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Obesity paradoxes

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Pages 773-782 | Accepted 09 Jan 2011, Published online: 16 Mar 2011

References

  • Arnlov , J. , Ingelsson , E. , Sundstrom , J. and Lind , L. 2010 . Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease death in middle-aged men . Circulation , 121 : 230 – 236 .
  • Badheka , A. O. , Rathod , A. , Kizilbash , M. A. , Garg , H. , Mohamad , T. Afonso , L. 2010 . Influence of obesity on outcomes in atrial fibrillation: Yet another obesity paradox . American Journal of Medicine , 123 : 646 – 651 .
  • Balint , P. and Balint , G. 2009 . The Semmelweis-relfex . Orvosi Hetilap , 150 : 1430
  • Beddu , S. , Ramkumar , N. and Samore , M. H. 2004 . The paradox of the “body mass index paradox” in dialysis patients: Associations of adiposity with inflammation . American Journal of Clinical Nutrition , 82 : 909 – 911 .
  • Blair , S. N. , Kampert , J. B. , Kohl , H. W. III , Barlow , C. E. , Macera , C. A. Paffenbarger , R. S. Jr. 1996 . Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women . Journal of the American Medical Association , 276 : 205 – 210 .
  • Bozkurt , B. and Deswal , A. 2005 . Obesity as a prognostic factor inchronic symptomatic heart failure . American Heart Journal , 150 : 1233 – 1239 .
  • Calle , E. E. , Rodriguez , C. , Walker-Thurmond , K. and Thun , M. J. 2003 . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults . New England Journal of Medicine , 348 : 1625 – 1638 .
  • Calle , E. E. , Thun , M. J. , Petrelli , J. M. , Rodriguez , C. and Heath , C. W. Jr. 1999 . Body-mass index and mortality in a prospective cohort of U.S. adults . New England Journal of Medicine , 341 : 1097 – 1105 .
  • Campos , P. , Saguy , A. , Ernsberger , P. , Oliver , E. and Gaesser , G. 2006 . The epidemiology of overweight and obesity: Publichealth crisis or moral panic? . International Journal of Epidemiology , 35 : 55 – 60 .
  • Collins , V. R. , Dowse , G. K. , Cabealawa , S. , Ram , P. and Zimmet , P. Z. 1996 . High mortality from cardiovascular disease and analysis of risk factors in Indian and Melanesian Fijians . Internatioinal Journal of Epidmemiology , 25 : 59 – 69 .
  • Curtis , J. P. , Selter , J. G. , Want , Y. , Rathore , S. S. , Jovin , I. S. Jadbabaie , F. 2005 . The obesity paradox: Body mass index and outcomes in patients with heart failure . Archives of Internal Medicine , 165 : 55 – 61 .
  • Degoulet , P. , Legrain , M. , Reach , I. , Aime , F. , Devries , C. Rojas , P. 1982 . Mortality risk factors in patients treated by chronic hemodialysis: Report of the Diaphane Collaborative Study . Nephronology , 31 : 103 – 110 .
  • Duncan , G. E. 2010 . The “fit but fat” concept revisited: Population-based estimates using NHANES . International Journal of Behavioral and Physical Activity , 7 : 47 – 51 .
  • Durazo-Arvizu , R. A. , McGee , D. L. , Cooper , R. S. , Liao , Y. and Luke , A. 1998 . Mortality and optimal body mass index in a sample of the US population . American Journal of Epidemiology , 147 : 739 – 749 .
  • Ellis , S. G. , Elliott , J. , Horrigan , M. , Raymond , R. E. and Howell , G. 1996 . Low-normal or excessive body mass index: Newly identified and powerful risk factors for death and other complications with percutaneous coronary intervention . American Journal of Cardiology , 78 : 642 – 646 .
  • Farrell , S. W. , Fitzgerald , S. J. , McAuley , P. A. and Barlow , C. E. 2010 . Cardiorespiratory fitness, adiposity, and all-cause mortality in women . Medicine and Science in Sports and Exercise , 42 : 2006 – 2012 .
  • Flegal , K. M. , Graubard , B. I. , Williamson , D. F. and Gail , M. H. 2007 . Cause-specific excess deaths associated with underweight, overweight, and obesity . Journal of the American Medical Association , 298 : 2028 – 2037 .
