2,449
Views
59
CrossRef citations to date
0
Altmetric
Physiology

Non-targeted metabolomics in sport and exercise science

ORCID Icon, ORCID Icon &
Pages 959-967 | Accepted 07 Mar 2017, Published online: 27 Mar 2017

References

  • Aubert, G., Martin, O. J., Horton, J. L., Lai, L., Vega, R. B., Leone, T. C., … Kelly, D. P. (2016). The failing heart relies on ketone bodies as a fuel. Circulation, 133(8), 698–705. doi:10.1161/circulationaha.115.017355
  • Bassini, A., & Cameron, L. C. (2014). Sportomics: Building a new concept in metabolic studies and exercise science. Biochemical and Biophysical Research Communications, 445(4), 708–716. doi:10.1016/j.bbrc.2013.12.137
  • Bedi, K. C., Jr., Snyder, N. W., Brandimarto, J., Aziz, M., Mesaros, C., Worth, A. J., … Rame, J. E. (2016). Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation, 133(8), 706–716. doi:10.1161/circulationaha.115.017545
  • Berton, R., Conceição, M. S., Libardi, C. A., Canevarolo, R. R., Gáspari, A. F., Chacon-Mikahil, M. P. T., … Cavaglieri, C. R. (2016). Metabolic time-course response after resistance exercise: A metabolomics approach. Journal of Sports Sciences. Advance online publication. doi:10.1080/02640414.2016.1218035
  • Bye, A., Vettukattil, R., Aspenes, S. T., Giskeødegård, G. F., Gribbestad, I. S., Wisløff, U., … Monleon, D. (2012). Serum levels of choline-containing compounds are associated with aerobic fitness level: The HUNT-study. PLoS One, 7(7), e42330. doi:10.1371/journal.pone.0042330
  • Chorell, E., Moritz, T., Branth, S., Antti, H., & Svensson, M. B. (2009). Predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise. Journal of Proteome Research, 8(6), 2966–2977. doi:10.1021/pr900081q
  • Creek, D. J., Jankevics, A., Breitling, R., Watson, D. G., Barrett, M. P., & Burgess, K. E. V. (2011). Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: Improved metabolite identification by retention time prediction. Analytical Chemistry, 83(22), 8703–8710. doi:10.1021/ac2021823
  • Di Guida, R., Engel, J., Allwood, J. W., Weber, R. J. M., Jones, M. R., Sommer, U., … Dunn, W. B. (2016). Non-targeted UHPLC-MS metabolomic data processing methods: A comparative investigation of normalisation, missing value imputation, transformation and scaling. Metabolomics, 12(5), 1–14. doi:10.1007/s11306-016-1030-9
  • Dunn, W. B., Broadhurst, I. B., Atherton, H. J., Goodacre, R. J., & Griffin, J. L. (2011). Systems level studies of mammalian metabolomes: The roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chemical Society Reviews, 40(1), 387–426. doi:10.1039/B906712B
  • Dunn, W. B., Broadhurst, I. B., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., … Goodacre, R. (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols, 6(7), 1060–1083. doi:10.1038/nprot.2011.335
  • Egan, B., Hawley, J. A., & Zierath, J. R. (2016). Snapshot: Exercise metabolism. Cell Metabolism, 24(2), 342–342.e1. doi:10.1016/j.cmet.2016.07.013
  • Enea, C., Seguin, F., Petitpas-Mulliez, J., Boildieu, N., Boisseau, N., Delpech, N., … Dugue, B. (2010). (1)H NMR-based metabolomics approach for exploring urinary metabolome modifications after acute and chronic physical exercise. Analytical and Bioanalytical Chemistry, 396(3), 1167–1176. doi:10.1007/s00216-009-3289-4
  • Frayn, K. N. (1983). Calculation of substrate oxidation rates in vivo from gaseous exchange. Journal of Applied Physiology, 55(2), 628–634.
