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Review Articles

Alzheimer’s disease and chronic traumatic encephalopathy: Distinct but possibly overlapping disease entities

, , , &
Pages 1279-1292 | Received 03 Jan 2016, Accepted 20 May 2016, Published online: 11 Aug 2016

References

  • Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, et al. National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers & Dementia 2012;8:1–13.
  • Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, et al. National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathologica 2012;123:1–11.
  • Gavett BE, Cantu RC, Shenton M, Lin AP, Nowinski CJ, McKee AC, Stern RA. Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions. Current Opinion in Neurology 2011;24:525–531.
  • McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. Journal of Neuropathology & Experimental Neurology 2009;68:709–735.
  • Tartaglia MC, Hazrati LN, Davis KD, Green RE, Wennberg R, Mikulis D, Ezerins LJ, Keightley M, Tator C. Chronic traumatic encephalopathy and other neurodegenerative proteinopathies. Frontiers in Human Neuroscience 2014;8:30.
  • Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathologica 2006;112:389–404.
  • Seifan A, Marder KS, Mez J, Noble JM, Cortes EP, Vonsattel JP, Honig LS. Hippocampal Laminar Distribution of Tau Relates to Alzheimer’s Disease and Age of Onset. Journal of Alzheimers Disease 2014;43:315–324.
  • Gavett BE, Stern RA, McKee AC. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clinical Sports Medicine 2011;30:179–188, xi.
  • McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers & Dementia 2014;10(Suppl 3):S242–253.
  • Bailes JE, Petraglia AL, Omalu BI, Nauman E, Talavage T. Role of subconcussion in repetitive mild traumatic brain injury. Journal of Neurosurgery 2013;119:1235–1245.
  • Dashnaw ML, Petraglia AL, Bailes JE. An overview of the basic science of concussion and subconcussion: where we are and where we are going. Neurosurgical Focus 2012;33:1–9.
  • Faul M, Xu L, Wald MM, Coronado VG. Trauamtic brain injury in the United States: emergency department visits, hospitalizations and deaths 2002–2006. Services UDoHaH 2010;60:1–32.
  • Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. Journal of Head Trauma Rehabilitation 2006;21:375–378.
  • Small GW, Kepe V, Siddarth P, Ercoli LM, Merrill DA, Donoghue N, Bookheimer SY, Martinez J, Omalu B, Bailes J, et al. PET scanning of brain tau in retired national football league players: preliminary findings. American Journal of Geriatric Psychiatry 2013;21:138–144.
  • Martland HS. Punch drunk. Journal of the American Medical Association 1928;91:1103–1107.
  • Corsellis JA, Bruton CJ, Freeman-Browne D. The aftermath of boxing. Psychological Medicine 1973;3:270–303.
  • Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 2005;57:128–134; discussion 128–134.
  • Omalu BI, DeKosky ST, Hamilton RL, Minster RL, Kamboh MI, Shakir AM, Wecht CH. Chronic traumatic encephalopathy in a national football league player: part II. Neurosurgery 2006;59:1086–1092; discussion 1092–1093.
  • McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. Journal of Neuropathology & Experimental Neurology 2010;69:918–929.
  • Omalu BI, Fitzsimmons RP, Hammers J, Bailes J. Chronic traumatic encephalopathy in a professional American wrestler. Journal of Forensic Nursing 2010;6:130–136.
  • Omalu B, Hammers JL, Bailes J, Hamilton RL, Kamboh MI, Webster G, Fitzsimmons RP. Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide. Neurosurgical Focus 2011;31:E3.
  • Omalu B, Bailes J, Hamilton RL, Kamboh MI, Hammers J, Case M, Fitzsimmons R. Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes. Neurosurgery 2011;69:173–183; discussion 183.
  • McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013;136:43–64.
  • McKee AC, Daneshvar DH, Alvarez VE, Stein TD. The neuropathology of sport. Acta Neuropathologica 2014;127:29–51.
  • Shively S, Scher AI, Perl DP, Diaz-Arrastia R. Dementia resulting from traumatic brain injury: what is the pathology? Archives of Neurology 2012;69:1245–1251.
