Review of the toxicology, human exposure and safety assessment for bisphenol A diglycidylether (BADGE)

References

• APME 2003 Commercial use and exposure (confidential data) (Brussels, Belgium)
   Google Scholar
• Basler W Gfeller W Zak F Skorpil V 1984 28 Days Subacute, Oral Toxicity Study in Rats GU Project No. 830199, Test Article-TK 10490, ID# 13722 Basle Ciba-Geigy
   Google Scholar
• Bennet D 1986 Log Pow by HPLC. Shell report SBGR 85. 291 Sittingbourne Shell Sittingbourne Research Centre
   Google Scholar
• Bentley , P , Bieri , F , Kuster , H , Muakkassah-Kelly , S , Sagelsdorff , P , Staubli , W and Waechter , F . 1989 . Hydrolysis of bisphenol A diglycidylether by epoxide hydrolases in cytosolic and microsomal fractions of mouse liver and skin: unhibition by bis epoxycyclopentyl ether and the effects upon the covalent binding to mouse skin DNA . Carcinogenesis , 10 : 321 – 327 .
   PubMed Web of Science ®Google Scholar
• Bhalla , V , Joshi , K , Vohra , H , Singh , G and Ganguly , NK . 2000 . Effect of growth factors on proliferation of normal, borderline and malignant breast epithelial cells . Experimental Molecular Pathology , 68 : 124 – 132 .
   PubMed Web of Science ®Google Scholar
• Boogaard , PJ , DeKloe , KP , Bierau , J , Kuiken , G , Borkulo , PED and Van Sittert , NJ . 2000b . Metabolic inactivation of five glycidyl ethers in lung and liver of humans, rats and mice in vitro . Xenobiotica , 30 : 485 – 502 .
   PubMed Web of Science ®Google Scholar
• Boogaard , PJ , Denneman , MA and Van Sittert , NJ . 2000a . Dermal penetration and metabolism of five glycidyl ethers in human, rat and mouse skin . Xenobiotica , 30 : 469 – 484 .
   PubMed Web of Science ®Google Scholar
• Breslin WJ Kirk HD Johnson KA 1986 Dermal Teratology Probe Study of Evaluation of Diglycidyl Ether of Bisphenol A (DGEBPA) in New Zealand White Rabbits Study ID: 6313-13 Midland Dow Chemical Co
   Google Scholar
• Breslin , WJ , Kirk , HD and Johnson , KA . 1988 . Teratogenic evaluation of diglycidyl ether of bisphenol A (DGEBPA) in New Zealand white rabbits following dermal exposure . Fundamental and Applied Toxicology , 10 : 736 – 743 .
   PubMedGoogle Scholar
• Canter , DA . 1986 . Comparative mutagenicity of aliphatic epoxides in Salmonella . Mutation Research , 172 : 105 – 138 .
   PubMed Web of Science ®Google Scholar
• Carroll , JS , Swarbrick , A , Musgrove , EA and Sutherland , RL . 2002 . Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: implications for the anti-proliferative effects of antiestrogens . Cancer Research , 62 : 3126 – 3131 .
   PubMed Web of Science ®Google Scholar
• Ciba-Geigy 1985 Biodegradation Internal Report 850599 Basle Ciba-Geigy
   Google Scholar
• Clark DG Cassidy SL 1978 Toxicology of Resins: Acute Mammalian Toxicity, Skin and Eye Irritancy and Skin Sensitising Potential of Epikote 828 ex PFS and SPLEC Processes and an Intermediate the Disodium Salt of Diphenylolpropane (Naz DPP) Report TLGR.0913.78 London Shell
   Google Scholar
• Climie , JTG , Hutson , DH and Stoydin , G . 1981a . Metabolism of epoxy resin component 2,2-bis(4-(2,3-epoxy-propoxy)phenyl)propane, the diglycidyl ether of bisphenol A (DGEBPA) in the mouse. Part I, A comparison of the fate of a single dermal application and of a single oral dose of 14C-DGEBPA . Xenobiotica , 11 : 391 – 399 .
