Key features of nano-emulsion formation by the phase inversion temperature method

References

• Solans, C.; Solé, I. Nano-Emulsions: Formation by Low-Energy Methods. Curr. Opin. Colloid Interface Sci. 2012, 17, 246–254. DOI: 10.1016/j.cocis.2012.07.003.
   Web of Science ®Google Scholar
• Ugelstad, J.; El-Aasser, M. S.; Vanderhoff, J. W. Emulsion Polymerization: Initiation of Polymerization in Monomer Droplets. J. Polym. Sci. B Polym. Lett. Ed. 1973, 11, 503–513. DOI: 10.1002/pol.1973.130110803.
   Web of Science ®Google Scholar
• El-Aasser, M. S.; Lack, C. D.; Choi, Y. T.; Min, T. I.; Vanderhoff, J. W.; Fowkes, F. M. Interfacial Aspects of Miniemulsions and Miniemulsion Polymers. Colloids Surf. 1984, 12, 79–97. DOI: 10.1016/0166-6622(84)80091-8.
   Google Scholar
• Antonietti, M.; Landfester, K. Polyreactions in Miniemulsions. Prog. Polym. Sci. 2002, 27, 689–757. DOI: 10.1016/S0079-6700(01)00051-X.
   Web of Science ®Google Scholar
• Sagitani, H. Making Homogeneous and Fine Droplet O/W Emulsions Using Nonionic Surfactants. J. Am. Oil Chem. Soc. 1981, 58, 738–743. DOI: 10.1007/BF02899466.
   Web of Science ®Google Scholar
• Amselem, S.; Friedman, D. Submicron Emulsions as Drug Carriers for Topical Administration. In Submicron Emulsions in Drug Targeting and Delivery; Benita, S., Ed.; Harwood Academic Publishers: Amsterdam, 1998; pp 153–173.
   Google Scholar
• Nakajima, H.; Tomomasa, S.; Okabe, M. Preparation of Nano-Emulsions. Proceedings of First World Emulsion Conference, Paris, 1993.
   Google Scholar
• Nakajima, H. Microemulsions in Cosmetics. In Industrial Applications of Microemulsions; Solans, C. K. H., Ed.; Marcel Dekker: New York, 1997; pp 175–197.
   Google Scholar
• Anton, N.; Vandamme, T. F. Nano-Emulsions and Micro-Emulsions: Clarifications of the Critical Differences. Pharm. Res. 2011, 28, 978–985. DOI: 10.1007/s11095-010-0309-1.
   PubMed Web of Science ®Google Scholar
• McClements, D. J. Nanoemulsions versus Microemulsions: Terminology, Differences, and Similarities. Soft Matter 2012, 8, 1719–1729. DOI: 10.1039/C2SM06903B.
   Web of Science ®Google Scholar
• McClements, D. J. Nanoemulsion-Based Oral Delivery Systems for Lipophilic Bioactive Components: Nutraceuticals and Pharmaceuticals. Ther. Deliv. 2013, 4, 841–857. DOI: 10.4155/tde.13.46.
   PubMedGoogle Scholar
• Muñoz-Espí, R.; Álvarez-Bermúdez, O. Application of Nanoemulsions in the Synthesis of Nanoparticles. In Nanoemulsions.Formulation, Applications, and Characterization; McClements, D. J., Jafari, S. M., Eds.; Academic Press: London, 2018; pp 477–515.
   Google Scholar
• Taylor, P. Ostwald Ripening in Emulsions. Adv. Colloid Interface Sci. 1998, 75, 107–163. DOI: 10.1016/S0001-8686(98)00035-9.
   Web of Science ®Google Scholar
• Tadros, T.; Izquierdo, P.; Esquena, J.; Solans, C. Formation and Stability of Nano-Emulsions. Adv. Colloid Interface Sci. 2004, 108–109, 303–318. DOI: 10.1016/j.cis.2003.10.023.
   PubMed Web of Science ®Google Scholar
• Sonneville-Aubrun, O.; Yukuyama, M. N.; Pizzino, A. Application of Nanoemulsions in Cosmetics. In Nanoemulsions. Formulation, Applications, and Characterization; McClements, D. J., Jafari, S. M., Eds.; Academic Press: London, 2018; pp 435–475.