  • Turner RC, Lucke-Wold BP, Robson MJ, Omalu BI, Petraglia AL, Bailes JE. Repetitive traumatic brain injury and development of chronic traumatic encephalopathy: a potential role for biomarkers in diagnosis, prognosis, and treatment? Frontiers in Neurology 2012;3:186.
  • Villemagne VL, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Hodges J, Harada R, Yates P, Piguet O, Pejoska S, Dore V, et al. In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease. European Journal of Nuclear Medicine & Molecular Imaging 2014;41:816–826.
  • Villemagne VL, Okamura N. In vivo tau imaging: obstacles and progress. Alzheimers Dement 2014;10(Suppl 3):S254–264.
  • Baugh CM, Robbins CA, Stern RA, McKee AC. Current understanding of chronic traumatic encephalopathy. Current Treatment Options in Neurology 2014;16:306.
  • Banks SJ, Mayer B, Obuchowski N, Shin W, Lowe M, Phillips M, Modic M, Bernick C. Impulsiveness in professional fighters. Journal of Neuropsychiatry & Clinical Neuroscience 2014;26:44–50.
  • Randolph C. Is chronic traumatic encephalopathy a real disease? Current Sports Medicine Reports 2014;13:33–37.
  • Wortzel HS, Shura RD, Brenner LA. Chronic traumatic encephalopathy and suicide: a systematic review. Biomed Research International 2013;2013:424280.
  • Love S, Solomon GS. Talking with parents of high school football players about chronic traumatic encephalopathy: a concise summary. American Journal of Sports Medicine 2014;43:1260–1264.
  • Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, et al. The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy. Journal of Neurotrauma 2014;31:1211–1224.
  • Mez J, Stern RA, McKee AC. Chronic traumatic encephalopathy: where are we and where are we going? Current Neurology & Neuroscince Report 2013;13:407.
  • Stein TD, Alvarez VE, McKee AC. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimers Research & Therapy 2014;6:4.
  • Bazarian JJ, Zhu T, Zhong J, Janigro D, Rozen E, Roberts A, Javien H, Merchant-Borna K, Abar B, Blackman EG. Persistent, long-term cerebral white matter changes after sports-related repetitive head impacts. PLoS One 2014;9:e94734.
  • Ling H, Kara E, Revesz T, Lees AJ, Plant GT, Martino D, Houlden H, Hardy J, Holton JL. Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer. Acta Neuropathologica Communications 2014;2:24.
  • Pedersen HA, Ferraro FR, Himle M, Schultz C, Poolman M. Neuropsychological factors related to college ice hockey concussions. American Journal of Alzheimers Disease & Other Dementias 2014;29:201–204.
  • Chauhan NB. Chronic neurodegenerative consequences of traumatic brain injury. Restorative Neurology & Neuroscience 2014;32:337–365.
  • Lehman EJ. Epidemiology of neurodegeneration in American-style professional football players. Alzheimers Research & Therapy 2013;5:34.
  • Nowinski C. Hit parade: the future of the sports concussion crisis. Cerebrum 2013;2013:2.
  • Rosenfeld JV, McFarlane AC, Bragge P, Armonda RA, Grimes JB, Ling GS. Blast-related traumatic brain injury. Lancet Neurology 2013;12:882–893.
  • Bernick C, Banks S. What boxing tells us about repetitive head trauma and the brain. Alzheimers Research & Therapy 2013;5:23.
  • Levin B, Bhardwaj A. Chronic traumatic encephalopathy: a critical appraisal. Neurocritical Care 2014;20:334–344.
  • Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, et al. Clinical presentation of chronic traumatic encephalopathy. Neurology 2013;81:1122–1129.
  • DeKosky ST, Blennow K, Ikonomovic MD, Gandy S. Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers. Nature Reviews Neurology 2013;9:192–200.
  • Lakis N, Corona RJ, Toshkezi G, Chin LS. Chronic traumatic encephalopathy - neuropathology in athletes and war veterans. Neurological Research 2013;35:290–299.
  • Jordan BD. The clinical spectrum of sport-related traumatic brain injury. Nature Reviews Neurology 2013;9:222–230.
  • Seichepine DR, Stamm JM, Daneshvar DH, Riley DO, Baugh CM, Gavett BE, Tripodis Y, Martin B, Chaisson C, McKee AC, et al. Profile of self-reported problems with executive functioning in college and professional football players. Journal of Neurotrauma 2013;30):1299–1304.
