Effects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique

References

• ALEX, R., and BODMEIER, R., 1990, Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on entrapment. Journal of Microencapsulation, 7, 347–335.
   PubMed Web of Science ®Google Scholar
• BODMER, D., KISSEL, T., and TRAECHSLIN, E., 1992, Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems. Journal of Controlled Release, 21, 129–138.
   Web of Science ®Google Scholar
• BRUNAUER, S., EMMETT, P. H., and TELLER, E., 1938, Adsorption of gases in multimolecular layers. journal of American Chemical Society, 60, 309–319.
   Google Scholar
• CHARMAN, S. A., MASON, K. L., and CHARMAN, W. N., 1993, Techniques for assessing the effects of pharmaceutical aggregation excipients on the aggregation of porcine growth hormone. Pharmaceutical Research, 10, 954–962.
   PubMed Web of Science ®Google Scholar
• CLELAND, J. L., and JONES, A. J. S., 1996, Stable formulations of recombinant human growth hormone and interferon for microencapsulation in biodegradable microspheres. Pharmaceutical Research, 13, 1464–1475.
   PubMed Web of Science ®Google Scholar
• COHEN, S., YOSHIOKA, T., LUCARELLI, M., HWANG, L. H., and LANGER, R., 1991, Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharmaceutical Research, 8, 713–720.
   PubMed Web of Science ®Google Scholar
• CROTTS, G., and PARK, T. G., 1995, Preparation of porous and nonporous biodegradable polymeric hollow microspheres. Journal of Controlled Release, 35, 91–105.
   Web of Science ®Google Scholar
• ESPOSITO, E., CORTESI, R., CERVELLATI, F., MENEGATTI, E., and NASTRUZZI, C., 1997, Biodegradable microparticles for sustained delivery of tetracycline to the periodontal pocket: formulatory and drug release studies. Journal of Microencapsulation, 14, 175–187.
   PubMed Web of Science ®Google Scholar
• FLORENCE, A. T., and WHITEHILL, D., 1982, The formulation and stability of multiple emulsions. International Journal of Pharmaceutics, 11, 277–308.
   Web of Science ®Google Scholar
• HEYA, T., OKADA, H., TANIGAWARA, Y., OGAWA, Y., and TOGUCHI, H., 1991, Effects of counter anion of TRH and loading amount on control of TRH release from copoly(DL-lactic/glycolic acid) microspheres prepared by an in-water drying method. International Journal of Pharmaceutics, 69, 69–75.
   Google Scholar
• JOHANSEN, P., MEN, Y., AUDRAN, R., CORRADIN, G., MERCKLE, H. P., and GANDER, B., 1998, Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives. Pharmaceutical Research, 15, 1103–1110.
   PubMed Web of Science ®Google Scholar
• LEO, E., PEQUET, D., ROJAS, J., COUVREUR, P., and FATTAL, E., 1998, Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. Journal of Microencapsulation, 15,412–430.
   Google Scholar
• Lu, W., and PARK, T. G., 1995, Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems. Journal of Pharmaceutical Science Technology, 1, 231–241.
   Google Scholar
• MANNING, M. C., PATEL, K., and BORCHARDT, R. T., 1989, Stability of protein pharmaceuticals. Pharmaceutical Research, 6, 903–918.
   PubMed Web of Science ®Google Scholar
• MORLOCK, M., KROLL, H., WINTER, G., and KISSEL, T., 1997, Microencapsulation of rh-Erythropoietin, using biodegradable poly(D,L-lactide-co-glycolide): protein stability and the effects of stabilizing excipients. European Journal of Pharmaceutics and Biopharmaceutics, 43, 29–36.
   Web of Science ®Google Scholar
• NIHANT, N., SCHUGENS, C., GRANDFILS, C., JEROME, R., and TEYssit, P., 1994, Polylactide microparticles prepared by double emulsion/evaporation technique: I: Effect of primary emulsion stability. Pharmaceutical Research, 11, 1479–1484.
   PubMed Web of Science ®Google Scholar
• OGAWA, Y., YAMAMOTO, M., OKADA, H., YASHIKI, T., and SHIMAMOTO, T., 1988, A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid. Chemical and Pharmaceutical Bulletin, 36, 1095–1103.
   PubMed Web of Science ®Google Scholar
• OKADA, H., and Tocucw, H., 1995, Biodegradable microspheres in drug delivery. Critical Reviews in Therapeutic Drug Carrier Systems, 12, 1–99.
   PubMed Web of Science ®Google Scholar
• PISTEL, K.-F., BITTNER, B., KoLL, H., WINTER, G., and KISSEL, T., 1999, Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: Influence of encapsulation technique and polymer composition on particle characteristics. Journal of Controlled Release, 59, 309–325.
   PubMed Web of Science ®Google Scholar
• SAH, H. K., TODDYWALA, R., and CHIEN, Y. W., 1994, The influence of biodegradable microcapsule formulations on the controlled release of a protein. Journal of Controlled Release, 30, 201–211.
   Web of Science ®Google Scholar
• SAH, H., TODDYWALA, R., and CHIEN, Y. W., 1995a, Continuous release of proteins from biodegradable microcapsules and in vivo evaluation of their potential as a vaccine adjuvant. Journal of Controlled Release, 35, 137–144.
   Web of Science ®Google Scholar
• SAH, H. K., TODDYWALA, R., and CHIEN, Y. W., 1995b, Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release. Journal of Microencapsulation, 12, 59–69.
   PubMed Web of Science ®Google Scholar
• SCHUGENS, C., LARUELLE, N., NIHANT, N., GRANDFILS, C., JEROME, R., and TEYSSIE, P., 1994, Effect of the emulsion stability on the morphology and porosity of semicrystalline poly L-lactide microparticles prepared by w/o/w double emulsion-evaporation. Journal of Controlled Release, 31, 161–176.
   Google Scholar
• TAKADA, S., KUROKAWA, T., MIYAZAKI, K., IwAsA, S., and OGAWA, Y., 1997, Sustained release of a water soluble GP IIb/IIIa antagonist from copoly(DL-lactic/glycolic) acid microspheres. International Journal of Pharmaceutics, 146, 147–157.
   Web of Science ®Google Scholar
• UCHIDA, T., YOSHIDA, K., and GOTO, S., 1996, Preparation and characterization of polylactic acid microspheres containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method. Journal of Microencapsulation, 13, 219–228.
   PubMed Web of Science ®Google Scholar
• UCHIDA, T., YOSHIDA, K., NINMIYA, A., and GOTO, S., 1996, Optimization of preparative conditions for polylactide (PLA) microspheres containing ovalbumin. Chemical and Pharmaceutical Bulletin, 43, 1569–1573.
   Web of Science ®Google Scholar