   Google Scholar
• Donsì, F. Application of Nanoemulsions in Foods. In Nanoemulsions.Formulation, Applications, and Characterization; McClements, D. J., Jafari, S. M., Eds.; Academic Press: London, 2018; pp 349–377.
   Google Scholar
• Sánchez-López, E.; Guerra, M.; Dias-Ferreira, J.; Lopez-Machado, A.; Ettcheto, M.; Cano, A.; Espina, M.; Camins, A.; Garcia, M. L.; Souto, E. B. Current Applications of Nanoemulsions in Cancer Therapeutics. Nanomaterials 2019, 9, 821. DOI: 10.3390/nano9060821.
   Web of Science ®Google Scholar
• Walstra, P. Formation of Emulsions. In Encyclopedia of Emulsion Technology; Becher, P., Ed.; Marcel Dekker: New York, 1983; pp 57–127.
   Google Scholar
• Gopal, E. S. R. Principles of Emulsion Formation. In Emulsion Science; Sherman, P., Ed.; Academic Press: London, 1968; pp 1–75.
   Google Scholar
• Solans, C.; Izquierdo, P.; Nolla, J.; Azemar, N.; Garcia-Celma, M. J. Nano-Emulsions. Curr. Opin. Colloid Interface Sci. 2005, 10, 102–110. DOI: 10.1016/j.cocis.2005.06.004.
   Web of Science ®Google Scholar
• Sagitani, H. Phase-Inversion and D-Phase Emulsification. In Organized Solutions; Friberg, S. E., Lindman, B., Eds.; Marcel Dekker: New York, 1992; pp 259–271.
   Google Scholar
• Solans, C.; García-Celma, M. J. Microemulsions and Nano-Emulsions for Cosmetic Applications. In Cosmetic Science and Technology: Theoretical Principles and Applications; Sakamoto, K., Lochhead, R., Maibach, H., Yamashita, Y., Eds.; Elsevier: Cambridge, 2017; pp 507–551.
   Google Scholar
• Guha, I. F.; Anand, S.; Varanasi, K. K. Creating Nanoscale Emulsions Using Condensation. Nat. Commun. 2017, 8, 1–6. DOI: 10.1038/s41467-017-01420-8.
   PubMed Web of Science ®Google Scholar
• Miller, C. A. Spontaneous Emulsification Produced by Diffusion—A Review. Colloids Surf. 1988, 29, 89–102. DOI: 10.1016/0166-6622(88)80173-2.
   Google Scholar
• Miller, C. Spontaneous Emulsification: Recent Developments with Emphasis on Self-Emulsification. In Emulsions and Emulsion Stability; Sjöblom, J., Ed.; Taylor & Francis: Boca Raton, 2006; pp 107–126.
   Google Scholar
• Shinoda, K.; Saito, H. The Stability of O/W Type Emulsions as Functions of Temperature and the HLB of Emulsifiers: The Emulsification by PIT-Method. J. Colloid Interface Sci. 1969, 30, 258–263. DOI: 10.1016/S0021-9797(69)80012-3.
   Web of Science ®Google Scholar
• Lin, T. J.; Kurihara, H.; Ohta, H. Effects of Phase Inversion and Surfactant Location on the Formation of O\/W Emulsions. J. Soc.Cosmet. Chem. 1975, 26, 121–139.
   Web of Science ®Google Scholar
• Strey, R. Microemulsion Microstructure and Interfacial Curvature. Colloid Polym. Sci. 1994, 272, 1005–1019. DOI: 10.1007/BF00658900.
   Web of Science ®Google Scholar
• Bouchemal, K.; Briançon, S.; Perrier, E.; Fessi, H. Nano-Emulsion Formulation Using Spontaneous Emulsification: Solvent, Oil and Surfactant Optimisation. Int. J. Pharm. 2004, 280, 241–251. DOI: 10.1016/j.ijpharm.2004.05.016.
   PubMed Web of Science ®Google Scholar
• Vitale, S. A.; Katz, J. L. Liquid Droplet Dispersions Formed by Homogeneous Liquid-Liquid Nucleation: “the Ouzo Effect. Langmuir 2003, 19, 4105–4110. DOI: 10.1021/la026842o.
