Therapeutic Effects and Uses of Ozone in Dentistry: A Systematic Review

References

• Al Habashneh, R, W Alsalman, and Y. Khader. 2015. “Ozone as an Adjunct to Conventional Nonsurgical Therapy in Chronic Periodontitis: A Randomized Controlled Clinical Trial.” Journal of Periodontal Research Khader 50 (1): 37–43. doi:10.1111/jre.12177
   PubMed Web of Science ®Google Scholar
• Al-Omiri, M. K., R. S. Abul Hassan, B. K. AlZarea, and E. Lynch. 2016. “Improved Tooth Bleaching Combining Ozone and Hydrogen peroxide–A Blinded Study.” Journal of Dentistry 46:30–35. doi: 10.1016/j.jdent.2016.01.010
   PubMed Web of Science ®Google Scholar
• Al-Omiri, M. K., N. M. Alqahtani, N. M. Alahmari, R. A. Hassan, A. A. Al Nazeh, and E. Lynch. 2021. “Treatment of Symptomatic, Deep, Almost Cariously Exposed Lesions Using Ozone.” Scientific Reports 11 (1): 11166. doi:10.1038/s41598-021-90824-0.
   PubMed Web of Science ®Google Scholar
• Al-Omiri, M. K., H. A. Lamfon, A. A. Al Nazeh, A. M. Kielbassa, and E. Lynch. 2018. “Randomized Clinical Trial on the Comparison of Bleaching Outcomes Using either Ozone or Hydrogen Peroxide.” Quintessence International 49 (8): 625–34. doi:10.3290/j.qi.a40783.
   PubMed Web of Science ®Google Scholar
• Al-Omiri, Mahmoud K, S Ra’ed, Bader K AlZarea, and Edward. 2016. “Effects of Combining Ozone and Hydrogren Peroxide on Tooth Bleaching: A Clinical Study.” Journal of Dentistry Lynch 53:88–93. doi: 10.1016/j.jdent.2016.08.002.
   PubMed Web of Science ®Google Scholar
• Baysan, A., and D. Beighton. 2007. “Assessment of the ozone-mediated Killing of Bacteria in Infected Dentine Associated with non-cavitated Occlusal Carious Lesions.” Caries Research 41 (5): 337–41. doi:10.1159/000104790.
   PubMed Web of Science ®Google Scholar
• Celakil, T., A. Muric, B. Gokcen Roehlig, G. Evlioglu, and H. Keskin. 2017. “Effect of high-frequency bio-oxidative Ozone Therapy for Masticatory Muscle Pain: A double-blind Randomised Clinical Trial.” Journal of Oral Rehabilitation 44 (6): 442–51. doi:10.1111/joor.12506.
   PubMed Web of Science ®Google Scholar
• Das, Sushma. 2011. “Application of Ozone Therapy in Dentistry.” Indian Journal of Dental 3 (2): 538–42.
   Google Scholar
• Dhingra, K., and K. L. Vandana. 2011. “Management of Gingival Inflammation in Orthodontic Patients with Ozonated Water irrigation–a Pilot Study.” International Journal of Dental Hygiene 9 (4): 296–302. doi:10.1111/j.1601-5037.2011.00506.x.
   PubMed Web of Science ®Google Scholar
• Domb, WC. 2014. “Ozone Therapy in Dentistry: A Brief Review for Physicians.” Interventional Neuroradiology 20 (5): 632–36. doi:10.15274/INR-2014-10083
   PubMed Web of Science ®Google Scholar
• Duggal, M. S., A. Nikolopoulou, and J. F. Tahmassebi. 2012. “The Additional Effect of Ozone in Combination with Adjunct Remineralisation Products on Inhibition of Demineralisation of the Dental Hard Tissues in Situ.” Journal of Dentistry 40 (11): 934–40. doi:10.1016/j.jdent.2012.07.012.
