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Original Articles

Quorum sensing: implications on Rhamnolipid biosurfactant production

, , , , &
Pages 159-184 | Published online: 15 Apr 2013

References

  • Abalos , A. , Pinazo , A. , Infante , M.R. , Casals , M. Garcia , F. 2001 . Physicochemical and antimicrobial properties of new rhamnolipids produced by Pseudomonas aeruginosa AT10 from soybean oil refinery wastes . Langmuir , 17 : 1367 – 1371 .
  • Albus , A.M. , Pesci , E. C. , Runyen-Janecky , L.J. , West , S.E.H. and Iglewski , B.H. 1997 . Vfr controls quorum sensing Pseudomonas aeruginosa . Journal of Bacteriology , 179 : 3928 – 3935 .
  • Al-tahhan , R.A. , Sandrin , T.R. , Bodour , A.A. and Maier , R.M. 2000 . Rhamnolipidinduced removal of lipopolysaccharide from Pseudomonas aeruginosa: effect on cell surface properties and interaction with hydrophobic substrates . Applied and Environmental Microbiology , 66 : 3262 – 3268 .
  • Arino , S. , Marchal , R. and Vandecasteele , J.P. 1996 . Identification and production of a rhamnolipidic biosurfactant by a Pseudomonas species . Applied Microbiology and Biotechnology , 45 : 162 – 168 .
  • Balagadde , F.K. , You , L. , Hansen , C.L. , Arnold , F.H. and Quake , S.R. 2005 . Longterm monitoring of bacteria undergoing programmed population control in a microchemostat . Science , 309 : 137 – 140 .
  • Balagadde , F.K. , Song , H. , Ozaki , J. , Collins , C.H. Barnet , M. 2008 . A synthetic Escherichia coli predator-prey ecosystem . Molecular and Systematic Biology , 4 : 1 – 8 .
  • Bassler , B.L. , Greenberg , E.P. and Stevens , A.M. 1997 . Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi . Journal of Bacteriology , 179 : 4043 – 4045 .
  • Basu , S. , Gerchman , Y. , Collins , C.H. , Arnold , F.H. and Weiss , R. 2005 . A synthetic multicellular system for programmed pattern formation . Nature , 434 : 1130 – 1134 .
  • Bejerano-sagie , M. and Xavier , K.B. 2007 . The role of small RNAs in quorum-sensing . Current Opinion in Microbiology , 10 : 189 – 98 .
  • Benka-coker , M.O. and Ekundaya , J.A. 1996 . Applicability of evaluating the ability of microbes isolated from an oil spill site to degrade oil . Environment Monitor Assessment , 45 : 259 – 272 .
  • Bjarnsholt , T. , Jensen , P.O. , Burmolle , M. , Hentzer , M. Haagensen , J.A.J . 2005 . Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent . Microbiology , 151 : 373 – 383 .
  • Boles , B.R. , Thoendel , M. and Singh , P.K. 2005 . Rhamnolipids mediate detachment of Pseudomonas aeruginosa from biofilms . Molecular Microbiology , 57 : 1210 – 1223 .
  • Borgund , A.E. , Erstad , K. and Barth , T. 2007 . Normal phase high performance liquid chromatography for fractionation of organic acid mixtures extracted from crude oils . Journal of Chromatography: A , 1149 : 189 – 196 .
  • Brenner , K. , Karig , D.K. , Weiss , R. and Arnold , F.H. 2007 . Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium . Proceedings of the National Academy of Sciences (USA) , 104 : 17300 – 17304 .
  • Bulter , T. , Lee , S.G. , Wong , W.W. , Fung , E. Conner , M.R. 2004 . Design of artificial cell-cell communication using gene and metabolic networks . Proceedings of the National Academy of Sciences (USA) , 101 : 2299 – 2304 .
  • Burger , M.M. , Glaser , L. and Burton , R.M. 1963 . The enzymatic synthesis of a rhamnose-containing glycolipid by extracts of Pseudomonas aeruginosa . Journal of Biological Chemistry , 238 : 2595 – 2602 .
  • Calfee , M.W. , Shelton , J.G. , Mccubrey , J.A. and Pesci , E.C. 2005 . Solubility and bioactivity of the Pseudomonas quinolone signal are increased by a Pseudomonas aeruginosa-produced surfactant . Infection Immunity , 73 : 878 – 882 .
  • Camara , M. , Williams , P. and Hardman , A. 2002 . Controlling infection by tuning in and turning down the volume of bacterial small-talk . Lancet , 2 : 667 – 676 .
  • Campos-garcia , A. , Jesu , S. , Caro , A. D. , Jera , R. Miller-maier , R.M. 1998 . The Pseudomonas aeruginosa rhlG gene encodes an NADPH dependent ?-ketoacyl reductase which is specifically involved in rhamnolipid synthesis . Journal of Bacteriology , 180 : 4442 – 4451 .