  • Broglio SP, Eckner JT, Paulson HL, Kutcher JS. Cognitive decline and aging: the role of concussive and subconcussive impacts. Exercise & Sport Sciences Reviews 2012;40:138–144.
  • Sayed N, Culver C, Dams-O’Connor K, Hammond F, Diaz-Arrastia R. Clinical phenotype of dementia after traumatic brain injury. Journal of Neurotrauma 2013;30):1117–1122.
  • Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of early pathological tau conformations and phosphorylation in chronic traumatic encephalopathy. Journal of Neuropathology & Experimental Neurology 2015;75:19–34.
  • Turner RC, Naser ZJ, Logsdon AF, DiPasquale KH, Jackson GJ, Robson MJ, Gettens RT, Matsumoto RR, Huber JD, Rosen CL. Modeling clinically relevant blast parameters based on scaling principles produces functional & histological deficits in rats. Experimental Neurology 2013;248:520–529.
  • Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Science Translational Medicine 2012;4: 134ra60.
  • Omalu B. Chronic traumatic encephalopathy. Progress in Neurological Surgery 2014;28:38–49.
  • Mouzon BC, Bachmeier C, Ferro A, Ojo JO, Crynen G, Acker CM, Davies P, Mullan M, Stewart W, Crawford F. Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model. Annals of Neurology 2014;75:241–254.
  • Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T. Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury. Frontiers in Neurology 2014;5:12.
  • Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, DeWitt DS, Kayed R. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. Journal of Biological Chemistyr 2013;288:17042–17050.
  • Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Cantu RC, Randolph C, Jordan BD. Association between recurrent concussion and late–life cognitive impairment in retired professional football players. Neurosurgery 2005;57:719–726; discussion 719–726.
  • Barnes DE, Kaup A, Kirby KA, Byers AL, Diaz-Arrastia R, Yaffe K. Traumatic brain injury and risk of dementia in older veterans. Neurology 2014;83:312–319.
  • Lee YK, Hou SW, Lee CC, Hsu CY, Huang YS, Su YC. Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study. PLoS One 2013;8:e62422.
  • Schofield PW, Tang M, Marder K, Bell K, Dooneief G, Chun M, Sano M, Stern Y, Mayeux R. Alzheimer’s disease after remote head injury: an incidence study. Journal of Neurology, Neurosurgery & Psychiatry 1997;62:119–124.
  • Wang HK, Lin SH, Sung PS, Wu MH, Hung KW, Wang LC, Huang CY, Lu K, Chen HJ, Tsai KJ. Population based study on patients with traumatic brain injury suggests increased risk of dementia. Journal of Neurology, Neurosurgery & Psychiatry 2012;83:1080–1085.
  • Nemetz PN, Leibson C, Naessens JM, Beard M, Kokmen E, Annegers JF, Kurland LT. Traumatic brain injury and time to onset of Alzheimer’s disease: a population-based study. American Journal of Epidemiology 1999;149:32–40.
  • Tran HT, LaFerla FM, Holtzman DM, Brody DL. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and independently accelerates the development of tau abnormalities. Journal of Neuroscience 2011;31:9513–9525.
  • Tran HT, Sanchez L, Brody DL. Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice. Journal of Neuropathology & Experimental Neurology 2012;71:116–129.
  • Tillement JP, Papadopoulos V. Subcellular injuries in Alzheimer’s disease. CNS & Neurological Disorders - Drug Targets 2014;13:593–605.
  • Kohler C, Dinekov M, Gotz J. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Abeta amyloidosis. Neurobiology of Disease 2014;71C:169–179.
  • Montague K, Malik B, Gray AL, La Spada AR, Hanna MG, Szabadkai G, Greensmith L. Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy. Brain 2014;137:1894–1906.
  • Itoh T, Satou T, Nishida S, Tsubaki M, Hashimoto S, Ito H. Expression of amyloid precursor protein after rat traumatic brain injury. Neurological Research 2009;31:103–109.
  • Johnson VE, Stewart W, Smith DH. Traumatic brain injury and amyloid-beta pathology: a link to Alzheimer’s disease? Nature Reviews Neuroscience 2010;11:361–370.
