Stability and ocular tolerance of cyclophosphamide-loaded nanospheres

References

• ABRAHAM, N. G., UN, J. H. C., DUNN, M. W. and SCHWARTZMAN, M. L., 1987, Presence of heme-oxygenase and NADPH-cytochrome P-450 reductase in human corneal epithelium. Investigations in Ophthalmology and Visual Sciences, 28, 1464–1472.
   Google Scholar
• BAEYEN, S. V. and GURNY, R., 1997, Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations. Pharmacologica Acta Helvetica, 72, 191–202.
   PubMedGoogle Scholar
• BEHAN, N., BIRKINSHAW, C. and CLARKE, N., 2001, Poly n-butyl cyanoacrylate nanoparticles, a mechanistic study of polymerisation and particle formation. Biomaterials, 22, 1335–1344.
   PubMedGoogle Scholar
• BROOKE, D., BEQUETTE, R. J. and DAVIS, R. E., 1973, Chemical stability of ciclophosphamide in parenteral solutions. American Journal of Hospital Pharmacology, 30, 134–137.
   PubMedGoogle Scholar
• CALVO, P., VILA-JATO, J. L. and ALONSO, M. J., 1997, Effect of lysozyme on the stability of polyester nanocapsules and nanoparticles, stabilization approaches. Biomaterials, 18, 1305–1310.
   Google Scholar
• CHANG, S. C. and LEE, V. H. L., 1983, Influence of chain length on the in vitro hydrolysis of model ester prodrugs by ocular esterases. Current Eye Research, 2, 651–656.
   Google Scholar
• CHIARINI, A., TARTARINI, A. and FINI, A., 1984, pH—solubility relationship and partition coefficients for some anti-inflammatory arylaliphatic acids. Archives Pharmazie, 317, 268–273.
   Google Scholar
• COUVREUR, P., GRISLAIN, L., LENEARTS, V., BRAUSSEUT, F., GUIOT, P. and BIERNACKI, A., 1986, Biodegradable polymeric nanoparticles as drug carrier for antitumor agents. In Polymeric Nanoparticles and Microspheres, edited by P. Guiot and P. Couvreur (Boca Raton: CRC Press), pp. 27–93.
   Google Scholar
• COUVREUR, P., KANTE, B., ROLAND, P., GUIOT, P., BAUDIN, P. and SPEISER, P., 1979, Polycyanoacrylate nanocapsules as potential lysosmotropic carrier, preparation, morphological and sortive properties. Journal of Pharmaceutics and Pharmacology, 31, 331–332.
   PubMedGoogle Scholar
• DONNELLY, E. F., JOHNSTON, D. S. and PEPPER, D. C., 1977, Ionic and zwitteronic polymerisation of n-alkyl-2-cyanoacrylates. Polymer Letters, 15, 339–405.
   Google Scholar
• DRAIZE, J. H., WOODARD, E. and CALVERY, H. 0., 1944, Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Journal of Pharmacology and Experimental Therapeutics, 82, 377–390.
   Google Scholar
• EGEA, M. A., GAMISANS, F., VALERO, J. ESPINA, M. and GARCIA, M. L., 1994, Entrapment of cisplatin into biodegradable polyalkylcyanoacrylate nanoparticles. Ii Farmaco, 49, 211–217.
   Google Scholar
• FRAUNFELDER, F. T., 1989, Drug Induced Ocular Side Effects and Drug Interactions (Philadelphia: Lea Febiger), pp 386–388.
   Google Scholar
• FRESTA, M., FONTANA, G., BUCOLO, C., CAVALLERO, G., GIAMMONA, G. and PUGLISI, G., 2001, Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethy1-2-cyanoacrylate nanosphere-encapsulated acyclovir. Journal of Pharmaceutical Sciences, 90, 288–297.
   PubMedGoogle Scholar
• FRESTA, M. and PUGLISI, G., 1994, Association of netilmicin sulphate to poly (alkylcyanoacrylate) nanoparticles. Factors influencing particle delivery behaviour. Drug Development and Industrial Pharmacy, 20, 2227–2243.
   Google Scholar
• GAMISANS, F., LACOULONCHE, F., CHAUVET, A., ESPINA, M., GARCIA, M. L. and EGEA, M. A., 1999, Flurbiprofen-loaded nanospheres, analysis of the matrix structure by thermal methods. International Journal of Pharmaceutics, 179, 37–48.
   PubMedGoogle Scholar
• GoLusovic, S. and RADMANOVIC, B. Z., 1988, Increase of corneal graft survival by use of topically immunosuppressive agents in rabbits. Graefes Archives of Clinical and Experimental Ophthalmology, 226, 288–290.