   PubMed Web of Science ®Google Scholar
• Climie , JTG , Hutson , DH and Stoydin , G . 1981b . Metabolism of epoxy rein component 2,2-bis(4-(2,3-epoxy-propoxy)phenyl)propane, the diglycidyl ether of bisphenol A (DGEBPA) in the mouse. Part II, Identification of metabolites in urine and faeces following a single oral dose of 14C-DGEBPA . Xenobiotica , 11 : 401 – 424 .
   PubMed Web of Science ®Google Scholar
• Commission Directive 2002/16/EC of 20 February 2002 . On the use of certain epoxy derivatives in materials and articles intended to come into contact with foodstuffs . Official Journal , L51 27 – 31 .
   Google Scholar
• Commission Directive 2004/13/EC . 2004 . On the use of certain epoxy derivatives in materials and articles intended to come into contact with foodstuffs . Official Journal , L27 : 46
   Google Scholar
• Commission Directive 90/128/EEC of 23 February 1990 Relating to Plastic Materials and Articles Intended to Come into Contact with Foodstuffs Brussels European Union
   Google Scholar
• Commission of the European Communities 2004 Draft Commission Regulation on the Restriction of Certain Epoxy Derivatives in Materials and Articles Intended to Come into Contact with Foodstuffs EMB/1055-REV.0
   Google Scholar
• Coveney PC 1983 The urinary excretion of an oral dose of Diglcidyl Ether of Bisphenol A (DGEBPA) in Rabbits Toxicology Laboratory SBGR.83.073 Sittingbourne Shell
   Google Scholar
• Crissman JW 1997 DGEBPA: Two-Generation Oral Gavage Reproduction Study in Sprague–Dawley Rats (Supplemental Sub-Chronic Toxicity Report). Toxicology & Environmental Research and Consulting Midland Dow Chemical Co
   Google Scholar
• Dinda , S , Sanchez , A and Moudgil , V . 2002 . Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53 and retinoblastoma, in breast cancer cells . Oncogene , 21 : 761 – 768 .
   PubMed Web of Science ®Google Scholar
• Dionisi , G and Oldring , PKT . 2002 . Estimates of per capita exposure to migrants from canned food and beverages . Food Additives and Contaminants , 19 : 891 – 903 .
   PubMed Web of Science ®Google Scholar
• Dow Chemical Report 2001 Evaluation of BADGE. 2HCl in an in Vitro Chromosomal Aberration Assay Utilizing Rat Lymphocytes Study ID: 001142,08 Midland Dow Chemical Co
   Google Scholar
• EFSA Journal 2004 Opinion of the E.U. Scientific Panel on Food Additives Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a Request from the Commission Related to 2,2-bis(4-hydroxyphenyl)propane bis(2,3-epoxypropyl)ether (bisphenol A diglycidyl ether BADGE0 Ref. No. 13510 and 39700 (EFSA-Q-2003-178)
   Google Scholar
• European Commission Health & Consumer Protection Directorate-General 2003 Opinion of the Scientific Committee, Ecotoxicity and Environment (CSTEE) on ‘Two Study Reports on Endocrine Disrupters by WRc-NSF and BKH Consulting Engineers’ C2/GF/csteeop/ED/12-131103D(03), 6-7 Brussels EC
   Google Scholar
• Food Standards Agency 2000 Food Surveillance Information Sheet 9/00 London FSA
   Google Scholar
• Gadd , SL , Hobbs , G and Miller , MR . 2002 . Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity . Toxicoligical Science , 66 : 233 – 243 .
   PubMed Web of Science ®Google Scholar
• Gardiner , TH , Waechter , JM , Wiedow , MA and Solomon , WT . 1992 . Glycidyloxy compounds used in epoxy resin systems. A toxicological review . Regulatory Toxicology and Pharmacology , 15 : 1 – 77 .