  • Cao , H. , Krishnan , G. , Goumnerov , B. , Tsongalis , J. Tompkins , R. 2001 . A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self regulatory mechanism . Proceedings of the National Academy of Sciences (USA) , 98 : 14613 – 14618 .
  • Cha , M. , Lee , N. , Kim , M. , Kim , M. and Lee , S. 2008 . Heterologous production of Pseudomonas aeruginosa EMS1 biosurfactant in Pseudomonas putida . Bioresource Technology , 99 : 2192 – 2199 .
  • Chandrasekaran , E.V. and Bemiller , J.N. 1980 . “ Constituent analysis of glycosaminoglycans ” . In Methods in Carbohydrate Chemistry , Edited by: Whistler , R. L. and Wolform , M. L. 89 – 96 . New York : Academic Press .
  • Chen , X. , Schauder , S. , Potier , N. , Van dorsselaer , A. Pelczer , I. 2002 . Structural identification of a bacterial quorum-sensing signal containing boron . Nature , 415 : 545 – 549 .
  • Chen , M.T. and Weiss , R. 2005 . Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana . Nature Biotechnology , 23 : 1551 – 1555 .
  • Choe , B.Y. , Krishna , N.R. and Pritchard , D.G. 1992 . Proton NMR study on rhamnolipids produced by Pseudomonas aeruginosa . Magnetic Resonance Chemistry , 30 : 1025 – 1026 .
  • Costerton , J.W. , Cheng , K.J. , Geesey , G.G. , Ladd , T.I. Nickel , J.C. 1987 . Bacterial biofilms in nature and disease . Annual Reviews of Microbiology , 41 : 435 – 464 .
  • Davey , M.E. and O'toole , G.A. 2000 . Microbial biofilms: from ecology to molecular genetics . Microbiology and Molecular Biology Reviews , 64 : 847 – 867 .
  • Davey , M.E. , Caiazza , N.C. and O'toole , G.A. 2003 . Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1 . Journal of Bacteriology , 185 : 1027 – 1036 .
  • Davies , D.G. , Parsek , M.R. , Pearson , J.P. , Iglewski , B.H. Costerton , J.W. 1998 . The involvement of cell-cell signals in the development of a bacterial biofilm . Science , 280 : 295 – 298 .
  • De kievit , T.R. and Iglewsky , B.H. 2000 . Bacterial quorum sensing in pathogenic relationships . Journal of Bacteriology , 68 : 4839 – 4849 .
  • De koster , C.G. , Vos , B. , Versluis , C. , Heerma , W. and Haverkamp , J. 1994 . High-performance TLC/fast atom bombardment (tandem) mass spectrometry of Pseudomonas rhamnolipids . Biological Mass Spectroscopy , 23 : 179 – 185 .
  • Desai , J.D. and Banat , I.M. 1997 . Microbial production of surfactants and their commercial potential . Microbiology and Molecular Biology Reviews , 61 : 47 – 64 .
  • Deziel , E. , Lepine , F. , Dennie , D. , Boismenu , D. Mamer , O.A. 1999 . Liquid chromatography/mass spectrometry analysis of mixtures of rhamnolipids produced by Pseudomonas aeruginosa strain 57RP grown on mannitol or naphthalene . Biochimica Biophysica Acta , 1440 : 244 – 252 .
  • Deziel , E. , Lepine , F. , Milot , S. and Villemur , R. 2000 . Mass spectrometry monitoring of rhamnolipids from a growing culture of Pseudomonas aeruginosa strain 57RP . Biochimica Biophysica Acta , 1485 : 145 – 152 .
  • Deziel , E. , Lepine , F. , Milot , S. and Villemur , R. 2003 . rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3- hydroxyalkanoyloxy) alkanoic acids (HAAs), the precursors of rhamnolipids . Microbiology , 149 : 2005 – 2013 .
  • Deziel , E. , Lepine , F. , Milot , S. , He , J. Mindrinos , M.N. 2004 . Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication . Proceedings of the National Academy of Sciences (USA) , 101 : 1339 – 1344 .
  • Diggle , S.P. , Winzer , K. , Chhabra , S.R. , Worrall , K.E. Camara , M. 2003 . The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell densitydependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR . Molecular Microbiology , 50 : 29 – 43 .
  • Duan , K. , Dammel , C. , Stein , J. , Rabin , H. and Surette , M.G. 2003 . Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication . Molecular Microbiology , 50 : 1477 – 1491 .
  • Engebrecht , J. , Nealson , K. and Silverman , M. 1983 . Bacterial bioluminescence: isolation and genetic analysis of functions from Vibrio fischeri . Cell , 32 : 773 – 781 .