  • Mills JD, Bailes JE, Turner RC, Dodson SC, Sakai J, Maroon JC. Anabolic steroids and head injury. Neurosurgery 2012;70:205–209; discussion 209–210.
  • Placido AI, Pereira CM, Duarte AI, Candeias E, Correia SC, Santos RX, Carvalho C, Cardoso S, Oliveira CR, Moreira PI. The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer’s disease. Biochimica Biophysica Acta 2014;1842:1444–1453.
  • Lin L, Yang SS, Chu J, Wang L, Ning LN, Zhang T, Jiang Q, Tian Q, Wang JZ. Region-Specific expression of tau, amyloid-beta protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. Journal of Alzheimers Disease 2014;41:1149–1163.
  • Blaylock RL, Maroon J. Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unifying hypothesis. Surgical Neurology International 2011;2:107.
  • Lucke-Wold BP, Turner RC, Logsdon AF, Bailes JE, Huber JD, Rosen CL. Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development. Journal of Neurotrauma 2014;31:1129–1138.
  • Fan Y, Li J, Zhang YQ, Jiang LH, Zhang YN, Yan CQ. Protein kinase C delta mediated cytotoxicity of 6-Hydroxydopamine via sustained extracellular signal-regulated kinase 1/2 activation in PC12 cells. Neurological Research 2014;36:53–64.
  • Lu X, Li Y, Wang W, Chen S, Liu T, Jia D, Quan X, Sun D, Chang AK, Gao B. 3 beta-hydroxysteroid-Delta 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress. PLoS One 2014;9:e86753.
  • Song J, Park KA, Lee WT, Lee JE. Apoptosis Signal Regulating Kinase 1 (ASK1): potential as a therapeutic target for alzheimer’s disease. International Journal of Molecular Sciences 2014;15:2119–2129.
  • Flight MH. Neurodegenerative diseases: new kinase targets for Alzheimer’s disease. Nature Reviews Drug Discovery 2013;12:739.
  • Reinhardt S, Schuck F, Grosgen S, Riemenschneider M, Hartmann T, Postina R, Grimm M, Endres K. Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer’s disease. FASEB Journal 2014;28:978–997.
  • Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, Perez-Otano I, et al. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease. Journal of Clinical Investigation 2013;123:2523–2538.
  • Zohar O, Lavy R, Zi X, Nelson TJ, Hongpaisan J, Pick CG, Alkon DL. PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiology of Disease 2011;41:329–337.
  • Liu XA, Song J, Jiang Q, Wang Q, Tian Q, Wang JZ. Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response. Apoptosis 2012;17:1039–1049.
  • Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. ER stress in Alzheimer’s disease: a novel neuronal trigger for inflammation and Alzheimer’s pathology. Journal of Neuroinflammation 2009;6:41.
  • Rubovitch V, Shachar A, Werner H, Pick CG. Does IGF-1 administration after a mild traumatic brain injury in mice activate the adaptive arm of ER stress? Neurochemistry International 2011;58:443–46.
  • De Felice FG, Ferreira ST. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 2014;63:2262–2272.
  • Bros H, Millward JM, Paul F, Niesner R, Infante-Duarte C. Oxidative damage to mitochondria at the nodes of Ranvier precedes axon degeneration in ex vivo transected axons. Experimental Neurology 2014;261C:127–135.
  • Saman S, Lee NC, Inoyo I, Jin J, Li Z, Doyle T, McKee AC, Hall GF. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer’s disease. Journal of Alzheimers Disease 2014;40(Suppl 1):S47–70.
  • Khatri N, Man HY. Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases. Frontiers in Neurology 2013;4:199.
  • Naviaux RK. Metabolic features of the cell danger response. Mitochondrion 2014;16:7–17.
  • Schreiner B, Hedskog L, Wiehager B, Ankarcrona M. Amyloid-beta peptides are generated in mitochondria-associated endoplasmic reticulum membranes. Journal of Alzheimers Disease 2014;43:369–374.
  • Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR, Halliwell B. The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease. Free Radical Biology & Medicine 2014;71:390–401.
  • Rachel W, Grela A, Zyss T, Zieba A, Piekoszewski W. [Biomarkers of Alzheimer disease]. Przeglad Lekarski 2014;71:98–101.
