Effect of using acoustic flo-tone training device and its smartphone application on enhancing inhalation technique from metered-dose inhaler with spacer in asthmatic children

References

• Vrijens B, Dima AL, Van Ganse E, et al. What we mean when we talk about adherence in respiratory medicine. J Allergy Clin Immunol Pract. 2016;4(5):802–812. doi:10.1016/j.jaip.2016.05.019.
   PubMed Web of Science ®Google Scholar
• Darbà J, et al. Identification of factors involved in medication compliance: incorrect inhaler technique of asthma treatment leads to poor compliance. Patient Preference and Adherence. 2016;10:135.
   PubMed Web of Science ®Google Scholar
• Roy A, Battle K, Lurslurchachai L, et al. Inhaler device, administration technique, and adherence to inhaled corticosteroids in patients with asthma. Prim Care Respir J. 2011;20(2):148–154. doi:10.4104/pcrj.2011.00022.
   PubMedGoogle Scholar
• Al-Jahdali H, Ahmed A, Al-Harbi A, et al. Improper inhaler technique is associated with poor asthma control and frequent emergency department visits. Allergy Asthma Clin Immunol. 2013;9(1):8. doi:10.1186/1710-1492-9-8.
   PubMed Web of Science ®Google Scholar
• Hussain FN, Paravattil B. Assessment of educational inhaler technique interventions among community pharmacists: A systematic review. Integr Pharm Res Pract. 2020;9:23–31. doi:10.2147/IPRP.S239215.
   PubMed Web of Science ®Google Scholar
• Bender BG. Advancing the science of adherence measurement: implications for the clinician. J Allergy Clin Immunol Pract. 2013;1(1):92–93.
   PubMed Web of Science ®Google Scholar
• Melani AS, Bonavia M, Cilenti V, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respiratory Med. 2011;105(6):930–938. doi:10.1016/j.rmed.2011.01.005.
   PubMed Web of Science ®Google Scholar
• Williams LK, Pladevall M, Xi H, et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol. 2004;114(6):1288–1293. doi:10.1016/j.jaci.2004.09.028.
   PubMed Web of Science ®Google Scholar
• Elgendy MO, Hassan AH, Saeed H, et al. Asthmatic children and MDI verbal inhalation technique counseling. Pulmonary Pharmacol Therapeutics. 2020;61:101900. doi:10.1016/j.pupt.2020.101900.
   PubMed Web of Science ®Google Scholar
• Al-Showair RA, Pearson SB, Chrystyn H. The potential of a 2Tone Trainer to help patients use their metered-dose inhalers. Chest. 2007;131(6):1776–1782. doi:10.1378/chest.06-2765.
   PubMed Web of Science ®Google Scholar
• Nicola M, Elberry A, Sayed O, et al. The impact of adding a training device to familiar counselling on inhalation technique and pulmonary function of asthmatics. Adv Ther. 2018;35(7):1049–1058. doi:10.1007/s12325-018-0737-6.
   PubMed Web of Science ®Google Scholar
• Shareef J, Sajitha M, Shastry C. Impact of pharmacist provided patient counseling on quality of life inpatients with asthma in a tertiary care teaching hospital. Int J Pharma Res Rev. 2014;3(2):1–10.
   Google Scholar
• Tony SM, Abdelrahman MA, Osama H, et al. Advanced counselling using training device and smartphone application on inhalation technique from metered‐dose inhaler with spacer equipped with different interfaces in asthmatic children. Int J Clin Pract. 2021;75(9):e14413. doi:10.1111/ijcp.14413.
   PubMed Web of Science ®Google Scholar
• Abegaz TM, Shegena EA, Gessie NF, et al. Barriers to and competency with the use of metered dose inhaler and its impact on disease control among adult asthmatic patients in Ethiopia. BMC Pulm Med. 2020;20(1):1–13. doi:10.1186/s12890-020-1081-6.
   PubMed Web of Science ®Google Scholar
• Aydemir Y. Assessment of the factors affecting the failure to use inhaler devices before and after training. Respir Med. 2015;109(4):451–458. doi:10.1016/j.rmed.2015.02.011.
   PubMed Web of Science ®Google Scholar
• Price D, Bosnic-Anticevich S, Briggs A, Inhaler Error Steering Committee, et al. Inhaler competence in asthma: common errors, barriers to use and recommended solutions. Respir Med. 2013;107(1):37–46. doi:10.1016/j.rmed.2012.09.017.
   PubMed Web of Science ®Google Scholar
• Barry P, O'callaghan C. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol. 1995;40(1):76–78. doi:10.1111/j.1365-2125.1995.tb04538.x.
   PubMed Web of Science ®Google Scholar
• Lavorini F, Fontana GA. Targeting drugs to the airways: the role of spacer devices. Expert Opin Drug Deliv. 2009;6(1):91–102. doi:10.1517/17425240802637862.