  • Finnerty , W.R. 1994 . Biosurfactants in environmental biotechnology . Current Opinion in Biotechnology , 5 : 291 – 295 .
  • Fuqua , W.C. , Winans , S.C. and Greenberg , E.P. 1994 . Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators . Journal of Bacteriology , 176 : 269 – 275 .
  • Fuqua , C. and Greenberg , E.P. 2002 . Listening in on bacteria: acyl-homoserine lactone signalling . Nature Reviews in Molecular and Cell Biology , 3 : 685 – 695 .
  • Gallagher , L.A. , Mcknight , S.L. , Kuznetsova , M.S. , Pesci , E.C. and Manoil , C. 2002 . Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa . Journal of Bacteriology , 184 : 6472 – 6480 .
  • Gambello , M.J. and Iglewski , B.H. 1991 . Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression . Journal of Bacteriology , 173 : 3000 – 3009 .
  • Gambello , M.J. , Kaye , S. and Iglewski , B.H. 1993 . LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression . Infection and Immunity , 61 : 1180 – 1184 .
  • Gartshore , J. , Lim , Y.C. and Cooper , D.G. 2000 . Quantitative analysis of biosurfactants using Fourier Transform Infrared (FT-IR) spectroscopy . Biotechnology Letters , 22 : 169 – 172 .
  • Gilson , L. , Kuo , A. and Dunlap , P.V. 1995 . AinS and a new family of autoinducer synthesis proteins . Journal of Bacteriology , 177 : 6946 – 6951 .
  • Givskov , M. , De nys , R. , Manefield , M. , Gram , L. Maximilien , R. 1996 . Eukaryotic intereference with homoserine lactone mediated prokaryotic signalling . Journal of Bacteriology , 178 : 6618 – 6622 .
  • Guerra-santos , L. , Kappeli , O. and Fiechter , A. 1984 . Pseudomonas aeruginosa biosurfactant production in continuous culture with glucose as carbon source . Applied and Environmental Microbiology , 48 : 301 – 305 .
  • Guerra-santos , L. , Kappeli , O. and Fiechter , A. 1986 . Dependence of Pseudomonas aeruginosa continuous culture biosurfactants production on nutritional and environmental factors . Applied Microbiology and Biotechnology , 24 : 443 – 448 .
  • Gunther , N.W. IV. , Nunez , A. , Fett , W. and Solaiman , D.K. 2005 . Production of rhamnolipids by Pseudomonas chlororaphis, a nonpathogenic bacterium . Applied Environmental Microbiology , 71 : 2288 – 2293 .
  • Haferburg , D. , Hommel , R. , Kleber , H.P. , Kluge , S. Schuster , G. 1987 . Antiphytoviral activity of a rhamnolipid from Pseudomonas aeruginosa . Acta Biotechnology , 7 : 353 – 356 .
  • Haussler , S. , Nimtz , M. , Domke , T. , Wray , V. and Steinmetz , I. 1998 . Purification and characterization of a cytotoxic exolipid of Burkholderia pseudomallei . Infection and Immunity , 66 : 1588 – 1593 .
  • Haussler , S. , Ziegler , I. , Lottel , A. , Von gotz , F. Rohde , M. 2003 . Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection . Journal of Medical Microbiology , 52 : 295 – 301 .
  • Helbert , J.R. and Brown , K.D. 1957 . Color reaction of anthrone with monosaccharide mixtures and oligo- and polysaccharides containing hexuronic acids . Analytical Chemistry , 29 : 1464 – 1466 .
  • Hentzer , M. , Teitzel , G.M. , Balzer , G.J. , Heydorn , A. Molin , S. 2001 . Alginate over-production affects Pseudomonas aeruginosa biofilm structure and function . Journal of Bacteriology , 183 : 5395 – 5401 .
  • Herman , D.C. , Zhang , Y. and Miller , R.M. 1997 . Rhamnolipid (biosurfactant) effects on cell aggregation and biodegradation of residual hexadecane under saturated flow conditions . Applied and Environmental Microbiology , 63 : 3622 – 3627 .
  • Heurlier , K. , Williams , F. , Heeb , S. , Dormond , C. Pessi , G. 2004 . Positive control of swarming, rhamnolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeruginosa PAO1 . Journal of Bacteriology , 186 : 2936 – 2945 .
  • Heyd , M. , Kohnert , A. , Tan , T.H. , Nusser , M. Kirschhofer , F. 2008 . Development and trends of biosurfactant analysis and purification using rhamnolipids as an example . Analytical and Bioanalytical Chemistry , 391 : 1579 – 1590 .
  • Hoffman , L.M. , Jendrisak , J.J. , Meis , R.J. , Goryshin , I.Y. and Reznikof , S.W. 2000 . Transposome insertional mutagenesis and direct sequencing of microbial genomes . Genetica , 108 : 19 – 24 .