   PubMed Web of Science ®Google Scholar
• Hanley TR Hagler AR Sullivan VD Stebbins KE 1996 DGEBPA: Two Generation Oral Gavage Study in Sprague–Dawley Rats Midland Dow Chemical Co
   Google Scholar
• Harnagea-Theophilus , E , Gadd , SL , Knight-Trent , AH , De George , GL and Miller , MR . 1999 . Acetaminophen-induced proliferation of breast cancer cells involves estrogen receptors . Toxicology and Applied Pharmacology , 155 : 273 – 279 .
   PubMed Web of Science ®Google Scholar
• Hend RW Clark DG Coombs AD 1978 Toxicity of Purified Diglycidyl Ether of Bisphenol A: Results of Preliminary Studies Toxicology Report TLGR.0010.77.TSCA 8(d) submission, EPA Doc. No. 878210040, OTS 206194 Sittingbourne Shell
   Google Scholar
• Hend RW Coombs AD Clark DG 1977a Toxicity of EPIKOTE 828: Results of Preliminary Short-term Studies Toxicology Report TLGR.0009.77; cited in GardinerT. H., WaechterJrJ. M. and SolomonW. T., 1992 TSCA 8(d) submission, EPA Doc. No. 878210007, OTS 206194 Sittingbourne Shell
   Google Scholar
• Hine , CH , Kodama , JK , Anderson , HH , Simonson , DW and Wellington , JS . 1958 . The toxicology of epoxy resins . AMA Archives of Industrial Health , 17 : 129 – 144 .
   PubMedGoogle Scholar
• Hutson , DH . 1998 . Bisphenol A diglycyl ether as a potential metabolic source of bisphenol A . Environmental Health Perspectives , 106 : A473
   Web of Science ®Google Scholar
• International Agency for Research on Cancer 1999 Re-evaluation of Some Organic ChemicalsPart 3Hydrazine and Hydrogen Peroxide Monographs on the Evaluation of Carcinogenic Risks to Humans Vol. 71 Lyon IARC pp. 1285–1289
   Google Scholar
• Lockwood DD Taylor HW 1982 Acute Toxicological Properties and Industrial Handling Hazards of D.E.R. 361 Epoxy Resin Internal Report Midland Dow Chemical Co
   Google Scholar
• Lyman WJ Reehl WF Rosenblatt DH 1990 Handbook of Chemical Property Estimation Methods Washington, DC American Chemical Society
   Google Scholar
• Mecchi MS 2001 Salmonella–Escherichia coli/Mammalian-Microsome Reverse Mutation Assay Preincubation Method with a Confirmatory Assay with BADGE 2HCl Covance Study No. 22284-0-422OECD
   Google Scholar
• Nakazawa , H , Yamaguchi , A , Inoue , K , Yamazaki , T , Kato , K , Yoshimura , Y and Makino , T . 2002 . In vitro assay of hydrolysis and chlorohydrolysis derivatives of bisphenol A diglycidyl ether for estrogenic activity . Food and Chemical Toxicology , 40 : 1827 – 1832 .
   PubMed Web of Science ®Google Scholar
• Nolan RJ Unger S Chatterton LS 1981 Diglyciyl Ether of Bisphenol A (DGEBPA): Fate in Male Fischer 344 Rats (Probe) Study ID: K-6313-(10). Internal Report Midland Dow Chemical Co
   Google Scholar
• OECD 1981 SIDS Dossier on the HPV Phase 6 Chemicals. Bisphenol A Giglycidyl ether Cas# 1675-54-3 Paris OECD
   Google Scholar
• Ogata A Ando H Kubo Y Yano N Takahashi H Nagasawa A Yuzawa K Sakamoto Y Uematsu Y Aoki N 2001 Low dose effects of BADGE on the uterus and vagina of ovariectomized ICR mice The 4th Annual Meeting of Japan Society of Endocrine Disrupters Research 14–15 December 2001 (Tokyo, Japan)
   Google Scholar
• Olea , N , Pulgar , R , Perez , P , Olea-Serrano , M , Rivas , A , Novillo-Fertrell , A , Pedraza , V , Soto , A and Sonnenschein , C . 1996 . Estrogenicity of resin-based composites and sealants used in dentistry . Environmental Health Perspectives , 104 : 298 – 305 .
