The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice

References

• Clark R, Fisher JE, Sketris IS, Johnston GM. Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study. BMC Clin Pharmacol. 2012;12:11. doi:10.1186/1472-6904-12-11.
   PubMedGoogle Scholar
• Herndon CM, Dankenbring DM. Patient perception and knowledge of acetaminophen in a large family medicine service. J Pain Palliat Care Pharmacother. 2014;28(2):109–116. doi:10.3109/15360288.2014.908993.
   PubMedGoogle Scholar
• Michna E, Duh MS, Korves C, Dahl JL. Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications. Pain Med. 2010;11(3):369–378. doi:10.1111/j.1526-4637.2010.00811.x.
   PubMed Web of Science ®Google Scholar
• Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev. 2012;44:88–106. doi:10.3109/03602532.2011.602688.
   PubMed Web of Science ®Google Scholar
• McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest. 2012;122(4):1574–1583. doi:10.1172/JCI59755.
   PubMed Web of Science ®Google Scholar
• Yuan L, Kaplowitz N. Mechanisms of drug-induced liver injury. Clin Liver Dis. 2013;17:507–518. doi:10.1016/j.cld.2013.07.002.
   PubMed Web of Science ®Google Scholar
• McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30:2174–2187. doi:10.1007/s11095-013-1007-6.
   PubMed Web of Science ®Google Scholar
• Jaeschke H, Williams CD, Ramachandran A, Bajt ML. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int. 2012;32(1):8–20. doi:10.1111/j.1478-3231.2011.02501.x.
   PubMed Web of Science ®Google Scholar
• Knight TR, Kurtz A, Bajt ML, et al. Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol Sci. 2001;62(2):212–220. doi:10.1093/toxsci/62.2.212.
   PubMed Web of Science ®Google Scholar
• Taylor AL, Watson CJE, Bradley JA. Immunosupressive agents in solid organ transplantation: mechanism of action and therapeutic efficacy. Crit Rev Oncol Hematol. 2005;56(1):23–46. doi:10.1016/j.critrevonc.2005.03.012.
   PubMed Web of Science ®Google Scholar
• Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. 2003;304(3):463–470. doi:10.1016/S0006-291X(03)00618-1.
   PubMed Web of Science ®Google Scholar
• Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmcol Exp Ther. 1973;187:185–194.
   PubMed Web of Science ®Google Scholar
• Larson AM, Polson J, Fontana RJ, et al. Acetaminophen induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42:1364–1372. doi:10.1002/hep.20948.
   PubMed Web of Science ®Google Scholar
• James LP, Mayeux PR, Hınson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos. 2003;31(12):1499–1506. doi:10.1124/dmd.31.12.1499.
   PubMed Web of Science ®Google Scholar
• Davis DC, Potter WZ, Jollow DJ, Mitchell JR. Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. Life Sci. 1974;14:2099–2109. doi:10.1016/0024-3205(74)90092-7.
   PubMed Web of Science ®Google Scholar
• Mitchell JR, Jollow DJ, Potter WZ, et al. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther. 1973;187(1):211–217.
   PubMed Web of Science ®Google Scholar
• Walker RM, Racz WJ, McElligott TF. Acetaminophen-induced hepatotoxicity in mice. Lab Invest. 1980;42:181–189.
   PubMed Web of Science ®Google Scholar
• Elbe H, Gul M, Cetin A, et al. Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: role of iNOS expression. Ultrastruct Pathol. 2017;42(1):39–48. doi:10.1080/01913123.2017.1374313.
   PubMed Web of Science ®Google Scholar
• Abdel-Zaher A, Abdel-Hady R, Mahmoud M, et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicol. 2008;243:261–270.
   PubMed Web of Science ®Google Scholar
• Elshazly S, Moselhy M, Barakat W. Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity. Eur J Pharmacol. 2014;726:116–123. doi:10.1016/j.ejphar.2014.01.042.
