577
Views
22
CrossRef citations to date
0
Altmetric
Clinical Research

PTSD confounds detection of compromised cerebral white matter integrity in military veterans reporting a history of mild traumatic brain injury

, , , , &
Pages 1491-1500 | Received 26 Feb 2016, Accepted 07 Jul 2016, Published online: 11 Nov 2016

References

  • Taber KH, Warden DL, Hurley RA. Blast-related traumatic brain injury: what is known? Journal of Neuropsychiatry and Clinical Neurosciences 2006;18:141–145.
  • Warden DL, French L. Traumatic brain injury in the war zone. The New England Journal of Medicine 2005;353:633–634.
  • Warden D. Military TBI during the Iraq and Afghanistan wars. Journal of Head Trauma Rehabilitation 2006;21:398–402.
  • Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA, Xydakis MS, Robbins AS, Grant GA. Mild traumatic brain injury in US soldiers returning from Iraq. New England Journal of Medicine 2008;358:453–463.
  • Terrio H, Brenner LA, Ivins BJ, Cho JM, Helmick K, Schwab K, Seally K, Bretthauer R, Warden D. Traumatic brain injury screening: Preliminary findings in a US army Brigade Combat Team. Journal of Head Trauma Rehabilitation 2009;24:14–23.
  • Wilk JE, Thomas JL, McGurk DM, Riviere LA, Castro CA, Hoge CW. Mild traumatic brain injury (concussion) during combat: lack of association of blast mechanism with persistent postconcussive symptoms. Journal of Head Trauma Rehabilitation 2010;25:9–14.
  • Cernak I, Noble-Haeusslein LJ. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. Journal of Cerebral Blood Flow & Metabolism 2010;30:255–266.
  • Belanger HG, Vanderploeg RD, Soble JR, Richardson M, Groer S. Validity of the Veterans Health Administration’s Traumatic Brain Injury Screen. Archives of Physical Medicine and Rehabilitation 2012;93:1234–1239.
  • Bryant R, Harvey AG. Relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. American Journal of Psychiatry 1998;155:625–629.
  • Nelson NW, Anderson CR, Thuras P, Kehle-Forbes SM, Arbisi PA, Erbes CR, Polusny MA. Factors associated with inconsistency in self-reported mild traumatic brain injury over time among military personnel in Iraq. British Journal of Psychiatry 2015 206: 237–244:1–8.
  • Lew HL, Vanderploeg RD, Moore DF, Schwab K, Friedman L, Yesavage J, Keane TM, Warden DL, Sigford BJ. Overlap of mild TBI and mental health conditions in returning OIF/OEF service members and veterans. Journal of Rehabilitation Research and Development 2008;45(3):xi–xvi.
  • Mittl RL, Grossman RI, Hiehle JF, Hurst RW, Kauder DR, Gennarelli TA, Alburger GW. Prevalence of MR evidence of diffuse axonal injury in patients with mild head injury and normal head CT findings. AJNR. American Journal of Neuroradiology 1994;15:1583–1589.
  • Shenton ME, Hamoda HM, Schneiderman JS, Bouix S, Pasternak O, Rathi Y, Vu MA, Purohit MP, Helmer K, Koerte I, Lin P, Westin CF, Kikinis R, Kubicki M, Stern R, Zafonte R. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging and Behavior 2012;6:137–192.
  • Niogi SN, Mukherjee P. Diffusion tensor imaging of mild traumatic brain injury. Journal of Head Trauma Rehabilitation 2010;25:241–255.
  • Chong CD, Schwedt TJ. White matter damage and brain network alterations in concussed patients: A review of recent diffusion tensor imaging and resting-state functional connectivity data. Current Pain and Headache Reports 2015;19:12.
  • Hulkower MB, Poliak DB, Rosenbaum SB, Zimmerman ME, Lipton ML. A decade of DTI in traumatic brain injury: 10 years and 100 articles later. AJNR American Journal of Neuroradiology 2013;34:2064–2074.
  • Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomedicine 2002;15:435–455.
  • Basser PJ, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. Journal of Magnetic Resonanace Series B 1996;111:209–219.
  • Aoki Y, Inokuchi R, Gunshin M, Yahagi N, Suwa H. Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis. Journal of Neurology, Neurosurgery & Psychiatry 2012;83:870–876.
  • Levin HS, Wilde E, Troyanskaya M, Petersen NJ, Scheibel R, Newsome M, Radaideh M, Wu T, Yallampalli R, Chu Z, Li X. Diffusion tensor imaging of mild-to-moderate blast-related traumatic brain injury and its sequelae. Journal of Neurotrauma 2010;27:683–694.
  • Sponheim SR, Mcguire KA, Kang SS, Davenport ND, Aviyente S, Bernat EM, Lim KO. Evidence of disrupted functional connectivity in the brain after combat-related blast injury. Neuroimage 2011;54:S21–S29.
