DNA damage and repair tests for the detection of genotoxic agents

References

• Ehrenberg , L. , Brookes , P. , Druckrey , H. , Lagerlof , B. , Litwin , J. and Williams , G. M. 1973 . “ The relation of cancer induction and genetic damage ” . In Evaluation of Genetic Risks of Environmental Chemicals , Ambio Special Report no. 3 Edited by: Ramel , C. 15 – 16 .
   Google Scholar
• International Agency for Research on Cancer . 1980 . Long‐term and Short‐term Screening Assays for Carcinogens: [Agrave] Critical Appraisal , Lyon : IARC . Supplement 2
   Google Scholar
• Maslansky , C. J. and Williams , G. M. 1982 . Primary cultures and the levels of cytochrome P‐450 in hepatocytes from mouse, rat, hamster and rabbit liver . In vitro , 18 : 683 – 693 .
   PubMedGoogle Scholar
• McQueen , C. A. and Williams , G. M. 1983 . The use of cells from rat, mouse, hamster and rabbit in the hepatocyte primary culture/DNA repair test . Annals of the New York Academy of Sciences , 407 : 119 – 130 .
   PubMed Web of Science ®Google Scholar
• McQueen , C. A. , Maslansky , C. J. , Crescenzi , S. and Williams , G. M. 1981 . The genotoxicity of 4,4'‐methylene‐bis‐2‐chloroaniline in rat, mouse and hamster, hepatocytes . Toxicology and Applied Pharmacology , 58 : 231 – 235 .
   PubMed Web of Science ®Google Scholar
• McQueen , C. A. , Maslansky , C. J. , Glowinski , I. B. , Crescenzi , S. B. , Weber , W. W. and Williams , G. M. 1982 . Relationship between the genetically determined acetylator phenotype and DNA damage by hydralazine and 2‐aminofluorene in cultured rabbit hepatocytes . Proceedings of the National Academy of Sciences, U.S.A. , 79 : 1269 – 1272 .
   PubMed Web of Science ®Google Scholar
• McQueen , C. A. , Kreiser , D. M. and Williams , G. M. 1983 . The hepatocyte primary culture (HPC)/DNA repair assay using mouse or hamster hepatocytes . Environmental Mutagenesis , 5 : 1 – 8 .
   PubMedGoogle Scholar
• McQueen , C. A. , Maslansky , C. J. and Williams , G. M. 1983 . The role of the acetylation polymorphism in determining susceptibility of cultured rabbit hepatocytes to DNA damage by aromatic amines . Cancer Research , 43 : 3120 – 3123 .
   PubMed Web of Science ®Google Scholar
• Mitchell , A. D. , Casciano , D. A. , Meltz , M. L. , Robinson , D. E. , San , R. H. C. , Williams , G. M. and von Halle , W. S. 1983 . Unscheduled DNA synthesis tests: A report of the “Genetox”; program . Mutation Research , 123 : 363 – 410 .
   PubMed Web of Science ®Google Scholar
• Weber , W. W. 1973 . “ Acetylation of drugs ” . In Metabolic Conjugation and Metabolic Hydrolysis , Volume 111 , 249 – 296 . New York : Academic Press .
   Google Scholar
• Weisburger , J. H. and Williams , G. M. 1980 . “ Chemical carcinogens ” . In Toxicology The Basic Science of Poisons , 2nd edn , Edited by: Doul , J. , Klaasen , C. D. and Amdur , M. O. 84 – 138 . New York : Macmillan .
   Google Scholar
• Weisburger , J. H. and Williams , G. M. 1982 . “ Metabolism of chemical carcinogens ” . In Cancer, a Comprehensive Treatise , 2nd edn , Edited by: Becker , F. F. 241 – 333 . New York : Plenum Press .
   Google Scholar
• Williams , G. M. 1976 . Carcinogen‐induced DNA repair in primary rat liver cell cultures; a possible screen for chemical carcinogens . Cancer Letters , 1 : 231 – 236 .
   PubMed Web of Science ®Google Scholar
• Williams , G. M. 1977 . The detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures . Cancer Research , 37 : 1845 – 1851 .
