Identifying mediating variables with graphical models: an application to the study of causal pathways in people living with HIV

References

• A. Agresti, Categorical Data Analysis, John Wiley & Sons, New York, 1990.
   Google Scholar
• I. Al-Dakkak, S. Patel, E. McCann, A. Gadkari, G. Prajapati, and E.M. Maiese, The impact of specific HIV treatment-related adverse events on adherence to antiretroviral therapy: A systematic review and meta-analysis, AIDS Care 25 (2012), pp. 400–414. doi: 10.1080/09540121.2012.712667
   PubMed Web of Science ®Google Scholar
• B.C. Arnold and S.J. Press, Compatible conditional distributions, J. Am. Stat. Assoc. 84 (1989), pp. 152–156. doi: 10.1080/01621459.1989.10478750
   Web of Science ®Google Scholar
• R.M. Baron and D.A. Kenny, The moderator mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations, J. Pers. Soc. Psychol. 51 (1986), pp. 1173–1182. doi: 10.1037/0022-3514.51.6.1173
   PubMed Web of Science ®Google Scholar
• J. Barroso, B.G. Hammill, J. Leserman, N. Salahuddin, J.L. Harmon and B.W. Pence, Physiological and psychosocial factors that predict HIV-related fatigue, AIDS Behav. 14 (2010), pp. 1415–1427. doi: 10.1007/s10461-010-9691-2
   PubMed Web of Science ®Google Scholar
• J. Barroso and J. Voss, Fatigue in HIV and AIDS: An analysis of evidence, J. Assoc. Nurses AIDS Care 24 (2013), pp. S5–S14. doi: 10.1016/j.jana.2012.07.003
   PubMed Web of Science ®Google Scholar
• K. Benamar, S. Addou, M. Yondorf, E.B. Geller, T.K. Eisenstein, and M.W. Adler, Intrahypothalamic injection of the HIV-1 envelope glycoprotein induces fever via interaction with the chemokine system, J. Pharmacol. Exp. Ther. 332 (2010), pp. 549–553. doi: 10.1124/jpet.109.160309
   PubMed Web of Science ®Google Scholar
• Y.M.M. Bishop, S.E. Fienberg, and P.W. Holland, Discrete Multivariate Analysis: Theory and Practice, MIT Press, Cambridge, MA, 1975.
   Google Scholar
• A. Buseh, S.T. Kelber, P.E. Stevens, and C.G. Park, Relationship of symptoms, perceived health, and stigma with quality of life among urban HIV-infected African American men, Public Health Nurs. 25 (2008), pp. 409–419. doi: 10.1111/j.1525-1446.2008.00725.x
   PubMed Web of Science ®Google Scholar
• W.T. Chen, S.Y. Lee, C.S. Shiu, J.M. Simoni, C. Pan, M. Bao, and H. Lu, Fatigue and sleep disturbance in HIV-positive women: A qualitative and biomedical approach, J. Clin. Nurs. 22 (2012), pp. 1262–1269. doi: 10.1111/jocn.12012
   PubMed Web of Science ®Google Scholar
• P.F. Cook, K.H. Sousa, E.E. Matthews, P.M. Meek, and J. Kwong, Patterns of change in symptom clusters with HIV disease progression, J. Pain. Symptom Manage. 42 (2011), pp. 12–23. doi: 10.1016/j.jpainsymman.2010.09.021
   PubMed Web of Science ®Google Scholar
• M. daCosta DiBonaventura, S. Gupta, M. Cho, and J. Mrus, The association of HIV/AIDS treatment side effects with health status, work productivity, and resource use, AIDS Care 24 (2012), pp. 744–755. doi: 10.1080/09540121.2011.630363
   PubMed Web of Science ®Google Scholar
• M.C. Dalakas, Toxic and drug-induced myopathies, J. Neurol. Neurosurg. Psychiatry 80 (2009), pp. 832–838. doi: 10.1136/jnnp.2008.168294
   PubMed Web of Science ®Google Scholar
• P. Dellaportas and J.J. Forster, Markov chain Monte Carlo model determination for hierarchical and graphical log-linear models, Biometrika 86 (1999), pp. 615–633. doi: 10.1093/biomet/86.3.615