  • Holden , P.A. , Lamontagne , M.G. , Bruce , A.K. , Miller , W.G. and Lindow , S.E. 2002 . Assessing the role of Pseudomonas aeruginosa surface-active gene expression in hexadecane biodegradation in sand . Applied and Environmental Microbiology , 68 : 2509 – 2518 .
  • Hommel , R. 1990 . Formation and physiological role of biosurfactants produced by hydrocarbon utilizing microorganisms . Biodegradation , 1 : 107 – 119 .
  • Ilori , M.O. , Amobi , C.J. and Odocha , A.C. 2005 . Factors affecting the production of oil degrading Aeromonas sp. isolated from a typical environment . Chemosphere , 61 : 985 – 992 .
  • Inakollu , S. , Hung , H.C. and Shreve , G.S. 2004 . Biosurfactant enhancement of microbial degradation of various structural classes of hydrocarbon in mixed water systems . Environmental Engineering Science , 21 : 463 – 469 .
  • Inoue , T. , Shingaki , R. and Fukui , K. 2008 . Inhibition of swarming motility of Pseudomonas aeruginosa by branched-chain fatty acids . FEMS Microbiology Letters , 281 : 81 – 86 .
  • Irie , Y. , O'toole , G. and Yuk , M.H. 2005 . Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms . FEMS Microbiology Letters , 250 : 237 – 243 .
  • Jarvis , F.G. and Johnson , M.J.A. 1949 . Glycolipid produced by Pseudomonas aeruginosa . Journal of Americal Chemical Society , 71 : 4124 – 4126 .
  • Jensen , P.O. , Bjarnsholt , T. , Phipps , R. , Rasmussen , T.B. Calum , H. 2007 . Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensingcontrolled production of rhamnolipid by Pseudomonas aeruginosa . Microbiology , 153 : 1329 – 1338 .
  • Jirasripongpun , K. 2002 . The characterization of oil-degrading microorganisms from lubricating oil contaminated (scale) soil . Letters in Applied Microbiology , 35 : 296 – 300 .
  • Johnson , M.K. and Boese-marazzo , O. 1980 . Production and properties of heat-stable extracellular hemolysin from Pseudomonas aeruginosa . Infection and Immunity , 29 : 1028 – 1033 .
  • King , A.T. , Davey , M.R. , Mellor , I.R. , Mulligan , B.J. and Lowe , K.C. 1991 . Surfactant effects on yeast cells . Enzyme and Microbial Technology , 13 : 148 – 153 .
  • Kleerebezem , M. , Quadri , L.E.N. , Kuipers , O.P. and Devos , W.M. 1997 . Quorum sensing by peptide pheromones and two component signal transduction systems in Gram positive bacteria . Molecular Microbiology , 24 : 895 – 904 .
  • Koch , A.K. , Kappeli , O. , Fiechter , A. and Reiser , K. 1991 . Hydrocarbon assimilation and biosurfactant production in Pseudomonas aeruginosa mutants . Journal of Bacteriology , 173 : 4212?4219
  • Kohler , T. , Curty , L.K. , Barja , F. , Van delden , C. and Pechere , J.C. 2000 . Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili . Journal of Bacteriology , 182 : 5990 – 5996 .
  • Kohler , T. , Dumas , J.L. and Van delden , C . 2007 . Ribosome protection prevents azithromycin-mediated quorum sensing modulation and stationary phase killing of Pseudomonas aeruginosa . Antimicrobial Agents Chemotherapy , 51 : 4243 – 4248 .
  • Kownatzki , R. , Tummler , B. and Doring , G. 1987 . Rhamnolipid of Pseudomonas aeruginosa in sputum of cystic fibrosis patients . Lancet , 1 : 1026 – 1027 .
  • Kuniho , N. , Yoshimot , A. and Yamada , Y. 1998 . Correlation between autoinducers and rhamnolipids production by Pseudomonas aeruginosa IFO 3924 . Journal of Fermentation Bioengineering , 86 : 608 – 610 .
  • Lang , S. and Wullbrandt , D. 1999 . Rhamnose lipids-biosynthesis, microbial production and application potential . Applied Microbiology and Biotechnology , 51 : 22 – 32 .
  • Latifi , A. , Foglino , M. , Tanaka , K. , Williams , P. and Lazdunski , A. 1996 . A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS . Molecular Microbiology , 21 : 1137 – 1146 .
  • Lazdunski , A.M. , Ventre , I. and Sturgis , J.N. 2004 . Regulatory circuits and communication in gram-negative bacteria . Nature Reviews in Microbiology , 2 : 581 – 592 .