  • Fudge, B. W., Westerterp, K. R., Kiplamai, F. K., Onywera, V. O., Boit, M. K., Kayser, B., & Pitsiladis, Y. P. (2006). Evidence of negative energy balance using doubly labelled water in elite Kenyan endurance runners prior to competition. British Journal of Nutrition, 95(1), 59–66. doi:10.1079/BJN20051608
  • Fuhrer, T., & Zamboni, N. (2015). High-throughput discovery metabolomics. Current Opinion in Biotechnology, 31, 73–78. doi:10.1016/j.copbio.2014.08.006
  • Gleeson, M., McDonald, W. A., Pyne, D. B., Cripps, A. W., Francis, J. L., Fricker, P. A., & Clancy, R. L. (1999). Salivary IgA levels and infection risk in elite swimmers. Medicine and Science in Sports and Exercise, 31(1), 67–73. doi:10.1097/00005768-199901000-00012
  • Gonzalez, J. T., Fuchs, C. J., Smith, F. E., Thelwall, P. E., Taylor, R., Stevenson, E. J., … Van Loon, L. J. (2015). Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. American Journal of Physiology, Endocrinology & Metabolism, 309(12), E1032–E1039. doi:10.1152/ajpendo.00376.2015
  • Griffiths, W. J., Koal, T., Wang, Y., Kohl, M., Enot, D. P., & Deigner, H. (2010). Targeted metabolomics for biomarker discovery. Angewandte Chemie International Edition, 49(32), 5426–5445. doi:10.1002/anie.200905579
  • Heaney, L. M., Ruszkiewicz, D. M., Arthur, K. L., Hadjithekli, A., Aldcroft, C., Lindley, M. R., … Reynolds, J. C. (2016). Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer. Bioanalysis, 8(13), 1325–1336. doi:10.4155/bio-2016-0045
  • Hough, J., Corney, R., Kouris, A., & Gleeson, M. (2013). Salivary cortisol and testosterone responses to high-intensity cycling before and after an 11-day intensified training period. Journal of Sports Sciences, 31(14), 1614–1623. doi:10.1080/02640414.2013.792952
  • Impey, S. G., Hammond, K. M., Shepherd, S. O., Sharples, A. P., Stewart, C., Limb, M., … Morton, J. P. (2016). Fuel for the work required: A practical approach to amalgamating train-low paradigms for endurance athletes. Physiological Reports, 4, e12803. doi:10.14814/phy2.12803
  • Jones, A. M., Wilkerson, D. P., & Fulford, J. (2008). Muscle [phosphocreatine] dynamics following the onset of exercise in humans: The influence of baseline work-rate. The Journal of Physiology, 586(3), 889–898. doi:10.1113/jphysiol.2007.142026
  • Kováts, E. (1958). Gas-chromatographische Charakterisierung organischer Verbindungen. Teil 1: Retentionsindices aliphatischer Halogenide, Alkohole, Aldehyde und Ketone. Helvetica Chimica Acta, 41(7), 1915–1932. doi:10.1002/hlca.19580410703
  • Krug, S., Kastenmuller, G., Stuckler, F., Rist, M. J., Skurk, T., Sailer, M., … Daniel, H. (2012). The dynamic range of the human metabolome revealed by challenges. The FASEB Journal, 26(6), 2607–2619. doi:10.1096/fj.11-198093
  • Lee, R., West, D., Phillips, S. M., & Britz-McKibbin, P. (2010). Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: Thiol-specific regulation of cellular metabolism with N-acetyl-L-cysteine pretreatment. Analytical Chemistry, 82(7), 2959–2968. doi:10.1021/ac9029746
  • Lehmann, R., Zhao, X., Weigert, C., Simon, P., Fehrenbach, E., Fritsche, J., … Niess, A. M. (2010). Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation. PLoS One, 5(7), e11519. doi:10.1371/journal.pone.0011519
  • Lustgarten, M. S., Price, L. L., Logvinenko, T., Hatzis, C., Padukone, N., Reo, N. V., … Fielding, R. A. (2013). Identification of serum analytes and metabolites associated with aerobic capacity. European Journal of Applied Physiology, 113(5), 1311–1320. doi:10.1007/s00421-012-2555-x