   Web of Science ®Google Scholar
• P. Dellaportas and C. Tarantola, Model determination for categorical data with factor level merging, J. R. Stat. Soc.: Ser. B (Stat. Methodol.) 67 (2005), pp. 269–283. doi: 10.1111/j.1467-9868.2005.00501.x
   Web of Science ®Google Scholar
• A. Dobra and A. Lenkoski, Copula Gaussian graphical models and their application to modeling functional disability data, Ann. Appl. Stat. 5 (2011), pp. 969–993. doi: 10.1214/10-AOAS397
   Web of Science ®Google Scholar
• A. Dobra and H. Massam, The mode oriented stochastic search (MOSS) algorithm for log-linear models with conjugate priors, Stat. Methodol. 7 (2010), pp. 240–253. doi: 10.1016/j.stamet.2009.04.002
   Google Scholar
• A. Dobra and A. Mohammadi, Loglinear model selection and human mobility, Ann. Appl. Stat. 12 (2018), pp. 815–845. doi: 10.1214/18-AOAS1164
   Web of Science ®Google Scholar
• M. Duracinsky, S. Herrmann, B. Berzins, A. Armstrong, R. Kohli, S.L. Coeur, A. Diouf, I. Fournier, M. Schechter, and O. Chassany, The development of PROQOL-HIV: An international instrument to assess the health-related quality of life of persons living with HIV/AIDS, J. Acquir. Immune Defic. Syndr. 59 (2012), pp. 498–505. doi: 10.1097/QAI.0b013e318245cafe
   PubMed Web of Science ®Google Scholar
• D.E. Edwards and T. Havranek, A fast procedure for model search in multidimensional contingency tables, Biometrika 72 (1985), pp. 339–351. doi: 10.1093/biomet/72.2.339
   Web of Science ®Google Scholar
• L. Estanislao, D. Thomas, and D. Simpson, HIV neuromuscular disease and mitochondrial function, Mitochondrion 4 (2004), pp. 131–139. doi: 10.1016/j.mito.2004.06.007
   PubMed Web of Science ®Google Scholar
• S.E. Fienberg, The analysis of multidimensional contingency tables, Ecology 51 (1970), pp. 419–433. doi: 10.2307/1935377
   Web of Science ®Google Scholar
• J. Finsterer and S.Z. Mahjoub, Fatigue in healthy and diseased individuals, Am. J. Hospice Palliat. Med. 31 (2014), pp. 562–575. doi: 10.1177/1049909113494748
   PubMed Web of Science ®Google Scholar
• M.S. Fritz and D.P. MacKinnon, A graphical representation of the mediated effect, Behav. Res. Methods 40 (2008), pp. 55–60. doi: 10.3758/BRM.40.1.55
   PubMed Web of Science ®Google Scholar
• M. Hidalgo, A. Camozzato, L. Cardoso, C. Preussler, C. Nunes, R. Tavares, M. Posser, and M. Chaves, Evaluation of behavioral states among morning and evening active healthy individuals, Braz. J. Med. Biol. Res. 35 (2002), pp. 837–842. doi: 10.1590/S0100-879X2002000700012
   PubMed Web of Science ®Google Scholar
• S. Hojsgaard, D. Edwards, and S. Lauritzen, Graphical Models with R, Springer-Verlag, New York, 2012.
   Google Scholar
• K. Imai, L. Keele, and D. Tingley, A general approach to causal mediation analysis, Psychol. Methods 15 (2010), pp. 309–334. doi: 10.1037/a0020761
   PubMed Web of Science ®Google Scholar
• K. Imai, D. Tingley, and T. Yamamoto, Experimental designs for identifying causal mechanisms, J. R. Stat. Soc. Ser. A 176 (2013), pp. 5–51. doi: 10.1111/j.1467-985X.2012.01032.x
   Web of Science ®Google Scholar
• L.A. Jason and M. Choi, Dimensions and assessment of fatigue, in Fatigue Science for Human Health, Y. Yatanabe, B. Evengard, B.H. Natelson, L.A. Jason, and H. Kuratsune, eds., Springer, Tokyo, 2008, pp. 1–16.
