High amplitude stretching of ATII cells and fibroblasts results in profibrotic effects

References

• King TE, Jr., Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011;378(9807):1949–1961. doi: 10.1016/S0140-6736(11)60052-4.
   PubMed Web of Science ®Google Scholar
• Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014;43(1):276–285. doi: 10.1183/09031936.00196412.
   PubMed Web of Science ®Google Scholar
• Cabrera-Benitez NE, Laffey JG, Parotto M, et al. Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome. Anesthesiology. 2014;121(1):189–198. doi: 10.1097/ALN.0000000000000264.
   PubMed Web of Science ®Google Scholar
• Martin C, Papazian L, Payan MJ, Saux P, Gouin F. Pulmonary fibrosis correlates with outcome in adult respiratory distress syndrome. A study in mechanically ventilated patients. Chest. 1995;107(1):196–200. doi: 10.1378/chest.107.1.196.
   PubMed Web of Science ®Google Scholar
• Knudsen L, Ruppert C, Ochs M. Tissue remodelling in pulmonary fibrosis. Cell Tissue Res. 2017;367(3):607–626. doi: 10.1007/s00441-016-2543-2.
   PubMed Web of Science ®Google Scholar
• Froese AR, Shimbori C, Bellaye PS, et al. Stretch-induced activation of transforming growth factor-beta1 in pulmonary fibrosis. Am J Respir Crit Care Med. 2016;194(1):84–96. doi: 10.1164/rccm.201508-1638OC.
   PubMed Web of Science ®Google Scholar
• Mokra D, Kosutova P. Biomarkers in acute lung injury. Respir Physiol Neurobiol. 2015;209:52–58. doi: 10.1016/j.resp.2014.10.006.
   PubMed Web of Science ®Google Scholar
• Willis BC, Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol. 2007;293(3):L525–L534. doi: 10.1152/ajplung.00163.2007.
   PubMed Web of Science ®Google Scholar
• Sanchez-Duffhues G, Garcia D,V, Ten DP. Endothelial-to-mesenchymal transition in cardiovascular diseases: developmental signaling pathways gone awry. Dev Dyn. 2018;247(3):492–508.
   PubMed Web of Science ®Google Scholar
• Lee JG, Ko MK, Kay EP. Endothelial mesenchymal transformation mediated by IL-1beta-induced FGF-2 in corneal endothelial cells. Exp Eye Res. 2012;95(1):35–39. doi: 10.1016/j.exer.2011.08.003.
   PubMed Web of Science ®Google Scholar
• Shintani Y, Fujiwara A, Kimura T, et al. IL-6 secreted from cancer-associated fibroblasts mediates chemoresistance in NSCLC by increasing epithelial-mesenchymal transition signaling. J Thorac Oncol. 2016;11(9):1482–1492. doi: 10.1016/j.jtho.2016.05.025.
   PubMed Web of Science ®Google Scholar
• Miao C, Xiong Y, Zhang G, Chang J. MicroRNAs in idiopathic pulmonary fibrosis, new research progress and their pathophysiological implication. Exp Lung Res. 2018;23:1–13.
   Google Scholar
• Ferruelo A, Penuelas O, Lorente JA. MicroRNAs as biomarkers of acute lung injury. Ann Transl Med. 2018;6(2):34. doi: 10.21037/atm.2018.01.10.
   PubMed Web of Science ®Google Scholar
• Hammerschmidt S, Kuhn H, Grasenack T, Gessner C, Wirtz H. Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type II cells. Am J Respir Cell Mol Biol. 2004;30(3):396–402. doi: 10.1165/rcmb.2003-0136OC.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25(4):402–408. doi: 10.1006/meth.2001.1262.
   PubMed Web of Science ®Google Scholar
• Rock JR, Barkauskas CE, Cronce MJ, et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci USA. 2011;108(52):E1475–E1483. doi: 10.1073/pnas.1117988108.
   PubMed Web of Science ®Google Scholar
• Legras A, Pecuchet N, Imbeaud S, et al. Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer. Cancers (Basel). 2017;9(12):101. doi: 10.3390/cancers9080101.
   Google Scholar
• Kendall RT, Feghali-Bostwick CA. Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol. 2014;5:123.
   PubMed Web of Science ®Google Scholar
• Willis BC, duBois RM, Borok Z. Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc. 2006;3(4):377–382. doi: 10.1513/pats.200601-004TK.
