MiR-200a and miR-200b restrain inflammation by targeting ORMDL3 to regulate the ERK/MMP-9 pathway in asthma

References

• Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–2196. doi:10.1016/S0140-6736(12)61729-2.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang H, Ni R, Jia W-Q, Wang Y-Y. IL-4R suppresses airway inflammation in bronchial asthma by inhibiting the IL-4/STAT6 pathway. Pulm Pharmacol Ther. 2017;43:32–38. doi:10.1016/j.pupt.2017.01.006.
   PubMed Web of Science ®Google Scholar
• Chen W-Q, Xie Z-Z, Wang X, et al. Influences of PON1 on airway inflammation and remodeling in bronchial asthma. J Cell Biochem. 2018;119(1):793–805. doi:10.1002/jcb.26242.
   PubMed Web of Science ®Google Scholar
• Baroffio M, Barisione G, Crimi E, Brusasco V. Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: an overview. Ther Adv Respir Dis. 2009;3(4):163–174. doi:10.1177/1753465809343595.
   PubMedGoogle Scholar
• Nakagome K, Nagata M. Pathogenesis of airway inflammation in bronchial asthma. Auris Nasus Larynx. 2011;38(5):555–563. doi:10.1016/j.anl.2011.01.011.
   PubMed Web of Science ®Google Scholar
• Qu X, Chen Y, Yin C. Effect of montelukast on the expression of CD4(+)CD25(+) regulatory T cells in children with acute bronchial asthma. Exp Ther Med. 2018;16(3):2381–2386. doi:10.3892/etm.2018.6485.
   PubMed Web of Science ®Google Scholar
• Ravi A, Chowdhury S, Dijkhuis A, Bonta PI, Sterk PJ, Lutter R. Neutrophilic inflammation in asthma and defective epithelial translational control. Eur Respir J. 2019;54(2):1900547. doi:10.1183/13993003.00547-2019.
   PubMed Web of Science ®Google Scholar
• Laxmi V, Gupta R, Bhattacharya SK, Ray A, Gulati K. Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma. Pharmacol Rep. 2019;71(3):517–521. doi:10.1016/j.pharep.2019.02.008.
   PubMed Web of Science ®Google Scholar
• Cheng Q, Shang Y. ORMDL3 may participate in the pathogenesis of bronchial epithelial‑mesenchymal transition in asthmatic mice with airway remodeling. Mol Med Rep. 2018;17(1):995–1005. doi:10.3892/mmr.2017.7972.
   PubMed Web of Science ®Google Scholar
• Miller M, Rosenthal P, Beppu A, et al. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol. 2014;192(8):3475–3487. doi:10.4049/jimmunol.1303047.
   PubMed Web of Science ®Google Scholar
• Anatriello E, Cunha M, Nogueira J, et al. Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet. Cell Immunol. 2019;341:103928. doi:10.1016/j.cellimm.2019.103928.
   PubMed Web of Science ®Google Scholar
• Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367(3):551–569. doi:10.1007/s00441-016-2566-8.
   PubMed Web of Science ®Google Scholar
• Hur GY, Broide DH. Genes and pathways regulating decline in lung function and airway remodeling in asthma. Allergy Asthma Immunol Res. 2019;11(5):604–621. doi:10.4168/aair.2019.11.5.604.
   PubMed Web of Science ®Google Scholar
• Yu F, Sun Y, Yu J, et al. ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway. Mol Med Rep. 2017;15(5):2969–2976. doi:10.3892/mmr.2017.6413.
   PubMed Web of Science ®Google Scholar
• Das S, Miller M, Broide DH. Chromosome 17q21 Genes ORMDL3 and GSDMB in asthma and immune diseases. Adv Immunol. 2017;135:1–52. doi:10.1016/bs.ai.2017.06.001.
   PubMed Web of Science ®Google Scholar
• Wu X-L, Li R, Zhang H-W, et al. Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression. Exp Cell Res. 2018;372(1):43–51. doi:10.1016/j.yexcr.2018.09.008.
   PubMed Web of Science ®Google Scholar
• Liu Y, Miao Y, Gao X, et al. MicroRNA-200a affects the proliferation of airway smooth muscle cells and airway remodeling by targeting FOXC1 via the PI3K/AKT signaling pathway in ovalbumin-induced asthmatic mice. Cell Physiol Biochem. 2018;50(6):2365–2389. doi:10.1159/000495097.