   Google Scholar
• L.A. Jason, M. Evans, M. Brown, and N. Porter, What is fatigue? Pathological and nonpathological fatigue, PM R 2 (2010), pp. 327–331. doi: 10.1016/j.pmrj.2010.03.028
   PubMedGoogle Scholar
• P. Jenkin, T. Koch, and D. Kralik, The experience of fatigue for adults living with HIV, J. Clin. Nurs. 15 (2006), pp. 1123–1131. doi: 10.1111/j.1365-2702.2006.01343.x
   PubMed Web of Science ®Google Scholar
• E. Jong, L. Oudhoff, C. Epskamp, M. Wagener, M. van Duijn, S. Fischer, and E. van Gorp, Predictors and treatment strategies of HIV-related fatigue in the combined antiretroviral therapy era, AIDS 24 (2010), pp. 1387–1405. doi: 10.1097/QAD.0b013e328339d004
   PubMed Web of Science ®Google Scholar
• M.I. Jordan, Graphical models, Stat. Sci. 19 (2004), pp. 140–155. doi: 10.1214/088342304000000026
   Web of Science ®Google Scholar
• R.E. Keyser, Peripheral fatigue: High-energy phosphates and hydrogen ions, PM R 2 (2010), pp. 347–358. doi: 10.1016/j.pmrj.2010.04.009
   PubMedGoogle Scholar
• D. Koller and N. Friedman, Probabilistic Graphical Models: Principles and Techniques, Adaptive Computation and Machine Learning Series, The MIT Press, 2009.
   Google Scholar
• S. Lauritzen, Graphical Models, Clarendon Press, Oxford, 1996.
   Google Scholar
• V.M. Leavitt and J. DeLuca, Central fatigue: Issues related to cognition, mood and behavior, and psychiatric diagnoses, PM R 2 (2010), pp. 332–337. doi: 10.1016/j.pmrj.2010.03.027
   PubMedGoogle Scholar
• J. Leserman, J. Barroso, B.W. Pence, N. Salahuddin, and J.L. Harmon, Trauma, stressful life events and depression predict HIV-related fatigue, AIDS Care 20 (2008), pp. 1258–1265. doi: 10.1080/09540120801919410
   PubMed Web of Science ®Google Scholar
• D.P. MacKinnon, A.J. Fairchild, and M.S. Fritz, Mediation analysis, Annu. Rev. Psychol. 58 (2007), pp. 593–614. doi: 10.1146/annurev.psych.58.110405.085542
   PubMed Web of Science ®Google Scholar
• D. Madigan and A. Raftery, Model selection and accounting for model uncertainty in graphical models using Occam's window, J. Am. Stat. Assoc. 89 (1994), pp. 1535–1546. doi: 10.1080/01621459.1994.10476894
   Web of Science ®Google Scholar
• D. Madigan and J. York, Bayesian graphical models for discrete data, Int. Stat. Rev. 63 (1995), pp. 215–232. doi: 10.2307/1403615
   Web of Science ®Google Scholar
• D. Madigan and J. York, Bayesian methods for estimation of the size of a closed population, Biometrika 84 (1997), pp. 19–31. doi: 10.1093/biomet/84.1.19
   Web of Science ®Google Scholar
• V.C. Marconi, B. Wu, J. Hampton, C.E. Ordóñez, B.A. Johnson, D. Singh, S. John, M. Gordon, A. Hare, R. Murphy, J. Nachega, D.R. Kuritzkes, C. del Rio, H. Sunpath, and South Africa Resistance Cohort Study Team Group Authors, Early warning indicators for first-line virologic failure independent of adherence measures in a South African urban clinic, AIDS Patient Care STDs 27 (2013), pp. 657–668. doi: 10.1089/apc.2013.0263
   PubMed Web of Science ®Google Scholar
• S. Nixon, K. O'Brien, R. Glazier, and A.M. Tynan, Aerobic Exercise Interventions for Adults Living with HIV/AIDS, Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd., 2005.
   Google Scholar
• N.F. Önen, A. Önen, E. Shacham, K.E. Stamm, A.R. Onen, and E.T. Overton, Frailty among HIV-infected persons in an urban outpatient care setting, J. Infect. 59 (2009), pp. 346–352. doi: 10.1016/j.jinf.2009.08.008
   PubMed Web of Science ®Google Scholar
• J. Pearl, Causality: Models, Reasoning, and Inference, Cambridge University Press, New York, 2000.
   Google Scholar
• B.W. Pence, J. Barroso, J.L. Harmon, J. Leserman, N. Salahuddin, and B.G. Hammill, Chronicity and remission of fatigue in patients with established HIV infection, AIDS Patient Care STDs 23 (2009), pp. 239–244. doi: 10.1089/apc.2008.0175
   PubMed Web of Science ®Google Scholar
• S.K. Powers, Exercise Physiology Theory and Application to Performance, 6th ed., McGraw Hill, Boston, MA, 2007.
