In-vitro and in-vivo evaluation and anti-colitis activity of esculetin-loaded nanostructured lipid carrier decorated with DSPE-MPEG2000

References

• Arora, R., et al., 2016. Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Molecular cancer, 15 (1), 64.
   PubMed Web of Science ®Google Scholar
• Bao, R., et al., 2020. Improved oral bioavailability and target delivery of 6-shogaol via vitamin E TPGS-modified liposomes: preparation, in-vitro and in-vivo characterizations. Journal of drug delivery science and technology, 59, 101842.
   Web of Science ®Google Scholar
• Bilsborough, J., Fiorino, M.F., and Henkle, B.W., 2021. Select animal models of colitis and their value in predicting clinical efficacy of biological therapies in ulcerative colitis. Expert opinion on drug discovery, 16 (5), 567–577.
   PubMed Web of Science ®Google Scholar
• Bozzuto, G., and Molinari, A., 2015. Liposomes as nanomedical devices. International journal of nanomedicine, 10, 975–999.
   PubMed Web of Science ®Google Scholar
• Bramhall, M., et al., 2015. Quality of methods reporting in animal models of colitis. Inflammatory bowel diseases, 21 (6), 1248–1259.
   PubMed Web of Science ®Google Scholar
• Chen, W.L., et al., 2016. Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro. International journal of nanomedicine, 11, 325–336.
   PubMed Web of Science ®Google Scholar
• Duan, L.S., et al., 2021. Natural anti-inflammatory compounds as drug candidates for inflammatory bowel disease. Frontiers in pharmacology, 12, 22.
   Web of Science ®Google Scholar
• Eichele, D.D., and Kharbanda, K.K., 2017. Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis. World journal of gastroenterology, 23 (33), 6016–6029.
   PubMed Web of Science ®Google Scholar
• Feng, Y., et al., 2016. Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation. International journal of pharmaceutics, 501 (1-2), 342–349.
   PubMed Web of Science ®Google Scholar
• Fylaktakidou, K.C., et al., 2004. Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities. Current pharmaceutical design, 10 (30), 3813–3833.
   PubMed Web of Science ®Google Scholar
• Hsia, C.W., et al., 2019. Esculetin, a coumarin derivative, prevents thrombosis: inhibitory signaling on PLCgamma2-PKC-AKT activation in human platelets. International journal of molecular sciences, 20 (11), 2731–2747.
   PubMed Web of Science ®Google Scholar
• Huang, Y., Guo, J., and Gui, S., 2018. Orally targeted galactosylated chitosan poly(lactic-co-glycolic acid) nanoparticles loaded with TNF-a siRNA provide a novel strategy for the experimental treatment of ulcerative colitis. European journal of pharmaceutical sciences, 125, 232–243.
   PubMed Web of Science ®Google Scholar
• Jialing, L., et al., 2020. Changes in serum inflammatory cytokine levels and intestinal flora in a self-healing dextran sodium sulfate-induced ulcerative colitis murine model. Life sciences, 263, 118587.
   PubMed Web of Science ®Google Scholar
• Kadakol, A., et al., 2016. Esculetin: A phytochemical endeavor fortifying effect against non-communicable diseases. Biomedicine & pharmacotherapy, 84, 1442–1448.
   PubMed Web of Science ®Google Scholar
• Karatug Kacar, A., et al., 2020. Investigation of cell death mechanism and activity of esculetin-loaded PLGA nanoparticles on insulinoma cells in vitro. The journal of pharmacy and pharmacology, 72 (4), 592–606.
   PubMed Web of Science ®Google Scholar
• Kim, Y., et al., 2014. Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes. Food & function, 5 (9), 2371–2377.
   PubMed Web of Science ®Google Scholar
• Kitabatake, M., et al., 2021. Persimmon-derived tannin ameliorates the pathogenesis of ulcerative colitis in a murine model through inhibition of the inflammatory response and alteration of microbiota. Scientific reports, 11 (1), 7286.
