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International Journal of Hyperthermia Volume 38, 2021 - Issue 1
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Articles

ESHO benchmarks for computational modeling and optimization in hyperthermia therapy

Margarethus M. Paulidesa Electromagnetics for Care & Cure Laboratory (EM4C&C), Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;b Department of Radiotherapy, Erasmus University Medical Center Cancer Institute, Rotterdam, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5891-2139View further author information
ORCID Icon,
Dario B. Rodriguesc Hyperthermia Therapy Program, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, USAORCID Iconhttps://orcid.org/0000-0001-6805-5989View further author information
ORCID Icon,
Gennaro G. Bellizzib Department of Radiotherapy, Erasmus University Medical Center Cancer Institute, Rotterdam, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-2866-2973View further author information
ORCID Icon,
Kemal Sumserb Department of Radiotherapy, Erasmus University Medical Center Cancer Institute, Rotterdam, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-6695-2659View further author information
ORCID Icon,
Sergio Curtob Department of Radiotherapy, Erasmus University Medical Center Cancer Institute, Rotterdam, The NetherlandsView further author information
,
Esra Neufeldd Foundation for Research on Information Technologies in Society (IT’IS), Zurich, SwitzerlandView further author information
,
Hazael Montanarod Foundation for Research on Information Technologies in Society (IT’IS), Zurich, Switzerland;e Laboratory for Acoustics/Noise control, Swiss Federal Laboratories for Materials Science and Technology (EMPA), Dubendorf, SwitzerlandView further author information
,
H. Petra Kokf Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-8504-136XView further author information
ORCID Icon &
Hana Dobsicek Trefnag Biomedical Electromagnetics Group, Department of Electrical Engineering, Chalmers University of Technology, Göteborg, SwedenView further author information
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Pages 1425-1442 | Received 06 Jan 2021, Accepted 06 Sep 2021, Published online: 28 Sep 2021

References

  • Elming PB, et al. Hyperthermia: the optimal treatment to overcome radiation resistant hypoxia. Cancers. 2019;11(1):60.
  • Peeken JC, Vaupel P, Combs SE. Integrating hyperthermia into modern radiation oncology: What evidence is necessary? Front Oncol. 2017;7:132.
  • Paulides MM, Dobsicek Trefna H, Curto S, et al. Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery. Adv Drug Deliv Rev. 2020;163–164:3–18.
  • Kok HP, Cressman ENK, Ceelen W, et al. Heating technology for malignant tumors: a review. Int J Hyperthermia. 2020;37(1):711–741.
  • Oei AL, Vriend LEM, Crezee J, et al. Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiat Oncol. 2015;10(1):165.,
  • van Rhoon GC. Is CEM43 still a relevant thermal dose parameter for hyperthermia treatment monitoring? Int J Hyperthermia. 2016;32(1):50–62.
  • Rossmann C, Haemmerich D. Review of temperature dependence of thermal properties, dielectric properties, and perfusion of biological tissues at hyperthermic and ablation temperatures. Crit Rev Biomed Eng. 2014;42(6):467–492.
  • Kok HP, Kotte A, Crezee J. Planning, optimisation and evaluation of hyperthermia treatments. Int J Hyperthermia. 2017;33(6):593–607.
  • Paulides MM, Stauffer PR, Neufeld E, et al. Simulation techniques in hyperthermia treatment planning. Int J Hyperthermia. 2013;29(4):346–357.
  • Verhaart RF, Verduijn GM, Fortunati V, et al. Accurate 3D temperature dosimetry during hyperthermia therapy by combining invasive measurements and patient-specific simulations. Int J Hyperthermia. 2015;31(6):686–692.
  • Drizdal T, Paulides MM, van Holthe N, et al. Hyperthermia treatment planning guided applicator selection for Sub-superficial head and neck tumors heating. Int J Hyperthermia. 2018;34(6):704–713.
  • de Bruijne M, Wielheesen DHM, van der Zee J, et al. Benefits of superficial hyperthermia treatment planning: five case studies. Int J Hyperthermia. 2007;23(5):417–429.
  • Kok HP, Navarro F, Strigari L, et al. Locoregional hyperthermia of deep-seated tumours applied with capacitive and radiative systems: a simulation study. International Journal of Hyperthermia. 2018;34(6):714–730.
