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Original Articles

Oral Bioavailability of Flutamide from 1‐O‐Alkylglycerol Stabilized o/w Nanoemulsions

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Pages 1254-1261 | Received 26 Oct 2006, Accepted 05 Nov 2006, Published online: 23 Dec 2010

References

  • Benet , L. Z. , Wu , C.‐Y. , Hebert , M. F. and Wacher , V. J. 1996 . Intestinal drug metabolism and anti‐transport processes: a potential paradigm shift in oral drug delivery . J. Control. Release , 39 : 139 – 143 .
  • Wacher , V. J. , Salphati , L. and Benet , L. Z. 1996 . Active secretion and enterocytic drug metabolism barriers to drug absorption . Adv. Drug Del. Rev. , 20 : 99 – 112 .
  • LianDong , H. , Xing , T. and FuDe , C. 2004 . Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs . J. Pharm. Pharmacol. , 9 : 1527 – 1535 .
  • Pandey , R. , Sharma , S. and Khuller , G. K. 2005 . Oral solid lipid nanoparticle‐based antitubercular chemotherapy . Tuberculosis (Edinb). , 85 : 415 – 420 .
  • Lamprecht , A. , Saumet , J. L. , Roux , J. and Benoit , J. P. 2004 . Lipid nanocarriers as drug delivery system for ibuprofen in pain treatmetn . Int. J. Pharm. , 278 : 407 – 414 .
  • Prego , C. , Fabre , M. , Torres , D. and Alonso , M. J. 2006 . Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery . Pharm. Res. , 23 : 549 – 556 .
  • Rubinstein , A. , Pathak , Y. V. , Kleinstern , J. , Reches , A. and Benita , S. 1991 . In vitro release and intestinal absorption of physostigmine salicylate from submicron emulsion . J. Pharm. Sci. , 80 : 643 – 647 .
  • Myers , R. A. and Stella , V. J. 1992 . Systemic bioavailability of penclomedine (NSC‐ 338720) from oil‐in‐water emulsion administered intraduodenally to rats . Int. J. Pharm. , 78 : 217 – 226 .
  • Nicolaos , G. , Crauste‐Manciet , S. , Farinotti , R. and Brossard , D. 2003 . Improvement of cefpodoxime proxetil absorption in rats by an oil‐in‐water submicron emulsion . Int. J. Pharm. , 263 : 165 – 171 .
  • De Smidt , P. C. , Campanero , M. A. and Troconiz , I. F. 2004 . Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility . Int. J. Pharm. , 270 : 109 – 118 .
  • Zheng , J. Y. and Fulu , M. Y. 2006 . Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide microemulsion . Int. J. Pharm. , 307 : 209 – 215 .
  • Carlucci , A. , Vidal , M. C. , Garcia , R. and Bregni , C. 2003 . O/W microemulsions for oral drug delivery . Boll. Chim. Farm. , 142 : 324 – 329 .
  • Thongborisute , J. , Takeuchi , H. , Yamamoto , H. and Kawashima , Y. 2006 . Properties of liposomes coated with hydrophobically modified chitosan in oral liposomal drug delivery . Pharmazie , 61 : 106 – 111 .
  • Li , H. , An , J. H. , Park , J. S. and Han , K. 2005 . Multivesicular liposomes for oral delivery of recombinant human epidermal growth factor . Arch. Pharm. Res. , 28 : 988 – 994 .
  • Perrie , Y. , Obrenovic , M. , McGarthy , D. and Gregoriadis , G. 2002 . Liposome (Lipodine)‐mediated DNA vaccination by the oral route . J. Liposome Res. , 12 : 185 – 197 .
  • D'Souza , S. A. , Ray , J. , Pandey , S. and Udupa , N. 1997 . Absorption of ciprofloxacin and norfloxacin when administered as niosome‐encapsulated inclusion complexes . J. Pharm. Pharmacol. , 49 : 145 – 149 .
  • Carrigan , P. J. and Bates , T. R. 1973 . Biopharmaceutics of drugs administered in lipid‐containing dosage forms. I:GI absorption of griseofulvin from oil‐in‐water emulsion in the rat . J. Pharm. Sci. , 62 : 1476 – 1479 .
  • Palin , K. J. , Phillips , A. J. and Ning , A. 1986 . The oral absorption of cefaxitin from oil and water emulsion vehicles in rats . Int. J. Pharm. , 33 : 99 – 104 .