   Web of Science ®Google Scholar
• Ganachaud, F.; Katz, J. L. Nanoparticles and Nanocapsules Created Using the Ouzo Effect: Spontaneous Emulsification as an Alternative to Ultrasonic and High-Shear Devices. ChemPhysChem 2005, 6, 209–216. DOI: 10.1002/cphc.200400527.
   PubMed Web of Science ®Google Scholar
• Solans, C.; Morales, D.; Homs, M. Spontaneous Emulsification. Curr. Opin. Colloid Interface Sci. 2016, 22, 88–93. DOI: 10.1016/j.cocis.2016.03.002.
   Web of Science ®Google Scholar
• Gad, J. Zur Lehre Von Der Fettresorption. Arch. Anat. Physiol. 1878, 181–192.
   Google Scholar
• Davies, J. T.; Rideal, E. K. Interfacial Phenomena, 2nd ed.; Academic Press: New York, 1963.
   Google Scholar
• Shinoda, K.; Saito, H. The Effect of Temperature on the Phase Equilibria and the Types of Dispersions of the Ternary System Composed of Water, Cyclohexane, and Nonionic Surfactant. J. Colloid Interface Sci. 1968, 26, 70–74. DOI: 10.1016/0021-9797(68)90273-7.
   Web of Science ®Google Scholar
• Salager, J. L.; Miñana-Pérez, M.; Pérez-Sánchez, M.; Ramfrez-Gouveia, M.; Rojas, C. I. Surfactant-Oil-Water Systems near the Affinity Inversion Part III: The Two Kinds of Emulsion Inversion. J. Dispers. Sci. Technol. 1983, 4, 313–329. DOI: 10.1080/01932698308943373.
   Web of Science ®Google Scholar
• Förster, T.; Schambil, F.; von Rybinski, W. Production of Fine Disperse and Long-Term Stable Oil-in-Water Emulsions by the Phase Inversion Temperature Method. J. Dispers. Sci. Technol. 1992, 13, 183–193. DOI: 10.1080/01932699208943306.
   Web of Science ®Google Scholar
• Miñana-Perez, M.; Gutron, C.; Zundel, C.; Anderez, J. M.; Salager, J. L. Miniemulsion Formation by Transitional Inversion. J. Dispers. Sci. Technol. 1999, 20, 893–905. DOI: 10.1080/01932699908943826.
   Web of Science ®Google Scholar
• Friberg, S.; Solans, C. Emulsification and the HLB-Temperature. J. Colloid Interface Sci. 1978, 66, 367–368. DOI: 10.1016/0021-9797(78)90319-3.
   Web of Science ®Google Scholar
• Shinoda, K.; Kunieda, H. Phase Properties of Emulsions: PIT and HLB. In Encyclopedia of Emulsion Technology; Becher, P., Ed.; Marcel Dekker: New York, 1983; pp 337–367.
   Google Scholar
• Kunieda, H.; Shinoda, K. Evaluation of the Hydrophile-Lipophile Balance (HLB) of Nonionic Surfactants. I. Multisurfactant Systems. J. Colloid Interface Sci. 1985, 107, 107–121. DOI: 10.1016/0021-9797(85)90154-7
   Web of Science ®Google Scholar
• Forgiarini, A.; Esquena, J.; González, C.; Solans, C. Formation of Nano-Emulsions by Low-Energy Emulsification Methods at Constant Temperature. Langmuir 2001, 17, 2076–2083. DOI: 10.1021/la001362n.
   Web of Science ®Google Scholar
• Izquierdo, P.; Esquena, J.; Tadros, T. F.; Dederen, C.; Garcia, M. J.; Azemar, N.; Solans, C. Formation and Stability of Nano-Emulsions Prepared Using the Phase Inversion Temperature Method. Langmuir 2002, 18, 26–30. DOI: 10.1021/la010808c.
   Web of Science ®Google Scholar
• Morales, D.; Gutiérrez, J. M.; García-Celma, M. J.; Solans, Y. C. A Study of the Relation between Bicontinuous Microemulsions and Oil/Water Nano-Emulsion Formation. Langmuir 2003, 19, 7196–7200. DOI: 10.1021/la0300737.