   PubMed Web of Science ®Google Scholar
• Olson K 1958a Results of Range-Finding Toxicological Tests on Dow Epoxy Resin X-2633. 1 (Shell Epon 828-Type Resin-Crude) or (ET 257) TSCA 8(d) submission, EPA Doc. No. 878214856, OTS 0206671. Internal Report Midland Dow Chemical Co
   Google Scholar
• Perez , P , Pulger , R , Olea-Serrano , F , Villalobos , M , Rivas , A , Metzler , M , Pedraza , V and Olea , N . 1998 . The estrogenicity of bisphenol A-diphenylalkanes with various substituents at the central carbon and hydroxy groups . Environmental Health Perspectives , 106 : 167 – 173 .
   PubMed Web of Science ®Google Scholar
• Pfeiffer E Metzler M 2000 Genetic toxicity in vitro of bisphenol A-diglycidylether (BADGE) and its hydrolysis products In Hormonal Carcinogenesis III, edited by J. J. Li, J. R. Daling and S. A. Li New York Springer pp. 521–526
   Google Scholar
• Price JR Ciba-Geigy Limited, Unpublished report 1986 Basle Switzerland
   Google Scholar
• Pullin TG Legator MS 1977 Integrated mutagenicity program on several epoxy compounds Unpublished Report Study ID: K-6313-(50) Midland Dow Chemical Co
   Google Scholar
• Redmond JM Crissman JW 1995a DGEBPA: Two-week Dermal Irritation Probe Study In Male B6C3F1 Mice Report to The Society of the Plastics Industry, Inc. The Toxicology Research Laboratory, Health and Environmental Sciences. TSCA 8(d) submission, EPA Doc. No. #44620, OTS 0558842 Midland Dow Chemical Co
   Google Scholar
• Redmond JM Crissman JW 1995b DGEBPA: Two-week Dermal Irritation Probe Study in Fischer 344 Rats Report to The Society of the Plastics Industry, Inc. The Toxicology Research Laboratory, Health and Environmental Sciences. TSCA 8(d) submission, EPA Doc. No. #44620, OTS 0558841 Midland Dow Chemical Co
   Google Scholar
• Redmond JM Crissman JW 1996a DGEBPA: 13-Week Repeated Dose Dermal Toxicity Study in the Fischer 344 Rat Report to The Society of the Plastics Industry, Inc. The Toxicology Research Laboratory, Health and Environmental Sciences. TSCA 8(d) submission, EPA Doc. No. #44628, OTS 0558862 Midland Dow Chemical Co
   Google Scholar
• Redmond JM Crissman JW 1996b DGEBPA: 13-Week Repeated Dose Dermal Toxicity Study in the Male B6C3FI Mouse Report to The Society of the Plastics Industry, Inc. The Toxicology Research Laboratory, Health and Environmental Sciences. TSCA 8(d) submission, EPA Doc. No. #44626, OTS 0558858 Midland Dow Chemical Co
   Google Scholar
• Rowe VK 1948 Results of Range-Finding Toxicological Tests on Bis(p-(2,3-epoxypropoxy)phenyl)propane Internal Report Midland Dow Chemical Co
   Google Scholar
• Satoh , K , Ohyama , K , Aoki , N , Iida , M and Nagai , F . 2004 . Study on anti-androgenic effects of bisphenol a diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen . Food and Chemical Toxicology , 42 : 983 – 993 .
