–326.
   Google Scholar
• Tian FC, Wang XY, Huang Q, et al. Effect of nanolayering of calcium salts of phosphoric acid ester monomers on the durability of resin-dentin bonds. Acta Biomater. 2016;38:190–200.
   PubMed Web of Science ®Google Scholar
• Yoshihara K, Nagaoka N, Hayakawa S, et al. Chemical interaction of glycero-phosphate dimethacrylate (GPDM) with hydroxyapatite and dentin. Dent Mater. 2018;34(7):1072–1081.
   PubMed Web of Science ®Google Scholar
• Van Landuyt KL, Kanumilli P, De Munck J, et al. Bond strength of a mild self-etch adhesive with and without prior acid-etching. J Dent. 2006;34(1):77–85.
   PubMed Web of Science ®Google Scholar
• Van Meerbeek B, Peumans M, Poitevin A, et al. Relationship between bond-strength tests and clinical outcomes. Dent Mater. 2010;26(2):e100–e121.
   PubMed Web of Science ®Google Scholar
• Tay FR, Pashley DH, Suh BI, et al. Single-step adhesives are permeable membranes. J Dent. 2002;30(7–8):371–382.
   PubMed Web of Science ®Google Scholar
• Eliades G, Vougiouklakis G, Palaghias G. Heterogeneous distribution of single-bottle adhesive monomers in the resin–dentin interdiffusion zone. Dent Mater. 2001;17(4):277–283.
   PubMed Web of Science ®Google Scholar
• Tay FR, Frankenberger R, Krejci I, et al. Single-bottle adhesives behave as permeable membranes after polymerization. I. In vivo evidence. J Dent. 2004;32(8):611–621.
   PubMed Web of Science ®Google Scholar
• Wang Y, Spencer P. Continuing etching of an all-in-one adhesive in wet dentin tubules. J Dent Res. 2005;84(4):350–354.
   PubMed Web of Science ®Google Scholar
• Moszner N, Salz U, Zimmermann J. Chemical aspects of self-etching enamel-dentin adhesives: a systematic review. Dent Mater. 2005;21(10):895–910.
   PubMed Web of Science ®Google Scholar
• Nishiyama N, Tay FR, Fujita K, et al. Hydrolysis of functional monomers in a single-bottle self-etching primer-correlation of 13C NMR and TEM findings. J Dent Res. 2006;85(5):422–426.
   PubMed Web of Science ®Google Scholar
• Jacobsen T, Soderholm KJ. Some effects of water on dentin bonding. Dent Mater. 1995;11(2):132–136.
   PubMed Web of Science ®Google Scholar
• Van Landuyt KL, Snauwaert J, Peumans M, et al. The role of HEMA in one-step self-etch adhesives. Dent Mater. 2008;24(10):1412–1419.
   PubMed Web of Science ®Google Scholar
• Van Landuyt KL, De Munck J, Ermis RB, et al. Five-year clinical performance of a HEMA-free one-step self-etch adhesive in noncarious cervical lesions. Clin Oral Investig. 2014;18(4):1045–1052.
   PubMed Web of Science ®Google Scholar
• Sandberg E, Bergenholtz G, Eklund C, et al. HEMA bound to self-protein promotes auto-antibody production in mice. J Dent Res. 2002;81(9):633–636.
   PubMed Web of Science ®Google Scholar
• Katsuno K, Manabe A, Itoh K, et al. A delayed hypersensitivity reaction to dentine primer in the guinea-pig. J Dent. 1995;23(5):295–299.
   PubMed Web of Science ®Google Scholar
• Krifka S, Seidenader C, Hiller KA, et al. Oxidative stress and cytotoxicity generated by dental composites in human pulp cells. Clin Oral Investig. 2012;16(1):215–224.
   PubMed Web of Science ®Google Scholar
• da Silva TSP, de Castro RF, Magno MB, et al. Do HEMA-free adhesive systems have better clinical performance than HEMA-containing systems in noncarious cervical lesions? A systematic review and meta-analysis. J Dent. 2018;74:1–14.