  • Malkar, A., Devenport, N. A., Martin, H. J., Patel, P., Turner, M. A., Watson, P., … Creaser, C. S. (2013). Metabolic profiling of human saliva before and after induced physiological stress by ultra-high performance liquid chromatography–ion mobility–mass spectrometry. Metabolomics, 9(6), 1192–1201. doi:10.1007/s11306-013-0541-x
  • Mathe, E. A., Patterson, A. D., Haznadar, M., Manna, S. K., Krausz, K. W., Bowman, E. D., … Harris, C. C. (2014). Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. Cancer Research, 74(12), 3259–3270. doi:10.1158/0008-5472.can-14-0109
  • McCarthy, M. (2015). Obama seeks $213m to fund “precision medicine”. Bmj, 350, h578. doi:10.1136/bmj.h587
  • Meeusen, R., Duclos, M., Foster, C., Fry, A., Gleeson, M., Nieman, D., … Urhausen, A. (2013). Prevention, diagnosis, and treatment of the overtraining syndrome: Joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Medicine and Science in Sports and Exercise, 45(1), 186–205. doi:10.1249/MSS.0b013e318279a10a
  • Miccheli, A., Marini, F., Capuani, G., Miccheli, A. T., Delfini, M., Di Cocco, M. E., … Spataro, A. (2009). The influence of a sports drink on the postexercise metabolism of elite athletes as investigated by NMR-based metabolomics. Journal of the American College of Nutrition, 28(5), 553–564. doi:10.1080/07315724.2009.10719787
  • Morris, C., Grada, C. O., Ryan, M., Roche, H. M., De Vito, G., Gibney, M. J., … Brennan, L. (2013). The relationship between aerobic fitness level and metabolic profiles in healthy adults. Molecluar Nutrition & Food Research, 57(7), 1246–1254. doi:10.1002/mnfr.201200629
  • Neville, V., Gleeson, M., & Folland, J. P. (2008). Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Medicine and Science in Sports and Exercise, 40(7), 1228–1236. doi:10.1249/MSS.0b013e31816be9c3
  • Nicholson, J. K., Lindon, J. C., & Holmes, E. (1999). ‘Metabonomics’: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica, 29(11), 1181–1189. doi:10.1080/004982599238047
  • Nicholson, J. K., & Wilson, I. D. (2003). Understanding ‘global’ systems biology: Metabonomics and the continuum of metabolism. Nature Reviews Drug Discovery, 2(8), 668–676. doi:10.1038/nrd1157
  • Nieman, D. C., Gillitt, N. D., Knab, A. M., Shanely, R. A., Pappan, K. L., Jin, F., & Lila, M. A. (2013). Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: A randomized trial using a metabolomics approach. PLoS One, 8(8), e72215. doi:10.1371/journal.pone.0072215
  • Nieman, D. C., Shanely, R. A., Gillitt, N. D., Pappan, K. L., & Lila, M. A. (2013). Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runners. Journal of Proteome Research, 12(10), 4577–4584. doi:10.1021/pr400717j
  • Nieman, D. C., Shanely, R. A., Luo, B., Meaney, M. P., Dew, D. A., & Pappan, K. L. (2014). Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 307(1), R68–74. doi:10.1152/ajpregu.00092.2014
  • O’Gorman, D. J., Karlsson, H. K., McQuaid, S., Yousif, O., Rahman, Y., Gasparro, D., … Nolan, J. J. (2006). Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia, 49(12), 2983–2992. doi:10.1007/s00125-006-0457-3
  • O’Hara, J. P., Carroll, S., Cooke, C. B., Morrison, D. J., Preston, T., & King, R. F. (2012). Preexercise galactose and glucose ingestion on fuel use during exercise. Medicine and Science in Sports and Exercise, 44(10), 1958–1967. doi:10.1249/MSS.0b013e318258bf85
  • Pechlivanis, A., Kostidis, S., Saraslanidis, P., Petridou, A., Tsalis, G., Veselkov, K., … Theodoridis, G. A. (2013). 1H NMR study on the short- and long-term impact of two training programs of sprint running on the metabolic fingerprint of human serum. Journal of Proteome Research, 12(1), 470–480. doi:10.1021/pr300846x
