Regulation of angiopoietin-2 secretion from human pulmonary microvascular endothelial cells

References

• Levy M, Fink M, Marshall J, Abraham E, Angus D, Cook D, et al. SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intens Care Med. 2003;29:530–538.
   PubMedGoogle Scholar
• Angus D, Linde-Zwirble W, Lidicker J, Clermont G, Carcillo J, Pinsky M. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–1310.
   PubMed Web of Science ®Google Scholar
• Vincent J-L, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study*. Crit Care Med. 2006;34(2):344–353.
   PubMed Web of Science ®Google Scholar
• Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–1596.
   PubMed Web of Science ®Google Scholar
• Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009;136(5):1237–1348.
   PubMed Web of Science ®Google Scholar
• Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368–1377.
   PubMed Web of Science ®Google Scholar
• Micek ST, Roubinian N, Heuring T, Bode M, Williams J, Harrison C, et al. Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med. 2006;34(11):2707–2713.
   PubMed Web of Science ®Google Scholar
• Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intens Care Med. 2013;39(2):165–228.
   PubMed Web of Science ®Google Scholar
• Stalker AL. The microcirculation in shock. J Clin Pathol Suppl (R Coll Pathol). 1970;4:10–15.
   PubMedGoogle Scholar
• Lehr HA, Bittinger F, Kirkpatrick CJ. Microcirculatory dysfunction in sepsis: a pathogenetic basis for therapy? J Pathol. 2000;190(3):373–386.
   PubMed Web of Science ®Google Scholar
• Vincent JL, De Backer D. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care. 2005;9(Suppl 4):S9–S12.
   Google Scholar
• Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34(2):344–353.
   PubMed Web of Science ®Google Scholar
• Miller EJ, Cohen AB, Matthay MA. Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med. 1996;24(9):1448–1454.
   PubMed Web of Science ®Google Scholar
• Russell JA, Singer J, Bernard GR, Wheeler A, Fulkerson W, Hudson L, et al. Changing pattern of organ dysfunction in early human sepsis is related to mortality. Crit Care Med. 2000;28(10):3405–3411.
   PubMed Web of Science ®Google Scholar
• Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, et al. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med. 1997;336(13):912–918.
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348(2):138–150.
   PubMed Web of Science ®Google Scholar
• David S, Kümpers P, van Slyke P, Parikh SM. Mending Leaky blood vessels: The angiopoietin-Tie2 pathway in sepsis. J Pharmacol Exp Ther. 2013;345(1):2–6.
   PubMed Web of Science ®Google Scholar
• Park HY, Hahm CR, Jeon K, Koh WJ, Suh GY, Chung MP, et al. Serum vascular endothelial growth factor and angiopoietin-2 are associated with the severity of systemic inflammation rather than the presence of hemoptysis in patients with inflammatory lung disease. Yonsei Med J. 2012;53(2):369–376.
   PubMed Web of Science ®Google Scholar
• Lukasz A, Hellpap J, Horn R, Kielstein JT, David S, Haller H, et al. Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. Crit Care (London, England). 2008;12(4):R94.
   Google Scholar
• Gallagher DC, Parikh SM, Balonov K, Miller A, Gautam S, Talmor D, et al. Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock. 2008;29(6):656–661.
   PubMed Web of Science ®Google Scholar
• van der Heijden M, Pickkers P, van Nieuw Amerongen GP, van Hinsbergh VW, Bouw MP, van der Hoeven JG, et al. Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality. Intens Care Med. 2009;35(9):1567–1574.
   PubMed Web of Science ®Google Scholar
• van der Heijden M, van Nieuw Amerongen GP, Chedamni S, van Hinsbergh VW, Johan Groeneveld AB. The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury. Expert Opin Ther Targets. 2009;13(1):39–53.
   PubMed Web of Science ®Google Scholar
• van der Heijden M, van Nieuw Amerongen GP, van Hinsbergh VW, Groeneveld AB. The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients. Shock. 2010;33(3):263–268.
   PubMed Web of Science ®Google Scholar
• Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010;38(9):1845–1851.
   PubMed Web of Science ®Google Scholar
• Ebihara I, Hirayama K, Nagai M, Kakita T, Sakai K, Tajima R, et al. Angiopoietin balance in septic shock patients with acute lung injury: effect of direct hemoperfusion with polymyxin B-immobilized fiber. Ther Apher Dial. 2011;15(4):349–354.
   PubMed Web of Science ®Google Scholar
• Choi JS, Kwak KA, Park MJ, Kim YH, Gil HW, Song HY, et al. Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat. Med Sci Monit. 2013;19:28–33.
   PubMed Web of Science ®Google Scholar
• Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, et al. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically Ill patients. Am J Respir Crit Care Med. 2013;Apr 1;187(7):736–742.
