NF-κB p65 Knock-down inhibits TF, PAI-1 and promotes activated protein C production in lipopolysaccharide-stimulated alveolar epithelial cells type II

References

• Xiao M, Zhu T, Zhang W, et al. Emodin Ameliorates LPS-induced acute lung injury, involving the inactivation of NF-κB in mice. Int J Mol Sci. 2014;15(11):19355–19368.
   PubMed Web of Science ®Google Scholar
• Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301–1308.
   PubMed Web of Science ®Google Scholar
• Newell CP, Martin MJ, Richardson N, Bourdeaux CP. Protective mechanical ventilation in United Kingdom critical care units: A multicentre audit. J Intensive Care Soc. 2017;18(2):106–112.
   PubMedGoogle Scholar
• Gotts JE, Matthay MA. Treating ARDS: New hope for a tough problem. Lancet Respir Med. 2014;2(2):84–85.
   PubMed Web of Science ®Google Scholar
• Ferguson ND, Fan E, Camporota L, et al. The Berlin definition of ARDS: An expanded rationale, justification, and supplementary material. Intensive Care Med. 2012;38(10):1573–1582.
   PubMed Web of Science ®Google Scholar
• Sebag SC, Bastarache JA, Ware LB. Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol. 2011;12(9):1481–1496.
   PubMed Web of Science ®Google Scholar
• Ozolina A, Sarkele M, Sabelnikovs O, et al. Activation of coagulation and fibrinolysis in acute respiratory distress syndrome: a prospective pilot study. Frontiers in Med. 2016;3:64.
   PubMed Web of Science ®Google Scholar
• Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity . Trends Immunol. 2004;25(6):280–288.
   PubMed Web of Science ®Google Scholar
• Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004;18(18):2195–2224.
   PubMed Web of Science ®Google Scholar
• Gao MY, Chen L, Yang L, Yu X, Kou JP, Yu BY. Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells. Pharmacol Rep. 2014;66(3):480–484.
   PubMed Web of Science ®Google Scholar
• Jeffers A, Owens S, Koenig K, et al. Thrombin down-regulates tissue factor pathway inhibitor expression in a PI3K/Nuclear Factor-kB–dependent manner in human pleural mesothelial cells. Am J Respir Cell Mol Biol. 2015;52(6):674–682.
   PubMed Web of Science ®Google Scholar
• Kebir DE, Damlaj A, Makhezer N, Filep JG. Toll-like receptor 9 signaling regulates tissue factor and tissue factor pathway inhibitor expression in human endothelial cells and coagulation in mice. Crit Care Med. 2015;43:e179–e189.
   PubMed Web of Science ®Google Scholar
• Kitasato L, Yamaoka-Tojo M, Hashikata T, et al. Factor Xa in mouse fibroblasts may induce fibrosis more than thrombin. Int Heart J. 2014;55(4):357–361.
   PubMed Web of Science ®Google Scholar
• Bastarache JA, Wang L, Geiser T, et al. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007;62(7):608–616.
   PubMed Web of Science ®Google Scholar
• Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB. Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2009;297(6):L1035–L1041.
   PubMed Web of Science ®Google Scholar
• Ling W, Bastarache JA, Nancy W, Fang XH, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007;36(4):497–503.
   PubMed Web of Science ®Google Scholar
• Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008;294(5):L874–L881.
   PubMed Web of Science ®Google Scholar
• Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003;285(1):L20–L28.
   PubMed Web of Science ®Google Scholar
• Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol. 2004;22(3):326–330.
   PubMed Web of Science ®Google Scholar
• Mittal V. Improving the efficiency of RNA interference in mammals. Nat Rev Genet. 2004;5(5):355–365.
   PubMed Web of Science ®Google Scholar
• Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 2001;15(2):188–200.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 − ΔΔCt method. Methods 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391(6669):806–811.
   PubMed Web of Science ®Google Scholar
• Wang G, Li S, Wang F, et al. RNAi screen to identify protein phosphatases that regulate the NF-kappaB signaling. Front Biol. 2010;5(3):263–271.