  • Leitermann , F. , Syldatk , C. and Hausmann , R. 2008 . Fast quantitative determination of microbial rhamnolipids from cultivation broths by ATR-FTIR Spectroscopy . Journal of Biological Engineering , 2 : 13 doi:10.1186/1754–1611-2–13
  • Lepine , F. , Deziel , E. , Milot , S. and Villemur , R. 2002 . Liquid chromatographic/mass spectrometric detection of the 3-(3-hydroxyalkanoyloxy)alkanoic acid precursors of rhamnolipids in Pseudomonas aeruginosa cultures . Journal of Mass Spectrometry , 37 : 41 – 46 .
  • Linhardt , R.J. , Bakhit , R. , Daniels , L. , Mayerl , F. and Pickenhagen , W. 1989 . Microbially produced rhamnolipid as a source of rhamnose . Biotechnology and Bioengineering , 33 : 365 – 368 .
  • Lubelski , J. , Rink , R. , Khusainov , R. , Moll , G.N. and Kuipers , O.P. 2008 . Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin . Cell and Molecular Life Sciences , 65 : 455 – 476 .
  • Maier , R.M. and Soberon-chavez , G. 2000 . Pseudomonas aeruginosa rhamnolipids: biosynthesis and potential applications . Applied Microbiology and Biotechnology , 54 : 625 – 633 .
  • Mashburn , L.M. and Whiteley , M. 2005 . Membrane vesicles traffic signals and facilitate group activities in a prokaryote . Nature , 437 : 422 – 425 .
  • Mashburn-warren , L. , Howe , J. , Garidel , P. , Richter , W. Steiniger , F. 2008 . Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation . Molecular Microbiology , 69 : 491 – 502 .
  • Mashburn-warren , L. , Howe , J. , Brandenburg , K. and Whiteley , M. 2009 . Structural requirement of the Pseudomonas quinolone signal for membrane vesicle stimulation . Journal of Bacteriology , 191 : 3411 – 3414 .
  • Masse , E. , Majdalani , N. and Gottesman , S. 2003 . Regulatory roles for small RNAs in bacteria . Current Opinion in Microbiology , 6 : 120 – 124 .
  • Mata-sandoval , J.C. , Karns , J. and Torrents , A. 1999 . HPLC method for the characterization of rhamnolipid mixtures produced by P. aeruginosa UG2 on corn oil . Journal of Chromatography A , 864 : 211 – 220 .
  • Mata-sandoval , J.C. , Karns , J. and Torrents , A. 2000 . Effect of rhamnolipids produced by Pseudomonas aeruginosa UG2 on the solubilization of pesticides . Environmental Science and Technology , 34 : 4923 – 4930 .
  • Mcclure , C.D. and Schiller , N.L. 1992 . Effects of Pseudomonas aeruginosa rhamnolipids on human monocyte derived macrophages . Journal of Leukocyte Biology , 51 : 97 – 102 .
  • Mcknight , S.L. , Iglewski , B.H. and Pesci , E.C. 2000 . The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa . Journal of Bacteriology , 182 : 2702 – 2708 .
  • Mclean , R.J.C. , Whiteley , M. , Stickler , D.J. and Fuqua , W.C. 1997 . Evidence of autoinducer activity in naturally occurring biofilms . FEMS Microbiology Letters , 154 : 259 – 263 .
  • Miller , M.B. and Bassler , B.L. 2001 . Quorum sensing in bacteria . Annual Reviews of Microbiology , 55 : 165 – 199 .
  • Monteiro , S.A. , Sassaki , G.L. , De souza , L.M. , Meira , J.A. De araujo , J.M. 2007 . Molecular and structural characterization of the biosurfactant produced by Pseudomonas aeruginosa DAUPE 614 . Chemical and Physical Lipids , 147 : 1 – 13 .
  • Morihara , K. and Homma , J.Y. 1985 . “ Pseudomonas protease ” . In Bacterial Enzymes and Virulence , Edited by: Holder , I.A. 41 – 79 . Boca Raton : FL, CRC Press .
  • Muller-hurtig , R. , Blaszczyk , R. , Wagner , F. and Kosaric , N. 1993 . “ Biosurfactants for environmental control ” . In Biosurfactant , Edited by: Kosaric , N. 447 – 469 . New York : Marcel Dekker Inc .
  • Mulligan , C.N. , Yong , R.N. and Gibbs , B.F. 2001 . Heavy metal removal from sediments by biosurfactants . Journal of Hazardous Materials , 85 : 111 – 125 .
  • Mulligan , C.N. 2005 . Environmental applications for biosurfactants . Environmental Pollution , 133 : 183 – 198 .
  • Nealson , K.H. , Platt , T. and Hastings , J.W. 1970 . Cellular control of the synthesis and activity of the bacterial luminescent system . Journal of Bacteriology , 104 : 313 – 322 .
  • Nealson , K.H. and Hastings , J.W. 1979 . Bacterial bioluminescence: its control and ecological significance . Microbiology Reviews , 43 : 496 – 518 .