  • Hroudova J, Singh N, Fisar Z. Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer’s disease. Biomedical Research International 2014;2014:175062.
  • Coon KD, Valla J, Szelinger S, Schneider LE, Niedzielko TL, Brown KM, Pearson JV, Halperin R, Dunckley T, Papassotiropoulos A, et al. Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing. Mitochondrion 2006;6:194–210.
  • Avila-Munoz E, Arias C. When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer’s disease. Ageing Research Reviews 2014;18C:29–40.
  • Diamandis T, Gonzales-Portillo C, Gonzales-Portillo GS, Staples M, Borlongan MC, Hernandez D, Acosta S, Borlongan CV. Diabetes insipidus contributes to traumatic brain injury pathology via CD36 neuroinflammation. Medical Hypotheses 2013;81:936–939.
  • Fenn AM, Skendelas JP, Moussa DN, Muccigrosso MM, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. Journal of Neurotrauma 2014;32(2):127–138.
  • Sharp DJ, Scott G, Leech R. Network dysfunction after traumatic brain injury. Nature Reviews Neurology 2014;10:156–166.
  • Loane DJ, Kumar A, Stoica BA, Cabatbat R, Faden AI. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. Journal of Neuropathology & Experimental Neurology 2014;73:14–29.
  • Dela Pena I, Sanberg PR, Acosta S, Tajiri N, Lin SZ, Borlongan CV. Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor. Journal of Neurosurgical Sciences 2014;58:145–149.
  • Li Y, Chavko M, Slack JL, Liu B, McCarron RM, Ross JD, Dalle Lucca JJ. Protective effects of decay-accelerating factor on blast-induced neurotrauma in rats. Acta Neuropathologica Communications 2013;1:52.
  • Luo T, Wu J, Kabadi SV, Sabirzhanov B, Guanciale K, Hanscom M, Faden J, Cardiff K, Bengson CJ, Faden AI. Propofol limits microglial activation after experimental brain trauma through inhibition of nicotinamide adenine dinucleotide phosphate oxidase. Anesthesiology 2013;119:1370–1388.
  • Shultz SR, Bao F, Weaver LC, Cain DP, Brown A. Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion. Journal of Neuroinflammation 2013;10:26.
  • Ansari MA, Roberts KN, Scheff SW. A time course of contusion-induced oxidative stress and synaptic proteins in cortex in a rat model of TBI. Journal of Neurotrauma 2008;25:513–526.
  • Huang Y, Huang X. [Course of acute oxidative damage after traumatic brain injury: problem and strategy]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2014;39:195–198.
  • Wang F, Franco R, Skotak M, Hu G, Chandra N. Mechanical stretch exacerbates the cell death in SH-SY5Y cells exposed to paraquat: mitochondrial dysfunction and oxidative stress. Neurotoxicology 2014;41:54–63.
  • Mazzeo AT, Beat A, Singh A, Bullock MR. The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI. Experimental Neurology 2009;218:363–370.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Mizuguchi N, Hashimoto S, Ito A, Satou T. Increased apoptotic neuronal cell death and cognitive impairment at early phase after traumatic brain injury in aged rats. Brain Structure & Function 2013;218:209–220.
  • Ansari MA, Roberts KN, Scheff SW. Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radical Biology & Medicine 2008;45:443–452.
  • Kochanek PM, Dixon CE, Shellington DK, Shin SS, Bayir H, Jackson EK, Kagan VE, Yan HQ, Swauger PV, Parks SA, et al. Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats. Journal of Neurotrauma 2013;30:920–937.
  • Smith JA, Park S, Krause JS, Banik NL. Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochemistry International 2013;62:764–775.
  • Sivanandam TM, Thakur MK. Traumatic brain injury: a risk factor for Alzheimer’s disease. Neuroscience & Biobehavioral Reviews 2012;36:1376–1381.
  • Potts MB, Rola R, Claus CP, Ferriero DM, Fike JR, Noble-Haeusslein LJ. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. Journal of Neuroscience Research 2009;87:1848–1857.
  • Wang JW, Wang HD, Cong ZX, Zhou XM, Xu JG, Jia Y, Ding Y. Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. Journal of Surgical Research 2014;186:328–337.

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