  • Pohjanen, E., Thysell, E., Jonsson, P., Eklund, C., Silfver, A., Carlsson, I. B., … Antti, H. (2007). A multivariate screening strategy for investigating metabolic effects of strenuous physical exercise in human serum. Journal of Proteome Research, 6(6), 2113–2120. doi:10.1021/pr070007g
  • Ra, S.-G., Maeda, S., Higashino, R., Imai, T., & Miyakawa, S. (2014). Metabolomics of salivary fatigue markers in soccer players after consecutive games. Applied Physiology, Nutrition, and Metabolism, 39(10), 1120–1126. doi:10.1139/apnm-2013-0546
  • Santone, C., Dinallo, V., Paci, M., D’Ottavio, S., Barbato, G., & Bernardini, S. (2014). Saliva metabolomics by NMR for the evaluation of sport performance. Journal of Pharmaceutical and Biomedical Analysis, 88, 441–446. doi:10.1016/j.jpba.2013.09.021
  • Suzuki, T., Heaney, L. M., Bhandari, S. S., Jones, D. J. L., & Ng, L. L. (2016). Trimethylamine N-oxide and prognosis in acute heart failure. Heart, 102(11), 841–848. doi:10.1136/heartjnl-2015-308826
  • Suzuki, T., Heaney, L. M., Jones, D. J. L., & Ng, L. L. (2016). Trimethylamine N-ozide and risk stratification after acute myocardial infarction. Clinical Chemistry, 63(1), 420–428. doi:10.1373/clinchem.2016.264853
  • Tang, W. H., Wang, Z., Fan, Y., Levison, B., Hazen, J. E., Donahue, L. M., … Hazen, S. L. (2014). Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: Refining the gut hypothesis. Journal of the American College of Cardiology, 64(18), 1908–1914. doi:10.1016/j.jacc.2014.02.617
  • The Human Metabolome Database. (2016, 12 August). Retrieved from http://www.hmdb.ca
  • Thevis, M., Kuuranne, T., Walpurgis, K., Geyer, H., & Schänzer, W. (2016). Annual banned-substance review: Analytical approaches in human sports drug testing. Drug Testing and Analysis, 8(1), 7–29. doi:10.1002/dta.1928
  • Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., Dugar, B., … Hazen, S. L. (2011). Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature, 472(7341), 57–63. doi:10.1038/nature09922
  • Wang, Z., Tang, W. H., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., … Hazen, S. L. (2014). Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. European Heart Journal, 35(14), 904–910. doi:10.1093/eurheartj/ehu002
  • Want, E. J., Wilson, I. D., Gika, H., Theodoridis, G., Plumb, R. S., Shockcor, J., … Nicholson, J. K. (2010). Global metabolic profiling procedures for urine using UPLC–MS. Nature Protocols, 5(6), 1005–1018. doi:10.1038/nprot.2010.50
  • Wiklund, S., Johansson, E., Sjöström, L., Mellerowicz, E. J., Edlund, U., Shockcor, J. P., … Trygg, J. (2008). Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Analytical Chemistry, 80(1), 115–122. doi:10.1021/ac0713510
  • Wishart, D. S., Jewison, T., Guo, A. C., Wilson, M., Knox, C., Liu, Y., … Scalbert, A. (2013). HMDB 3.0–The Human Metabolome Database in 2013. Nucleic Acids Research, 41(Database issue), D801–807. doi:10.1093/nar/gks1065
  • Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., … Querengesser, L. (2007). HMDB: The Human Metabolome Database. Nucleic Acids Research, 35(Database issue), D521–526. doi:10.1093/nar/gkl923
  • Worley, B., & Powers, R. (2013). Multivariate analysis in metabolomics. Current Metabolomics, 1(1), 92–107. doi:10.2174/2213235X11301010092
  • Yan, B., Jiye, A., Wang, G., Lu, H., Huang, X., Liu, Y., … Sun, J. (2009). Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training. Journal of Applied Physiology, 106(2), 531–538. doi:10.1152/japplphysiol.90816.2008

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.