  • Noordman , W.H. and Janssen , D.B. 2002 . Rhamnolipid stimulates uptake of hydrophobic compounds by Pseudomonas aeruginosa . Applied and Environmental Microbiology , 68 : 4502 – 4508 .
  • Ochoa-loza , F.J. , Artiola , J.F. and Maier , R.M. 2001 . Stability constants for the complexation of various metals with a rhamnolipid biosurfactant . Journal of Environmental Quality , 30 : 479 – 485 .
  • Ochsner , U.A. , Fiechter , A. and Reiser , J. 1994 . Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis . Journal of Biological Chemistry , 269 : 19787 – 19795 .
  • Ochsner , U.A. , Koch , A.K. , Fiechter , A. and Reiser , J. 1994 . Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa . Journal of Bacteriology , 176 : 2044 – 2054 .
  • Ochsner , U.A. and Reiser , J. 1995 . Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa . Proceedings of the National Academy of Sciences (USA) , 92 : 6424 – 6428 .
  • Ochsner , U. , Reiser , J. , Fiechter , A. and Witholt , B. 1995 . Production of Pseudomonas aeruginosa rhamnolipid biosurfactants in heterologous hosts . Applied and Environmental Microbiology , 61 : 3503 – 3506 .
  • O'toole , G.A. and Kolter , R. 1998 . Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development . Molecular Microbiology , 30 : 295 – 304 .
  • Pamp , S.J. and Tolker-nielsen , T. 2007 . Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa . Journal of Bacteriology , 189 : 2531 – 2539 .
  • Pappas , K. , Weingart , C.L. and Winans , S.C. 2004 . Chemical communication in proteobacteria: biochemical and structural studies of signal synthases and receptors required for intercellular signaling . Molecular Microbiology , 53 : 755 – 769 .
  • Parsek , M.R. and Greenberg , E.P. 2000 . Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: a signaling mechanism involved in associations with higher organisms . Proceedings of the National Academy of Sciences (USA) , 97 : 8789 – 8793 .
  • Passador , L. , Cook , J.M. , Gambello , M.J. , Rust , L. and Iglewski , B.H. 1993 . Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication . Science , 260 : 1127 – 1130 .
  • Pearson , J.P. , Gray , K.M. , Passador , L. , Tucker , K.D. Eberhard , A. 1994 . Structure of the autoinducer required for expression of P. aeruginosa virulence genes . Proceedings of the National Academy of Sciences (USA) , 91 : 197 – 201 .
  • Pearson , J.P. , Passador , L. , Iglewski , B.H. and Greenberg , E.P. 1995 . A second N-acyl homoserine lactone signal produced by Pseudomonas aeruginosa . Proceedings of the National Academy of Sciences (USA) , 92 : 1490 – 1494 .
  • Pearson , J.P. , Pesci , E.C. and Iglewski , B.H. 1997 . Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes . Journal of Bacteriology , 179 : 5756 – 5767 .
  • Pesci , E.C. , Milbank , J.B. , Pearson , J.P. , Mcknight , S. Kende , A.S. 1999 . Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa . Proceedings of the National Academy of Sciences (USA , 96 : 11229 – 11234 .
  • Pierson , L.S. , Keppenne , V.D. and Wood , D.W. 1994 . Phenazine antibiotic biosynthesis in Pseudomonas aureofaciens is regulated by PhzR in response to cell density . Journal of Bacteriology , 176 : 3966 – 3974 .
  • Pinzon , N.M. and Ju , L.K. 2009 . Analysis of rhamnolipid biosurfactants by methylene blue complexation . Applied Microbiology and Biotechnology , 82 : 975 – 981 .
  • Rahim , R. , Ochsner , U.A. , Olvera , C. , Graninger , M. Messner , P. 2001 . Cloning and functional characterization of the Pseudomonas aeruginosa rhlC gene that encodes rhamnosyltransferase 2, an enzyme responsible for dirhamnolipid biosynthesis . Molecular Microbiology , 40 : 708 – 718 .
  • Rahman , K.S.M. , Rahman , T.J. , Mcclean , S. , Marchant , R. and Banat , I.M. 2002 . Rhamnolipid biosurfactant production by strains of Pseudomonas aeruginosa using low-cost raw materials . Biotechnology Progress , 18 : 1277 – 1281 .
  • Rahman , K.S.M. , Rahman , T.J. , Kourkoutas , Y. , Petsas , I. Marchant , R. 2003 . Enhanced bioremediation of n-alkanes in petroleum sludge using bacterial consortium amended with rhamnolipid and micronutrients . Bioresource Technology , 90 : 159 – 168 .
  • Rahman , K.S.M. and Gakpe , E. 2008 . Production, characterization and applications of biosurfactants - Review . Biotechnology , 7 : 360 – 370 .