  • Fleischmann , E. , Teal , N. , Dudley , J. , May , W. , Bower , J. D. and Salahudeen , A. K. 1999 . Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients . Kidney International , 55 : 1560 – 1567 .
  • Fogelholm , M. 2010 . Physical activity, fitness and fatness: Relations to mortality, morbidity and disease risk factors. A systematic review . Obesity Reviews , 11 : 202 – 221 .
  • Gaesser , G. A. 1999 . Thinness and weight loss: Beneficial or detrimental to longevity? . Medicine and Science in Sports and Exercise , 31 : 1118 – 1128 .
  • Galal , W. , van Domburg , R. T. , Feringa , H. H. H. , Schouten , O. , Elhendy , A. Bax , J. J. 2007 . Relation of body mass index to outcome in patients with known or suspected coronary artery disease . American Journal of Cardiology , 99 : 1485 – 1490 .
  • Galal , W. , van Gestel , Y. R. , Hoeks , S. E. , Sin , D. D. , Winkel , T. A. Bax , J. J. 2008 . The obesity paradox in patients with peripheral arterial disease . Chest , 134 : 925 – 930 .
  • Gruberg , L. , Weissman , N. J. , Waksman , R. , Fuchs , S. , Deible , R. Pinnow , E. E. 2002 . The impact of obesity on theshort-term and long-term outcomes after percutaneous coronary intervention: The obesity paradox? . Journal of the American College of Cardiology , 39 : 578 – 584 .
  • Gustafsson , F. , Kragelund , C. B. , Torp-Pedersen , C. , Seibaek , M. , Burchardt , H. Akkan , D. 2005 . Effect of obesity and being overweight on long-term mortality in congestive heart failure: Influence of left ventricular systolic function . European Heart Journal , 26 : 58 – 64 .
  • Habbu , A. , Lakkis , N. M. and Dokainish , H. 2006 . The obesity paradox: Fact or fiction? . American Journal of Cardiology , 98 : 944 – 948 .
  • Hall , J. A. , French , T. K. , Rasmusson , K. D. , Vesty , J. C. , Roberts , C. A. Rimmasch , H. L. 2005 . The paradox of obesity in patients with heart failure . Journal of the American Academy of Nurse Practitioners , 17 : 542 – 546 .
  • Hanson , R. L. , McCance , D. R. , Jacobsson , L. T. H. , Narayan , K. M. V. , Nelson , R. G. Pettitt , D. J. 1995 . The U-shaped association between body mass index and mortality: Relationship with weight gain in a Native American population . Journal of Clinical Epidemiology , 48 : 903 – 916 .
  • Harrington , M. , Gibson , S. and Cottrell , R. C. 2009 . A review and meta-analysis of the effect of weight loss on all-cause mortality risk . Nutrition Research Reviews , 22 : 93 – 108 .
  • Haskell , W. L. , Lee , I. M. , Pate , R. R. , Powell , K. E. , Blair , S. N. Franklin , B. A. 2007 . Physical activity and public health: Updated recommendations for adults from the American College of Sports Medicine and the American Heart Association . Circulation , 116 : 1081 – 1093 .
  • Hastie , C. E. , Padmanabhan , S. , Slack , R. , Pell , A. C. H. , Oldroyd , K. G. Flapan , A. D. 2010 . Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention . European Heart Journal , 31 : 222 – 226 .
  • Heitmann , B. L. and Frederiksen , P. 2009 . Thigh circumference and risk of heart disease and premature death: Prospective cohort study . British Medical Journal , 339 : b3292
  • Horwich , T. B. , Fonarow , G. C. , Hamilton , M. A. , MacLellan , W. R. , Woo , M. A. and Tillisch , J. H. 2001 . The relationship between obesity and mortality in patients with heart failure . Journal of the American College of Cardiology , 38 : 789 – 795 .
  • Hunter , G. A. , Chandler-Laney , P. C. , Brock , D. W. , Lara-Castro , C. , Fernandez , J. R. and Gower , B. A. 2010 . Fat distribution, aerobic fitness, blood lipids, and insulin sensitivity in African-American and European-American women . Obesity , 18 : 274 – 281 .
  • Ingram , D. D. and Mussolino , M. E. 2010 . Weight loss from maximum body weight and mortality: The Third National Health and Nutrition Examination Survey Linked Mortality File . International Journal of Obesity , 34 : 1044 – 1050 .