   PubMedGoogle Scholar
• Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res. 2005;6(1):56. doi: 10.1186/1465-9921-6-56.
   PubMedGoogle Scholar
• Yang J, Wheeler SE, Velikoff M, et al. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013;183(5):1559–1570. doi: 10.1016/j.ajpath.2013.07.016.
   PubMed Web of Science ®Google Scholar
• Urushiyama H, Terasaki Y, Nagasaka S, et al. Role of alpha1 and alpha2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts. Lab Invest. 2015;95(8):872–885. doi: 10.1038/labinvest.2015.66.
   PubMed Web of Science ®Google Scholar
• Hahn E, Wick G, Pencev D, Timpl R. Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin. Gut. 1980;21(1):63–71. doi: 10.1136/gut.21.1.63.
   PubMed Web of Science ®Google Scholar
• Shirakihara T, Horiguchi K, Miyazawa K, et al. TGF-beta regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. Embo J. 2011;30(4):783–795. doi: 10.1038/emboj.2010.351.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Sanada H, Shigetomi S, Katoh T, Watanabe T. Urinary excretion of type IV collagen as a specific indicator of the progression of diabetic nephropathy. Nephron. 2000;86(1):27–35.
   PubMed Web of Science ®Google Scholar
• Horejs CM. Basement membrane fragments in the context of the epithelial-to-mesenchymal transition. Eur J Cell Biol. 2016;95(11):427–440. doi: 10.1016/j.ejcb.2016.06.002.
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Lee DY, White ES, et al. Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem. 2003;278(14):12384–12389. doi: 10.1074/jbc.M208544200.
   PubMed Web of Science ®Google Scholar
• Chen QK, Lee K, Radisky DC, Nelson CM. Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation. 2013;86(3):126–132. doi: 10.1016/j.diff.2013.03.003.
   PubMed Web of Science ®Google Scholar
• Dobbs LG, Williams MC, Brandt AE. Changes in biochemical characteristics and pattern of lectin binding of alveolar type II cells with time in culture. Biochim Biophys Acta. 1985;846(1):155–166. doi: 10.1016/0167-4889(85)90121-1.
   PubMedGoogle Scholar
• Mao P, Li J, Huang Y, et al. MicroRNA-19b mediates lung epithelial-mesenchymal transition via phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase in response to mechanical stretch. Am J Respir Cell Mol Biol. 2017;56(1):11–19. doi: 10.1165/rcmb.2015-0377OC.
   PubMed Web of Science ®Google Scholar
• Zhang WL, Zhang JH, Wu XZ, Yan T, Lv W. miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer. Int J Oncol. 2015;47(3):1043–1053. doi: 10.3892/ijo.2015.3076.
   PubMed Web of Science ®Google Scholar
• Wang X, Guo H, Yao B, Helms J. miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer. Oncol Rep. 2017;37(5):2720–2726. doi: 10.3892/or.2017.5532.
   PubMed Web of Science ®Google Scholar
• Liu D, Liu T, Teng Y, Chen W, Zhao L, Li X. Ginsenoside Rb1 inhibits hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells by regulating microRNA-25. Exp Ther Med. 2017;14(4):2895–2902. doi: 10.3892/etm.2017.4889.
   PubMed Web of Science ®Google Scholar
• Song J, Li Y. miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells. Cancer Sci. 2017;108(1):23–31. doi: 10.1111/cas.13104.
   PubMed Web of Science ®Google Scholar
• Huleihel L, Ben-Yehudah A, Milosevic J, et al. Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2014;306(6):L534–L542. doi: 10.1152/ajplung.00149.2013.
   PubMed Web of Science ®Google Scholar
• Kroon AA, Delriccio V, Tseu I, Kavanagh BP, Post M. Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway. Am J Physiol Lung Cell Mol Physiol. 2013;305(11):L795–L804. doi: 10.1152/ajplung.00048.2013.
   PubMed Web of Science ®Google Scholar
• Pinhu L, Park JE, Yao W, Griffiths MJ. Reference gene selection for real-time polymerase chain reaction in human lung cells subjected to cyclic mechanical strain. Respirology. 2008;13(7):990–999. doi: 10.1111/j.1440-1843.2008.01396.x.
   PubMed Web of Science ®Google Scholar