   PubMed Web of Science ®Google Scholar
• Durmus, N., Y. T. Tok, S. Kaya, and M. Akcay. 2019. “Effectiveness of the Ozone Application in two-visit Indirect Pulp Therapy of Permanent Molars with Deep Carious Lesion: A Randomized Clinical Trial.” Clinical Oral Investigations 23 (10): 3789–99. doi:10.1007/s00784-019-02808-0.
   PubMed Web of Science ®Google Scholar
• Eldien, AM, and Nadia Fathy Hassabou. 2022. “Clinical and Cytological Assessment of platelet-rich Fibrin versus Topical Ozonated Oil in Palatal Wound Healing after Free Gingival Graft Harvesting: Randomized Controlled Trial.” Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 34 (3): 343–51. doi:10.1016/j.ajoms.2021.10.006.
   Web of Science ®Google Scholar
• Filippi, Andreas. 2001. “The Influence Of Ozonised Water On The Epithelial Wound Healing Process In The Oral Cavity.” Dtsch Zahnarztl 56.
   Google Scholar
• Filippi, A. 2002. “Water Disinfection of Dental Units Using Ozone – Microbiological Results after 11 Years and Technical Problems.” Ozone: Science & Engineering 24 (6): 479–83. doi:10.1080/01919510208901637.
   Web of Science ®Google Scholar
• Goztas, Z., H. Onat, G. Tosun, Y. Sener, and H. H. HadimLi. 2014. “Antimicrobial Effect of Ozonated Water, Sodium Hypochlorite and Chlorhexidine Gluconate in Primary Molar Root Canals.” European Journal of Dentistry 8 (4): 469–74. doi:10.4103/1305-7456.143627.
   PubMedGoogle Scholar
• Grocholewicz, K., G. Matkowska-Cichocka, P. Makowiecki, A. Drozdzik, H. Ey-Chmielewska, A. Dziewulska, M. Tomasik, G. Trybek, and J. Janiszewska-Olszowska. 2020. “Effect of nano-hydroxyapatite and Ozone on Approximal Initial Caries: A Randomized Clinical Trial.” Scientific Reports 10 (1): 11192. doi:10.1038/s41598-020-67885-8.
   PubMed Web of Science ®Google Scholar
• Hauser-Gerspach, I., V. Pfaffli-Savtchenko, J. E. Dahnhardt, J. Meyer, and A. Lussi. 2009. “Comparison of the Immediate Effects of Gaseous Ozone and Chlorhexidine Gel on Bacteria in Cavitated Carious Lesions in Children in Vivo.” Clinical Oral Investigations 13 (3): 287–91. doi:10.1007/s00784-008-0234-4.
   PubMed Web of Science ®Google Scholar
• Hayakumo, S., S. Arakawa, Y. Mano, and Y. Izumi. 2013. “Clinical and Microbiological Effects of Ozone nano-bubble Water Irrigation as an Adjunct to Mechanical Subgingival Debridement in Periodontitis Patients in a Randomized Controlled Trial.” Clinical Oral Investigations 17 (2): 379–88. doi:10.1007/s00784-012-0711-7.
   PubMed Web of Science ®Google Scholar
• Isler S Cagri, Uraz A, Guler B, Ozdemir Y, Cula S and Cetiner D. (2018). Effects of Laser Photobiomodulation and Ozone Therapy on Palatal Epithelial Wound Healing and Patient Morbidity. Photomedicine and Laser Surgery, 36(11), 571–580. 10.1089/pho.2018.4492
   PubMed Web of Science ®Google Scholar
• Johansson, E., J. W. van Dijken, L. Karlsson, and I. Andersson-Wenckert. 2014. “Treatment Effect of Ozone and Fluoride Varnish Application on Occlusal Caries in Primary Molars: A 12-month Study.” Clinical Oral Investigations 18 (7): 1785–92. doi:10.1007/s00784-013-1160-7.