   Web of Science ®Google Scholar
• Fernandez, P.; André, V.; Rieger, J.; Kühnle, A. Nano-Emulsion Formation by Emulsion Phase Inversion. Colloids Surf. A Physicochem. Eng. Asp. 2004, 251, 53–58. DOI: 10.1016/j.colsurfa.2004.09.029.
   Web of Science ®Google Scholar
• Izquierdo, P.; Esquena, J.; Tadros, T. F.; Dederen, J. C.; Feng, J.; Garcia-Celma, M. J.; Azemar, N.; Solans, C. Phase Behavior and Nano-Emulsion Formation by the Phase Inversion Temperature Method. Langmuir 2004, 20, 6594–6598. DOI: 10.1021/la049566h.
   PubMed Web of Science ®Google Scholar
• Izquierdo, P.; Feng, J.; Esquena, J.; Tadros, T. F.; Dederen, J. C.; Garcia, M. J.; Azemar, N.; Solans, C. The Influence of Surfactant Mixing Ratio on Nano-Emulsion Formation by the Pit Method. J. Colloid Interface Sci. 2005, 285, 388–394. DOI: 10.1016/j.jcis.2004.10.047.
   PubMed Web of Science ®Google Scholar
• Morales, D.; Solans, C.; Gutiérrez, J. M.; Garcia-Celma, M. J.; Olsson, U. Oil/Water Droplet Formation by Temperature Change in the Water/C16E6/Mineral Oil System. Langmuir 2006, 22, 3014–3020. DOI: 10.1021/la052324c.
   PubMed Web of Science ®Google Scholar
• Sajjadi, S. Nanoemulsion Formation by Phase Inversion Emulsification: On the Nature of Inversion. Langmuir 2006, 22, 5597–5603. DOI: 10.1021/la060043e.
   PubMed Web of Science ®Google Scholar
• Sonneville-Aubrun, O.; Babayan, D.; Bordeaux, D.; Lindner, P.; Rata, G.; Cabane, B. Phase Transition Pathways for the Production of 100 Nm Oil-in-Water Emulsions. Phys. Chem. Chem. Phys. 2009, 11, 101–110. DOI: 10.1039/B813502A.
   PubMed Web of Science ®Google Scholar
• Wang, L.; Tabor, R.; Eastoe, J.; Li, X.; Heenan, R. K.; Dong, J. Formation and Stability of Nanoemulsions with Mixed Ionic–Nonionic Surfactants. Phys. Chem. Chem. Phys. 2009, 11, 9772. DOI: 10.1039/b912460h.
   PubMed Web of Science ®Google Scholar
• Roger, K.; Cabane, B.; Olsson, U. Formation of 10-100 Nm Size-Controlled Emulsions through a Sub-PIT Cycle. Langmuir 2010, 26, 3860–3867. DOI: 10.1021/la903401g.
   PubMed Web of Science ®Google Scholar
• Rao, J.; McClements, D. J. Stabilization of Phase Inversion Temperature Nanoemulsions by Surfactant Displacement. J. Agric. Food Chem. 2010, 58, 7059–7066. DOI: 10.1021/jf100990r.
   PubMed Web of Science ®Google Scholar
• Roger, K.; Cabane, B.; Olsson, U. Emulsification through Surfactant Hydration: The PIC Process Revisited. Langmuir 2011, 27, 604–611. DOI: 10.1021/la1042603.
   PubMed Web of Science ®Google Scholar
• Heunemann, P.; Prévost, S.; Grillo, I.; Marino, C. M.; Meyer, J.; Gradzielski, M. Formation and Structure of Slightly Anionically Charged Nanoemulsions Obtained by the Phase Inversion Concentration (PIC) Method. Soft Matter 2011, 7, 5697–5710. DOI: 10.1039/c0sm01556c.
   Web of Science ®Google Scholar
• Roger, K.; Olsson, U.; Zackrisson-Oskolkova, M.; Lindner, P.; Cabane, B. Superswollen Microemulsions Stabilized by Shear and Trapped by a Temperature Quench. Langmuir 2011, 27, 10447–10454. DOI: 10.1021/la201685x.
