PULMONARY AND SYSTEMIC TOXICITY OF BLEOMYCIN ON SEVERE COMBINED IMMUNE DEFICIENCY MICE

REFERENCES

• Dorr R T. Bleomycin pharmacology: mechanism of action and resistance, and clinical pharmacokinetics. Semin Oncol. 1992; 19: 3–8
   PubMedGoogle Scholar
• Hecht S M. Bleomycin: new perspectives on the mechanism of action. J Natural Products. 2000; 63: 158–168
   PubMed Web of Science ®Google Scholar
• Abraham A T, Lin J J, Newton D L, Rybak S, Hecht S M. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 2003; 10: 45–52
   PubMed Web of Science ®Google Scholar
• Sleijfer S. Bleomycin-induced pneumonitis. Chest. 2001; 120: 617–624
   PubMed Web of Science ®Google Scholar
• Chua F, Gauldie J, Laurent G J. Pulmonary fibrosis: searching for model answers. Am J Respir Cell Mol Biol 2005; 33: 9–13
   PubMed Web of Science ®Google Scholar
• Piguet P F, Collart M A, Grau G E, Kapanci Y, Vassalli P. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med. 1989; 170: 655–663
   PubMed Web of Science ®Google Scholar
• Santana A, Saxena B, Noble N A, Gold L I, Marshall B C. Increased expression of transforming growth factor beta isoforms (beta 1, beta 2, beta 3) in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 1995; 13: 34–44
   PubMed Web of Science ®Google Scholar
• Phan S H, Kunkel S L. Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res. 1992; 18: 29–43
   PubMed Web of Science ®Google Scholar
• Piguet P F, Rosen H, Vesin C, Grau G E. Effective treatment of the pulmonary fibrosis elicited in mice by bleomycin or silica with anti-CD-11 antibodies. Am Rev Respir Dis. 1993; 147: 435–441
   PubMed Web of Science ®Google Scholar
• Hagimoto N, Kuwano K, Nomoto Y, Kunitake R, Hara N. Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 1997; 16: 91–101
   PubMed Web of Science ®Google Scholar
• Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, Suda T, Kunitake R, Maeyama T, Miyazaki H, Hara N. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest. 1999; 104: 13–19
   PubMed Web of Science ®Google Scholar
• Moseley P L, Hemken C, Hunninghake G W. Augmentation of fibroblast proliferation by bleomycin. J Clin Invest. 1986; 78: 1150–1154
   PubMed Web of Science ®Google Scholar
• Sugarman B J, Aggarwal B B, Hass P E, Figari I S, Palladino M A, Jr, Shepard H M. Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science. 1985; 230: 943–945
   PubMed Web of Science ®Google Scholar
• Schmidt J A, Mizel S B, Cohen D, Green I. Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol. 1982; 128: 2177–2182
   PubMed Web of Science ®Google Scholar
• Giri S N, Hyde D M, Hollinger M A. Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax. 1993; 48: 959–966
   PubMed Web of Science ®Google Scholar
• Bosma M J, Carroll A M. The SCID mouse mutant: definition, characterization, and potential uses. Ann Rev Immunol. 1991; 9: 323–350
   PubMed Web of Science ®Google Scholar
• Blunt T, Finnie N J, Taccioli G E, Smith G C, Demengeot J, Gottlieb T M, Mizuta R, Varghese A J, Alt F W, Jeggo P A, Jackson J P. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell. 1995; 80: 813–823
   PubMed Web of Science ®Google Scholar
• Fulop G M, Phillips R A. The scid mutation in mice causes a general defect in DNA repair. Nature. 1990; 347: 479–482
   PubMed Web of Science ®Google Scholar
• Biedermann K A, Sun J R, Giaccia A J, Tosto L M, Brown J M. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A 1991; 88: 1394–1397
   PubMed Web of Science ®Google Scholar
• Budach W, Hartford A, Gioioso D, Freeman J, Taghian A, Suit H D. Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues. Cancer Res. 1992; 52: 6292–6296
   PubMed Web of Science ®Google Scholar