  • Kok HP, Crezee J. A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. Int J Hyperthermia. 2017;33(4):378–386.
  • Kok HP, de Greef M, van Wieringen N, et al. Comparison of two different 70 MHz applicators for large extremity lesions: simulation and application. Int J Hyperthermia. 2010;26(4):376–388.
  • Kok HP, Beck M, Löke DR, et al. Locoregional peritoneal hyperthermia to enhance the effectiveness of chemotherapy in patients with peritoneal carcinomatosis: a simulation study comparing different locoregional heating systems. Int J Hyperthermia. 2020;37(1):76–88.
  • Trujillo-Romero CJ, Paulides MM, Drizdal T, et al. Impact of silicone and metal port-a-cath implants on superficial hyperthermia treatment quality. Int J Hyperthermia. 2015;31(1):15–22.
  • Sreenivasa G, Gellermann J, Rau B, et al. Clinical use of the hyperthermia treatment planning system HyperPlan to predict effectiveness and toxicity. Int J Radiat Oncol Biol Phys. 2003;55(2):407–419.
  • Rijnen Z, Bakker JF, Canters RAM, et al. Clinical integration of software tool VEDO for adaptive and quantitative application of phased array hyperthermia in the head and neck. Int J Hyperthermia. 2013;29(3):181–193.
  • Kok HP, Korshuize-van Straten L, Bakker A, et al. Online adaptive hyperthermia treatment planning during locoregional heating to suppress treatment-limiting hot spots. Int J Radiat Oncol Biol Phys. 2017;99(4):1039–1047.
  • Kok HP, Korshuize-van Straten L, Bakker A, et al. Feasibility of on-line temperature-based hyperthermia treatment planning to improve tumour temperatures during locoregional hyperthermia. Int J Hyperthermia. 2018;34(7):1082–1091.
  • Kok HP, Wust P, Stauffer PR, et al. Current state of the art of regional hyperthermia treatment planning: a review. Radiat Oncol. 2015;10:196–114.
  • Lagendijk JJ. Hyperthermia treatment planning. Phys Med Biol. 2000;45(5):R61–76.
  • Bruggmoser G, Bauchowitz S, Canters R, et al.; European Society for Hyperthermic Oncology. Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia: quality management in regional deep hyperthermia. Strahlenther Onkol. 2012;188(Suppl 2):198–211.,
  • Franckena M, Canters R, Termorshuizen F, et al. Clinical implementation of hyperthermia treatment planning guided steering: a cross over trial to assess its current contribution to treatment quality. Int J Hyperthermia. 2010;26(2):145–157.
  • Dobšíček Trefná H, Schmidt M, van Rhoon GC, et al. Quality assurance guidelines for interstitial hyperthermia. Int J Hyperthermia. 2019;36(1):277–294.
  • Dobšíček Trefná H, Crezee J, Schmidt M, et al. Quality assurance guidelines for superficial hyperthermia clinical trials: II. Technical requirements for heating devices. Strahlenther Onkol. 2017;193(5):351–366.
  • Hasgall PA, Di Gennaro F, Baumgartner C, et al. IT’IS database for thermal and electromagnetic parameters of biological tissues (version 4.0). 2018. DOI:https://doi.org/10.13099/VIP21000-04-0. itis.swiss/database.
  • Bellizzi GG, Sumser K, VilasBoas-Ribeiro I, et al. Standardization of patient modeling in hyperthermia simulation studies: introducing the erasmus virtual patient repository. Int J Hyperthermia. 2020;37(1):608–616.
  • Paulides MM, Wielheesen DHM, Van Der Zee J, et al. Assessment of the local SAR distortion by major anatomical structures in a cylindrical neck phantom. Int J Hyperthermia. 2005;21(2):125–140.
  • Rodrigues DB, Ellsworth J, Turner P. Feasibility of heating brain tumors using a 915 MHz annular phased-array. Antennas Wirel Propag Lett. 2021;20(4):423–427.
  • Oberacker E, Kuehne A, Oezerdem C, et al. Radiofrequency applicator concepts for thermal magnetic resonance of brain tumors at 297 MHz (7.0 Tesla).Int J Hyperthermia. 2020;37(1):549–563.
  • Takook P, Persson M, Trefná HD. Performance evaluation of hyperthermia applicators to heat Deep-Seated brain tumors. IEEE J Electromagn RF Microw Med Biol. 2018;2(1):18–24.