   PubMed Web of Science ®Google Scholar
• Anton, N.; Saulnier, P. Adhesive Water-in-Oil Nano-Emulsions Generated by the Phase Inversion Temperature Method. Soft Matter 2013, 9, 6465–6474. DOI: 10.1039/c3sm51064f.
   Web of Science ®Google Scholar
• Nazarzadeh, E.; Anthonypillai, T.; Sajjadi, S. On the Growth Mechanisms of Nanoemulsions. J. Colloid Interface Sci. 2013, 397, 154–162. DOI: 10.1016/j.jcis.2012.12.018.
   PubMed Web of Science ®Google Scholar
• Wang, L.; Dong, J.; Chen, J.; Eastoe, J.; Li, X. Design and Optimization of a New Self-Nanoemulsifying Drug Delivery System. J. Colloid Interface Sci. 2009, 330, 443–448. DOI: 10.1016/j.jcis.2008.10.077.
   PubMed Web of Science ®Google Scholar
• Aubry, J.; Ganachaud, F.; Addad, J.-P. C.; Cabane, B. Nanoprecipitation of Polymethylmethacrylate by Solvent Shifting: 1. Boundaries. Langmuir 2009, 25, 1970–1979. DOI: 10.1021/la803000e.
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter, M.; Rytting, E.; Lebhardt, T.; Wang, X.; Kissel, T. Preparation of Nanoparticles by Solvent Displacement for Drug Delivery: A Shift in the “Ouzo Region” upon Drug Loading. Eur. J. Pharm. Sci. 2010, 41, 244–253. DOI: 10.1016/j.ejps.2010.06.007.
   PubMed Web of Science ®Google Scholar
• Vandamme, T. F.; Anton, N. Low-Energy Nanoemulsification to Design Veterinary Controlled Drug Delivery Devices. Int. J. Nanomed. 2010, 5, 867–873. DOI: 10.2147/IJN.S13273.
   PubMed Web of Science ®Google Scholar
• Anton, N.; Mojzisova, H.; Porcher, E.; Benoit, J.-P.; Saulnier, P. Reverse Micelle-Loaded Lipid Nano-Emulsions: New Technology for Nano-Encapsulation of Hydrophilic Materials. Int. J. Pharm. 2010, 398, 204–209. DOI: 10.1016/j.ijpharm.2010.07.039.
   PubMed Web of Science ®Google Scholar
• Henry, J. V. L.; Fryer, P. J.; Frith, W. J.; Norton, I. T. The Influence of Phospholipids and Food Proteins on the Size and Stability of Model Sub-Micron Emulsions. Food Hydrocoll. 2010, 24, 66–71. DOI: 10.1016/j.foodhyd.2009.08.006.
   Web of Science ®Google Scholar
• Calderó, G.; García-Celma, M. J.; Solans, C. Formation of Polymeric Nano-Emulsions by a Low-Energy Method and Their Use for Nanoparticle Preparation. J. Colloid Interface Sci. 2011, 353, 406–411. DOI: 10.1016/j.jcis.2010.09.073.
   PubMed Web of Science ®Google Scholar
• Rao, J.; McClements, D. J. Formation of Flavor Oil Microemulsions, Nanoemulsions and Emulsions: Influence of Composition and Preparation Method. J. Agric. Food Chem. 2011, 59, 5026–5035. DOI: 10.1021/jf200094m.
   PubMed Web of Science ®Google Scholar
• Lucas, P.; Vaysse, M.; Aubry, J.; Mariot, D.; Sonnier, R.; Ganachaud, F. Finest Nanocomposite Films from Carbon Nanotube-Loaded Poly(Methyl Methacrylate) Nanoparticles Obtained by the Ouzo Effect. Soft Matter 2011, 7, 5528–5531. DOI: 10.1039/c1sm05609c.
   Web of Science ®Google Scholar
• Ragupathy, L.; Ziener, U.; Robert, G.; Landfester, K. Grafting Polyacrylates on Natural Rubber Latex by Miniemulsion Polymerization. Colloid Polym. Sci. 2011, 289, 229–235. DOI: 10.1007/s00396-010-2360-1.
   Web of Science ®Google Scholar
• MacHado, A. H. E.; Lundberg, D.; Ribeiro, A. J.; Veiga, F. J.; Lindman, B.; Miguel, M. G.; Olsson, U. Preparation of Calcium Alginate Nanoparticles Using Water-in-Oil (W/O) Nanoemulsions. Langmuir 2012, 28, 4131–4141. DOI: 10.1021/la204944j.