   PubMed Web of Science ®Google Scholar
• Krunić, Jelena, Nikola Stojanović, Ljiljana Đukić, Jelena Roganović, Branka Popović, Ivana Simić, and D Stojić. 2019. “Clinical Antibacterial Effectiveness and Biocompatibility of Gaseous Ozone after Incomplete Caries Removal.” Clinical Oral Investigations 23 (2): 785–92. doi:10.1007/s00784-018-2495-x
   PubMed Web of Science ®Google Scholar
• Kucuk, F., S. Yildirim, and S. Cetiner. 2021. “Cytotoxicity Assessment of Different Doses of Ozonated Water on Dental Pulp Cells.” BMC Oral Health 21 (1): 32. doi:10.1186/s12903-021-01392-8.
   PubMed Web of Science ®Google Scholar
• Küçük, Ferdiye, Sibel Yıldırım, and S Çetiner. 2021. “Cytotoxicity Assessment of Different Doses of Ozonated Water on Dental Pulp Cells.” BMC Oral Health 21 (1): 1–7. doi:10.1186/s12903-021-01392-8
   PubMed Web of Science ®Google Scholar
• Lubojanski, A., M. Dobrzynski, N. Nowak, J. Rewak-Soroczynska, K. Sztyler, W. Zakrzewski, W. Dobrzynski, M. Szymonowicz, Z. Rybak, K. Wiglusz, et al. 2021a. “Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.” Nanomaterials (Basel) 11 (2). doi:10.3390/nano11020259.
   Google Scholar
• Lubojanski, A, M Dobrzynski, N Nowak, J Rewak-Soroczynska, K Sztyler, W Zakrzewski, W Dobrzynski, M Szymonowicz, Z Rybak, K Wiglusz, et al. 2021b. “Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.” Nanomaterials (Basel, Switzerland) 11 (2): 259. doi:10.3390/nano11020259
   PubMedGoogle Scholar
• Manton, D. J., R. Bhide, M. S. Hopcraft, and E. C. Reynolds. 2008. “Effect of Ozone and Tooth Mousse TM on the Efficacy of Peroxide Bleaching.” Australian Dental Journal 53 (2): 128–32. doi:10.1111/j.1834-7819.2008.00021.x.
   PubMed Web of Science ®Google Scholar
• Matys, J., E. Jaszczak, R. Flieger, K. Kostrzewska-Kaminiarz, K. Grzech-Lesniak, and M. Dominiak. 2020. “Effect of Ozone and Diode Laser (635 Nm) in Reducing Orthodontic Pain in the Maxillary arch-a Randomized Clinical Controlled Trial.” Lasers in Medical Science 35 (2): 487–96. doi:10.1007/s10103-019-02896-0.
   PubMed Web of Science ®Google Scholar
• Naik, S. V., R. K, S. Kohli, S. Zohabhasan, and S. Bhatia. 2016. “Ozone- A Biological Therapy in Dentistry- Reality or Myth?????” The Open Dentistry Journal 10:196–206. doi: 10.2174/1874210601610010196
   PubMedGoogle Scholar
• Nicolini, A. C., I. D. S. Rotta, G. P. J. Langa, S. A. Friedrich, D. A. Arroyo-Bonilla, M. C. Wagner, P. Weidlich, C. K. Rosing, and J. Cavagni. 2021. “Efficacy of Ozonated Water Mouthwash on Early Plaque Formation and Gingival Inflammation: A Randomized Controlled Crossover Clinical Trial.” Clinical Oral Investigations 25 (3): 1337–44. doi:10.1007/s00784-020-03441-y.
   PubMed Web of Science ®Google Scholar
• Noites, R., C. Pina-Vaz, R. Rocha, M. F. Carvalho, A. Goncalves, and I. Pina-Vaz. 2014. “Synergistic Antimicrobial Action of Chlorhexidine and Ozone in Endodontic Treatment.” BioMed Research International 2014:592423. doi: 10.1155/2014/592423
   PubMed Web of Science ®Google Scholar
• Polydorou, O., A. Halili, A. Wittmer, K. Pelz, and P. Hahn. 2012. “The Antibacterial Effect of Gas Ozone after 2 months of in Vitro Evaluation.” Clinical Oral Investigations 16 (2): 545–50. doi:10.1007/s00784-011-0524-0.