  • Jeffery , R. W. , Drewnowski , A. , Epstein , L. H. , Stunkard , A. J. , Wilson , G. T. Wing , R. R. 2000 . Long-term maintenance of weight loss: Current status . Health Psychology , 19 ( 1 suppl. ) : 5 – 16 .
  • Johnson , N. P. , Wu , E. , Bonow , R. O. and Holly , T. A. 2008 . Relation of exercise capacity and body mass index to mortality in patients with intermediate to high risk of coronary artery disease . American Journal of Cardiology , 102 : 1028 – 1033 .
  • Karelis , A. D. 2008 . Metabolically healthy but obese individuals . Lancet , 372 : 1281 – 1283 .
  • Kenchaiah , S. , Pocock , S. J. , Wang , D. , Finn , P. W. , Zornoff , L. A. M. Skali , H. 2007 . Body mass index and prognosis in patients with chronic heart failure . Circulation , 116 : 627 – 636 .
  • Kim , S. and Popkin , B. M. 2006 . Commentary. Understanding the epidemiology of overweight and obesity: A real global publichealth concern . International Journal of Epidemiology , 35 : 60 – 67 .
  • Kodama , S. , Saito , K. , Tanaka , S. , Maki , M. , Yachi , Y. Asumi , M. 2009 . Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis . Journal of the American Medical Association , 301 : 2024 – 2035 .
  • Kragelund , C. and Omland , T. 2005 . A farewell to body-mass index? . Lancet , 366 : 1589 – 1591 .
  • Lancefield , T. , Clark , D. J. , Andrianopoulos , N. , Brennan , A. L. , Reid , C. M. Johns , J. 2010 . Is there an obesity paradox after percutaneous coronary intervention in the contemporary era? An analysis from a multicenter Australian registry . Journal of the American College of Cardiology: Cardiovascular Interventions , 3 : 660 – 668 .
  • Lantz , P. M. , Golberstein , E. , House , J. S. and Morenoff , J. 2010 . Socioeconomic and behavioral risk factors for mortality in a national 19-year prospective study of U.S. adults . Social Science and Medicine , 70 : 1558 – 1566 .
  • Lavie , C. J. , Milani , R. V. , Artham , S. M. , Dharmendrakumar , P. A. and Ventura , H. O. 2009 . The obesity paradox, weight loss, and coronary artery disease . American Journal of Medicine , 122 : 1106 – 1114 .
  • Lavie , C. J. , Osman , A. F. , Milani , R. V. and Mehra , M. R. 2003 . Body composition and prognosis in chronic systolic heart failure: The obesity paradox . American Journal of Cardiology , 91 : 891 – 894 .
  • Leavey , S. F. , McCullough , K. , Hecking , E. , Goodkin , D. , Port , F. K. and Young , E. W. 2001 . Body mass index and mortality in “healthier” as compared with “sicker” haemodialysis patients: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS) . Nephrology Dialysis Transplantation , 16 : 2386 – 2394 .
  • Lee , C. D. , Blair , S. N. and Jackson , A. S. 1999 . Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men . American Journal of Clinical Nutrition , 69 : 373 – 380 .
  • Lee , D. C. , Sui , X. and Blair , S. N. 2009 . Does physical activity ameliorate the health hazards of obesity? . British Journal of Sports Medicine , 43 : 49 – 51 .
  • Levitan , E. B. , Song , Y. , Ford , E. S. and Liu , S. 2004 . Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies . Archives of Internal Medicine , 164 : 2147 – 2155 .
  • Lewis , C. E. , McTigue , K. M. , Burke , L. E. , Poirier , P. , Eckel , R. H. Howard , B. V. 2009 . Mortality, health outcomes, and body mass index in the overweight range: A science advisory from the American Heart Association . Circulation , 119 : 3263 – 3271 .
  • Lyerly , G. W. , Sui , X. , Lavie , C. J. , Church , T. S. , Hand , G. A. and Blair , S. N. 2009 . The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus . Mayo Clinic Proceedings , 84 : 780 – 786 .
  • Manolopoulos , K. N. , Karpe , F. and Frayn , K. N. 2010 . Gluteofemoral body fat as a determinant of metabolic health . International Journal of Obesity , 34 : 949 – 959 .