   PubMed Web of Science ®Google Scholar
• Ilic S, Drmic D, Zarkovic K, et al. High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736). J Physiol Pharmacol. 2010;61(2):241–250.
   PubMed Web of Science ®Google Scholar
• Mahmoud Y, Mahmoud AA. Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: nicotinamide effect in acetaminophen-damaged liver. Exp Toxicol Pathol. 2016;68(6):345–354. doi:10.1016/j.etp.2016.05.003.
   PubMedGoogle Scholar
• Jaeschke J, Gujral JS, Bajt ML. Apoptosis and necrosis in liver disease. Liver Int. 2004;24:85–89. doi:10.1111/j.1478-3231.2004.0906.x.
   PubMed Web of Science ®Google Scholar
• Atlas SM, Farber E. On the molecular weight of cytochrome c from mammalian heart muscle. J Biol Chem. 1955;219:31–37.
   Web of Science ®Google Scholar
• Marchetti P, Castedo M, Susin SA, et al. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med. 1996;184(3):1155–1160.
   PubMed Web of Science ®Google Scholar
• Ben-Ari Z, Schmilovotz-Weiss H, Belinki A, et al. Circulating soluble cytochrome c in liver disease as a marker of apoptosis. J Intern Med. 2003;254:168–175. doi:10.1046/j.1365-2796.2003.01171.x.
   PubMed Web of Science ®Google Scholar
• Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol. 2007;47:143–183. doi:10.1146/annurev.pharmtox.47.120505.105122.
   PubMed Web of Science ®Google Scholar
• Schild L, Keilhoff G, Augustin W, et al. Distinct Ca2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria. Faseb J. 2001;15(3):565–567. doi:10.1096/fj.00-0551fje.
   PubMed Web of Science ®Google Scholar
• Miller TJ, Knapton A, Adeyemo O, Noory L, Weaver J, Hanig JP. Cytochrome c: a non-invasive biomarker of drug-induced liver injury. J Appl Toxicol. 2008;28(7):815–828. doi:10.1002/jat.1347.
   PubMed Web of Science ®Google Scholar
• Hinson JA, Michael SL, Ault SG, et al. Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice. Toxicol Sci. 2000;53(2):467–473. doi:10.1093/toxsci/53.2.467.
   PubMed Web of Science ®Google Scholar
• Hinson JA, Pike SL, Pumford NR, Mayeux PR. Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol. 1998;11:604–607. doi:10.1021/tx9800349.
   PubMed Web of Science ®Google Scholar
• Michael SL, Mayeux PR, Bucci TJ, et al. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide. 2001;5(5):432–441. doi:10.1006/niox.2001.0385.
   PubMed Web of Science ®Google Scholar
• Ersoy O. Karaciğer Enzim Yüksekliğinin Değerlendirilmesi. Ankara Med J. 2012;12:129–135.
   Google Scholar
• Atteya M, Ahmed AM, AlRabiah A. Thymoquinone and curcumin modify inducible nitric oxide synthase, caspase 3, and thioredoxin immunohistochemical expression in acetaminophen hepatotoxicity. Folia Morphol. 2019;78(4):773–788. doi:10.5603/FM.a2019.0027.
   PubMed Web of Science ®Google Scholar
• Prescott LF. Paracetamol, alcohol and the liver. Br J Clin Pharmacol. 2000;49(4):291–301. doi:10.1046/j.1365-2125.2000.00167.x.
   PubMed Web of Science ®Google Scholar
• Sener G, Toklu HZ, Sehirli AO, Velioglu-Ogunc A, Cetinel S, Gedik N. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res. 2006;35(1):62–68. doi:10.1016/j.hepres.2006.02.005.
   PubMed Web of Science ®Google Scholar
• Wang Y, Jiang Y, Fan X, et al. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways. Toxicol Lett. 2015;236(2):82–89. doi:10.1016/j.toxlet.2015.05.001.
   PubMed Web of Science ®Google Scholar