   PubMed Web of Science ®Google Scholar
• Raafat Abdelaziz, R., R. S. Mosallam, and M. M. Yousry. 2011. “Tubular Occlusion of Simulated Hypersensitive Dentin by the Combined Use of Ozone and Desensitizing Agents.” Acta Odontologica Scandinavica 69 (6): 395–400. doi:10.3109/00016357.2011.572290.
   PubMed Web of Science ®Google Scholar
• Rodrigues, P. C., J. B. Souza, C. J. Soares, L. G. Lopes, and C. Estrela. 2011. “Effect of Ozone Application on the resin-dentin Microtensile Bond Strength.” Operative Dentistry 36 (5): 537–44. doi:10.2341/10-062-L.
   PubMed Web of Science ®Google Scholar
• Rowen, R. J. 2019. “Ozone and Oxidation Therapies as a Solution to the Emerging Crisis in Infectious Disease Management: A Review of Current Knowledge and Experience.” Medical Gas Research 9 (4): 232–37. doi:10.4103/2045-9912.273962.
   PubMed Web of Science ®Google Scholar
• Sadatullah S, Mohamed N Himazian and Razak F Abdul. (2012). The antimicrobial effect of 0.1 ppm ozonated water on 24-hour plaque microorganisms in situ. Braz. oral res., 26(2), 126–131. 10.1590/S1806-83242012000200007
   PubMed Web of Science ®Google Scholar
• Safwat, O., M. Elkateb, K. Dowidar, H. A. Salam, and O. El Meligy. 2018. “Microbiological Evaluation of Ozone on Dentinal Lesions in Young Permanent Molars Using the Stepwise Excavation.” Journal of Clinical Pediatric Dentistry 42 (1): 11–20. doi:10.17796/1053-4628-42.1.3.
   PubMed Web of Science ®Google Scholar
• Suh, Y., S. Patel, R. Kaitlyn, J. Gandhi, G. Joshi, N. L. Smith, and S. A. Khan. 2019. “Clinical Utility of Ozone Therapy in Dental and Oral Medicine.” Medical Gas Research 9 (3): 163–67. doi:10.4103/2045-9912.266997.
   PubMed Web of Science ®Google Scholar
• Torabzadeh H, Jamali M, Razmavar S, Baghban A, Zanjani V and Ghasemi A. (2015). Bleaching effect of ozone on pigmented teeth. Dent Res J, 12(1), 20 10.4103/1735-3327.150295
   PubMedGoogle Scholar
• Uraz, A., B. Karaduman, S. C. Isler, S. Gonen, and D. Cetiner. 2019. “Ozone Application as Adjunctive Therapy in Chronic Periodontitis: Clinical, Microbiological and Biochemical Aspects.” Journal of Dental Sciences 14 (1): 27–37. doi:10.1016/j.jds.2018.06.005.
   PubMed Web of Science ®Google Scholar
• Ximenes, M., M. Cardoso, F. Astorga, R. Arnold, L. A. Pimenta, and R. S. Viera. 2017. “Antimicrobial Activity of Ozone and NaF-chlorhexidine on Early Childhood Caries.” Brazilian Oral Research 31:e2. doi: 10.1590/1807-3107BOR-2017.vol31.0002
   PubMed Web of Science ®Google Scholar
• Yilmaz, S., S. Algan, H. Gursoy, U. Noyan, B. E. Kuru, and T. Kadir. 2013. “Evaluation of the Clinical and Antimicrobial Effects of the Er:YAG Laser or Topical Gaseous Ozone as Adjuncts to Initial Periodontal Therapy.” Photomedicine and Laser Surgery 31 (6): 293–98. doi:10.1089/pho.2012.3379.
   PubMed Web of Science ®Google Scholar
• Zhang, J. J., Y. Wei, and Z. Fang. 2019. “Ozone Pollution: A Major Health Hazard Worldwide.” Frontiers in Immunology 10:2518. doi: 10.3389/fimmu.2019.02518
   PubMed Web of Science ®Google Scholar