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Research Article

Poly (ε-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: Effects of some formulation parameters on microparticle characteristics

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Pages 63-74 | Received 23 Jul 2007, Accepted 17 Apr 2008, Published online: 20 Oct 2008

References

  • Alex R, Bodmeier R. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment. J Microencapsulation 1990; 7: 347–355
  • Allemann E, Gurny R, Doelker E. Drug loaded nanoparticles, preparation methods and drug targeting issues. Eur J Pharm Biopharm 1993; 39: 173–191
  • Antunes MCM, Felisberti MI. Blends of poly(hydroxybutyrate) and poly (ε-caprolactone) obtained from melting mixture. Polimeros 2005; 15: 134–138
  • Bala I, Bhardwaj V, Hariharan S, Sitterberg J, Bakowsky U, Ravi Kumar MNV. Design of biodegradable nanoparticles: A novel approach to encapsulating poorly soluble phytochemical ellagic acid. Nanotechnology 2005; 16: 2819–2822
  • Benoit MA, Baras B, Gillard J. Preparation and characterization of protein-loaded poly (ε-caprolactone) microparticles for oral vaccine delivery. Int J Pharm 1999; 184: 73–84
  • Blanco MD, Alonso MJ. Development and characrerization of protein-loaded poly(lactide-coglycolide) nanopheres. Eur J Pharm Biopharm 1997; 43: 287–294
  • Bodmeier R, McGinity JW. Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique: II. Some process parameters influencing the preparation and properties of microcapsules. J Microencapsulation 1987a; 4: 289–297
  • Bodmeier R, McGinity JW. The preparation and evaluation of drug containing poly(D,L-Lactide) micropheres formed by the solvent evaporation method. Pharm Res 1987b; 4: 465–471
  • Bodmeier R, McGinity JW. Solvent selection in the preparation of poly (D,L-lactide) micropheres prepared by the solvent evaporation method. Int J Pharm 1988; 43: 179–186
  • Boury F, Ivanova T, Panaiotov I, Proust JE, Bois A, Richou J. Dynamic properties of poly(D,L-lactide) and polyvinyl alcohol monolayers at the air/water and dichloromethane/water interfaces. J Colloid Interface Sci 1995; 169: 380–392
  • Cinotti A, Cinotti D, Grant W, Jacobs I, Galin M, Silverstone D, Shin D, Esters J, Lee J, Bouchey R, et al. Levobunolol vs timolol for open angle glaucoma and ocular hypertension. Am J Oftalmol 1985; 99: 11–17
  • Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001; 13: 123–133
  • Couvreur P, Barratt G, Fattal E, Legrand P, Vauthier C. Nanocapsule technology: A review. Crit Rev Therapeut Drug Carrier Syst 2002; 19: 99–134
  • Desai SD, Blanchard J. Pluronic® F127-based ocular delivery system containing biodegradable polyisobutylcyanoacrylate nanocapsules of pilocarpine. Drug Deliv 2000; 7: 201–207
  • Dinarvand R, Mirfattahi S, Atyabi F. Preparation, characterization an in vitro drug release of isosorbide dinitrate micropheres. J Microencapsulation 2002; 19: 73–81
  • Ding S. Recent developments in ophthalmic drug delivery. Pharm Sci Tech Today 1998; 1: 328–335
  • Elbahri Z, Taverdet JL. Optimization of an herbicide release from ethylcellulose micropheres. Polym Bull 2005; 54: 353–363
  • El-Kamel AH. In vitro and in vivo evaluation of Pluronic F127-based ocular delivery systems for timolol maleate. Int J Pharm 2002; 241: 47–55
  • Gonzalez JP, Clissold SP. Ocular levobunolol: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 1987; 34: 648–661
  • Govender S, Lutchman D, Pillay V, Chetty DJ, Govender T. Enhancing drug incorporation into tetracycline-loaded chitosan microspheres for periodontal therapy. J Microencapsulation 2006; 23: 750–761
  • Govender T, Stolnik S, Garnett MC, Illum L, Davis SS. PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J Contr Rel 1999; 57: 171–185
  • Hoyng PFJ, Beek LMV. Pharmacological therapy for glaucoma: A review. Drugs 2000; 59: 411–434
  • Huatan H, Collett JH, Attwood D. The microencapsulation of protein using a novel ternary blend based on poly (ε-caprolactone). J Microencapsulation 1995; 12: 557–567
  • Guidline ICH. [Internet] 2005. Validation of analytical procedures: Text and methodology Q2(R1), Available online at: http:/www.ich.gov/LOB/media/MEDIA417.pdf
  • Jeong JC, Lee J, Cho K. effects of crystalline microstructure on drug release behaviour of poly (ε-caprolactone) micropheres. J Contr Rel 2003; 92: 249–258
  • Jones DS, Pearce KJ. An investigation of the effects of some process variables on the microencapsulation of propranolol hydrochloride by the solvent evaporation method. Int J Pharm 1995; 118: 199–205
  • Le Bourlais C, Acar L, Zia H, Sado PA, Needham T, Leverge R. Ophtalmic drug delivery systems-recent advances. Prog Retinal Eye Res 1998; 17: 33–58
  • Lee SC, Oh JT, Jang MH, Chung SI. Quantitative analysis of polyvinyl alcohol on the surface of poly (D,L-lactide-co-glycolide) microparticles prepared by solvent evaporation method: Effect of particle size and PVA concentration. J Contr Rel 1999; 59: 123–132