   PubMed Web of Science ®Google Scholar
• Rau JL. Practical problems with aerosol therapy in COPD. Respir Care. 2006;51(2):158–172.
   PubMed Web of Science ®Google Scholar
• Newman SP. Spacer devices for metered dose inhalers. Clin Pharmacokinet. 2004;43(6):349–360.
   PubMed Web of Science ®Google Scholar
• Saeed H, Abdelrahim ME, Rabea H, et al. Impact of advanced patient counseling using a training device and smartphone application on asthma control. Respir Care. 2020;65(3):326–332. doi:10.4187/respcare.06903.
   PubMed Web of Science ®Google Scholar
• Scullion J. The nurse practitioners’ perspective on inhaler education in asthma and chronic obstructive pulmonary disease. Can Respir J. 2018;2018:2525319. doi:10.1155/2018/2525319.
   PubMed Web of Science ®Google Scholar
• Tony SM, Abdelrahman MA, Osama H, et al. The effect of adding a training device and smartphone application to traditional verbal counseling in asthmatic children. Pulm Ther. 2021;7(2):549–562. doi:10.1007/s41030-021-00176-3.
   PubMedGoogle Scholar
• Morton RW, Elphick HE, Craven V, et al. Aerosol therapy in asthma–why we are failing our patients and how we can do better. Front Pediatr. 2020;8:305. doi:10.3389/fped.2020.00305.
   PubMed Web of Science ®Google Scholar
• Wilkinson AJ, Anderson G. Sustainability in inhaled drug delivery. Pharmaceut Med. 2020;34(3):191–199. doi:10.1007/s40290-020-00339-8.
   PubMed Web of Science ®Google Scholar
• Jiao X, Sheng D, Zhan X, et al. The potential benefit of continuous metered‐dose inhaler inhalation technique verbal counselling on asthmatic. Int J Clin Pract. 2021;75(3):e13682. doi:10.1111/ijcp.13682.
   PubMed Web of Science ®Google Scholar
• Laube BL, et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respiratory Soc. 2011;37(6):1308–31. doi:10.1183/09031936.00166410.
   PubMed Web of Science ®Google Scholar
• Carpenter DM, Roberts CA, Sage AJ, et al. A review of electronic devices to assess inhaler technique. Curr Allergy Asthma Rep. 2017;17(3):17. doi:10.1007/s11882-017-0684-3.
   PubMed Web of Science ®Google Scholar
• Hamdan A-J, et al. Improper inhaler technique is associated with poor asthma control and frequent emergency department visits. Allergy, Asthma & Clin Immunol. 2013;9(1):1–7.
   PubMed Web of Science ®Google Scholar
• Volerman A, Balachandran U, Siros M, et al. Mask use with spacers/valved holding chambers and metered dose inhalers among children with asthma. Ann Am Thorac Soc. 2021;18(1):17–22. doi:10.1513/AnnalsATS.202005-522CME.
   PubMed Web of Science ®Google Scholar
• Gardenhire DS, et al. Aerosol Delivery Devices for Respiratory Therapists. American Association for Respiratory Care. Irving, TX: American Association for Respiratory Care; 2017:61.
   Google Scholar
• Global initiative for asthma. Global strategy for asthma management and prevention updated 2021 [Internet]. 2020. Available from: https://ginasthma.org/wp-content/uploads/2021/05/GINATitleMain-Report-2021-V2-WMS.pdf
   Google Scholar
• Broeders M. l. E. A. C, Molema J, Hop WCJ, et al. Salbutamol pMDI gives less protection to methacholine induced airway obstruction than salbutamol via spacer or DPI. Eur J Clin Pharmacol. 2005;60(12):837–841. doi:10.1007/s00228-004-0844-y.
   PubMed Web of Science ®Google Scholar
• Lavorini F, Geri P, Camiciottoli G, et al. Agreement between two methods for assessing bioequivalence of inhaled salbutamol. Pulmonary Pharmacol Therapeutics. 2008;21(2):380–384. doi:10.1016/j.pupt.2007.10.001.
   PubMed Web of Science ®Google Scholar
• Lavorini F, Geri P, Luperini M, et al. Clinical and functional responses to salbutamol inhaled via different devices in asthmatic patients with induced bronchoconstriction. Br J Clin Pharmacol. 2004;58(5):512–520. doi:10.1111/j.1365-2125.2004.02185.x.
   PubMed Web of Science ®Google Scholar
• Levy ML, Hardwell A, McKnight E, et al. Asthma patients’ inability to use a pressurised metered-dose inhaler (pMDI) correctly correlates with poor asthma control as defined by the global initiative for asthma (GINA) strategy: a retrospective analysis. Primary Care Respiratory J. 2013;22(4):406–411. doi:10.4104/pcrj.2013.00084.