   PubMed Web of Science ®Google Scholar
• Chen C, Niu LN, Xie H, et al. Bonding of universal adhesives to dentine-old wine in new bottles? J Dent. 2015;43(5):525–536.
   PubMed Web of Science ®Google Scholar
• Alex G. Universal adhesives: the next evolution in adhesive dentistry? Compend Contin Educ Dent 2015;36:15–26.
   Google Scholar
• Ruschel VC, Shibata S, Stolf SC, et al. Eighteen-month clinical study of universal adhesives in noncarious cervical lesions. Oper Dent. 2018;43(3):241–249.
   PubMed Web of Science ®Google Scholar
• Rosa WL, Piva E, Silva AF. Bond strength of universal adhesives: a systematic review and meta-analysis. J Dent. 2015;43(7):765–776.
   PubMed Web of Science ®Google Scholar
• Makishi P, Andre CB, Ayres A, et al. Effect of storage time on bond strength and nanoleakage expression of universal adhesives bonded to dentin and etched enamel. Oper Dent. 2016;41(3):305–317.
   PubMed Web of Science ®Google Scholar
• Makishi P, Andre CB, Silva JL, et al. Effect of storage time on bond strength performance of multimode adhesives to indirect resin composite and lithium disilicate glass ceramic. Oper Dent. 2016;41(5):541–551.
   PubMed Web of Science ®Google Scholar
• Yoshida K, Tsuo Y, Atsuta M. Bonding of dual‐cured resin cement to zirconia ceramic using phosphate acid ester monomer and zirconate coupler. J Biomed Mater Res. 2006;77B(1):28–33.
   Web of Science ®Google Scholar
• Elkaffas AA, Hamama HHH, Mahmoud SH. Do universal adhesives promote bonding to dentin? A systematic review and meta-analysis. Restor Dent Endod. 2018;43(3):e29.
   PubMedGoogle Scholar
• Cuevas-Suarez CE, da Rosa WLO, Lund RG, et al. Bonding performance of universal adhesives: an updated systematic review and meta-analysis. J Adhes Dent. 2019;21:7–26.
   PubMed Web of Science ®Google Scholar
• Imazato S, Torii M, Tsuchitani Y, et al. Incorporation of bacterial inhibitor into resin composite. J Dent Res. 1994;73(8):1437–1443.
   PubMed Web of Science ®Google Scholar
• Imazato S, McCabe JF. Influence of incorporation of antibacterial monomer on curing behavior of a dental composite. J Dent Res. 1994;73(10):1641–1645.
   PubMed Web of Science ®Google Scholar
• Imazato S, Kinomoto Y, Tarumi H, et al. Incorporation of antibacterial monomer MDPB into dentin primer. J Dent Res. 1997;76(3):768–772.
   PubMed Web of Science ®Google Scholar
• Cheng L, Weir MD, Zhang K, et al. Dental primer and adhesive containing a new antibacterial quaternary ammonium monomer dimethylaminododecyl methacrylate. J Dent. 2013;41(4):345–355.
   PubMed Web of Science ®Google Scholar
• Imazato S, Ebi N, Tarumi H, et al. Bactericidal activity and cytotoxicity of antibacterial monomer MDPB. Biomaterials. 1999;20(9):899–903.
   PubMed Web of Science ®Google Scholar
• Imazato S, Ehara A, Torii M, et al. Antibacterial activity of dentine primer containing MDPB after curing. J Dent. 1998;26(3):267–271.
   PubMed Web of Science ®Google Scholar
• Imazato S, Kinomoto Y, Tarumi H, et al. Antibacterial activity and bonding characteristics of an adhesive resin containing antibacterial monomer MDPB. Dent Mater. 2003;19(4):313–319.