   PubMed Web of Science ®Google Scholar
• Scientific Committee on Food 1986 Seventeenth Series of Reports EUR 10778 Luxembourg Commission of the European Communities
   Google Scholar
• Scientific Committee on Food 1988 Nineteenth Series of Reports EUR 11322 Luxembourg Commission of the European Communities
   Google Scholar
• Scientific Committee on Food 1996 Opinion on bisphenol A-diglycidylether (BADGE) June 1996 Reports GT 07 97652 Luxembourg Commission of the European Communities
   Google Scholar
• Scientific Committee on Food 1999 Opinion on Bisphenol A diglycidyl ether (BADGE) 24 March 1999. SCF/CS/PM 3243 Brussels SCF
   Google Scholar
• Scientific Committee on Food 2002 Statement of the Scientific Committee on Food on Bisphenol A diglycidyl ether (BADGE) 4 December 2002. SCF/CS/OM/GEN/13510/221 Brussels SCF
   Google Scholar
• Shell Chemical Co., Houston, Texas 1981 cited in HINEC. H., KODAMAJ. S., ANDERSONH. H., Epoxy compounds. In Patty's Industrial Hygiene and Toxicology, 3rd edn, Vol. Iia, edited by G. D. Clayton and F. E. Clayton New York Wiley
   Google Scholar
• Smith JA Masters RE Dawe IS 1988a A Study of the Effect of TK 10490 on Pregnancy of the Rat Report CB442/87641 Huntingdon Ciba-Giegy
   Google Scholar
• Smith JA Masters RE Dawe IS 1988b A Study of the, Effect of TK 10490 on Pregnancy of the Rabbit Report CB440/87639 Huntingdon Ciba-Giegy
   Google Scholar
• Smith JA Masters RE Dawe IS 1989 A Study of the Effect of TK 10490 on the Reproductive Function of One Generation in the Rat Report CB451/881081 Huntingdon Ciba-Giegy
   Google Scholar
• Soto , A , Lin , T-M , Justicia , H , Silvia , RM and Sonnenschein , C . 1992 . An ‘in culture’ bioassay to assess the estrogenicity of xenobiotics (E-SCREEN) . Advances in Modern Environmental Toxicology , 21 : 295 – 309 .
   Google Scholar
• Spencer PJ Grundy J Linscombe VA 2003 Evaluation of Badge. 2HCl in the Mouse Bone Marrow Micronucleus Test Study ID: 031004 Midland Dow Chemical Co
   Google Scholar
• Stebbins KE Dryzga MD 2001 Bisphenol A Diglycidyl Ether (BADGE): Subchronic Oral Gavage Toxicity Study in Fischer 344 Rats Study ID: K-006313-038 Midland Dow Chemical Co
   Google Scholar
• Stebbins KE Dryzga MD 2003 Bisphenol A Diglycidyl Ether (BADGE): Two Year Gavage Chronic Toxicity/Oncogenicity Study in Fischer 344 Rats Study ID: 011134 Midland Dow Chemical Co
   Google Scholar
• Vinggaard AM 1998 Communication from Danish Veterinary and Food Administration(Soborg)
   Google Scholar
• Waechter JM Linscombe VA Schisler MR Beuthin DJ 2002 Evaluation of BADGE. 2HCl in the Mouse Lymphoma (L5178YTK) Forward Mutation Assay Study ID: 001143 Midland Dow Chemical Co
   Google Scholar
• Weil , CS , Condra , N , Haun , C and Striegel , JA . 1963 . Experimental carcinogenicity and acute toxicity of representative epoxides . American Industrial Hygiene Association Journal , 24 : 305 – 325 .
   PubMedGoogle Scholar
• Wolf MA 1958 Unpublished Report Midland Dow Chemical Co
   Google Scholar
• Wooder MF 1981 Studies on the Effects of Epokote 828 on the Integrity of Rat Liver DNA In Vivo Report Toxicology Laboratory Report TLGR 80.105 Sittingbourne Shell
   Google Scholar
• Zacharewski , T . 1997 . In vitrobioassays for assessing estrogenic substances . Environmental Science and Technology , 31 : 613 – 623 .
   Web of Science ®Google Scholar