  • Bazarian JJ, Donnelly K, Peterson DR, Warner GC, Zhu T, Zhong J. The relation between posttraumatic stress disorder and mild traumatic brain injury acquired during Operations Enduring Freedom and Iraqi Freedom. Journal of Head Trauma Rehabilitation 2013;28:1–12.
  • Hayes JP, Miller DR, Lafleche G, Salat DH, Verfaellie M. The nature of white matter abnormalities in blast-related mild traumatic brain injury. NeuroImage: Clinical 2015;8:148–156.
  • Miller DR, Hayes JP, Lafleche G, Salat DH, Verfaellie M. White matter abnormalities are associated with chronic postconcussion symptoms in blast-related mild traumatic brain injury. Human Brain Mapping 2016;37:220–229.
  • Sorg SF, Delano-Wood L, Luc N, Schiehser DM, Hanson KL, Nation DA, Lanni E, Jak AJ, Lu K, Meloy MJ, Frank LR, Lohr JB, Bondi MW. White matter integrity in Veterans with mild traumatic brain injury: Associations with executive function and loss of consciousness. Journal of Head Trauma Rehabilitation 2014;29:21–32.
  • MacDonald CL, Johnson AM, Cooper D, Nelson EC, Werner NJ, Shimony JS, Snyder AZ, Raichle ME, Witherow JR, Fang R, Flaherty SF, Brody DL. Detection of blast-related traumatic brain injury in U.S. military personnel. New England Journal of Medicine 2011;364:2091–2100.
  • Yeh P-H, Wang B, Oakes TR, French LM, Pan H, Graner J, Liu W, Riedy G. Postconcussional disorder and PTSD symptoms of military-related traumatic brain injury associated with compromised neurocircuitry. Human Brain Mapping 2014;35:2652–2673.
  • Jorge RE, Acion L, White T, Tordesillas-Gutierrez D, Pierson R, Crespo-Facorro B, Magnotta VA. White matter abnormalities in veterans with mild traumatic brain injury. The American Journal of Psychiatry 2012;169:1284–1291.
  • Davenport ND, Lim KO, Armstrong MT, Sponheim SR. Diffuse and spatially variable white matter disruptions are associated with blast-related mild traumatic brain injury. NeuroImage 2012;59:2017–2024.
  • Watts R, Thomas A, Filippi CG, Nickerson JP, Freeman K. Potholes and molehills: bias in the diagnostic performance of diffusion-tensor imaging in concussion. Radiology 2014;272:217–223.
  • Mayer AR, Bedrick EJ, Ling JM, Toulouse T, Dodd A. Methods for identifying subject-specific abnormalities in neuroimaging data. Human Brain Mapping 2014;35:5457–5470.
  • Morey RA, Haswell CC, Selgrade ES, Massoglia D, Liu C, Weiner J, Marx CE, Cernak I, McCarthy G. Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans. Human Brain Mapping 2013;34:2986–2999.
  • Davenport ND, Lim KO, Sponheim SR. White matter abnormalities associated with military PTSD in the context of blast TBI. Human Brain Mapping 2015;36:1053–1064.
  • Chen Y, Huang W. Non-impact, blast-induced mild TBI and PTSD: Concepts and caveats. Brain Injury 2011;25:641–650.
  • Moore DF, Jaffee MS. Military traumatic brain injury and blast. NeuroRehabilitation 2010;26:179–181.
  • Moore DF, Jérusalem A, Nyein M, Noels L, Jaffee MS, Radovitzky RA. Computational biology—modeling of primary blast effects on the central nervous system. NeuroImage 2009;47(Suppl 2):T10–T20.
  • Cernak I, Merkle AC, Koliatsos VE, Bilik JM, Luong QT, Mahota TM, Xu L, Slack N, Windle D, Ahmed FA. The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice. Neurobiology of Disease 2011;41:538–551.
  • Belanger HG, Proctor-Weber Z, Kretzmer T, Kim M, French LM, Vanderploeg RD. Symptom complaints following reports of blast versus non-blast mild TBI: does mechanism of injury matter? The Clinical Neuropsychologist 2011;25:702–715.
  • Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM. The development of a clinician-administered PTSD scale. Journal of Trauma Stress 1995;8:75–90.
  • First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York, NY: Biometrics Research, New York State Psychiatric Institute; 2002.
  • Nelson NW, Hoelzle JB, McGuire KA, Ferrier-Auerbach AG, Charlesworth MJ, Sponheim SR. Neuropsychological evaluation of blast-related concussion: Illustrating the challenges and complexities through OEF/OIF case studies. Brain Injury 2011;25:511–525.