   Google Scholar
• R Core Team, R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, 2018. Available at https://www.R-project.org/.
   Google Scholar
• N. Salahuddin, J. Barroso, J. Leserman, J.L. Harmon, and B.W. Pence, Daytime sleepiness, nighttime sleep quality, stressful life events, and HIV-related fatigue, J. Assoc. Nurses AIDS Care 20 (2009), pp. 6–13. doi: 10.1016/j.jana.2008.05.007
   PubMed Web of Science ®Google Scholar
• Y. Sliep, M. Poggenpoel, and A. Gmeiner, The experience of HIV reactive patients in rural Malawi – Part I, Curationis 24 (2001), pp. 56–65.
   PubMedGoogle Scholar
• C. Tarantola, MCMC model determination for discrete graphical models, Stat. Model. 4 (2004), pp. 39–61. doi: 10.1191/1471082X04st063oa
   Web of Science ®Google Scholar
• A.S. Terzian, S. Holman, N. Nathwani, E. Robison, K. Weber, M. Young, R.M. Greenblatt, S.J. Gange, and Women's Interagency HIV Study, Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART, J. Womens Health 18 (2009), pp. 1965–1974. doi: 10.1089/jwh.2008.1090
   PubMed Web of Science ®Google Scholar
• D. Tingley, T. Yamamoto, K. Hirose, L. Keele, and K. Imai, Mediation: R package for causal mediation analysis, J. Stat. Softw. 59 (2014), pp. 1–38. doi: 10.18637/jss.v059.i05
   PubMed Web of Science ®Google Scholar
• J.G. Voss, C.J. Portillo, W.L. Holzemer, and M.J. Dodd, Symptom cluster of fatigue and depression in HIV/AIDS, J. Prev. Interv. Community 33 (2007), pp. 19–34. doi: 10.1300/J005v33n01_03
   PubMedGoogle Scholar
• D.J. Wantland, J.P. Mullan, W.L. Holzemer, C.J. Portillo, S. Bakken, and E.M. McGhee, Additive effects of numbness and muscle aches on fatigue occurrence in individuals with HIV/AIDS who are taking antiretroviral therapy, J. Pain Symptom Manage. 41 (2011), pp. 469–477. doi: 10.1016/j.jpainsymman.2010.05.011
   PubMed Web of Science ®Google Scholar
• D.J. Wantland, W.L. Holzemer, S. Moezzi, S.S. Willard, J. Arudo, K.M. Kirksey, C.J. Portillo, I.B. Corless, M.E. Rosa, L.L. Robinson, P.K. Nicholas, M.J. Hamilton, E.F. Sefcik, S. Human, M.M. Rivero, M. Maryland, and E. Huang, A randomized controlled trial testing the efficacy of an HIV/AIDS symptom management manual, J. Pain Symptom Manage. 36 (2008), pp. 235–246. doi: 10.1016/j.jpainsymman.2007.10.011
   PubMed Web of Science ®Google Scholar
• J. Whittaker, Graphical Models in Applied Multivariate Statistics, John Wiley & Sons, 1990.
   Google Scholar
• S. Willard, W.L. Holzemer, D.J. Wantland, Y.P. Cuca, K.M. Kirksey, C.J. Portillo, I.B. Corless, M. Rivero-Méndez, M.E. Rosa, P.K. Nicholas, M.J. Hamilton, E. Sefcik, J. Kemppainen, G. Canaval, L. Robinson, S. Moezzi, S. Human, J. Arudo, L.S. Eller, E. Bunch, P.J. Dole, C. Coleman, K. Nokes, N.R. Reynolds, Y.F. Tsai, M. Maryland, J. Voss, and T. Lindgren, Does ‘asymptomatic’ mean without symptoms for those living with HIV infection? AIDS Care 21 (2009), pp. 322–328. doi: 10.1080/09540120802183511
   PubMed Web of Science ®Google Scholar
• X. Zhao, J.G. Lynch, and Q. Chen, Reconsidering Baron and Kenny: Myths and truths about mediation analysis, J. Consum. Res. 37 (2010), pp. 197–206. doi: 10.1086/651257
   Web of Science ®Google Scholar