   PubMedGoogle Scholar
• Salzman GA, Pyszczynski DR. Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol. 1988;81(2):424–428. doi:10.1016/0091-6749(88)90911-6.
   PubMed Web of Science ®Google Scholar
• Lavorini F, Barreto C, van Boven JFM, et al. Spacers and valved holding chambers—The risk of switching to different chambers. J Allergy Clin Immunol Pract. 2020;8(5):1569–1573. doi:10.1016/j.jaip.2019.12.035.
   PubMed Web of Science ®Google Scholar
• Newman SP, Woodman G, Clarke SW, et al. Effect of InspirEase on the deposition of metered-dose aerosols in the human respiratory tract. Chest. 1986;89(4):551–556. doi:10.1378/chest.89.4.551.
   PubMed Web of Science ®Google Scholar
• Ammari WG, et al. P100 Improving Paediatrics’ Pressurised Metered Dose Inhaler Technique and Asthma Control: Inhaler Verbal Counselling vs. Trainhaler. London, UK: BMJ Publishing Group Ltd; 2015.
   Google Scholar
• Ammari WG, Chrystyn H. Optimizing the inhalation flow and technique through metered dose inhalers of asthmatic adults and children attending a community pharmacy. J Asthma. 2013;50(5):505–513. doi:10.3109/02770903.2013.783064.
   PubMed Web of Science ®Google Scholar
• Abdelrahman MA, Saeed H, Osama H, et al. Effect of verbal counselling on metred‐dose inhaler proper use and lung function test amongst asthmatic patients: A meta‐analysis. Int J Clin Pract. 2021;75(6):e14077. doi:10.1111/ijcp.14077.
   PubMed Web of Science ®Google Scholar
• Wael W, et al. The effect of Clip-tone® and its smartphone application on optimization of metered-dose inhaler inhalation technique. Eur Respiratory Soc. 2020;56:4157. doi:10.1183/13993003.congress-2020.4157.
   Web of Science ®Google Scholar
• Haidl P, Heindl S, Siemon K, et al. Inhalation device requirements for patients’ inhalation maneuvers. Respir Med. 2016;118:65–75. doi:10.1016/j.rmed.2016.07.013.
   PubMed Web of Science ®Google Scholar
• Wael W, Sanders MJ, Hussein RRS, et al. The effect of Clip‐tone® and its smartphone application on optimisation of metered‐dose inhalers inhalation technique. Int J Clin Pract. 2021;75(6):e14088. doi:10.1111/ijcp.14088.
   PubMed Web of Science ®Google Scholar
• Fink JB, Rubin BK. Problems with inhaler use: a call for improved clinician and patient education. Respiratory Care. 2005;50(10):1360–1375.
   PubMedGoogle Scholar
• Van Holsbeke C, et al. P238 the Effect of Inhalation Duration on Lung Deposition with a Pressurised Metered-Dose Inhaler (PMDI). London, UK: BMJ Publishing Group Ltd; 2014.
   Google Scholar
• Rahmati H, et al. The effect of training inhalation technique with or without spacer on maximum expiratory flow rate and inhaler usage skills in asthmatic patients: a randomized controlled trial. Int J Community Based Nursing and Midwifery. 2014;2(4):211.
   PubMedGoogle Scholar
• Nicola M, Soliman YM, Hussein R, et al. Comparison between traditional and nontraditional add-on devices used with pressurised metered-dose inhalers. ERJ Open Res. 2020;6(4):00073-2020. doi:10.1183/23120541.00073-2020.
   PubMedGoogle Scholar
• Saeed H, Salem HF, Rabea H, et al. Effect of human error, inhalation flow, and inhalation volume on dose delivery from Ellipta® dry-powder inhaler. J Pharm Innov. 2019;14(3):239–244. doi:10.1007/s12247-018-9352-y.
   Web of Science ®Google Scholar
• Gillette C, Rockich-Winston N, Kuhn JA, et al. Inhaler technique in children with asthma: a systematic review. Acad Pediatr. 2016;16(7):605–615. doi:10.1016/j.acap.2016.04.006.
   PubMed Web of Science ®Google Scholar
• Elgendy MO, Abdelrahim ME, Eldin RS. Potential benefit of repeated MDI inhalation technique counselling for patients with asthma. Eur J Hosp Pharm. 2015;22(6):318–322. doi:10.1136/ejhpharm-2015-000648.
   Google Scholar
• Harb HS, Ibrahim Laz N, Rabea H, et al. Determinants of incorrect inhaler technique in chronic obstructive pulmonary disease patients. Int J Clin Pract. 2021;75(6):e14073. doi:10.1111/ijcp.14073.
