Olive oil and oleic acid-based self nano-emulsifying formulation of omega-3-fatty acids with improved strength, stability, and therapeutics

References

• Alhakamy, N.A., et al., 2020. Formulation design and pharmacokinetic evaluation of docosahexaenoic acid containing self-nanoemulsifying drug delivery system for oral administration. Nanomaterials and nanotechnology, 10, 1847980420950988.
   Web of Science ®Google Scholar
• An, L., and Sun, W., 2017. Prenatal melamine exposure impairs spatial cognition and hippocampal synaptic plasticity by presynaptic and postsynaptic inhibition of glutamatergic transmission in adolescent offspring. Toxicology letters, 269, 55–64.
   PubMed Web of Science ®Google Scholar
• An, L., Yang, Z., and Zhang, T., 2013. Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiology of learning and memory, 100, 18–24.
   PubMed Web of Science ®Google Scholar
• Bachynsky, M., et al., 1997. Factors affecting the efficiency of a self-emulsifying oral delivery system. Drug development and industrial pharmacy, 23 (8), 809–816.
   Web of Science ®Google Scholar
• Baloch, J., et al., 2019. Self-nanoemulsifying drug delivery system (SNEDDS) for improved oral bioavailability of chlorpromazine: in vitro and in vivo evaluation. Medicina, 55 (5), 210.
   PubMed Web of Science ®Google Scholar
• Beare-Rogers, J., Dieffenbacher, A., and Holm, J., 2001. Lexicon of lipid nutrition (IUPAC Technical Report). Pure and applied chemistry, 73 (4), 685–744.
   Web of Science ®Google Scholar
• Bourre, J., Piciotti, M., and Dumont, O., 1990. Δ6 desaturase in brain and liver during development and aging. Lipids, 25 (6), 354–356.
   PubMed Web of Science ®Google Scholar
• Chu, C., et al., 2010. Distribution of melamine in rat foetuses and neonates. Toxicology letters, 199 (3), 398–402.
   PubMed Web of Science ®Google Scholar
• Cook, H., 1978. In vitro formation of polyunsaturated fatty acids by desaturation in rat brain: some properties of the enzymes in developing brain and comparisons with liver 1. Journal of neurochemistry, 30 (6), 1327–1334.
   PubMed Web of Science ®Google Scholar
• Cooper, R.E., et al., 2015. Omega-3 polyunsaturated fatty acid supplementation and cognition: A systematic review and meta-analysis. Journal of psychopharmacology, 29 (7), 753–763.
   PubMed Web of Science ®Google Scholar
• Dahan, A., and Hoffman, A., 2007. The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats. European journal of pharmaceutics and biopharmaceutics: official journal of arbeitsgemeinschaft fur pharmazeutische verfahrenstechnik e.V, 67 (1), 96–105.
   PubMed Web of Science ®Google Scholar
• Date, A.A., et al., 2010. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine, 5 (10), 1595–1616.
   PubMed Web of Science ®Google Scholar
• Fan, F.R., Tang, W., and Wang, Z.L., 2016. Flexible nanogenerators for energy harvesting and Self-Powered Electronics. Advanced materials, 28 (22), 4283–4305.
   PubMed Web of Science ®Google Scholar
• Gharibzahedi, S.M.T., and Jafari, S.M., 2017. The importance of minerals in human nutrition: Bioavailability, food fortification, processing effects and nanoencapsulation. Trends in food science & technology, 62, 119–132.
   Web of Science ®Google Scholar
• Ghelichi, S., et al., 2017. Physical and oxidative stability of fish oil-in-water emulsions fortified with enzymatic hydrolysates from common carp (Cyprinus carpio) roe. Food chemistry, 237, 1048–1057.
   PubMed Web of Science ®Google Scholar
• Green, P., and Yavin, E., 1996. Fatty acid composition of late embryonic and early postnatal rat brain. Lipids, 31 (8), 859–865.
   PubMed Web of Science ®Google Scholar
• OECD Guidelines for the Testing of Chemicals 2001. 425: Acute oral toxicity—up-and-down procedure. Available from: https://www.epa.gov/sites/production/files/2015-06/documents/e425guideline.pdf [Accessed 25 December 2020].
   Google Scholar
• Inugala, S., et al., 2015. Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: in vitro and in vivo evaluation. European journal of pharmaceutical sciences : official journal of the european federation for pharmaceutical sciences, 74, 1–10.
   PubMed Web of Science ®Google Scholar
• Jablonski, S.A., Williams, M.T., and Vorhees, C.V., 2019. Learning and memory effects of neonatal methamphetamine exposure in sprague-dawley rats: test of the role of dopamine receptors D1 in mediating the long-term effects. Developmental neuroscience, 41 (1-2), 44–55.
   PubMed Web of Science ®Google Scholar
• Jaiswal, P., and Aggarwal, G., 2013. Bioavailability enhancdement of poorly soluble drugs by smedds: a review. Journal of drug delivery and therapeutics, 3 (1),
   Google Scholar
• Kabaradjian, C., 2015. Orodispersible composition comprising polyunsaturated fatty acids without bad odor or taste. Google Patents 20100216885.
   Google Scholar
• Klinkenberg, I., and Blokland, A., 2010. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neuroscience and biobehavioral reviews, 34 (8), 1307–1350.
   PubMed Web of Science ®Google Scholar
• Kosse, J.S., et al., 2001. A rapid method for iron determination in fortified foods. Food chemistry, 75 (3), 371–376.