   PubMed Web of Science ®Google Scholar
• Imazato S, Tay FR, Kaneshiro AV, et al. An in vivo evaluation of bonding ability of comprehensive antibacterial adhesive system incorporating MDPB. Dent Mater. 2007;23(2):170–176.
   PubMed Web of Science ®Google Scholar
• Andre CB, Gomes BP, Duque TM, et al. Dentine bond strength and antimicrobial activity evaluation of adhesive systems. J Dent. 2015;43(4):466–475.
   PubMed Web of Science ®Google Scholar
• André CB, Gomes BPFA, Duque TM, et al. Antimicrobial activity, effects on Streptococcus mutans biofilm and interfacial bonding of adhesive systems with and without antibacterial agent. Int J Adhes Adhes. 2017;72:123–129.
   Web of Science ®Google Scholar
• Brambilla E, Ionescu A, Fadini L, et al. Influence of MDPB-containing primer on Streptococcus mutans biofilm formation in simulated class I restorations. J Adhes Dent. 2013;15:431–438.
   PubMed Web of Science ®Google Scholar
• Imazato S, Kaneko T, Takahashi Y, et al. In vivo antibacterial effects of dentin primer incorporating MDPB. Oper Dent. 2004;29(4):369–375.
   PubMed Web of Science ®Google Scholar
• Uysal T, Amasyali M, Ozcan S, et al. Effect of antibacterial monomer-containing adhesive on enamel demineralization around orthodontic brackets: an in-vivo study. Am J Orthod Dentofacial Orthop. 2011;139(5):650–656.
   PubMed Web of Science ®Google Scholar
• Pinto CF, Paes Leme AF, Ambrosano GM, et al. Effect of a fluoride- and bromide-containing adhesive system on enamel around composite restorations under high cariogenic challenge in situ. J Adhes Dent. 2009;11:293–297.
   PubMed Web of Science ®Google Scholar
• Pinto CF, Berger SB, Cavalli V, et al. In situ antimicrobial activity and inhibition of secondary caries of self-etching adhesives containing an antibacterial agent and/or fluoride. Am J Dent. 2015;28:167–173.
   PubMed Web of Science ®Google Scholar
• Kitagawa H, Izutani N, Kitagawa R, et al. Evolution of resistance to cationic biocides in Streptococcus mutans and Enterococcus faecalis. J Dent. 2016;47:18–22.
   PubMed Web of Science ®Google Scholar
• Cocco AR, Rosa WL, Silva AF, et al. A systematic review about antibacterial monomers used in dental adhesive systems: current status and further prospects. Dent Mater. 2015;31(11):1345–1362.
   PubMed Web of Science ®Google Scholar
• Liang X, Huang Q, Liu F, et al. Synthesis of novel antibacterial monomers (UDMQA) and their potential application in dental resin. J Appl Polym Sci. 2013;129(6):3373–3381.
   Web of Science ®Google Scholar
• Zhou H, Liu H, Weir MD, et al. Three-dimensional biofilm properties on dental bonding agent with varying quaternary ammonium charge densities. J Dent. 2016;53:73–81.
   PubMed Web of Science ®Google Scholar
• Gou YP, Meghil MM, Pucci CR, et al. Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities. Acta Biomater. 2018;75:171–182.
   PubMed Web of Science ®Google Scholar
• Jun SK, Yang SA, Kim YJ, et al. Multi-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralization. Sci Rep. 2018;8(1):5663.
   PubMed Web of Science ®Google Scholar
• Andre CB, Rosalen PL, Galvao LCC, et al. Modulation of Streptococcus mutans virulence by dental adhesives containing anti-caries agents. Dent Mater. 2017;33(10):1084–1092.
   PubMed Web of Science ®Google Scholar
• Schmidlin PR, Zehnder M, Gohring TN, et al. Glutaraldehyde in bonding systems disinfects dentin in vitro. J Adhes Dent. 2004;6(1):61–64.