   PubMed Web of Science ®Google Scholar
• Manavathongchai M, Jaruchanapongtorn T, Suwan P. Prevalence and risk factors of incorrect inhaler technique in asthmatic children at Faculty of Medicine Vajira Hospital. Vajira Med J: J Urban Med. 2018;62(5):345–356.
   Google Scholar
• Deerojanawong J, Promsaka na Sakolnakorn V, Prapphal N, et al. Evaluation of metered-dose inhaler administration technique among asthmatic children and their caregivers in Thailand. Asian Pac J Allergy Immunol. 2009;27(2-3):87–93.
   PubMed Web of Science ®Google Scholar
• Ernst P. Inhaled drug delivery: a practical guide to prescribing inhaler devices. Can Respir J. 1998;5(3):180–183. doi:10.1155/1998/802829.
   PubMedGoogle Scholar
• Nicola M, Elberry AA, Sayed OM, et al. Effect of DPI's training-device on inhalation technique and clinical efficacy in asthmatics. Beni-Suef Univ J Basic and Appl Sci. 2018;7(2):178–183. doi:10.1016/j.bjbas.2017.10.005.
   Google Scholar
• Everard ML, Devadason SG, Summers QA, et al. Factors affecting total and” respirable” dose delivered by a salbutamol metered dose inhaler. Thorax. 1995;50(7):746–749. doi:10.1136/thx.50.7.746.
   PubMed Web of Science ®Google Scholar
• Nides MA, Tashkin DP, Simmons MS, et al. Improving inhaler adherence in a clinical trial through the use of the nebulizer chronolog. Chest. 1993;104(2):501–507. doi:10.1378/chest.104.2.501.
   PubMed Web of Science ®Google Scholar
• O'Callaghan C, Lynch J, Cant M, et al. Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug. Thorax. 1993;48(6):603–606. doi:10.1136/thx.48.6.603.
   PubMed Web of Science ®Google Scholar
• Ellepola A, Samaranayake L. Inhalational and topical steroids, and oral candidosis: a mini review. Oral Dis. 2001;7(4):211–216. doi:10.1034/j.1601-0825.2001.70402.x.
   PubMed Web of Science ®Google Scholar
• Thomas MS, Parolia A, Kundabala M, et al. Asthma and oral health: a review. Aust Dent J. 2010;55(2):128–133. doi:10.1111/j.1834-7819.2010.01226.x.
   PubMed Web of Science ®Google Scholar
• Chellaih P, et al. Effect of anti-asthmatic drugs on dental health: A comparative study. J Pharmacy & Bioallied Sci. 2016;8(Suppl 1):S77.
   PubMedGoogle Scholar
• Konde S, Agarwal M, Chaurasia R. Effects of inhalational anti-asthmatic medications on oral health between 7 and 14 years of age. Indian J Allergy Asthma Immunol. 2018;32(2):70. doi:10.4103/ijaai.ijaai_16_18.
   Google Scholar
• Fukushima C, Matsuse H, Tomari S, et al. Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone. Ann Allergy Asthma Immunol. 2003;90(6):646–651. doi:10.1016/S1081-1206(10)61870-4.
   PubMed Web of Science ®Google Scholar
• Lee JY, Her Y, Kim CW, et al. Topical corticosteroid phobia among parents of children with atopic eczema in Korea. Ann Dermatol. 2015;27(5):499–506. doi:10.5021/ad.2015.27.5.499.
   PubMed Web of Science ®Google Scholar
• Klok T, Kaptein AA, Duiverman EJ, et al. Long-term adherence to inhaled corticosteroids in children with asthma: observational study. Respir Med. 2015;109(9):1114–1119. doi:10.1016/j.rmed.2015.07.016.
   PubMed Web of Science ®Google Scholar
• Amer O, Morsy S. Underuse of controller medications in Egyptian asthmatic children. Egyptian J Pediatric Allergy and Immunol (the). 2013;11(1):29–34.
   Google Scholar
• Parikh K, Paul J, Fousheé N, et al. Barriers and facilitators to asthma care after hospitalization as reported by caregivers, health providers, and school nurses. Hosp Pediatr. 2018;8(11):706–717. doi:10.1542/hpeds.2017-0182.
   PubMedGoogle Scholar
• Desai M, Oppenheimer JJ. Medication adherence in the asthmatic child and adolescent. Curr Allergy Asthma Rep. 2011;11(6):454–464. doi:10.1007/s11882-011-0227-2.
   PubMed Web of Science ®Google Scholar
• Costello RW, Foster JM, Grigg J, Respiratory Effectiveness Group, et al. The seven stages of man: the role of developmental stage on medication adherence in respiratory diseases. J Allergy Clin Immunol Pract. 2016;4(5):813–820.
   PubMed Web of Science ®Google Scholar