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Articles

Preparation, optimization using a mixture design, and characterization of a novel astaxanthin-loaded rice bran oil self-microemulsifying delivery system formulation

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Pages 1336-1349 | Received 13 May 2021, Accepted 05 Dec 2021, Published online: 20 Dec 2021

References

  • Higuera-Ciapara, I.; Félix-Valenzuela, L.; Goycoolea, F. Astaxanthin: A Review of Its Chemistry and Applications. Crit Rev Food Sci Nutr .. 2006, 46, 185–196. DOI: 10.1080/10408690590957188.
  • Yang, Y.; Kim, B.; Lee, J. Y. Astaxanthin Structure, Metabolism, and Health Benefits. J. Hum. Nutr. Food. Sci 2013, 1, 1–1003.
  • Mao, X.; Sun, R.; Tian, Y.; Wang, D.; Ma, Y.; Wang, Q.; Huang, J.; Xia, Q. Development of a Solid Self‐Emulsification Delivery System for the Oral Delivery of Astaxanthin. Eur. J. Lipid Sci. Technol. 2019, 121, 1800258–1800210. DOI: 10.1002/ejlt.201800258.
  • Grimmig, B.; Kim, S.-H.; Nash, K.; Bickford, P. C.; Douglas Shytle, R. Neuroprotective Mechanisms of Astaxanthin: A Potential Therapeutic Role in Preserving Cognitive Function in Age and Neurodegeneration. Geroscience. 2017, 39, 19–32. DOI: 10.1007/s11357-017-9958-x.
  • Hong, L.; Zhou, C.-L.; Chen, F.-P.; Han, D.; Wang, C.-Y.; Li, J.-X.; Chi, Z.; Liu, C.-G. Development of a Carboxymethyl Chitosan Functionalized Nanoemulsion Formulation for Increasing Aqueous Solubility, Stability and Skin Permeability of Astaxanthin Using Low-Energy Method. J. Microencapsul. 2017, 34, 707–721. DOI: 10.1080/02652048.2017.1373154.
  • Khalid, N.; Shu, G.; Holland, B. J.; Kobayashi, I.; Nakajima, M.; Barrow, C. J. Formulation and Characterization of o/w Nanoemulsions Encapsulating High Concentration of Astaxanthin. Food Res Int 2017, 102, 364–371. DOI: 10.1016/j.foodres.2017.06.019.
  • Pan, L.; Zhang, S.; Gu, K.; Zhang, N. Preparation of Astaxanthin-Loaded Liposomes: Characterization, Storage Stability and Antioxidant Activity. CYTA J Food 2018, 16, 607–618. DOI: 10.1080/19476337.2018.1437080.
  • Tamjidi, F.; Shahedi, M.; Varshosaz, J.; Nasirpour, A. Design and Characterization of Astaxanthin-Loaded Nanostructured Lipid Carriers. Innov. Food Sci. Emerg. Technol 2014, 26, 366–374. DOI: 10.1016/j.ifset.2014.06.012.
  • Kim, S.; Cho, E.; Yoo, J.; Cho, E.; Choi, S. J.; Son, S. M.; Lee, J. M.; In, M.-J.; Kim, D. C.; Kim, J.-H. Β-Cd-Mediated Encapsulation Enhanced Stability and Solubility of Astaxanthin. J. Appl. Biol. Chem 2010, 53, 559–565. DOI: 10.3839/jksabc.2010.086.
  • Higuera-Ciapara, I.; Felix-Valenzuela, L.; Goycoolea, F. M.; Argüelles-Monal, W. Argüelles-Monal, W. Microencapsulation of Astaxanthin in a Chitosan Matrix. Carbohydr. Polym 2004, 56, 41–45. DOI: 10.1016/j.carbpol.2003.11.012.
  • Niizawa, I.; Espinaco, B. Y.; Zorrilla, S. E.; Sihufe, G. A. Natural Astaxanthin Encapsulation: Use of Response Surface Methodology for the Design of Alginate Beads. Int. J. Biol. Macromol. 2019, 121, 601–608. DOI: 10.1016/j.ijbiomac.2018.10.044.