  • Lionzo MIZ, Ré MI, Guterres SS, Pholmann AR. Microparticles prepared with poly(hydroxybutyrate-co-hydroxyvalerate) and poly (ε-caprolactone) blends to control the release of drug model. J Microencapsulation 2007; 24: 175–186
  • Luan X, Skupin M, Siepman J, Bodmeier R. Key parameters affecting the initial release (burst) and encapsulation efficiency of peptide-containing poly(lactide-co-glycolide) microparticles. Int J Pharm 2006; 324: 168–175
  • Mainardes RM, Evangelista RC. PLGA nanoparticles containing praziquantel: Effect of formulation variables on size distribution. Int J Pharm 2005; 290: 137–144
  • Marchal-Heussler L, Fessi H, Devissaguet JP, Hoffman M, Maincent P. Colloidal drug delivery systems for the eye a comparison of the efficacy of three different polymers: Polyisobutylcyanoacrylate, polylactic-co-glycolic acid, poly-epsilon-caprolacton. STP Pharma Sci 1992; 2: 98–104
  • Meng FT, Ma GH, Liu YD, Qiu W, Su ZG. Microencapsulation of bovine haemoglobin with high bio-activity and high entrapment efficiency using a W/O/W double emulsion technique. Colloids Surf B Biointerfaces 2004; 33: 177–183
  • Miyazaki S, Hashiguchi N, Hou W-M, Yokouchi C, Takada M. Preparation and evaluation in vitro and in vivo of fibrinogen microspheres containing adriamycin. Chem Pharm Bull 1986; 34: 3384–3393
  • Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y. Preparation of biodegradable nanopheres of water-soluble and insoluble drugs with D,L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behaviour. J Contr Rel 1993; 25: 89–98
  • Parikh RH, Parikh JR, Dubey RR, Soni HN, Kapadia KN. Poly(D,L-lactide-co-glycolide) micropheres containing 5-fluorouracil: Optimization of process parameters. AAPS PharmSciTech [serial online]; 4(2), Article 13. 2003, Available online at: www.aapspharmscitech.org, accessed 18 June 2007
  • Peltonen L, Aitta J, Hyvonen S, Karjalainen M, Hirvonen J. Improved entrapment efficiency of hydrophilic drug substance during nanoprecipitation of poly(l)lactide nanoparticles. AAPS. Pharm Sci Tech 5(1) 2004; 16: 1–6
  • Pérez MH, Zinnuti C, Lamprecht A, Ubrich N, Astier A, Hoffman M, Bodmeier R, Maincent P. The preparation and the evaluation of poly (ε-caprolactone) microparticles containing both a lipophilic and hydrophilic drug. J Contr Rel 2000; 65: 429–438
  • Pignatello R, Bucolo C, Ferrra P, Maltese A, Puleo A, Puglisi G. Eudrogit RS100® nanosuspansion for the ophthalmic controlled delivery of ibuprofen. Eur J Pharm Sci 2002; 16: 53–61
  • Quintanar-Guerrero D, Fessi H, Alleman E, Doelker E. Influence of stabilizing agents and preparative variables on the formation of poly(D,L-lactic acid) nanoparticles by an emulsification-diffusion technique. Int J Pharm 1996; 143: 133–141
  • Rafati H, Coombes AGA, Adler J, Holland J, Davis SS. Protein loaded poly(Dl-lactide-co-gylcolide) microparticles for oral administration: Formulation, structural and release characteristics. J Contr Rel 1997; 43: 89–102
  • Schugens C, Laruelle N, Nihant N, Grandfils C, Jérome R, Teyssié P. Effects of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by W/O/W double emulsion-evaporation. J Contr Rel 1994; 32: 161–176
  • Shin IG, Kim SY, Lee YM, Cho CS, Sung KY. Methoxy poly (ethylene glycol) ε-caprolactone amphiphilic block copolymeric micelle containing indomethacin. I. preparation and characterization. J Contr Rel 1998; 51: 1–11
  • Singh M, Briones M, Ott G, O’Hagan D. Cationic microparticles: A potent delivery systems for DNA vaccines. Proc Natl Acad Sci USA 2000; 97: 811–816
  • Sintzel MB, Bernatchez SF, Tabatabay C, Gurny R. Biomaterials in ophthalmic drug delivery. Eur J Pharm Biopharm 1996; 42: 358–374
  • Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, Levy RJ. Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Contr Rel 1997; 43: 197–212
  • Ubrich N, Bouillot P, Pellerin C, Hoffman M, Maincent P. Preparation and characterization of propranolol hydrochloride nanoparticles: A comparative study. J Contr Rel 2004; 97: 291–300
  • Walters RT, Maloney S, Slater D, Liss C, Wilson H, Hartenbaum D. Efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD compared with 0.5% levobunolol hydrochloride BID in patients with open-angle glaucoma or ocular hypertension. Clin Therapeut 1998; 20: 1170–1178
  • Yang YY, Chung TS, Bai XL, Chan WK. Effects of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion method. Chem Eng Sci 2000; 55: 2223–2236
  • Zambaux MF, Bonneaux F, Gref R, Maincent P, Dellacherie E, Alonso MJ, Labrude P, Vigneron C. Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Contr Rel 1998; 50: 31–40
  • Zidan AS, Sammour OA, Hammad MA, Megrab NA, Hussain MD, Khan MA, Habib MJ. Formulation of anastrozole microparticles as biodegradable anticancer drug carriers. AAPS PharmSciTech [serial online] 2006; 7(3), Article 61. Available online at http:/aapspharmscitech.org, accessed 2 July 2007
  • Zimmer AK, Kreuter J. Micropheres and nanoparticles used in ocular delivery systems. Adv Drug Deliv Rev 1995; 16: 61–73

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