   Google Scholar
• Osterholzer JJ, Christensen PJ, Lama V, et al. PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury. J Pathol. 2012;228(2):170–180.
   PubMed Web of Science ®Google Scholar
• Shaver CM, Grove BS, Putz ND, et al. Regulation of Alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Am J Respir Cell Mol Biol. 2015;53(5):719–727.
   PubMed Web of Science ®Google Scholar
• Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008;132(3):344–362.
   PubMed Web of Science ®Google Scholar
• Benjamin L, Maisonet TM, Londhe VA. Alveolar NF-κB signaling regulates endotoxin-induced lung inflammation. Exp Lung Res. 2015;41(2):103–114.
   PubMed Web of Science ®Google Scholar
• Hayden MS, Ghosh S. Regulation of NF-κB by TNF family cytokines. Semin Immunol. 2014;26(3):253–266.
   PubMed Web of Science ®Google Scholar
• Huang JH, Li L, Yuan WF, Zheng LX, Guo ZH, Huang WJ. NEMO- binding domain peptide attenuates lipopolysaccharide-induced acute lung injury by inhibiting the NF-κB signaling pathway. Mediators of Inflammation. 2016;2016:7349603.
   PubMed Web of Science ®Google Scholar
• Li N, Song YB, Zhao W, et al. Small interfering RNA targeting NF-κB attenuates lipopolysaccharide-induced acute lung injury in rats. BMC Physiol. 2016;16:7.
   PubMedGoogle Scholar
• Ding RY, Zhao DM, Li XX, Liu BY, Ma XC. Rho-kinase inhibitor treatment prevents pulmonary inflammation and coagulation in lipopolysaccharide-induced lung injury. Thrombosis Res. 2017;150:59–64.
   PubMed Web of Science ®Google Scholar
• He XL, Han B, Mura M, et al. Anti-human tissue factor antibody ameliorated intestinal ischemia reperfusion-induced acute lung injury in human tissue factor knock-in mice. PLoS One. 2008;3(1):e1527.
   PubMed Web of Science ®Google Scholar
• Levi M, Poll TVD, Büller HR. Bidirectional relation between inflammation and coagulation. Circulation 2004;109(22):2698–2704.
   PubMed Web of Science ®Google Scholar
• Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA. 2001;98(14):7742–7747.
   PubMed Web of Science ®Google Scholar
• Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000;407(6801):258–264.
   PubMed Web of Science ®Google Scholar
• Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA. 2000;97(10):5255–5260.
   PubMed Web of Science ®Google Scholar
• Kasthuri RS, Glover SL, Boles J, Mackman N. Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: Measurement of their levels in coagulation assays. Semin Thromb Hemost. 2010;36(7):764–771.
   PubMed Web of Science ®Google Scholar
• Idell S, Gonzalez K, Bradford H, et al. Procoagulant activity in broncho- alveolar lavage in the adult respiratory distress syndrome. Contribution of tissue factor associated with factor VII. Am Rev Respir Dis. 1987;136(6):1466–1474.
   PubMed Web of Science ®Google Scholar
• Idell S, James KK, Levin EG, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989;84(2):695–705.
   PubMed Web of Science ®Google Scholar
• Gross TJ, Simon RH, Kelly CJ, Sitrin RG. Rat alveolar epithelial cells concomitantly express plasminogen activator inhibitor-1 and urokinase. Am J Physiol. 1991;260(4 Pt 1):L286–L295.
   PubMed Web of Science ®Google Scholar
• Riewald M, Ruf W. Science review: Role of coagulation protease cascades in sepsis. Crit Care. 2003;7(2):123–129.
   PubMed Web of Science ®Google Scholar
• Okamoto T, Tanigami H, Suzuki K, Shimaoka M. Thrombomodulin: A bifunctional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract. 2012;2012:614545.
   PubMedGoogle Scholar