  • Jo, K.; Kim, H.; Khadka, P.; Jang, T.; Kim, S. J.; Hwang, S.-H.; Lee, J. Enhanced Intestinal Lymphatic Absorption of Saquinavir through Supersaturated Self-Microemulsifying Drug Delivery Systems. Asian J Pharm Sci 2020, 15, 336–346. DOI: 10.1016/j.ajps.2018.11.009.
  • Porter, C. J. H.; Pouton, C. W.; Cuine, J. F.; Charman, W. N. Enhancing Intestinal Drug Solubilisation Using Lipid-Based Delivery Systems. Adv Drug Deliv Rev .. 2008, 60, 673–691. DOI: 10.1016/j.addr.2007.10.014.
  • Liu, C.-S.; Chen, L.; Hu, Y.-N.; Dai, J.-L.; Ma, B.; Tang, Q.-F.; Tan, X.-M. Self-Microemulsifying Drug Delivery System for Improved Oral Delivery and Hypnotic Efficacy of Ferulic Acid. Int. J. Nanomedicine. 2020, 15, 2059–2070. DOI: 10.2147/IJN.S240449.
  • Sornsuvit, C.; Hongwiset, D.; Yotsawimonwat, S.; Toonkum, M.; Thongsawat, S.; Taesotikul, W. The Bioavailability and Pharmacokinetics of Silymarin Smedds Formulation Study in Healthy Thai Volunteers. Evid Based Complement Alternat Med .. 2018, 2018, 1507834 DOI: 10.1155/2018/1507834.
  • Visetvichaporn, V.; Kim, K.-H.; Jung, K.; Cho, Y.-S.; Kim, D.-D. Formulation of self-microemulsifying drug delivery system (SMEDDS) by D-optimal mixture design to enhance the oral bioavailability of a new cathepsin K inhibitor (HL235) ). Int. J. Pharm. 2020, 573, 118772 DOI: 10.1016/j.ijpharm.2019.118772.
  • Pouton, C. W. Lipid Formulations for Oral Administration of Drugs: Non-Emulsifying, Self-Emulsifying and ‘Self-Microemulsifying’ Drug Delivery Systems. Eur. J. Pharm. Sci 2000, 11, S93–S98. DOI: 10.1016/S0928-0987(00)00167-6.
  • Pawar, S. K.; Vavia, P. R. Rice Germ Oil as Multifunctional Excipient in Preparation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus. AAPS PharmSciTech 2012, 13, 254–261. DOI: 10.1208/s12249-011-9748-1.
  • Pouton, C. W.; Porter, C. J. H. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies . Adv. Drug Deliv. Rev. 2008, 60, 625–637. DOI: 10.1016/j.addr.2007.10.010.
  • Gao, P.; Witt, M. J.; Haskell, R. J.; Zamora, K. M.; Shifflett, J. R. Application of a Mixture Experimental Design in the Optimization of a Self-Emulsifying Formulation with a High Drug Load. Pharm. Dev. Technol. 2004, 9, 301–309. DOI: 10.1081/PDT-200031441.
  • Son, H. Y.; Chae, B. R.; Choi, J. Y.; Shin, D. J.; Goo, Y. T.; Lee, E. S.; Kang, T. H.; Kim, C. H.; Yoon, H. Y.; Choi, Y. W. Optimization of Self-Microemulsifying Drug Delivery System for Phospholipid Complex of Telmisartan Using d-Optimal Mixture Design. PLoS One 2018, 13, e0208339. DOI: 10.1371/journal.pone.0208339.
  • Xiong, Y.; Zou, Y.; Chen, L.; Xu, Y.; Wang, S. Development and in Vivo Evaluation of Ziyuglycoside I-Loaded Self-Microemulsifying Formulation for Activity of Increasing Leukocyte . AAPS PharmSciTech 2019, 20, 101 DOI: 10.1208/s12249-019-1313-3.
  • Buruk Şahin, Y.; Aktar Demirtas, E.; Burnak, N. Mixture Design: A Review of Recent Applications in the Food Industry. PAJES 2016, 22, 297–304. DOI: 10.5505/pajes.2015.98598.