   Web of Science ®Google Scholar
• Kulkarni, S. K., 1987. Hand book of experimental pharmacology. Vallabh prakashan.
   Google Scholar
• Lai, W.T., et al., 2017. A review: Modified agricultural by-products for the development and fortification of food products and nutraceuticals. Trends in food science & technology, 59, 148–160.
   Web of Science ®Google Scholar
• Luchtman, D.W., and Song, C., 2013. Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from animal and clinical studies. Neuropharmacology, 64, 550–565.
   PubMed Web of Science ®Google Scholar
• Lucio, E. d. A., et al., 2000. Avaliação toxicológica aguda e screening hipocrático da epiisopilosina, alcalóide secundário de Pilocarpus microphyllus Stapf. Revista brasileira de farmacognosia, 9 (1), 23–35.
   Google Scholar
• Makrides, M., et al., 1994. Fatty acid composition of brain, retina, and erythrocytes in breast-and formula-fed infants. The american journal of clinical nutrition, 60 (2), 189–194.
   PubMed Web of Science ®Google Scholar
• Mohsin, K., Long, M.A., and Pouton, C.W., 2009. Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. Journal of pharmaceutical sciences, 98 (10), 3582–3595.
   PubMed Web of Science ®Google Scholar
• Monti, M.C., et al., 2011. New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component. Food & function, 2 (7), 423–428.
   PubMed Web of Science ®Google Scholar
• Motghare, V., et al., 2018. Chicken ileum: a better option for conducting isolated tissue experiments and bioassay. Indian journal of pharmacy and pharmacology, 4 (2), 110–113.
   Google Scholar
• Puri, R., et al., 2016. Self-nanoemulsifying drug delivery system of docosahexanoic acid: Development, in vitro, in vivo characterization. Drug development and industrial pharmacy, 42 (7), 1032–1041.
   PubMed Web of Science ®Google Scholar
• Schulman, J.H., Stoeckenius, W., and Prince, L.M., 1959. Mechanism of formation and structure of micro emulsions by electron microscopy. The journal of physical chemistry, 63 (10), 1677–1680.
   Web of Science ®Google Scholar
• Scott, B.L., and Bazan, N.G., 1989. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proceedings of the national academy of sciences, 86 (8), 2903–2907.
   PubMed Web of Science ®Google Scholar
• Simopoulos, A.P., 2011. Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. Molecular neurobiology, 44 (2), 203–215.
   PubMed Web of Science ®Google Scholar
• Sinclair, A.J., Attar‐Bashi, N.M., and Li, D., 2002. What is the role of alpha-linolenic acid for mammals? Lipids, 37 (12), 1113–1123.
   PubMed Web of Science ®Google Scholar
• Singh, H., et al., 2018. Nanoencapsulation of docosahexaenoic acid (DHA) using a combination of food grade polymeric wall materials and its application for improvement in bioavailability and oxidative stability. Food & function, 9 (4), 2213–2227.
   PubMed Web of Science ®Google Scholar
• Singh, H., et al., 2019a. Development and characterization of Solid-SNEDDS formulation of DHA using hydrophilic carrier with improved shelf life, oxidative stability and therapeutic activity. Journal of drug delivery science and technology, 54, 101326.
   Web of Science ®Google Scholar
• Singh, H., et al., 2019b. Pre-clinical and cellular toxicity evaluation of 7-methylxanthine: an investigational drug for the treatment of myopia. Drug and chemical toxicology, 1–10.doi: 10.1080/01480545.2019.1635615.
   Web of Science ®Google Scholar
• Singh, H., et al., 2020. Recent Advances in the Novel Formulation of Docosahexaenoic Acid for Effective Delivery, Associated Challenges and Its Clinical Importance. Current drug delivery, 17 (6), 483–504.
   PubMed Web of Science ®Google Scholar
• Sinn, N., and Bryan, J., 2007. Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD. Journal of developmental and behavioral pediatrics, 28 (2), 82–91.
   PubMed Web of Science ®Google Scholar
• Stuffins, C., and Weatherall, H., 1945. Determination of the peroxide value of oils and fats. The analyst, 70 (836), 403–409.
   PubMed Web of Science ®Google Scholar
• Su, H.-M., et al., 2001. Fetal baboons convert 18: 3n-3 to 22: 6n-3 in vivo: a stable isotope tracer study. Journal of lipid research, 42 (4), 581–586.
   PubMed Web of Science ®Google Scholar
• Traesel, G.K., et al., 2014. Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats. Food and chemical toxicology : an international journal published for the british industrial biological research association, 74, 320–325.
   PubMed Web of Science ®Google Scholar
• Weinhart, M., et al., 2019. 3D organ models-Revolution in pharmacological research? Pharmacological research, 139, 446–451.
   PubMed Web of Science ®Google Scholar
• Yang, J.-J., Yang, Z., and Zhang, T., 2010. Action potential changes associated with impairment of functional properties of sodium channels in hippocampal neurons induced by melamine. Toxicology letters, 198 (2), 171–176.
   PubMed Web of Science ®Google Scholar
• Yang, J., et al., 2011. Melamine impairs spatial cognition and hippocampal synaptic plasticity by presynaptic inhibition of glutamatergic transmission in infant rats. Toxicology, 289 (2-3), 167–174.
   PubMed Web of Science ®Google Scholar