  • McAuley , P. A. , Kokkinos , P. F. , Oliveira , R. B. , Emerson , B. T. and Myers , J. N. 2010a . Obesity paradox and cardiorespiratory fitness in 12,417 male veterans aged 40 to 70 years . Mayo Clinic Proceedings , 85 : 115 – 121 .
  • McAuley , P. , Myers , J. , Abella , J. and Froelicher , V. 2007 . Body mass, fitness and survival in veteran patients: Another obesity paradox? . American Journal of Medicine , 120 : 518 – 524 .
  • McAuley , P. A. , Sui , X. and Blair , S. N. 2010b . Letter by McAuley, Sui, and Blair regarding article, “Impact of body mass index andthe metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men” . Circulation , 122 : e455
  • McAuley , P. A. , Sui , X. , Church , T. S. , Hardin , J. W. , Myers , J. N. and Blair , S. N. 2009 . The joint effects of cardiorespiratory fitness and adiposity on mortality risk in men with hypertension . American Journal of Hypertension , 22 : 1062 – 1069 .
  • McGee , D. L. 2005 . Body mass index and mortality: A meta-analysis based on person-level data from twenty-six observational studies . Annals of Epidemiology , 15 : 87 – 97 .
  • National Institutes of Health . 1998 . Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity inadults: The evidence report , Bethesda, MD : NIH . NIH Publication No. 98-4083
  • National Task Force on the Prevention and Treatment of Obesity . 2000 . Overweight, obesity, and health risk . Archives of Internal Medicine , 160 : 898 – 904 .
  • Nigam , A. , Wright , R. S. , Allison , T. G. , Williams , B. A. , Kopecky , S. L. Reeder , G. S. 2006 . Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac death . International Journal of Cardiology , 110 : 153 – 159 .
  • Ning , F. , Tuomilehto , J. , Pyorala , K. , Onat , A. , Soderberg , S. and Qiao , Q. 2010 . Cardiovascular disease mortality in Europeans in relation to fasting 2-h plasma glucose levels within a normoglycemic range . Diabetes Care , 33 : 2211 – 2216 .
  • Noori , N. , Kovesdy , C. P. , Dukkipati , R. , Kim , Y. , Duong , U. Bross , R. 2010 . Survival predictability of lean and fat mass in men and women undergoing maintenance hemodialysis . American Journal of Clinical Nutrition , 92 : 1060 – 1070 .
  • Okorodudu , D. O. , Jumean , M. F. , Montori , V. M. , Romero-Corral , A. , Somers , V. K. Erwin , P. J. 2010 . Diagnostic performance of body mass index to identify obesity as defined by body adiposity: A systematic review and meta-analysis . International Journal of Obesity , 34 : 791 – 799 .
  • Oreopoulos , A. , Padwal , R. , Kalantar-Zadeh , K. , Fonarow , G. C. , Norris , C. M. and McAlister , F. A. 2008 . Body mass index and mortality in heart failure: A meta-analysis . American Heart Journal , 156 : 13 – 22 .
  • Orpana , H. M. , Berthelot , J. M. , Kaplan , M. S. , Feeny , D. H. , McFarland , B. and Ross , N. A. 2010 . BMI and mortality: Results from a national longitudinal study of Canadian adults . Obesity , 18 : 214 – 218 .
  • Prospective Studies Collaboration . 2009 . Body-mass index and cause-specific mortality in 900 000 adults: Collabortive analysis of 57 prospective studies . Lancet , 373 : 1083 – 1096 .
  • Reaven , G. M. 2003 . Importance of identifying the overweight patient who will benefit the most by losing weight . Annals of Internal Medicine , 138 : 420 – 423 .
  • Romero-Corral , A. , Montori , V. M. , Somers , V. K. , Korinek , J. , Thomas , R. J. Allison , T. G. 2006 . Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies . Lancet , 368 : 666 – 678 .
  • Salahudeen , A. K. 2003 . Obesity and survival on dialysis . American Journal of Kidney Diseases , 41 : 925 – 932 .
  • Schmidt , D. S. and Salahudeen , A. K. 2007 . The obesity–survival paradox in hemodialysis patients: Why do overweight hemodialysis patients live longer? . Nutrition in Clinical Practice , 22 : 11 – 15 .