  • Andersson JLR, Skare S, Ashburner J. How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. NeuroImage 2003;20:870–888.
  • Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23(Suppl 1):S208–S219.
  • Behrens TEJ, Woolrich MW, Jenkinson M, Johansen-berg H, Nunes RG, Clare S, Matthews PM, Brady JM, Smith SM. Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magnetic Resonance Medicine 2003;50:1077–1088.
  • Assemlal H-E, Tschumperle D, Brun L. Fiber tracking on HARDI data using robust ODF fields. In: 2007 IEEE International Conference on Image Processing. Vol. 3. Piscataway (NJ): IEEE Signal Processing Society; 2007. p. III-133–III-136.
  • Zhang H, Avants BB, Yushkevich PA, Woo JH, Wang S, McCluskey LF, Elman LB, Melhem ER, Gee JC. High-dimensional spatial normalization of diffusion tensor images improves the detection of white matter differences: An example study using amyotrophic lateral sclerosis. IEEE Transactions on Medical Imaging 2007;26:1585–1597.
  • Andersson JLR, Jenkinson M, Smith S. Non-linear registration, aka Spatial normalization: FMRIB technical report TR07JA2. 2007 [cited 28 June 2007]. Available from www.fmrib.ox.ac.uk/analysis/techrep.
  • Davenport ND, Lim KO, Sponheim SR. Personality and neuroimaging measures differentiate PTSD from mTBI in veterans. Brain Imaging and Behavior 2015;9:472–483.
  • Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological) 1995;57:289–300.
  • Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002;15:870–878.
  • Belanger HG, Vanderploeg RD, Sayer N. Screening for remote history of mild traumatic brain injury in VHA. Journal of Head Trauma Rehabilitation 2016;31(3):204–214.
  • Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Erlbaum; 1988.
  • Miles J, Shevlin M. Applying regression and correlation: A guide for students and researchers. London, UK: SAGE Publications Ltd; 2001.
  • Wessely S, Unwin C, Hotopf M, Hull L, Ismail K, Nicolaou V, David A. Stability of recall of military hazards over time - Evidence from the Persian Gulf War of 1991. British Journal of Psychiatry 2003;183:314–322.
  • David A-C, Akerib V, Gaston L, Brunet A. Consistency of retrospective reports of peritraumatic responses and their relation to PTSD diagnostic status. Journal of Traumatic Stress 2010;23:599–605.
  • Engelhard IM, van den Hout MA, McNally RJ. Memory consistency for traumatic events in Dutch soldiers deployed to Iraq. Memory 2008;16:3–9.
  • Robinson ME, Lindemer ER, Fonda JR, Milberg WP, McGlinchey RE, Salat DH. Close-range blast exposure is associated with altered functional connectivity in Veterans independent of concussion symptoms at time of exposure. Human Brain Mapping 2015;36:911–922.
  • Belanger H, Kretzmer T, Yoash-Gantz R, Pickett T, Tupler L. Cognitive sequelae of blast-related versus other mechanisms of brain trauma. Journal of the International Neuropsychology Society 2009;15:1–8.
  • Luethcke CA, Bryan CJ, Morrow CE, Isler WC. Comparison of concussive symptoms, cognitive performance, and psychological symptoms between acute blast- versus nonblast-induced mild traumatic brain injury. Journal of the International Neuropsychological Society JINS 2011;17:36–45.
  • MacDonald CL, Johnson AM, Wierzechowski L, Kassner E, Stewart T, Nelson EC, Werner NJ, Zonies D, Oh J, Fang R, Brody DL. Prospectively assessed clinical outcomes in concussive blast vs nonblast traumatic brain injury among evacuated US military personnel. JAMA Neurology 2014;71:994–1002.
  • Petrie EC, Cross DJ, Yarnykh VL, Richards T, Martin NM, Pagulayan K, Hoff D, Hart K, Mayer C, Tarabochia M, et al. Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans. Journal of Neurotrauma 2014;31:425–436.
  • Verfaellie M, Lafleche G, Spiro A, Bousquet K. Neuropsychological outcomes in OEF/OIF veterans with self-report of blast exposure: associations with mental health, but not MTBI. Neuropsychology 2014;28:337–346.
  • Matthews SC, Strigo IA, Simmons AN, O’Connell RM, Reinhardt LE, Moseley SA. A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion. NeuroImage 2011;54:S69–S75.
  • Bryan CJ, Hernandez AM. Predictors of post-traumatic headache severity among deployed military personnel. Headache 2011;51:945–953.
  • Eskridge SL, Macera CA, Galarneau MR, Holbrook TL, Woodruff SI, Macgregor AJ, Morton DJ, Shaffer RA. Influence of combat blast-related mild traumatic brain injury acute symptoms on mental health and service discharge outcomes. Journal of Neurotrauma 2013;30:1391–1397.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.