  • Bellizzi GG, Crocco L, Battaglia GM, et al. Multi-Frequency constrained SAR focusing for patient specific hyperthermia treatment. IEEE J Electromagn RF Microw Med Biol. 2017;1(2):74–80.
  • De Greef M, Kok HP, Bel A, et al. 3D versus 2D steering in patient anatomies: a comparison using hyperthermia treatment planning. Int J Hyperthermia. 2011;27(1):74–85.
  • Canters RAM, Paulides MM, Franckena M, et al. Benefit of replacing the sigma-60 by the Sigma-Eye applicator. A monte carlo-based uncertainty analysis. Strahlenther Onkol. 2013;189(1):74–80.
  • Canters RAM, Paulides MM, Franckena MF, et al. Implementation of treatment planning in the routine clinical procedure of regional hyperthermia treatment of cervical cancer: an overview and the rotterdam experience. Int J Hyperthermia. 2012;28(6):570–581.
  • Paulides MM, Bakker JF, Neufeld E, et al. Winner of the "New Investigator Award" at the European Society of Hyperthermia Oncology Meeting 2007. The HYPERcollar: a novel applicator for hyperthermia in the head and neck. Int J Hyperthermia. 2007;23(7):567–576.
  • Paulides MM, Bakker JF, Linthorst M, et al. The clinical feasibility of deep hyperthermia treatment in the head and neck: new challenges for positioning and temperature measurement. Phys Med Biol. 2010;55(9):2465–2480.
  • Verduijn GM, de Wee EM, Rijnen Z, et al. Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma – a feasibility study. Int J Hyperthermia. 2018;34(7):994–1001.
  • Rijnen Z, Togni P, Roskam R, et al. Quality and comfort in head and neck hyperthermia: a redesign according to clinical experience and simulation studies. Int J Hyperthermia. 2015;31(8):823–830.
  • Paulides MM, Verduijn GM, Van Holthe N. Status quo and directions in deep head and neck hyperthermia. Radiat Oncol. 2016;11(1):21.
  • Bucci OM, Gennarelli C, Savarese C. Representation of electromagnetic fields over arbitrary surfaces by a finite and nonredundant number of samples. IEEE Trans Antennas Propagat. 1998;46(3):351–359.
  • Stauffer PR, et al. Using a conformal water bolus to adjust heating patterns of microwave waveguide applicators. Proceedings of SPIE, 2017. 10066(0N): p. 1–15.
  • Bakker J. Dosimetry of exposure to electromagnetic fields in daily life and medical applications. in Department of radiation oncology. Rotterdam: Erasmus MC Daniel den Hoed Cancer Center; 2012.
  • Rylander T, Ingelström P, Bondeson A. Computational electromagnetics. In: Texts in applied mathematics. 2nd ed. Vol. 51. New York: Springer-Verlag New York; 2013.
  • Berenger JP. A perfectly matched layer for the absorption of Electromagnetic-Waves. Comput Phys. 1994;114(2):185–200.
  • Bérenger J-P. Perfectly matched layer (PML) for computational electromagnetics. Synthesis Lectures on Computational Electromagnetics. 2007;2(1):1–117.
  • Weiland T, Timm M, Munteanu I. A practical guide to 3-D simulation. IEEE Microwave. 2008;9(6):62–75.
  • Joines WT, Zhang Y, Li C, et al. The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. Med Phys. 1994;21(4):547–550.
  • Pennes HH. Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol. 1948;1(2):93–122.
  • Arkin H, Xu LX, Holmes KR. Recent developments in modeling heat transfer in blood perfused tissues. IEEE Trans Biomed Eng. 1994;41(2):97–107.
  • Song CW. Effect of local hyperthermia on blood flow and microenvironment: a review. Cancer Res. 1984;44(10 Suppl):4721s–44730.
  • Guiot C, Madon E, Allegro D, et al. Perfusion and thermal field during hyperthermia. Experimental measurements and modelling in recurrent breast cancer. Phys Med Biol. 1998;43(10):2831–2843.
  • Cheng K-S, Stakhursky V, Stauffer P, et al. Online feedback focusing algorithm for hyperthermia cancer treatment. Int J Hyperthermia. 2007;23(7):539–554.