  • Kimura , T. , Takeda , K. , Kageyn , A. , Toda , M. , Kurpsaki , Y. and Nakayama , T. 1989 . Intestinal absorption of dolichol from emulsions and liposomes in rats . Chem. Pharm. Bull. , 37 : 463 – 466 .
  • Gershanik , T. and Benita , S. 1996 . Positively charged self‐emulsifying oil formulation for improving oral bioavailability of progesterone . Pharm. Dev. Technol. , 1 : 147 – 157 .
  • Buszello , K. and Muller , B. W. 2000 . “ Emulsions as drug delivery systems ” . In Pharmaceutical Emulsions and Suspensions Edited by: Nielloud , F. and Marti‐Mestres , G. 191 – 228 . New York : Marcel Dekker Inc .
  • Su , J. , He , L. , Zhang , N. and Ho , P. C. 2006 . Evaluation of Tributyrin Lipid Emulsion with Affinity to Low‐Density Lipoprotein: Pharmacokinetics in Adult Male Wistar Rats and Cellular Activity on Caco‐2 and HepG2 Cell Lines . J. Pharmacol. Exp. Ther. , 316 : 62 – 70 .
  • Davis , S. S. , Washington , C. , West , P. , Illum , L. , Liversidge , G. , Sternson , L. and Kirsh , R. 1987 . Lipid emulsions as drug delivery systems . Ann. NY Acad. Sci. , 507 : 75 – 88 .
  • Levy , M. Y. and Benita , S. 1989 . Design and characterization of submicronized o/w emulsion of diazepam for parenteral use . Int. J. Pharm. , 54 : 103 – 112 .
  • Prankerd , R. J. and Stella , V. J. 1990 . The use of oil‐in‐water emulsion as a vehicle for parenteral drug administration . J. Parent. Sci. Technol. , 44 : 139 – 149 .
  • Stevens , J. , Mims , P. and Coles , N. 2003 . Lipid Emulsions as Drug Delivery Systems , 5th edn. Business Briefing: Pharmatech, (May), Available online at http://www.touchbriefings.com/
  • Shawer , M. , Greenspan , P. , Oie , S. and Lu , D. R. 2002 . VLDL‐resembling phospholipid‐submicron emulsion for cholesterol‐based drug targeting . J. Pharm. Sci. , 91 : 1405 – 1413 .
  • Hashida , M. , Kawakami , S. and Yamashita , F. 2005 . Lipid carrier systems for targeted drug and gene delivery . Chem. Pharm. Bull. , 53 : 871 – 880 .
  • Yeeprae , W. , Kawakami , S. , Higuchi , Y. , Yamashita , F. and Hashida , M. 2005 . Biodistribution characteristics of mannosylated and fucosylated o/w emulsions in mice . J. Drug Target. , 13 : 479 – 487 .
  • Dierling , AM and Cui , Z. 2005 . Targeting primaquine into liver using chylomicron emulsions for potential vivax malaria therapy . Int. J. Pharm. , 303 : 143 – 152 .
  • Magalhaes , N. S. , Fessi , H. , Puisieux , F. , Benita , S. and Seiller , M. 1995 . An in vitro release kinetic examination and comparative evaluation between submicron emulsion and polylactic acid nanocapsules of clofibride . J. Microencapsul. , 12 : 195 – 205 .
  • Lundberg , B. B. , Griffiths , G. and Hansen , H. J. Conjugation of an anti‐B‐cell lymphoma monoclonal antibody, LL2, to long‐circulating drug‐carrier lipid emulsions . J. Pharm. Pharmacol. , 51 1099 – 105 .
  • Kararli , T. T. , Needham , T. E. , Griffin , M. , Schoenhard , G. , Ferro , L. J. and Alcorn , L. 1992 . Oral delivery of a renin inhibitor compound using emulsion formulations . Pharm. Res. , 9 : 888 – 893 .
  • Ilan , E. , Amselern , S. , Weisspapir , M. , Schwartz , J. , Yogev , A. , Zawoznik , E. and Friedman , D. 1996 . Improved oral delivery of desmopressin via a novel vehicle: mucoadhesive submicron emulsion . Pharm. Res. , 13 : 1083 – 1087 .
  • Hallgren , B. , Stallberg , G. and Boerd , B. 1978 . Occurrence, synthesis and biological effects of substituted glycerol ethers . Prog. Chem. Fats Other Lipids , 16 : 45 – 58 .
  • Hallgren , B. 1983 . “ Therapeutic effects of ether lipids ” . In Ether Lipids: Biochemical and Biomedical Aspects Edited by: Mangold , H. K. and Paltauf , F. 261 – 275 . New York : Academic Press .
  • Ved , H. S. , Gustow , E. , Mahadevan , V. and Pieringer , R. A. 1984 . Dodecylglycerol: a new type of antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790 . J. Biol. Chem. , 259 : 8115 – 8121 .