  • Qureshi, M. J.; Mallikarjun, C.; Kian, W. G. Enhancement of Solubility and Therapeutic Potential of Poorly Soluble Lovastatin by Smedds Formulation Adsorbed on Directly Compressed Spray Dried Magnesium Aluminometasilicate Liquid Loadable Tablets: A Study in Diet Induced Hyperlipidemic Rabbits. Asian J. Pharm. Sci 2015, 10, 40–56. DOI: 10.1016/j.ajps.2014.08.003.
  • Oh, H.; Lee, J. S.; Sung, D.; Lim, J.-M.; Choi, W. Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin . Int. J. Nanomedicine. 2020, 15, 9231–9240. DOI: 10.2147/IJN.S272650.
  • Aswar, M.; Bhalekar, M.; Trimukhe, A.; Aswar, U. Self-Microemulsifying Drug Delivery System (SMEDDS) of Curcumin Attenuates Depression in Olfactory Bulbectomized Rats. Heliyon 2020, 6, e04482 DOI: 10.1016/j.heliyon.2020.e04482.
  • Sahoo, S.; Pani, N. R.; Sahoo, S. K. Microemulsion Based Topical Hydrogel of Sertaconazole: Formulation, Characterization and evaluation. Colloids Surf B Biointerfaces 2014, 120, 193–199. DOI: 10.1016/j.colsurfb.2014.05.022.
  • Prajapati, S. T.; Joshi, H. A.; Patel, C. N. Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement. J Pharm (Cairo) .) 2013, 2013, 728425 DOI: 10.1155/2013/728425.
  • Wang, L.; Yan, W.; Tian, Y.; Xue, H.; Tang, J.; Zhang, L. Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation. Pharmaceutics 2020, 12, 130. DOI: 10.3390/pharmaceutics12020130.
  • Yeom, D. W.; Song, Y. S.; Kim, S. R.; Lee, S. G.; Kang, M. H.; Lee, S.; Choi, Y. W. Development and Optimization of a self-microemulsifying drug delivery system for atorvastatin calcium by using D-optimal mixture design . Int. J. Nanomedicine. 2015, 10, 3865–3877. DOI: 10.2147/IJN.S83520.
  • Liao, H.; Gao, Y.; Lian, C.; Zhang, Y.; Wang, B.; Yang, Y.; Ye, J.; Feng, Y.; Liu, Y. Oral Absorption and Lymphatic Transport of Baicalein following Drug-Phospholipid Complex Incorporation in Self-Microemulsifying Drug Delivery Systems. Int. J. Nanomedicine. 2019, 14, 7291–7306. DOI: 10.2147/ijn.s214883.
  • Alskär, L. C.; Porter, C. J. H.; Bergström, C. A. S. Tools for Early Prediction of Drug Loading in Lipid-Based Formulations. Mol. Pharm. 2016, 13, 251–261. DOI: 10.1021/acs.molpharmaceut.5b00704.
  • Thongrangsalit, S.; Phaechamud, T.; Lipipun, V.; Ritthidej, G. C. Bromocriptine Tablet of Self-Microemulsifying System Adsorbed onto Porous Carrier to Stimulate Lipoproteins Secretion for Brain Cellular Uptake. Colloids Surf. B 2015, 131, 162–169. DOI: 10.1016/j.colsurfb.2015.04.058.
  • Elnaggar, Y. S. R.; El-Massik, M. A.; Abdallah, O. Y. Self-Nanoemulsifying Drug Delivery Systems of Tamoxifen Citrate: Design and Optimization. Int. J. Pharm. 2009, 380, 133–141. DOI: 10.1016/j.ijpharm.2009.07.015.
  • Pandey, V.; Kohli, S. SMEDDS of Pioglitazone: Formulation, in-Vitro Evaluation and Stability Studies. Future J. Pharm. Sci 2017, 3, 53–59. 59. DOI: 10.1016/j.fjps.2017.02.003.