  • Drizdal T, Togni P, Vrba J, et al. Comparison of constant and temperature dependent blood perfusion in temperature prediction for superficial hyperthermia. Radioengineering. 2010;19(2):281–289.
  • Neufeld E, Paulides MM, van Rhoon GC, et al. Numerical modeling for simulation and treatment planning of thermal therapy. In: Moros EG, editor, Physics of thermal therapy: fundamentals and clinical applications. Boca Raton (FL): CRC Press; 2013. p. 119–138.
  • Van der Gaag ML, De Bruijne M, Samaras T, et al. Development of a guideline for the water bolus temperature in superficial hyperthermia. Int J Hyperthermia. 2006;22(8):637–656.
  • Nikita KS, Maratos NG, Uzunoglu NK. Optimal steady-state temperature distribution for a phased array hyperthermia system. IEEE Trans Biomed Eng. 1993;40(12):1299–1306.
  • Das SK, Clegg ST, Samulski TV. Computational techniques for fast hyperthermia temperature optimization. Med Phys. 1999;26(2):319–328.
  • Das SK, Clegg ST, Samulski TV. Electromagnetic thermal therapy power optimization for multiple source applicators. Int J Hyperthermia. 1999;15(4):291–308.
  • Bardati F, Borrani A, Gerardino A, et al. SAR optimization in a phased array radiofrequency hyperthermia system. Specific absorption rateIEEE Trans Biomed Eng. 1995;42(12):1201–1207.
  • Kok HP, Van Haaren PMA, Van de Kamer JB, et al. High-resolution temperature-based optimization for hyperthermia treatment planning. Phys Med Biol. 2005;50(13):3127–3141.
  • Wiersma J, Van Maarseveen RAM, van Dijk JDP. A flexible optimization tool for hyperthermia treatments with RF phased array systems. Int J Hyperthermia. 2002;18(2):73–85.
  • Wust P, Seebass M, Nadobny J, et al. Simulation studies promote technological development of radiofrequency phased array hyperthermia. Int J Hyperthermia. 1996;12(4):477–494.
  • Trefna HD, Vrba J, Persson M. Time-reversal focusing in microwave hyperthermia for deep-seated tumors. Phys Med Biol. 2010;55(8):2167–2185.
  • Bellizzi GG, Drizdal T, van Rhoon GC, et al. The potential of constrained SAR focusing for hyperthermia treatment planning: analysis for the head & neck region. Phys Med Biol. 2018;64(1):015013.
  • Bellizzi GG, Drizdal T, van Rhoon G, et al. Do SAR quality indicators predict temperature? A verification study in head and neck hyperthermia. In: 32nd annual meeting of the European society for hyperthermic oncology. Berlin: Strahlentherapie Und Onkologie; 2018. p. 504–505.
  • de Greef M, Kok HP, Correia D, et al. Optimization in hyperthermia treatment planning: the impact of tissue perfusion uncertainty. Med Phys. 2010;37(9):4540–4550.
  • Bellizzi GG, Drizdal T, van Rhoon GC, et al. Predictive value of SAR based quality indicators for head and neck hyperthermia treatment quality. Int J Hyperthermia. 2019;36(1):456–465.
  • Canters RAM, Wust P, Bakker JF, et al. A literature survey on indicators for characterisation and optimisation of SAR distributions in deep hyperthermia, a plea for standardisation. Int J Hyperthermia. 2009;25(7):593–608.
  • Canters RAM, Franckena M, Paulides MM, et al. Patient positioning in deep hyperthermia: influences of inaccuracies, signal correction possibilities and optimization potential. Phys Med Biol. 2009;54(12):3923–3936.
  • Canters RAM, Franckena M, van der Zee J, et al. Complaint-adaptive power density optimization as a tool for HTP-guided steering in deep hyperthermia treatment of pelvic tumors. Phys Med Biol. 2008;53(23):6799–6820.
  • Kok HP, van Haaren PMA, van de Kamer JB, et al. Prospective treatment planning to improve locoregional hyperthermia for oesophageal cancer. Int J Hyperthermia. 2006;22(5):375–389.
  • Lee HK, Antell AG, Perez CA, et al. Superficial hyperthermia and irradiation for recurrent breast carcinoma of the chest wall: prognostic factors in 196 tumors. Int J Radiat Oncol Biol Phys. 1998;40:365–375
  • Ghanouni P, Pauly KB, Elias WJ, et al. Transcranial MRI-Guided focused ultrasound: a review of the technologic and neurologic applications. AJR Am J Roentgenol. 2015;205(1):150–159.