   PubMed Web of Science ®Google Scholar
• Atalayin C, Turkun LS, Ates M, et al. Are antibacterial component additions in etchants and adhesives effective against Streptococcus Mutans? J Adhes Sci Technol. 2018;32(2):197–206.
   Web of Science ®Google Scholar
• Brambilla E, Ionescu AC, Cazzaniga G, et al. In vitro Streptococcus mutans biofilm formation on surfaces of chlorhexidine-containing dentin bonding systems. Int J Adhes Adhes. 2017;75:23–30.
   Web of Science ®Google Scholar
• Sabatini C, Mennito AS, Wolf BJ, et al. Incorporation of bactericidal poly-acrylic acid modified copper iodide particles into adhesive resins. J Dent. 2015;43(5):546–555.
   PubMed Web of Science ®Google Scholar
• Genari B, Leitune VCB, Jornada DS, et al. Antimicrobial effect and physicochemical properties of an adhesive system containing nanocapsules. Dent Mater. 2017;33(6):735–742.
   PubMed Web of Science ®Google Scholar
• Zhang K, Melo MA, Cheng L, et al. Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms. Dent Mater. 2012;28(8):842–852.
   PubMed Web of Science ®Google Scholar
• Dutra-Correa M, Leite A, de Cara S, et al. Antibacterial effects and cytotoxicity of an adhesive containing low concentration of silver nanoparticles. J Dent. 2018;77:66–71.
   PubMed Web of Science ®Google Scholar
• Melo MA, Cheng L, Zhang K, et al. Novel dental adhesives containing nanoparticles of silver and amorphous calcium phosphate. Dent Mater. 2013;29(2):199–210.
   PubMed Web of Science ®Google Scholar
• Priyadarshini BM, Mitali K, Lu TB, et al. PLGA nanoparticles as chlorhexidine-delivery carrier to resin-dentin adhesive interface. Dent Mater. 2017;33(7):830–846.
   PubMed Web of Science ®Google Scholar
• Su M, Yao S, Gu L, et al. Antibacterial effect and bond strength of a modified dental adhesive containing the peptide nisin. Peptides. 2018;99:189–194.
   PubMed Web of Science ®Google Scholar
• Zhang N, Weir MD, Romberg E, et al. Development of novel dental adhesive with double benefits of protein-repellent and antibacterial capabilities. Dent Mater. 2015;31(7):845–854.
   PubMed Web of Science ®Google Scholar
• Wang B, Zhang N, Wang X, et al. Novel self-etch adhesive with antibacterial and protein-repellent functions to prevent enamel demineralization. Dent Mater J. 2018;37(6):904–911.
   PubMed Web of Science ®Google Scholar
• Zhang N, Zhang K, Xie X, et al. Nanostructured polymeric materials with protein-repellent and anti-caries properties for dental applications. Nanomaterials (Basel. 2018;8(6):393.
   PubMedGoogle Scholar
• Elsaka SE. Antibacterial activity and adhesive properties of a chitosan-containing dental adhesive. Quintessence Int. 2012;43:603–613.
   PubMed Web of Science ®Google Scholar
• Elsaka S, Elnaghy A. Effect of addition of chitosan to self-etching primer: antibacterial activity and push-out bond strength to radicular dentin. J Biomed Res. 2012;26(4):288–294.
   PubMedGoogle Scholar
• Du X, Huang X, Huang C, et al. Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive. J Dent. 2012;40(6):485–492.
   PubMed Web of Science ®Google Scholar
• Peralta SL, Carvalho PH, van de Sande FH, et al. Self-etching dental adhesive containing a natural essential oil: anti-biofouling performance and mechanical properties. Biofouling. 2013;29(4):345–355.
   PubMed Web of Science ®Google Scholar
• Noronha VT, Paula AJ, Duran G, et al. Silver nanoparticles in dentistry. Dent Mater. 2017;33(10):1110–1126.
   PubMed Web of Science ®Google Scholar
• Ge L, Li Q, Wang M, et al. Nanosilver particles in medical applications: synthesis, performance, and toxicity. Int J Nanomedicine. 2014;9:2399–2407.