   PubMed Web of Science ®Google Scholar
• Kwak, J.H., et al., 2021. Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats. Xenobiotica; the fate of foreign compounds in biological systems, 51 (7), 811–817.
   PubMed Web of Science ®Google Scholar
• Lee, H.C., et al., 2020. Esculetin ameliorates lipopolysaccharide-induced acute lung injury in mice via modulation of the AKT/ERK/NF-kappaB and RORgammat/IL-17 Pathways. Inflammation, 43 (3), 962–974.
   PubMed Web of Science ®Google Scholar
• Li, Y.Y., et al., 2012. Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC-ESI-MS/MS and its application in pharmacokinetic study. Journal of chromatography., 907, 27–33.
   Web of Science ®Google Scholar
• Li, X., et al., 2023. Preparation, physical characterization, pharmacokinetics and anti-hyperglycemic activity of esculetin-loaded mixed micelles. Journal of pharmaceutical sciences, 112 (1), 148–157.
   PubMed Web of Science ®Google Scholar
• Liu, J., et al., 2019. Preparation, in vitro and in vivo evaluation of isoliquiritigenin-loaded TPGS modified proliposomes. International journal of pharmaceutics, 563, 53–62.
   PubMed Web of Science ®Google Scholar
• Liu, Y., et al., 2017. Preparation, characterization and in vivo pharmacokinetic study of PVP-modified oleanolic acid liposomes. International journal of pharmaceutics, 517 (1-2), 1–7.
   PubMed Web of Science ®Google Scholar
• Low, D., Nguyen, D.D., and Mizoguchi, E., 2013. Animal models of ulcerative colitis and their application in drug research. Drug design, development and therapy, 7, 1341–1357.
   PubMed Web of Science ®Google Scholar
• Maloy, K.J., and Powrie, F., 2011. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature, 474 (7351), 298–306.
   PubMed Web of Science ®Google Scholar
• Mare, R., et al., 2018. Post-insertion parameters of PEG-derivatives in phosphocholine-liposomes. International journal of pharmaceutics, 552 (1-2), 414–421.
   PubMed Web of Science ®Google Scholar
• Man, N., et al., 2019. Improved oral bioavailability of myricitrin by liquid self-microemulsifying drug delivery systems. Journal of drug delivery science and technology, 52, 597–606.
   Web of Science ®Google Scholar
• Mastrotto, F., et al., 2020. In vitro and in vivo behavior of liposomes decorated with pegs with different chemical features. Molecular pharmaceutics, 17 (2), 472–487.
   PubMed Web of Science ®Google Scholar
• Modesto, R., et al., 2022. Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review. Journal of clinical medicine, 11 (10), 2739.
   PubMed Web of Science ®Google Scholar
• Mohammed, A.R., et al., 2004. Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability. International journal of pharmaceutics, 285 (1-2), 23–34.
   PubMed Web of Science ®Google Scholar
• Moosavian, S.A., et al., 2021. Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy. Seminars in cancer biology, 69, 337–348.
   PubMed Web of Science ®Google Scholar
• Nascimento, R.P.D., et al., 2020. Ulcerative colitis: gut microbiota, immunopathogenesis and application of natural products in animal models. Life sciences, 258, 118129.
   PubMed Web of Science ®Google Scholar
• Ozawa, K., et al., 2020. Comparison of the anti-colitis activities of Qing Dai/Indigo naturalis constituents in mice. Journal of pharmacological sciences, 142 (4), 148–156.
   PubMed Web of Science ®Google Scholar
• Perse, M., and Cerar, A., 2012. Dextran sodium sulphate colitis mouse model: traps and tricks. Journal of biomedicine & biotechnology, 2012, 718617.
   PubMedGoogle Scholar
• Porter, C.J., Trevaskis, N.L., and Charman, W.N., 2007. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nature reviews, 6 (3), 231–248.