  • Rendell , N.B. , Taylor , G.W. , Somerville , M. , Todd , H. Wilson , R. 1990 . Characterization of Pseudomonas rhamnolipids . Biochimica Biophysica Acta , 1045 : 189 – 193 .
  • Robert , M. , Mercade , M.E. , Bosch , M.P. , Parra , J.L. Espuny , M.J. 1989 . Effect of carbon source on biosurfactant production by Pseudomonas aeruginosa 44T1 . Biotechnology Letters , 11 : 871 – 874 .
  • Rosenberg , E. and Ron , E.Z. 1999 . High and low molecular mass microbial surfactants . Applied Microbiology and Biotechnology , 52 : 154 – 162 .
  • Rumbaugh , K.P. , Griswold , J.A. and Hamood , A.N. 2000 . The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa . Microbes and Infection , 2 : 1721 – 1731 .
  • Sauer , K. , Camper , A.K. , Ehrlich , D. , Costerton , J.W. and Davies , D.G. 2002 . Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm . Journal of Bacteriology , 184 : 1140 – 1154 .
  • Schauder , S. , Shokat , K. , Surette , M.G. and Bassler , B.L. 2001 . The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule . Molecular Microbiology , 41 : 463 – 476 .
  • Shrout , J.D. , Chopp , D.L. , Just , C.L. , Hentzer , M. Givskov , M. 2006 . The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa is nutritionally conditional . Molecular Microbiology , 62 : 1264 – 1277 .
  • Siegmund , I. and Wagner , F. 1991 . New method for detecting rhamnolipids excreted by Pseudomonas species during growth on mineral agar . Biotechnology Techniques , 5 : 265 – 268 .
  • Sim , L. , Ward , O.P. and Li , Z.Y. 1997 . Production and characterization of a biosurfactant isolated form Pseudomonas aeruginosa UW-1 . J Ind Microbiol Biotechnol , 19 : 232 – 238 .
  • Singh , P.K. , Schaefer , A.L. , Parsek , M.R. , Moninger , T.O. Welsh , M.J. 2000 . Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms . Nature , 407 : 762 – 764 .
  • Smith , R.S. and Iglewski , B.H. 2003 . P. aeruginosa quorum-sensing systems and virulence . Current Opinion in Microbiology , 6 : 56 – 60 .
  • Sotirova , A.V. , Spasova , D.I. , Vasileva-tonkova , E. and Galabova , D.N. 2007 . Effects of rhamnolipid-biosurfactant on cell surface of Pseudomonas aeruginosa . Microbiology Research , 164 : 297 – 303 .
  • Sotirova , A.V. , Spasova , D.I. , Galabova , D.N. , Karpenko , E. and Shulga , A. 2008 . Rhamnolipid biosurfactant permeabilizing effects on Gram positive and Gram negative bacterial strains . Current Microbiology , 56 : 639 – 644 .
  • Stanghellini , M.E. and Miller , R.M. 1997 . Biosurfactants: their identity and potential efficacy in the biological control of zoosporic plant pathogens . Plant Disease , 81 : 4 – 12 .
  • Stanghellini , M.E. , Miller , R.M. , Rasmussen , S.L. , Kim , D.H. and Zhang , Y. 1998 . Microbially produced rhamnolipids (biosurfactants) for the control of plant pathogenic zoosporic fungi . United States Patent , : 5767090
  • Syldatk , C. , Lang , S. , Matulovic , U. and Wagner , F. 1985 . Production of four interfacial active rhamnolipids from n-alkanes or glycerol by resting cells of Pseudomonas aeruginosa species DSM 2874 . Z Naturforsch C , 40 : 61 – 67 .
  • Tatjana , P. and Goran , P. 2007 . Use of rhamnolipids in wound healing, treating burn shock, atherosclerosis, organ transplants, depression, schizophrenia and cosmetics . US Patent , : 7262171
  • Toder , D.S. , Gambello , M.J. and Iglewski , B.H. 1991 . Pseudomonas aeruginosa LasA: a second elastase gene under transcriptional control of LasR . Molecular Microbiology , 5 : 2003 – 2010 .
  • Toder , D.S. , Ferrell , S.J. , Nezezon , J.L. , Rust , L. and Iglewski , B.H. 1994 . lasA and lasB genes of Pseudomonas aeruginosa: analysis of transcription and gene product activity . Infection and Immunity , 62 : 1320 – 1327 .
  • Tremblay , J. , Richardson , A.P. , Lepine , F. and Deziel , E. 2007 . Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviour . Environmental Microbiology , 9 : 2622 – 2630 .
  • Tu , K.C. , Waters , C.M. , Svenningsen , S.L. and Bassler , B. 2008 . A small RNA-mediated feedback loop controls quourm-sensing dynamics in Vibrio harveyi . Molecular Microbiology , 70 : 896 – 907 .
