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Ultrastructural Pathology Volume 45, 2021 - Issue 1
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BASIC RESEARCH

Smoking effect on the ultrastructural properties of cultured lung myofibroblasts

Siri Lehtonena Department of Obstetrics and Gynecology, PEDEGO Research Unit and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, FinlandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5578-8232View further author information
ORCID Icon,
Ninni-Ingrid Nurmosb Research Unit of Internal Medicine and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, FinlandView further author information
,
Henna M Karvonenb Research Unit of Internal Medicine and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, FinlandView further author information
,
Elisa Lappi-Blancoc Department of Pathology, Cancer and Translational Medicine Research Unit, University of Oulu and Oulu University Hospital, Oulu, FinlandView further author information
,
Terttu Harjub Research Unit of Internal Medicine and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, FinlandView further author information
,
Magnus Sköldd Respiratory Medicine Unit, Department of Medicine Solna and Centre for Molecular Medicine, Karolinska Institutet and Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, SwedenView further author information
&
Riitta Kaarteenahob Research Unit of Internal Medicine and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, FinlandView further author information
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Pages 37-48 | Received 25 Aug 2020, Accepted 27 Nov 2020, Published online: 30 Dec 2020

References

  • Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur.Respir.J. 2003;22(4):672–688. doi:10.1183/09031936.03.00040703.
  • Burgess JK, Mauad T, Tjin G, Karlsson JC, Westergren-Thorsson G. The extracellular matrix - the under-recognized element in lung disease? J.Pathol. 2016;240(4):397–409. doi:10.1002/path.4808.
  • Hussell T, Lui S, Jagger C, Morgan D, Brand O. The consequence of matrix dysfunction on lung immunity and the microbiome in COPD. Eur.Respir.Rev. 2018;27(148):180032. doi:10.1183/16000617.0032-2018. Print 2018 Jun 30.
  • Annoni R, Lancas T, Yukimatsu Tanigawa R, et al. Extracellular matrix composition in COPD. Eur.Respir.J. 2012;40(6):1362–1373. doi:10.1183/09031936.00192611.
  • Gabbiani G, Ryan GB, Majne G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia. 1971;27(5):549–550. doi:10.1007/BF02147594.
  • Klingberg F, Hinz B, White ES. The myofibroblast matrix: implications for tissue repair and fibrosis. J.Pathol. 2013;229:298–309.
  • Darby IA, Zakuan N, Billet F, Desmouliere A. The myofibroblast, a key cell in normal and pathological tissue repair. Cell Mol.Life Sci. 2016;73(6):1145–1157. doi:10.1007/s00018-015-2110-0.
  • Eyden B. The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. J.Cell.Mol.Med. 2008;12(1):22–37. doi:10.1111/j.1582-4934.2007.00213.x.
  • Singer II, Kazazis DM, Kawka DW. Localization of the fibronexus at the surface of granulation tissue myofibroblasts using double-label immunogold electron microscopy on ultrathin frozen sections. Eur.J.Cell Biol. 1985;38:94–101.
  • Eyden B. The fibronexus in reactive and tumoral myofibroblasts: further characterisation by electron microscopy. Histol.Histopathol. 2001;16:57–70.
  • Singer II, Kawka DW, Kazazis DM, Clark RA. In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface. J.Cell Biol. 1984;98(6):2091–2106. doi:10.1083/jcb.98.6.2091.
  • Karvonen HM, Lehtonen ST, Sormunen RT, et al. Myofibroblasts in interstitial lung diseases show diverse electron microscopic and invasive features. Lab.Invest. 2012;92(9):1270–1284. doi:10.1038/labinvest.2012.95.
  • Karvonen HM, Lehtonen ST, Sormunen RT, Lappi-Blanco E, Skold CM, Kaarteenaho RL. Lung cancer-associated myofibroblasts reveal distinctive ultrastructure and function. J.Thorac.Oncol. 2014;9(5):664–674. doi:10.1097/JTO.0000000000000149.
  • Karvonen HM, Lehtonen ST, Harju T, et al. Myofibroblast expression in airways and alveoli is affected by smoking and COPD. Respir.Res. 2013;14(1):84. doi:10.1186/1465-9921-14-84.
  • Lofdahl M, Kaarteenaho R, Lappi-Blanco E, Tornling G, Skold MC. Tenascin-C and alpha-smooth muscle actin positive cells are increased in the large airways in patients with COPD. Respir.Res. 2011;12(1):48. doi:10.1186/1465-9921-12-48.
  • Harju T, Kinnula VL, Paakko P, Salmenkivi K, Risteli J, Kaarteenaho R. Variability in the precursor proteins of collagen I and III in different stages of COPD. Respir.Res. 2010;11(1):165. doi:10.1186/1465-9921-11-165.
  • Hallgren O, Rolandsson S, Andersson-Sjoland A, et al. Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients. J.Transl.Med. 2012;10(1):171. doi:10.1186/1479-5876-10-171.
  • Lehtonen ST, Karvonen HM, Harju T, et al. Stromal cells can be cultured and characterized from diagnostic bronchoalveolar fluid samples obtained from patients with various types of interstitial lung diseases. APMIS. 2014;122(4):301–316. doi:10.1111/apm.12146.
  • Kaarteenaho-Wiik R, Paakko P, Sormunen R. Ultrastructural features of lung fibroblast differentiation into myofibroblasts. Ultrastruct.Pathol. 2009;33(1):6–15. doi:10.1080/01913120802608430.
  • D’Anna C, Cigna D, Di Sano C, et al. Exposure to cigarette smoke extract and lipopolysaccharide modifies cytoskeleton organization in bronchial epithelial cells. Exp.Lung Res. 2017;43(9–10):347–358. doi:10.1080/01902148.2017.1377784.
  • Schneider DJ, Speth JM, Penke LR, Wettlaufer SH, Swanson JA, Peters-Golden M. Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication. J.Biol.Chem. 2017;292(51):20897–20910. doi:10.1074/jbc.M117.792416.
  • Eyden BP. Brief review of the fibronexus and its significance for myofibroblastic differentiation and tumor diagnosis. Ultrastruct.Pathol. 1993;17(6):611–622. doi:10.3109/01913129309027797.
  • Eyden B. Fibronexus junctions associated with in vivo human endothelium. Ultrastruct.Pathol. 2009;33(1):28–32. doi:10.1080/01913120802625822.

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