  • Westervelt PJ. Parametric acoustic array. J Acoust Soc Am. 1963;35(4):535–537.
  • Vyas U, Christensen D. Ultrasound beam simulations in inhomogeneous tissue geometries using the hybrid angular spectrum method. IEEE Trans Ultrason Ferroelectr Freq Control. 2012;59(6):1093–1100.
  • Kane Y. Numerical solution of initial boundary value problems involving maxwell's equations in isotropic media. IEEE Trans Antennas Propag. 1966;14(3):302–307.
  • Zienkiewicz OC, Taylor RL. The finite element method. London: McGraw-Hill (UK); 1977.
  • Mast TD, Souriau LP, Liu D-LD, et al. A k-space method for large-scale models of wave propagation in tissue. IEEE Trans Ultrason, Ferroelect, Freq Contr. 2001;48(2):341–354.
  • Neufeld E, Kyriacou A, Kainz W, et al. Approach to validate Simulation-Based distribution predictions combining the Gamma-Method and uncertainty assessment: application to focused ultrasound. J Verific Valid Uncertainty Quantific. 2016;1(3):031006.
  • Montanaro H, Pasquinelli C, Lee HJ, et al. The impact of CT image parameters and skull heterogeneity modeling on the accuracy of transcranial focused ultrasound simulations. J Neural Eng. Under Revision.
  • Berjano EJ. Theoretical modeling for radiofrequency ablation: state-of-the-art and challenges for the future. Biomed Eng Online. 2006;5:24.
  • John AP. Relationship between arrhenius models of thermal damage and the CEM 43 thermal dose. Proceedings of SPIE. 2009;7181(04):1–15.
  • Pasquinelli C, Montanaro H, Lee HJ, et al. Transducer modeling for accurate acoustic simulations of transcranial focused ultrasound stimulation. J Neural Eng. 2020;17(4):046010.
  • Kyriakou A, Neufeld E, Werner B, et al. A review of numerical and experimental compensation techniques for skull-induced phase aberrations in transcranial focused ultrasound. Int J Hyperthermia. 2014;30(1):36–46.
  • Okita K, Narumi R, Azuma T, et al. Effects of breast structure on high-intensity focused ultrasound focal error. J Ther Ultrasound. 2018;6:4.
  • Sapareto SA, Dewey WC. Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys. 1984;10(6):787–800.
  • Dewhirst MW, Vujaskovic Z, Jones E, et al. Re-setting the biologic rationale for thermal therapy. Int J Hyperthermia. 2005;21(8):779–790.
  • Stoll AM, Greene LC. Relationship between pain and tissue damage due to thermal radiation. J Appl Physiol. 1959;14(3):373–382.
  • Lee HK, Antell AG, Perez CA, et al. Superficial hyperthermia and irradiation for recurrent breast carcinoma of the chest wall: prognostic factors in 196 tumors. Inter J Rad Oncol Biol Phys. 1998;40(2):365–375.
  • Myerson RJ, Perez CA, Emami B, et al. Tumor control in long-term survivors following superficial hyperthermia. Int J Radiat Oncol Biol Phys. 1990;18(5):1123–1129.
  • Wust P, Rau B, Gellerman J, et al. Radiochemotherapy and hyperthermia in the treatment of rectal cancer. Recent Results Cancer Res. 1998;146:175–191.
  • Oleson JR, Samulski TV, Leopold KA, et al. Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment. Int J Radiat Oncol Biol Phys. 1993;25(2):289–297.,
  • Seebass M, Beck R, Gellermann J, et al. Electromagnetic phased arrays for regional hyperthermia: optimal frequency and antenna arrangement. Int J Hyperthermia. 2001;17(4):321–336.
  • Cheng K-S, Stakhursky V, Craciunescu OI, et al. Fast temperature optimization of multi-source hyperthermia applicators with reduced-order modeling of 'virtual sources'. Phys Med Biol. 2008;53(6):1619–1635.
  • Kok HP, van den Berg CAT, Bel A, et al. Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. Med Phys. 2013;40(10):103303.
  • Aklan B, Zilles B, Paprottka P, et al. Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma. Int J Hyperthermia. 2019;36(1):170–185.