  • Baek, M.-K.; Lee, J.-H.; Cho, Y.-H.; Kim, H.-H.; Lee, G.-W. Self-Microemulsifying Drug-Delivery System for Improved Oral Bioavailability of Pranlukast Hemihydrate: Preparation and Evaluation. Int. J. Nanomedicine. 2013, 8, 167–176. DOI: 10.2147/IJN.S37338.
  • Piriyaprasarth, S.; Juttulapa, M.; Sriamornsak, P. Stability of Rice Bran Oil-in-Water Emulsions Stabilized by Pectin–Zein Complexes: Effect of Composition and Order of Mixing. Food Hydrocoll 2016, 61, 589–598. DOI: 10.1016/j.foodhyd.2016.06.015.
  • Goyal, U.; Gupta, A.; Rana, A. C.; Aggarwal, G. Self Microemulsifying Drug Delivery System: A Method for Enhancement of Bioavailability. Int. J. Pharm. Sci. Res 2012, 3, 66–79. DOI: 10.13040/IJPSR.0975-8232.3(1).66-79.
  • Nikolakakis, I.; Partheniadis, I. Self-Emulsifying Granules and Pellets: Composition and Formation Mechanisms for Instant or Controlled Release. Pharmaceutics 2017, 9,50. DOI: 10.3390/pharmaceutics90400.
  • Genot, C.; Kabri, T. H.; Meynier, A. Stabilization of Omega-3 Oils and Enriched Foods Using Emulsifiers. in Food Enrichment with Omega-3 Fatty Acids, C. Jacobsen;N. S. Nielsen;A. F. Horn.A.-D. M. Sørensen, Eds; Woodhead Publishing Limited: UK, 2013; pp 150–193
  • Bernardi, D. S.; Pereira, T. A.; Maciel, N. R.; Bortoloto, J.; Viera, G. S.; Oliveira, G. C.; Rocha-Filho, P. A. Formation and Stability of Oil-in-Water Nanoemulsions Containing Rice Bran Oil: In Vitro and in Vivo Assessments. J. Nanobiotechnol. 2011, 9, 44–49. DOI: 10.1186/1477-3155-9-44.
  • Mundada, V.; Sawant, K. Enhanced Oral Bioavailability and Anticoagulant Activity of Dabigatran Etexilate by Self-Micro Emulsifying Drug Delivery System: Systematic Development, in Vitro, Ex Vivo and in Vivo Evaluation. J. Nanomed. Nanotechnol 2018, 9, 480–493. DOI: 10.4172/2157-7439.1000480.
  • AboulFotouh, K.; Allam, A. A.; El-Badry, M.; El-Sayed, A. M. Development and in Vitro/in Vivo Performance of Self-Nanoemulsifying Drug Delivery Systems Loaded with Candesartan Cilexetil. Eur. J. Pharm. Sci 2017, 109, 503–513. DOI: 10.1016/j.ejps.2017.09.001.
  • Liu, J.; Wang, Q.; Omari-Siaw, E.; Adu-Frimpong, M.; Liu, J.; Xu, X.; Yu, J. Enhanced Oral Bioavailability of Bisdemethoxycurcumin-Loaded Self-Microemulsifying Drug Delivery System: Formulation Design, in Vitro and in Vivo Evaluation. Int. J. Pharm 2020, 590, 119887. DOI: 10.1016/j.ijpharm.2020.119887.
  • Borhade, V.; Nair, H.; Hegde, D. Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus. AAPS PharmSciTech 2008, 9, 13–21. DOI: 10.1208/s12249-007-9014-8.
  • Aveyard, R.; Binks, B. P.; Clark, S.; Fletcher, P. D. I. Cloud Points, Solubilisation and Interfacial Tensions in Systems Containing Nonionic Surfactants. J. Chem. Technol. Biotechnol. 1990, 48, 161–171. DOI: 10.1002/jctb.280480206.
  • Tichý, E.; Žabka, M.; Gardavska, K.; Halenarova, A.; Kontšeková Scheerová, Z.; Potúčková, M. Dissolution and Spectrophotometric Determination of Astaxanthin in Aqueous Solutions. Pharmazie 2011, 66, 560–563. DOI: 10.1691/ph.2011.1024.

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