  • Unger , C. , Eibl , H. , Heyden von , H. W. , Krisch , B. and Nagel , G. A. 1984 . “ Ein neues Prinzip zur Uberwindung der Blut‐Hirnschranke ” . In Pathophysiologie, Dioagnostic and Therapie Edited by: Heyden ven , H. W. and Krauseneck , H. 31 – 38 . Munchen : Zuckerschwerdt .
  • Unger , C. , Eibl , H. , Heyden von , H. W. , Krisch , B. and Nagel , G. A. 1985 . Blood brain barrier and penetration of cytostatic drugs . Klin. Wschr. , 63 : 565 – 571 .
  • Brissette , J. L. , Cabacungan , E. A. and Pieringer , R. A. 1986 . Studies on the antibacterial activity of dodecylglycerol: its limited metabolism and inhibition of glycerolipid and lipoteichoic acid biosynthesis in Streptococcus mutans BHT . J. Biol. Chem. , 261 : 6338 – 6345 .
  • Weber , N. 1988 . “ Biological effects of alkylglycerols ” . In Progress in Biochemical Pharmacology Edited by: Braquet , P. , Mangold , H. K. and Vargaftig , B. B. Vol. 22 , 48 – 57 . Basel : Karger .
  • Paltauf , F. 1983 . “ Ether lipids in biological and model membranes ” . In Ether Lipids: Biochemical and Biomedical Aspects Edited by: Mangold , H. K. and Paltauf , F. 309 – 353 . New York : Academic Press .
  • Gopinath , D. , Ravi , D. , Rao , B. R. , Apte , S. S. and Rambhau , D. 2002 . 1‐O‐Alkylglycerol vesicles (Algosomes): their formulation and characterization . Int. J. Pharm. , 246 : 187 – 197 .
  • Baumann , W. J. and Mangold , H. K. 1964 . Reactions of aliphatic methanesulfonates I: syntheses of long‐chain Glycerol‐(1) Ethers . J. Org. Chem. , 29 : 3055 – 3057 .
  • Benita , S. and Levy , M. Y. 1993 . Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization . J. Pharm. Sci. , 82 : 1069 – 1079 .
  • Doluisio , J. T. , Billups , N. F. , Dittert , L. W. , Sugita , E. T. and Swintosky , J. V. 1969 . Drug absorption I: an in situ rat gut technique yielding realistic absorption rates . J. Pharm. Sci. , 58 : 1196 – 1200 .
  • Erdlenbruch , B. , Jendrossed , V. , Eibl , H. and Lakomek , M. 2000 . Transient and controllable opening of the blood‐brain barrier to cytostatic and antibiotic agents by alkylglycerols in rats . Exp. Brain Res. , 135 : 417 – 422 .
  • Garti , N. and Aserin , A. 1996 . “ Pharmaceutical Emulsions, Double Emulsions and Microemulsions ” . In Microencapsulation: Methods and Industrial Applications Edited by: Benita , S. 411 – 518 . New York : Marcel Dekker .
  • Toguchi , H. , Ogawa , Y. , Iga , K. , Yashiki , T. and Shimamoto , T. 1990 . Gastro‐intestinal absorption of ethyl 2‐chloro‐3‐[4‐(2‐methyl‐2‐phenylpropyloxy) propionate from different dosage forms in rats and dogs . Chem. Pharm. Bull. , 38 : 2796 – 2992 .
  • Embleton , J. K. and Pouton , C. W. 1997 . Stucture and function of gastrointestinal lipases . Adv. Drug Del. Rev. , 25 : 15 – 32 .
  • Mac Gregor , K. J. , Embleton , J. K. , Lacy , J. E. , Perry , E. A. , Solomon , L. J. , Seager , H. and Pouton , C. W. 1997 . Influence of lipolysis on drug absorption from gastro‐intestinal tract . Adv. Drug Deliv. , 25 : 33 – 46 .
  • Armand , M. , Pasquier , B. , Andre , M. , Borel , P. , Senft , M. , Peyrot , J. , Salducci , J. , Portugal , H. , Jaussan , V. and Lairon , D. 1999 . Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tracts . Am. J. Clin. Nutr. , 70 : 1096 – 1106 .
  • Baumann , W. J. 1972 . In Ether Lipids. Chemistry and Biology Edited by: Snyder , F. 51 – 79 . New York : Academic Press .
  • Paltauf , F. 1983 . “ Ether lipids in biological and model membranes ” . In Ether Lipids: Biochemical and Biomedical Aspects Edited by: Mangold , H. K. and Paltauf , F. 49 – 84 . New York : Academic press .

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