  • Kok HP, Ciampa S, de Kroon-Oldenhof R, et al. Toward on-line adaptive hyperthermia treatment planning: correlation between measured and simulated specific absorption rate changes caused by phase steering in patients. Inter J Rad Oncol Biol Phys. 2014;90(2):438–445.
  • Van de Kamer JB, Van Wieringen N, De Leeuw AA, et al. The significance of accurate dielectric tissue data for hyperthermia treatment planning. Int J Hyperthermia. 2001;17(2):123–142.
  • de Greef M, Kok HP, Correia D, et al. Uncertainty in hyperthermia treatment planning: the need for robust system design. Phys Med Biol. 2011;56(11):3233–3250.
  • Kok HP, Schooneveldt G, Bakker A, et al. Predictive value of simulated SAR and temperature for changes in measured temperature after phase-amplitude steering during locoregional hyperthermia treatments. Int J Hyperthermia. 2018;35(1):330–339.
  • Sumser K, Neufeld E, Verhaart RF, et al. Feasibility and relevance of discrete vasculature modeling in routine hyperthermia treatment planning. Int J Hyperthermia. 2019;36(1):801–811.
  • Van den Berg CAT, Van de Kamer JB, De Leeuw AAC, et al. Towards patient specific thermal modelling of the prostate. Phys Med Biol. 2006;51(4):809–825.
  • Mitchell JW, Myers GE. An analytical model of the counter-current heat exchange phenomena. Biophys J. 1968;8(8):897–911.
  • Lagendijk JJW. The influence of bloodflow in large vessels on the temperature distribution in hyperthermia. Phys Med Biol. 1982;27(1):17–23.
  • Kolios MC, Sherar MD, Hunt JW. Large blood vessel cooling in heated tissues: a numerical study. Phys Med Biol. 1995;40(4):477–494.
  • Zhu L, Xu LX, He Q, et al. A new fundamental bioheat equation for muscle tissue-part II: Temperature of SAV vessels. J Biomech Eng. 2002;124(1):121–132.
  • Kotte A, van Leeuwen G, de Bree J, et al. A description of discrete vessel segments in thermal modelling of tissues. Phys Med Biol. 1996;41(5):865–884.
  • Shrivastava D, Vaughan JT. A generic bioheat transfer thermal model for a perfused tissue. J Biomech Eng. 2009;131(7):074506.
  • Gavazzi S, van Lier ALHMW, Zachiu C, et al. Advanced patient-specific hyperthermia treatment planning. Int J Hyperthermia. 2020;37(1):992–1007.
  • Dudar TE, Jain RK. Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res. 1984;44(2):605–612.
  • Waterman FM, Tupchong L, Nerlinger RE, et al. Blood flow in human tumors during local hyperthermia. Int J Radiat Oncol Biol Phys. 1991;20(6):1255–1262.
  • Fiala D, Havenith G, Bröde P, et al. UTCI-Fiala multi-node model of human heat transfer and temperature regulation. Int J Biometeorol. 2012;56(3):429–441.
  • Food and Drug Administration. Reporting of computational modeling studies in medical device Submissions - Guidance for industry and FDA staff. Food and Drug Administration. 2016. p. 1–45.
  • American Society of Mechanical Engineers. V&V40 assessing credibility of computational modeling through verification and validation: application to medical devices. ASME. 2018. p. 1–60.
  • Paulides MM, Bakker JF, Hofstetter LW, et al. Laboratory prototype for experimental validation of MR-guided radiofrequency head and neck hyperthermia. Phys Med Biol. 2014;59(9):2139–2154.
  • Farina L, Sumser K, van Rhoon G, et al. Thermal characterization of phantoms used for quality assurance of deep hyperthermia systems. Sensors. 2020;20(16):4549.
  • Mobashsher AT, Abbosh AM. Artificial human phantoms: Human proxy in testing microwave apparatuses that have electromagnetic interaction with the human body. IEEE Microwave. 2015;16(6):42–62.
  • Trefná HD, Crezee H, Schmidt M, et al. Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. Int J Hyperthermia. 2017;33(4):471–482.
  • Kainz W, Neufeld E, Bolch WE, et al. Advances in computational human phantoms and their applications in biomedical Engineering - A Topical Review. IEEE Trans Radiat Plasma Med Sci. 2019;3(1):1–23.

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