   PubMed Web of Science ®Google Scholar
• Marambio-Jones C, Hoek EMV. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res. 2010;12(5):1531–1551.
   Web of Science ®Google Scholar
• Koo H, Schobel B, Scott-Anne K, et al. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. J Dent Res. 2005;84(11):1016–1020.
   PubMed Web of Science ®Google Scholar
• Mashwani ZUR, Khan T, Khan MA, et al. Synthesis in plants and plant extracts of silver nanoparticles with potent antimicrobial properties: current status and future prospects. Appl Microbiol Biotechnol. 2015;99(23):9923–9934.
   PubMed Web of Science ®Google Scholar
• Jeon JG, Klein MI, Xiao J, et al. Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. BMC Microbiol. 2009;9(1):228.
   PubMed Web of Science ®Google Scholar
• Kong M, Chen XG, Xing K, et al. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010;144(1):51–63.
   PubMed Web of Science ®Google Scholar
• de Macedo FAA, Souza NO, Lemos MVS, et al. Dentin bonding and physicochemical properties of adhesives incorporated with epigallocatechin-3-gallate. Odontology. 2019;107(1):23–28.
   PubMed Web of Science ®Google Scholar
• Epasinghe DJ, Yiu CKY, Burrow MF. Mechanical properties, water sorption characteristics, and compound release of grape seed extract-incorporated resins. J Appl Oral Sci. 2017;25(4):412–419.
   PubMed Web of Science ®Google Scholar
• Pashley DH, Tay FR, Yiu C, et al. Collagen degradation by host-derived enzymes during aging. J Dent Res. 2004;83(3):216–221.
   PubMed Web of Science ®Google Scholar
• Li F, Majd H, Weir MD, et al. Inhibition of matrix metalloproteinase activity in human dentin via novel antibacterial monomer. Dent Mater. 2015;31(3):284–292.
   PubMed Web of Science ®Google Scholar
• Almahdy A, Koller G, Sauro S, et al. Effects of MMP inhibitors incorporated within dental adhesives. J Dent Res. 2012;91(6):605–611.
   PubMed Web of Science ®Google Scholar
• Zhou J, Tan J, Yang X, et al. MMP-inhibitory effect of chlorhexidine applied in a self-etching adhesive. J Adhes Dent. 2011;13(2):111–115.
   PubMed Web of Science ®Google Scholar
• Feitosa SA, Palasuk J, Kamocki K, et al. Doxycycline-encapsulated nanotube-modified dentin adhesives. J Dent Res. 2014;93(12):1270–1276.
   PubMed Web of Science ®Google Scholar
• Almahdy A, Koller G, Festy F, et al. An MMP-inhibitor modified adhesive primer enhances bond durability to carious dentin. Dent Mater. 2015;31(5):594–602.
   PubMed Web of Science ®Google Scholar
• Rizk M, Hohlfeld L, Thanh LT, et al. Bioactivity and properties of a dental adhesive functionalized with polyhedral oligomeric silsesquioxanes (POSS) and bioactive glass. Dent Mater. 2017;33(9):1056–1065.
   PubMed Web of Science ®Google Scholar
• Taubock TT, Zehnder M, Schweizer T, et al. Functionalizing a dentin bonding resin to become bioactive. Dent Mater. 2014;30(8):868–875.
   PubMed Web of Science ®Google Scholar
• Sauro S, Osorio R, Watson TF, et al. Therapeutic effects of novel resin bonding systems containing bioactive glasses on mineral-depleted areas within the bonded-dentine interface. J Mater Sci Mater Med. 2012;23(6):1521–1532.
   PubMed Web of Science ®Google Scholar
• Van Meerbeek B, Perdigao J, Lambrechts P, et al. The clinical performance of adhesives. J Dent. 1998;26(1):1–20.
   PubMed Web of Science ®Google Scholar