   PubMedGoogle Scholar
• Lu Y, Li Z, Xie B, Song Y, Ye X, Liu P. hsa-miR-20a-5p attenuates allergic inflammation in HMC-1 cells by targeting HDAC4. Mol Immunol. 2019;107:84–90. doi:10.1016/j.molimm.2019.01.010.
   PubMed Web of Science ®Google Scholar
• Ding XQ, Wu WY, Jiao RQ, et al. Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition. Pharmacol Res. 2018;137:64–75. doi:10.1016/j.phrs.2018.09.021.
   PubMed Web of Science ®Google Scholar
• Lo W-Y, Yang W-K, Peng C-T, Pai W-Y, Wang H-J. MicroRNA-200a/200b Modulate high glucose-induced endothelial inflammation by targeting O-linked N-Acetylglucosamine transferase expression. Front Physiol. 2018;9:355–355.
   PubMed Web of Science ®Google Scholar
• Kozak J, Wdowiak P, Maciejewski R, Torres A. Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis. Mol Cell Biochem. 2019;459(1–2):21–34. doi:10.1007/s11010-019-03547-2.
   PubMed Web of Science ®Google Scholar
• Tang X, Wu F, Fan J, Jin Y, Wang J, Yang G. Posttranscriptional regulation of Interleukin-33 expression by MicroRNA-200 in bronchial asthma. Mol Ther. 2018;26(7):1808–1817. doi:10.1016/j.ymthe.2018.04.016.
   PubMed Web of Science ®Google Scholar
• Matsui S, Zhou L, Nakayama Y, et al. MiR-200b attenuates IL-6 production through IKKβ and ZEB1 in human gingival fibroblasts. Inflamm Res. 2018;67(11–12):965–973. doi:10.1007/s00011-018-1192-1.
   PubMed Web of Science ®Google Scholar
• Shen Y, Zhou M, Yan J, et al. miR-200b inhibits TNF-α-induced IL-8 secretion and tight junction disruption of intestinal epithelial cells in vitro. Am J Physiol Gastrointest Liver Physiol. 2017;312(2):G123–G132. doi:10.1152/ajpgi.00316.2016.
   PubMed Web of Science ®Google Scholar
• Sphingolipids TW. ORMDL3 and asthma: what is the evidence. Curr Opin Clin Nutr Metab Care. 2017;20(2):99–103.
   PubMed Web of Science ®Google Scholar
• James B, Milstien S, Spiegel S. ORMDL3 and allergic asthma: From physiology to pathology. J Allergy Clin Immunol. 2019;144(3):634–640. doi:10.1016/j.jaci.2019.07.023.
   PubMed Web of Science ®Google Scholar
• Gerard CR, César F, Fanny RM, Valverde MA, Rubén V. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet. 2010;19(1):111–121. doi:10.1093/hmg/ddp471.
   PubMed Web of Science ®Google Scholar
• Ono JG, Worgall TS, Worgall S. 17q21 locus and ORMDL3: an increased risk for childhood asthma. Pediatr Res. 2014;75(1–2):165–170. doi:10.1038/pr.2013.186.
   PubMed Web of Science ®Google Scholar
• Shanmuganathan S, Angayarkanni N. Chebulagic acid Chebulinic acid and Gallic acid, the active principles of Triphala, inhibit TNFα induced pro-angiogenic and pro-inflammatory activities in retinal capillary endothelial cells by inhibiting p38, ERK and NFkB phosphorylation. Vascul Pharmacol. 2018;108:23–35. doi:10.1016/j.vph.2018.04.005.
   PubMed Web of Science ®Google Scholar
• Patruno A, Ferrone A, Costantini E, et al. Extremely low-frequency electromagnetic fields accelerates wound healing modulating MMP-9 and inflammatory cytokines. Cell Prolif. 2018;51(2):e12432. doi:10.1111/cpr.12432.
   PubMed Web of Science ®Google Scholar
• Kim S-J, Pham T-H, Bak Y, Ryu H-W, Oh S-R, Yoon D-Y. Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCα/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells. Phytomedicine. 2018;50:35–42. doi:10.1016/j.phymed.2018.09.172.
   PubMed Web of Science ®Google Scholar
• Naik SP, Mahesh PA, Jeyaraj BS, Madhunapantula SV, Jahromi SR, Yadav MK. Evaluation of inflammatory markers interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) in asthma. J Asthma. 2017;54(6):584–593. doi:10.1080/02770903.2016.1244828.
   PubMed Web of Science ®Google Scholar