Advanced search
Publication Cover
International Journal of Hyperthermia Volume 35, 2018 - Issue 1
Submit an article Journal homepage
1,061
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

An analysis of the survival impact of dexmedetomidine in children undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Pascal Owusu-AgyemangDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; ;Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA; Correspondence[email protected]
,
Juan P. CataDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; ;Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA;
,
Ravish KapoorDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Acsa M. ZavalaDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Uduak U. WilliamsDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Antoinette Van MeterDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; ORCID Iconhttp://orcid.org/0000-0001-7688-8155
ORCID Icon,
January Y. TsaiDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Wei H. ZhangDepartment of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
,
Lei FengDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
&
Andrea Hayes-JordanDivision of Pediatric Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA
 show all
Pages 435-440 | Received 09 Jun 2018, Accepted 25 Jul 2018, Published online: 10 Oct 2018

References

  • Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs. 2000;59:263–268.
  • Yuen VM. Dexmedetomidine: perioperative applications in children. Paediatr Anaesth. 2010;20:256–264.
  • Gorges M, West N, Deyell R, et al. Dexmedetomidine and hydromorphone: a novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children. Pediatr Blood Cancer. 2015;62:29–34.
  • Sadhasivam S, Boat A, Mahmoud M. Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children. J Clin Anesth. 2009;21:493–501.
  • Divatia JV, Ambulkar R. Anesthesia and cancer recurrence: what is the evidence?. J Anaesthesiol Clin Pharmacol. 2014;30:147–150.
  • Horowitz M, Neeman E, Sharon E, et al. Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol. 2015;12:213–226.
  • Kurosawa S. Anesthesia in patients with cancer disorders. Curr Opin Anaesthesiol. 2012;25:376–384.
  • Lavon H, Matzner P, Benbenishty A, et al. Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers. Br J Anaesth. 2018;120:188–196.
  • Bruzzone A, Pinero CP, Castillo LF, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008;155:494–504.
  • Xia M, Ji NN, Duan ML, et al. Dexmedetomidine regulate the malignancy of breast cancer cells by activating alpha2-adrenoceptor/ERK signaling pathway. Eur Rev Med Pharmacol Sci. 2016;20:3500–3506.
  • Szpunar MJ, Burke KA, Dawes RP, et al. The antidepressant desipramine and alpha2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure. Cancer Prev Res (Phila). 2013;6:1262–1272.
  • Cata JP, Singh V, Lee BM, et al. Intraoperative use of dexmedetomidine is associated with decreased overall survival after lung cancer surgery. J Anaesthesiol Clin Pharmacol. 2017;33:317–323.
  • Sugarbaker P. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of gastrointestinal cancers with peritoneal metastases: progress toward a new standard of care. Cancer Treatment Rev. 2016;48:42–49.
  • Hayes-Jordan A, Green H, Lin H, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for children, adolescents, and young adults: the first 50 cases. Ann Sur Oncol. 2015;22:1726–1732.
  • Schoenfeld D. Chi-squared goodness-of-fit tests for the proportional hazards regression model. Biometrika. 1980;67:145–153.
  • Cai QH, Tang Y, Fan SH, et al. In vivo effects of dexmedetomidine on immune function and tumor growth in rats with ovarian cancer through inhibiting the p38MAPK/NF-kappaB signaling pathway. Biomed Pharmacother. 2017;95:1830–1837.
  • Bulbul A, Fahy BN, Xiu J, et al. Desmoplastic small round blue cell tumor: a review of treatment and potential therapeutic genomic alterations. Sarcoma. 2017;2017:1278268.
  • Hettmer S, Li Z, Billin AN, et al. Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014;4:a025650.
  • Oyeniyi J, Wu J, Liu D, et al. Treatment of carcinomatosis using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in adolescents and young adults. Am J Surg. 2015;209:610–615.
  • Gerlach AT, Murphy CV, Dasta JF. An updated focused review of dexmedetomidine in adults. Ann Pharmacother. 2009;43:2064–2074.
  • Hayes-Jordan A, Green HL, Lin H, et al. Complete cytoreduction and HIPEC improves survival in desmoplastic small round cell tumor. Ann Surg Oncol. 2014;21:220–224.
  • Esquivel J, Sticca R, Sugarbaker P, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Ann Surg Oncol. 2007;14:128–133.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.