   Web of Science ®Google Scholar
• van der Heijden M, van Nieuw Amerongen GP, Koolwijk P, van Hinsbergh VWM, Groeneveld ABJ. Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax. 2008;63(10):903–909.
   PubMed Web of Science ®Google Scholar
• Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, et al. Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*. Crit Care Med. 2011;39(4):702–10.
   PubMed Web of Science ®Google Scholar
• Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546–1554.
   PubMed Web of Science ®Google Scholar
• Wang JE, Dahle MK, McDonald M, Foster SJ, Aasen AO, Thiemermann C. Peptidoglycan and lipoteichoic acid in gram-positive bacterial sepsis: receptors, signal transduction, biological effects, and synergism. Shock (Augusta, Ga). 2003;20(5):402–414.
   PubMed Web of Science ®Google Scholar
• Unger RE, Krump-Konvalinkova V, Peters K, Kirkpatrick CJ. In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R. Microvasc Res. 2002;64(3):384–397.
   PubMed Web of Science ®Google Scholar
• Krump-Konvalinkova V, Bittinger F, Unger RE, Peters K, Lehr H-A, Kirkpatrick CJ. Generation of human pulmonary microvascular endothelial cell lines. Lab Invest. 0000;81(12):1717–1727.
   PubMed Web of Science ®Google Scholar
• Jang C, Koh YJ, Lim NK, Kang HJ, Kim DH, Park SK, et al. Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. Arterioscler, Thromb Vasc Biol. 2009;29(3):401–407.
   PubMed Web of Science ®Google Scholar
• Chen YA, Scheller RH. SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol. 2001;2(2):98–106.
   PubMed Web of Science ®Google Scholar
• Matsushita K, Morrell CN, Lowenstein CJ. A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol. 2005;67(4):1137–1144.
   PubMed Web of Science ®Google Scholar
• Akata T. Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells. J Anesth. 2007;21:232–242 LA—English.
   PubMed Web of Science ®Google Scholar
• Jaiswal JK, Rivera VM, Simon SM. Exocytosis of post-Golgi vesicles is regulated by components of the endocytic machinery. Cell. 2009;137(7):1308–1319.
   PubMed Web of Science ®Google Scholar
• Linge HM, Lee JY, Ochani K, Koga K, Kohn N, Ojamaa K, et al. Age influences inflammatory responses, hemodynamics, and cardiac proteasome activation during acute lung injury. Exp Lung Res. 2015;41(4):216–227.
   PubMed Web of Science ®Google Scholar
• Lee JY, Linge HM, Ochani K, Lin K, Miller EJ. N-Ethylmaleimide sensitive factor (NSF) inhibition prevents vascular instability following gram-positive pulmonary challenge. PLoS One. 2016;11(6):e0157837.
   Google Scholar
• Rondaij MG, Bierings R, van Agtmaal EL, Gijzen KA, Sellink E, Kragt A, et al. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood. 2008;112(1):56–63.
   PubMed Web of Science ®Google Scholar
• Nightingale TD, White IJ, Doyle EL, Turmaine M, Harrison-Lavoie KJ, Webb KF, et al. Actomyosin II contractility expels von Willebrand factor from Weibel†“Palade bodies during exocytosis. J Cell Biol. 2011;Aug 22;194(4):613–629.
   Google Scholar
• Lee JY, Miller EJ. Angiopoietin-2: a key to understanding sepsis and its pulmonary sequelae? J Pulmonary & Resp Med. 2014;4:172.
   Google Scholar
• Deleuze V, El-Hajj R, Chalhoub E, Dohet C, Pinet Vr, Couttet P, et al. Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells. PLoS One. 2012;7(7):e40484.
   Google Scholar
• Russell FD. Evidence using immunoelectron microscopy for regulated and constitutive pathways in the transport and release of endothelin. J Cardiovasc Pharmacol. 1998;Mar;31(3):424–430.
   Google Scholar
• Giblin JP, Hewlett LJ, Hannah MJ. Basal secretion of von Willebrand factor from human endothelial cells. Blood. 2008;112(4):957–964.
   PubMed Web of Science ®Google Scholar
• Miller SG, Moore HP. Reconstitution of constitutive secretion using semi-intact cells: regulation by GTP but not calcium. J Cell Biol. 1991;112(1):39–54.
   PubMed Web of Science ®Google Scholar
• Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt J, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004;103:4150–4156.
   PubMed Web of Science ®Google Scholar
• Lee JW. Fluid and electrolyte disturbances in critically ill patients. Electrolyte Blood Press. 2010;8:72–81.
   PubMedGoogle Scholar
• Kraft MD, Btaiche IF, Sacks GS, Kudsk KA. Treatment of electrolyte disorders in adult patients in the intensive care unit. Am J Health Syst Ph. 2005;62(16):1663–1682.