• Schuler W, Weiler I J, Schuler A, Phillips R A, Rosenberg N, Mak T W, Kearney J F, Perry R P, Bosma M J. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell. 1986; 46: 963–972
   PubMed Web of Science ®Google Scholar
• Malynn B A, Blackwell T K, Fulop G M, Rathbun G A, Furley A J, Ferrier P, Heinke L B, Phillips R A, Yancopoulos G D, Alt F W. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988; 54: 453–460
   PubMed Web of Science ®Google Scholar
• Blackwell T K, Malynn B A, Pollock R R, Ferrier P, Covey L R, Fulop G M, Phillips R A, Yancopoulos G D, Alt F W. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 1989; 8: 735–742
   PubMed Web of Science ®Google Scholar
• Tanaka T, Yamagami T, Oka Y, Nomura T, Sugiyama H. The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links. Mutation Res. 1993; 288: 277–280
   PubMed Web of Science ®Google Scholar
• Omori S, Takiguchi Y, Suda A, Sugimoto T, Miyazawa H, Takiguchi Y, Tanabe N, Tatsumi K, Kimura H, Pardington P E, Chen F, Chen D J, Kuriyama T. Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA Repair. 2002; 1: 299–310
   PubMed Web of Science ®Google Scholar
• Harrison J H, Jr, Lazo J S. High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis. J Pharmacol Exp Ther. 1987; 243: 1185–1194
   PubMed Web of Science ®Google Scholar
• Huszar G, Maiocco J, Naftolin F. Monitoring of collagen and collagen fragments in chromatography of protein mixtures. Anal Biochem. 1980; 105: 424–429
   PubMed Web of Science ®Google Scholar
• Shellito J, Sniezek M, Warnock M. Acquisition of peroxidase activity by rat alveolar macrophages during pulmonary inflammation. Am J Pathol 1987; 129: 567–577
   PubMed Web of Science ®Google Scholar
• Okudela K, Ito T, Mitsui H, Hayashi H, Udaka N, Kanisawa M, Kitamura H. The role of p53 in bleomycin-induced DNA damage in the lung. A comparative study with the small intestine. Am J Pathol. 1999; 155: 1341–1351
   Google Scholar
• Onuma T, Holland J F, Masuda H, Waligunda J A, Goldberg G A. Microbiological assay of bleomycin: inactivation, tissue distribution, and clearance. Cancer. 1974; 33: 1230–1238
   PubMed Web of Science ®Google Scholar
• Copur M S, Rose M G, Chu E. Miscellaneous chemotherapeutic agents. Cancer-Principles & Practice of Oncology, 7th ed., V DeVita, S Hellman, S Rosenberg. Lippincott Williams & Wilkins, Philadelphia 2005; 416–422
   Google Scholar
• Sharma S K, MacLean J A, Pinto C, Kradin R L. The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury. Am J Respir Crit Care Med 1996; 154: 193–200
   PubMed Web of Science ®Google Scholar
• Schrier D J. Phan SH: Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells. Am J Pathol 1984; 116: 270–278
   PubMed Web of Science ®Google Scholar
• Schrier D J, Phan S H, McGarry B M. The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. A biochemical evaluation. Am Rev Respir Dis. 1983; 127: 614–617
   PubMed Web of Science ®Google Scholar
• Szapiel S V, Elson N A, Fulmer J D, Hunninghake G W, Crystal R G. Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis. 1979; 120: 893–899
   PubMed Web of Science ®Google Scholar
• Zhu J, Cohen D A, Goud S N, Kaplan A M. Contribution of T lymphocytes to the development of bleomycin-induced pulmonary fibrosis. Ann N Y Acad Sci 1996; 796: 194–202
   PubMed Web of Science ®Google Scholar
• Helene M, Lake-Bullock V, Zhu J, Hao H, Cohen D A, Kaplan A M. T cell independence of bleomycin-induced pulmonary fibrosis. J Leuk Biol. 1999; 65: 187–195
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Nishioka K. Animal model of sclerotic skin. IV: induction of dermal sclerosis by bleomycin is T cell independent. J Invest Dermatol. 2001; 117: 999–1001
   Google Scholar