   PubMedGoogle Scholar
• HALL, J. M., OHNO, S. and PRIBNOW, J. F., 1977, The effect of cyclophosphamide on an ocular immune response. Clinical and Experimental Immunology, 30, 309–316.
   PubMedGoogle Scholar
• HIRANO, T., RINGSDORF, H. and ZAHARKO, D. S., 1980, Antitumor activity of monomeric and polymeric cyclophosphamide derivatives compared with in vitro hydrolysis. Cancer Research, 40, 2263–2267.
   PubMedGoogle Scholar
• KABANOV, A. V, BATRAKOVA, E. V. and MILLER, D. W., 2003, Pluronic block copolymers as modulators of drug efflux transporter activity in the blood—brain barrier. Advanced Drug Delivery Reviews, 55, 151–164.
   PubMedGoogle Scholar
• KAY, J. H. and CALANDRA, J. C., 1962, Interpretation of eye irritation test. Journal of the Society of Cosmetics Chemistry, 13, 281–289.
   Google Scholar
• KREUTER, J., 1983, Physicochemical characterization of polyacrylic nanoparticles. International Journal of Pharmaceutics, 14, 43–58.
   Google Scholar
• LEE, V. H., 1985, Topical ocular drug delivery systems, recent advances and future prospective. Pharmacology International, 6, 135–138.
   Google Scholar
• LUDWIG, A. and VAN OOTEGHEM, M., 1987, The influence of the osmolality on the pre-corneal retention of ophthalmic solutions. Journal de Pharmacie de Belgique, 42, 259.
   PubMedGoogle Scholar
• MARCHAL-HEUSSLER, L., MAINCENT, P., HOFFMAN, M., SPITTLER, and COUVREUR, P., 1990, Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations. International Journal of Pharma-ceutics, 58, 115–122.
   Google Scholar
• MASSON, V., MAURIN, F, DEVISSAGUET, J. P. and FESSI, M., 1996, Stability of poly-c-caprolactone nanospheres in sterile aqueous media. International Journal of Pharmaceutics, 139, 113–123.
   Google Scholar
• MOLLER, R. H., LHERM, C., HERBORT, J., BLUNK, T. and COUVREUR, P., 1992, Alkylcyanoacrylate drug carriers: physicochemical characterization of nano-particles with different alkyl chain length. International Journal of Pharmaceutics, 84, 1–11.
   Google Scholar
• SALGUEIRO, A., EGEA, M. A., VALLS, R., ESPINA, M. and GARCIA, M. L., 1999, An inductively coupled method for determination of cyclophosphamide loaded to polymeric systems. Journal of Pharmaceutical and Biomedical Analysis, 21, 611–618.
   PubMedGoogle Scholar
• SALGUEIRO, M. A., GARCIA., M. L., ESPINA, M., VALLS, 0. and EGEA, M. A., 2000, Asociación de ciclofosfamida a nanoesferas de polibutilcianoacrilato. Ciencia y Tecnologia Pharmace'utica, 10, 14–19.
   Google Scholar
• SCHERER, D., KREUTER, J. and ROBINSON, J. R., 1994, Influence of enzymes on the stability of polybutylcyanoacrylate nanoparticles. International Journal of Pharmaceutics, 101, 165–168.
   Google Scholar
• SCHOENWALD, R. D. and STEWART, P., 1980, Effect of particle size on ophthalmic bioavailability of dexamethasone suspensions in rabbits. Journal of Pharmaceutical Sciences, 69, 391–394.
   PubMedGoogle Scholar
• SHICHI, H., MAHALAK, S. M., SAKAMOTO, S. and SUGIYAMA, T, 1991, Immunocytochemical study of phenobarbital and 3-methylcholanthrene-inducible Cytochrome P450 Isozymes in primary cultures or porcine ciliary epithelium. Current Eye Research, 10, 779–788.
   PubMedGoogle Scholar
• STEIN, M. and HAMACHER, E., 1992, Degradation of polybuty1-2-cyanoacrylate micro-particles. International Journal of Pharmaceutics, 80, R11—R13.
   Google Scholar
• TANAKA, H., HASEGAWA, T., MIICHI, H., HIRAYAMA, M. and HAYASHI, S., 1985, Rabbit blinking test. Journal of the Eye, 2, 1127–1129.
   Google Scholar
• TANIGUCHI, K., YAKAMOTO, Y., ITAKURA, K., MILCHI, H. and HAYASHI, S., 1988, Assess-ment of ocular irritability of liposome preparations. Journal of Pharmacobiological Dynamics, 11, 607–611.
   PubMedGoogle Scholar