   Web of Science ®Google Scholar
• Rehman, S.U., et al., 2015. HPLC determination of esculin and esculetin in rat plasma for pharmacokinetic studies. Journal of chromatographic science, 53 (8), 1322–1327.
   PubMed Web of Science ®Google Scholar
• Rojo, E., Casanova, M.J., and Gisbert, J.P., 2020. Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. Revista espanola de enfermedades digestivas, 112 (1), 53–58.
   PubMed Web of Science ®Google Scholar
• Rubio, V., et al., 2017. Esculetin modulates cytotoxicity induced by oxidants in NB4 human leukemia cells. Experimental and toxicologic pathology, 69 (8), 700–712.
   PubMedGoogle Scholar
• Shi, H., et al., 2020. Acid-resistant ROS-responsive hyperbranched polythioether micelles for ulcerative colitis therapy. Chinese chemical letters, 31 (12), 3102–3106.
   Web of Science ®Google Scholar
• Song, Z., et al., 2017. Cyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects. International journal of nanomedicine, 12, 1941–1958.
   PubMed Web of Science ®Google Scholar
• Uhl, P., et al., 2016. A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B. European journal of pharmaceutics and biopharmaceutics, 103, 159–166.
   PubMed Web of Science ®Google Scholar
• Ungaro, R., et al., 2017. Ulcerative colitis. Lancet, 389 (10080), 1756–1770.
   PubMed Web of Science ®Google Scholar
• Verma, A.K., et al., 2016. Vitamin B12 grafted layer-by-layer liposomes bearing hbsag facilitate oral immunization: effect of modulated biomechanical properties. Molecular pharmaceutics, 13 (7), 2531–2542.
   PubMed Web of Science ®Google Scholar
• Wang, Q., et al., 2018a. A novel formulation of [6]-gingerol: proliposomes with enhanced oral bioavailability and antitumor effect. International journal of pharmaceutics, 535 (1-2), 308–315.
   PubMed Web of Science ®Google Scholar
• Wang, Q., et al., 2018b. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles. International journal of pharmaceutics, 550 (1-2), 24–34.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2017. Enhanced solubility and bioavailability of naringenin via liposomal nanoformulation: preparation and in vitro and in vivo evaluations. AAPS PharmSciTech, 18 (3), 586–594.
   PubMed Web of Science ®Google Scholar
• Wei, Q., et al., 2018. Formulation, characterization, and pharmacokinetic studies of 6-gingerol-loaded nanostructured lipid carriers. AAPS PharmSciTech, 19 (8), 3661–3669.
   PubMed Web of Science ®Google Scholar
• Wu, Y., et al., 2011. Epirubicin-encapsulated long-circulating thermosensitive liposome improves pharmacokinetics and antitumor therapeutic efficacy in animals. Journal of liposome research, 21 (3), 221–228.
   PubMed Web of Science ®Google Scholar
• Yuan, S., et al., 2022. Traditional Chinese medicine and natural products: potential approaches for inflammatory bowel disease. Frontiers in pharmacology, 13, 23.
   Web of Science ®Google Scholar
• Yum, S., et al., 2015. HIF-prolyl hydroxylase is a potential molecular target for esculetin-mediated anti-colitic effects. Fitoterapia, 103, 55–62.
   PubMed Web of Science ®Google Scholar
• Zhang, K., et al., 2019. Enhancement of oral bioavailability and anti-hyperuricemic activity of isoliquiritigenin via self-microemulsifying drug delivery system. AAPS PharmSciTech, 20 (5), 218.
   PubMed Web of Science ®Google Scholar
• Zhang, L.L., Xie, Q.X., and Li, X.F., 2022. Esculetin: a review of its pharmacology and pharmacokinetics. Phytotherapy research, 36 (1), 279–298.
   PubMed Web of Science ®Google Scholar
• Zuo, J., et al., 2020. Design space approach in the development of esculetin nanocrystals by a small-scale wet-bead milling process. Journal of drug delivery science and technology, 55, 101486.
   Web of Science ®Google Scholar