   PubMed Web of Science ®Google Scholar
• JB B, PG S. Toxic effects of electrolyte and trace mineral administration in the intensive care unit. Crit Care Clin. 1991;7(3):659–993.
   PubMed Web of Science ®Google Scholar
• Khardori R, Castillo D. Endocrine and metabolic changes during sepsis: an update. Med Clin North America Intervent Infect Dis Emergencies. 2012;96(6):1095–1105.
   Google Scholar
• Siegel LM, Grinspoon SK, Garvey GJ, Bilezikian JP. Sepsis and adrenal function. Trends Endocrinol Metab. 1994;5(8):324–328.
   PubMed Web of Science ®Google Scholar
• Vezzosi D, Bertherat JRM. Phosphodiesterases in endocrine physiology and disease. Eur J Endocrinol. 2011;165(2):177–188.
   PubMed Web of Science ®Google Scholar
• Tsai L-CL, Shimizu-Albergine M, Beavo JA. The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol Pharmacol. 2011;79(4):639–648.
   PubMed Web of Science ®Google Scholar
• Klijn E, Den Uil CA, Bakker J, Ince C. The heterogeneity of the microcirculation in critical illness. Clin Chest Med. 2008;29(4):643–654.
   PubMed Web of Science ®Google Scholar
• Thorin E, Shreeve SM. Heterogeneity of vascular endothelial cells in normal and disease states. Pharmacol Ther. 1998;78(3):155–166.
   PubMed Web of Science ®Google Scholar
• Wu S, Zhou C, King JAC, Stevens T. A unique pulmonary microvascular endothelial cell niche revealed by Weibel-Palade bodies and Griffonia simplicifolia. Pulmon Circ. 2014;4(1):110–115.
   PubMedGoogle Scholar
• Weibel ER. Fifty years of Weibel-Palade bodies: the discovery and early history of an enigmatic organelle of endothelial cells. J Thromb Haemost. 2012;10(6):979–984.
   PubMed Web of Science ®Google Scholar
• Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004;103(11):4150–4156.
   PubMed Web of Science ®Google Scholar
• Rondaij MG, Bierings R, Kragt A, van Mourik JA, Voorberg J. Dynamics and plasticity of Weibel-Palade bodies in endothelial cells. Arterioscler Thromb Vasc Biol. 2006;26(5):1002–1007.
   PubMed Web of Science ®Google Scholar
• Lowenstein C, Morrell C, Yamakuchi M. Regulation of Weibel-Palade body exocytosis. Trends Cardiovasc Med. 2005;15:302–308.
   PubMed Web of Science ®Google Scholar
• Polgár J, Reed GL. A critical role for N-ethylmaleimide-sensitive fusion protein (NSF) in platelet granule secretion: presented in part in abstract form at the 1998 national meeting of the American Heart Association in Dallas, TX. Blood. 1999;94(4):1313–1318.
   Google Scholar
• Matsushita K, Morrell CN, Lowenstein CJ. A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol. 2005;67(4):1137–1344.
   PubMed Web of Science ®Google Scholar
• Morrell CN, Matsushita K, Lowenstein CJ. A Novel Inhibitor of N-Ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis. J Pharmacol Exp Ther. 2005;314(1):155–161.
   PubMed Web of Science ®Google Scholar
• Lee JY, Miller EJ. Angiopoietin-2: a key to understanding sepsis and its pulmonary sequelae? J Pulm Respir Med. 2014;4172.
   Google Scholar
• Kumpers P, van Meurs M, David S, Molema G, Bijzet J, Lukasz A, et al. Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis. Crit Care. 2009;13:R64.
   Google Scholar
• Giuliano J, Lahni P, Harmon K, Wong H, Doughty L, Carcillo J, et al. Admission angiopoietin levels in children with septic shock. Shock. 2007;28(6):650–654.
   PubMed Web of Science ®Google Scholar
• Davis J, Yeo T, Piera K, Woodberry T, Celermajer D, Stephens D, et al. Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care. 2010;14:R89.
   Google Scholar
• Kranidioti H, Orfanos S, Vaki I, Kotanidou A, Raftogiannis M, Dimopoulou I, et al. Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes. Immunol Lett. 2009;125:65–71.
   PubMed Web of Science ®Google Scholar
• Orfanos S, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, et al. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit Care Med. 2007;35(1):199–206.
   PubMed Web of Science ®Google Scholar
• David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, et al. Angiopoietin-2 may contribute to multiorgan dysfunction and death in sepsis. Crit Care Med. 2012 Nov;40(11):3034–3041.
   Google Scholar
• Heijden M, Nieuw Amerongen G, Koolwijk P, van Hinsbergh V, Groeneveld A. Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax. 2008;63:903–909.
   PubMed Web of Science ®Google Scholar