  • Schreiner , P. J. , Terry , J. G. , Evans , G. W. , Hinson , W. H. , Crouse , J. R. III and Heiss , G. 1996 . Sex-specific associations of magnetic resonance imaging-derived intra-abdominal and subcutaneous fat areas with conventional anthropometric indices: The Atherosclerosis Risk in Communities Study . American Journal of Epidemiology , 144 : 335 – 345 .
  • Stefan , N. , Kantartzis , K. , Machann , J. , Schick , F. , Thamer , C. Rittig , K. 2008 . Identification and characterization of metabolically benign obesity in humans . Archives of Internal Medicine , 168 : 1609 – 1616 .
  • Tanko , L. B. and Christiansen , C. 2005 . Can the obesity paradox be explained by the protective effects of peripheral adiposity? . Archives of Internal Medicine , 165 : 1796 – 1797 .
  • Terry , R. B. , Stefanick , M. L. , Haskell , W. L. and Wood , P. D. 1991 . Contributions of regional adipose tissue depots to plasma lipoprotein concentrations in overweight men and women: Possible protective effect of thigh fat . Metabolism , 40 : 733 – 740 .
  • Troiano , R. P. , Frongillo , E. A. Jr. , Sobal , J. and Levitsky , D. A. 1996 . The relationship between body weight and mortality: A quantitative analysis of combined information from existing studies . International Journal of Obesity , 20 : 63 – 75 .
  • Tsai , S. P. , Wen , C. P. , Chan , H. T. , Chiang , P. H. , Tsai , M. K. and Cheng , T. Y. 2008 . The effects of pre-disease risk factors within metabolic syndrome on all-cause and cardiovascular disease mortality . Diabetes Research and Clinical Practice , 82 : 148 – 156 .
  • Tucker , M. D. , Palmer , A. J. , Valentine , W. J. , Roze , S. and Ray , J. A. 2006 . Counting the costs of overweight and obesity: Modeling clinical and cost outcomes . Current Medical Research and Opinions , 22 : 575 – 586 .
  • Uretsky , S. , Messerli , F. H. , Bangalore , S. , Champion , A. , Cooper-DeHoff , R. M. Zhou , Q. 2007 . Obesity paradox in patients with hypertension and coronary artery disease . American Journal of Medicine , 120 : 863 – 870 .
  • Uretsky , S. , Supariwala , A. , Singh , P. , Atluri , P. , Khokhar , S. S. Koppuravuri , H. K. 2010 . Impact of weight on long-term survival among patients without known coronary artery disease and a normal stress SPECT MPI . Journal of Nuclear Cardiology , 17 : 390 – 397 .
  • Van Poppel , M. N. M. , Chiapaw , M. J. M. , Mokkink , L. B. , van Mechelen , W. and Terwee , C. B. 2010 . Physical activity questionnaires for adults: A systematic review of measurement properties . Sports Medicine , 40 : 565 – 600 .
  • Wei , M. , Kampert , J. B. , Barlow , C. E. , Nichaman , M. Z. , Gibbons , L. W. Paffenbarger , R. S. Jr. 1999 . Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men . Journal of the American Medical Association , 282 : 1547 – 1553 .
  • Westerterp , K. R. 2009 . Assessment of physical activity: A critical appraisal . European Journal of Applied Physiology , 105 : 823 – 828 .
  • Wildman , R. P. 2009 . Healthy obesity . Current Opinion in Clinical Nutrition and Metabolic Care , 12 : 438 – 443 .
  • Wildman , R. P. , Muntner , P. , Reynolds , K. , McGinn , A. P. , Rajpathak , S. Wylie-Rosett , J. 2008 . The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk clustering . Archives of Internal Medicine , 168 : 1617 – 1624 .
  • World Health Organization . 1995 . Physical status: The use and interpretation of anthropometry , Geneva : WHO . WHO Technical Report Series No. 854
  • Wu , A. H. , Pitt , B. , Anker , S. D. , Vincent , J. , Mujib , M. and Ahmed , A. 2010 . Association of obesity and survival in systolic heart failure after acute myocardial infarction: Potential confounding by age . European Journal of Heart Failure , 12 : 566 – 573 .
  • Zamboni , M. , Mazzali , G. , Zoico , E. , Harris , T. B. , Meigs , J. B. Di Francesco , V. 2005 . Health consequences of obesity in the elderly: A review of four unresolved questions . International Journal of Obesity , 29 : 1011 – 1029 .

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