   PubMed Web of Science ®Google Scholar
• Fornaguera, C.; Dols-Perez, A.; Calderó, G.; García-Celma, M. J.; Camarasa, J.; Solans, C. PLGA Nanoparticles Prepared by Nano-Emulsion Templating Using Low-Energy Methods as Efficient Nanocarriers for Drug Delivery across the Blood-Brain Barrier. J. Control. Release 2015, 211, 134–143. DOI: 10.1016/j.jconrel.2015.06.002.
   PubMed Web of Science ®Google Scholar
• Anton, N.; Benoit, J. P.; Saulnier, P. Design and Production of Nanoparticles Formulated from Nano-Emulsion Templates-A Review. J. Control. Release 2008, 128, 185–199. DOI: 10.1016/j.jconrel.2008.02.007.
   PubMed Web of Science ®Google Scholar
• Date, A. A.; Desai, N.; Dixit, R.; Nagarsenker, M. Self-Nanoemulsifying Drug Delivery Systems: Formulation Insights, Applications and Advances. Nanomedicine 2010, 5, 1595–1616. DOI: 10.2217/nnm.10.126.
   PubMed Web of Science ®Google Scholar
• Silva, H. D.; Cerqueira, M. A.; Vicente, A. A. Nanoemulsions for Food Applications: Development and Characterization. Food Bioprocess Technol. 2012, 5, 854–867. DOI: 10.1007/s11947-011-0683-7.
   Web of Science ®Google Scholar
• Maali, A.; Mosavian, M. T. H. Preparation and Application of Nanoemulsions in the Last Decade (2000-2010). J. Dispers. Sci. Technol. 2013, 34, 92–105. DOI: 10.1080/01932691.2011.648498.
   Web of Science ®Google Scholar
• Muñoz-Espí, R.; Weiss, C. K.; Landfester, K. Inorganic Nanoparticles Prepared in Miniemulsion. Curr. Opin. Colloid Interface Sci. 2012, 17, 212–224. DOI: 10.1016/j.cocis.2012.04.002.
   Web of Science ®Google Scholar
• Gupta, A.; Eral, H. B.; Hatton, T. A.; Doyle, P. S. Nanoemulsions: Formation, Properties and Applications. Soft Matter 2016, 12, 2826–2841. DOI: 10.1039/C5SM02958A.
   PubMed Web of Science ®Google Scholar
• Roger, K. Nanoemulsification in the Vicinity of Phase Inversion: Disruption of Bicontinuous Structures in Oil/Surfactant/Water Systems. Curr. Opin. Colloid Interface Sci. 2016, 25, 120–128. DOI: 10.1016/j.cocis.2016.09.015.
   Web of Science ®Google Scholar
• Montes de Oca-Ávalos, J. M.; Candal, R. J.; Herrera, M. L. Nanoemulsions: Stability and Physical Properties. Curr. Opin. Food Sci. 2017, 16, 1–6. DOI: 10.1016/j.cofs.2017.06.003.
   Web of Science ®Google Scholar
• Espitia, P. J. P.; Fuenmayor, C. A.; Otoni, C. G. Nanoemulsions: Synthesis, Characterization, and Application in Bio-Based Active Food Packaging. Compr. Rev. Food Sci. Food Saf. 2019, 18, 264–285. DOI: 10.1111/1541-4337.12405.
   PubMed Web of Science ®Google Scholar
• Aramaki, K.; Hayashi, T.; Katsuragi, T.; Ishitobi, M.; Kunieda, H. Effect of Adding an Amphiphilic Solubilization Improver, Sucrose Distearate, on the Solubilization Capacity of Nonionic Microemulsions. J. Colloid Interface Sci. 2001, 236, 14–19. DOI: 10.1006/jcis.2000.7366.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Abreu, C.; Vila, A. Nano-Droplet Systems by Surfactant Self-Assembly and Applications in the Pharmaceutical Industry. Curr Top Med Chem. 2014, 14, 747–765. DOI: 10.2174/1568026614666140118221658.
   PubMed Web of Science ®Google Scholar