   PubMed Web of Science ®Google Scholar
• Williams , G. M. 1979a . “ A comparison of m vivo and in vitro metabolic activation systems ” . In Critical Reviews in Toxicology‐Strategies for Short‐term Testing for Mutagens/Carcinogens , Edited by: Butterworth , B. 96 – 97 . West Palm Beach, Fl : C.R.C. Press .
   Google Scholar
• Williams , G. M. 1979b . Review of m vitro test systems using DNA damage and repair for screening of chemical carcinogens . Journal of the Association of Official Analytical Chemists , 62 : 857 – 863 .
   PubMedGoogle Scholar
• Williams , G. M. Advances in Medical Oncology, Research and Education . Proceedings of the XIIth International Cancer Congress, Carcinogenesis . Liver cell culture systems for the study of hepatocarcinogenesis , Edited by: Margison , G. P. Volume 1 , pp. 273 – 280 . New York : Pergamon Press .
   Google Scholar
• Williams , G. M. 1980a . “ The detection of chemical mutagens/carcinogens by DNA repair and mutagenesis in liver cultures ” . In Chemical Mutagens , Edited by: de Serres , F. J. and Hollaender , A. Volume VI , 61 – 79 . New York : Plenum Press .
   Google Scholar
• Williams , G. M. 1980b . Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays . Annals of the New York Academy of Science , 349 : 273 – 282 .
   PubMedGoogle Scholar
• Williams , G. M. 1980c . “ The predictive value of DNA damage and repair assays for carcinogenicity ” . In The Predictive Value of In Vitro Short‐Term Screening Tests in Carcinogenicity Evaluation , Edited by: Williams , G. M. , Kroes , R. , Waaijers , H. W. and Van de Poll , K. W. 213 – 230 . Amsterdam : Elsevier/North Holland Biomedical Press .
   Google Scholar
• Williams , G. M. 1980d . “ Batteries of short‐term tests for carcinogen screening ” . In The Predictive Value of In Vitro Short‐Term Screening Tests in Carcinogenicity Evaluation , Edited by: Williams , G. M. , Kroes , R. , Waaijers , H. W. and Van de Poll , K.W. 327 – 346 . Amsterdam : Elsevier/North Holland Biomedical Press .
   Google Scholar
• Williams , G. M. 1981 . “ The detection of genotoxic chemicals in the hepatocyte primary culture/DNA repair test ” . In Mutation Promotion and Transformation , Gan Monograph on Cancer Research Edited by: Inui , N. , Kuroki , T. , Yamada , M. A. and Heidelberger , C. Vol. 27 , 47 – 57 .
   Google Scholar
• Williams , G. M. 1983a . “ Drug effects during development and carcinogenicity ” . In Veterinary Pharmacology and Toxicology , Edited by: Ruckebusch , Y. , Toutain , P. L. and Koritz , G. D. 73 – 93 . MTP Press .
   Google Scholar
• Williams , G. M. 1983b . “ Mechanisms of action of foodborne carcinogens ” . In Environmental Aspects of Cancer; the Role of Macro and Micro Components of Food , Food and Nutrition Edited by: Leveille , G. A. , Weisburger , J. H. and Livingston , G. W. 83 – 100 .
   Google Scholar
• Williams , G. M. and Weisburger , J. H. 1981 . Systematic carcinogen testing through the decision point approach . Annual Reviews in Pharmacology and Toxicology , 21 : 393 – 416 .
   PubMed Web of Science ®Google Scholar
• Williams , G. M. and Weisburger , J. H. 1983 . “ Risk assessment of dietary carcinogens and tumor promoters ” . In Diet, Nutrition and Cancer: From Basic Research to Policy Implications , Edited by: Campbell , T. C. and Schottenfeld , D. 203 – 219 . New York : A. R. Liss, Inc. .
   Google Scholar
• Williams , G. M. , Laspia , M. F. , Mori , H. and Hirono , I. 1981 . Genotoxicity of cycasin in the hepatocyte primary culture/DNA repair test supplemented with ß‐glucosidase . Cancer Letters , 12 : 329 – 333 .
   PubMed Web of Science ®Google Scholar
• Williams , G. M. , Laspia , M. F. and Dunkel , V. C. 1982 . Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and non carcinogens . Mutation Research , 97 : 359 – 370 .
   PubMed Web of Science ®Google Scholar