  • Tuleva , B.K. , Ivanov , G.R. and Christova , N.E. 2002 . Biosurfactant production by a new Pseudomonas putida strain . Z Naturforsch C , 57 : 356 – 360 .
  • Tummler , B. , Koopmann , U. , Grothues , D. , Weissbrodt , H. Steinkamp , G. 1991 . Nosocomial acquisition of Pseudomonas aeruginosa by cystic fibrosis patients . Journal of Clinical Microbiology , 29 : 1265 – 1267 .
  • Urum , K. , Grigson , S. , Pekdemir , T. and Mcmenamy , S. 2006 . A comparison of the efficiency of different surfactants for removal of crude oil from contaminated soils . Chemosphere , 62 : 1403 – 1410 .
  • Van dyke , M.I. , Couture , P. , Brauer , M. , Lee , H. and Trevors , J.T. 1993 . Pseudomonas aeruginosa UG2 rhamnolipid biosurfactants: structural characterization and their use in removing hydrophobic compounds from soil . Canadian Journal of Microbiology , 39 : 1071 – 1078 .
  • Van haesendonck, Ingrid paula, H., Van zeveren, Emmanuel claude, A.L.B. (2004) Rhamnolipids in bakery products PURATOS NV (BE) EP1415538.
  • Volkering , F. , Breure , A.M. , Van andel , J.G. and Rulkens , W.H. 1995 . Influence of nonionic surfactants on bioavailability and biodegradation of polycyclic aromatic hydrocarbons . Applied and Environmental Microbiology , 61 : 1699 – 1705 .
  • Wang , D. , Ding , X. and Rather , P.N. 2001 . Indole can act as an extracellular signal in Escherichia coli . Journal of Bacteriology , 183 : 4210 – 4216 .
  • Wang , X. , Gong , L. , Liang , S. , Han , X. Zhu , C. 2005 . Algicidal activity of rhamnolipid biosurfactants produced by Pseudomonas aeruginosa . Harmful Algae , 4 : 433 – 443 .
  • Wang , Q.H. , Fang , X. , Bai , B.J. , Liang , X.L. Shuler , P.L. 2007 . Engineering bacteria for production of rhamnolipid as an agent for enhanced oil recovery . Biotechnology and Bioengineering , 98 : 842 – 853 .
  • Waters , C.M. and Bassler , B.L. 2005 . Quorum sensing: cell-to-cell communication in bacteria . Annual Reviews in Cell Developmental Biology , 21 : 319 – 346 .
  • Whitehead , N.A. , Barnard , A. M. , Slater , H. , Simpson , N.J. and Salmond , G.P. 2001 . Quorum-sensing in gram-negative bacteria . FEMS Microbiology Review , 25 : 365 – 404 .
  • Wienholds , E. and Plasterk , R.H. 2005 . MicroRNA function in animal development . FEBS Letters , 579 : 5911 – 5922 .
  • Williams , P. , Winzer , K. , Chan , W.C. and Camara , M. 2007 . Look who's talking: communication and quorum sensing in the bacterial world . Philosophical Transactions of the Royal Society London B: Biological Sciences , 362 : 1119 – 1134 .
  • Williams , P. and Camara , M. 2009 . Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules . Current Opinion in Microbiology , 12 : 182 – 91 .
  • Winson , M.K. , Camara , M. , Latifi , A. , Foglino , M. Chhabra , S.R. 1995 . Multiple N-acyl-Lhomoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa . Proceedings of the National Academy of Sciences (USA) , 92 : 9427 – 9431 .
  • Wu , J.Y. , Yeh , K.L. , Lu , W.B. , Lin , C.L. and Chang , J.S. 2008 . Rhamnolipid production with indigenous Pseudomonas aeruginosa EM1 isolated from oil-contaminated site . Bioresource Technology , 99 : 1157 – 1164 .
  • You , L. , Cox , R.S. , Weiss , R. and Arnold , F.H. 2004 . Programmed population control by cell-cell communication and regulated killing . Nature , 428 : 868 – 871 .
  • Zhang , Y. and Miller , R.M. 1994 . Effect of a Pseudomonas rhamnolipid biosurfactant on cell hydrophobicity and biodegradation of octadecane . Applied and Environmental Microbiology , 60 : 2101 – 2106 .
  • Zhang , Y. and Miller , R.M. 1995 . Effect of rhamnolipid (biosurfactant) structure on solubilization and biodegradation of n-alkanes . Applied and Environmental Microbiology , 61 : 2247 – 2251 .
  • Zulianello , L. , Canard , C. , Kohler , T. , Caille , D. Lacroix , J.S. 2006 . Rhamnolipids are virulence factors that promote early infiltration of primary human airway epithelia by Pseudomonas aeruginosa . Infection and Immunity , 74 : 3134 – 3147 .

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